만성신부전증에서 혈청 CEA치에 관한 연구

이정상,신영태,정순일,고창순,김성권,표희정,권인순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1979년 3월부터 1980년 10월까지 서울대학교병원내과에 입원하여 만성신부전증으로 진단받고 혈액투석요법을 받지 않은 환자 15예, 혈액투석요법을 시행중인 환자 39예 및 신장이식술을 받고 신장능이 호전된 환자 23예에서 혈청 CEA치를 방사면역측정법으로 측정하여 정상대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 정상 성인 65명의 혈청 CEA치의 범위는 1.0∼4.3 ng/ml이었으며 평균은 1.6±0.66 ng이었다. 2) 혈액투석요법을 시행치 않은 만성신부전증 환자 15예의 혈청 CEA치는 0.3∼8.3 ng/ml이었고 평균은 3.6±2.10 ng/ml로써 정상대조군에 비하여 유의하게 증가되어 있었다(p$lt;0.001). 3) 혈액투석요법으로 치료중인 만성신부전증 환자 39예의 혈청 CEA치는 0.7∼6.7 ng/ml로 평균이 3.0±1.52 ng/ml이며, 정상대조군에 비하여 유의하게 상승되어 있으나(p$lt;0.001), 혈액투석을 받지 않은 환자군과는 유의한 차이가 없었다. 4) 신이식 환자 23예의 혈청 CEA치의 분포는 1.8∼10.8 ng/ml이고 평균은 3.8±1.96 ng/ml로 역시 정상대조군에 비하여 유의하게 증가되어 있으나(p$lt;0.001), 만성신부전증 환자군과는 유의한 차이가 없었다. 5) 이상의 혈청 CEA치가 정상범위 이상으로 상승된 49명��환자중 이학적 소견이나 검사소견상 악성종양은 발견되지 않았다. The serum CEA levels were measured by radioimmunoassay technique in 15 patients with chronic renal failure, who were not treated with hemodialysis, in 39 patients under hemodialysis and in 23 patients who received renal transplantation. The results were compared with those in 65 normal adults and the following results were obtained. 1) Serum CEA concentrations in 65 normal adults were in the range of 1.0 to 4.3 ng/ml with a mean value of 1.6±0.66 ng/ml. 2) Serum CEA concentrations in 15 chronic renal failure patients who were not treated with hemodialysis, were in the range of 0.3 to 8.3 ng/ml with a mean value of 3.6±2.10 ng/m1 which was significantly higher than those of normal controls(P$lt;0.001). 3) Serum CEA concentrations in 39 chronic renal failure patients under hemodialysis were also much higher than normal controls(p$lt;0.001), but not significantly different from those of the patients who were not under hemodialysis(P$gt;0.05). 4) In 23 patients who received renal transplantation, serum CEA levels were snificantly higher than normal controls(P$lt;0.001), but not significantly different from those of chronic renal failure patients.

Gentamicin 투여에 따른 혈중 및 요중 β2-Microglobulin 동태에 관한 연구

이정상,신영태,정순일,이문호,김병국,김승택,최경원 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자는 1980년 3월부터 7월까지 서울대학교병원 내과에 입원하여 게타마이신을 투여받았던 각종 감염증환자 10예를 대상으로 겐타마이신의 혈중농도, 혈청크레아티닌, 혈중 및 24시간 요 베타-2-마이크로글로불린을 측정하여 다음과 같은 결론을 얻었다. 1) 겐타마이신의 혈중농도는 최고농도(peak level)는 4.5∼8.2μg/ml, Trough치는 0.2∼2.1μg/ml를 유지하여 안전치료 영역내에 있었다. 2) 혈청 크레아티닌(creatinine)치는 겐타마이신 투여기간중 대상 전원에서 통계학적으로 유의한 증가를 보이지 않았다. 3) 혈중 베타-2-마이크로글로블린치는 겐타마이신 투여기간중 대상 전원에서 통계학적으로 유의한 증감을 보이지 않았다. 4) 24시간 요 베타-2-마이크로 글로블린은 겐타마이신 투여후 전예에서 통계학적으로 유의한 증가를 보여 제 5일에 기저치보다 평균 5.8±1.62배 증가하였으며, 그 이후로는 감소하는 경향을 보였다. 이상의 결과를 종합하면 24시간 요 베타-2-마이크로글로블린 측정은 겐타마이신의 초기 신독성을 예민하게 반영한다는 사실을 알 수 있었으며, 이의 임상적 신독성과의 관계는 앞으로 추시가 필요하다고 생각된다. Gentamicin is useful to the Gram negative bacterial infection, but its nephrotoxicity is a serious problem and the incidence is probably increasing. The toxicity of gcntamicin to the kidney is site-specific to the proximal tubule. In this study, we measured daily peak and trough level of gentamicin, serum creatinine, serum Beta2-microglobulin and 24-hr urine Beta2-microglolbulin in 10 gentamicin treated patients. All the patients had their peak levels of gentamicin in the safe therapeutic range, and their trough level showed no evidence of gentamicin accumulation. There was no patient who showed his daily serum creatinine and Beta2-microglobulin rise significantly. But 24-hour urine Beta2-microglobulin showed significant rise from basal level(mean 5.8±1.62×) on the 5 th day of gentamicin treatment. Thus, serial monitoring of proximal tubular function with urinary Beta2-microglobulin excretion has potential value in the assessment of insults of gentamicin to this site. But clinical significance of raised uriry Beta2-microglobulin excretion in relation to the serum creatinine should be further studied.

HWE 방법에 의한 CdSe 박막 성장과 광전기적 특성

신영진,홍광준,이상열,유상하,서상석,문종대,김택성,정태수,신용진,이관교,김혜숙,정준우,정경아 한국센서학회 1997 센서학회지 Vol.6 No.4

The CdSe thin films were grown on the Si(100) wafers by a hot wall epitaxy method (HWE). The source and substrate temperature are 600� and 430 respectively. The crystalline structure of epilayers was investigated by double crystal X-ray diffraction(DCXD). Hall effect on the sample was measured by the van der Pauw method and studied on the carrier density and mobility dependence on temperature. From Hall data, the mobility was increased in the temperature range 30K to 150K by impurity scattering and decreased in the temperature range 150K to 293K by the lattice scattering. In order to explore the applicability as a photoconductive cell, we measured the sensitivity(γ), the ratio of photocurrent to darkcurrent(pc/dc), maximum allowable power dissipation(MAPD), spectral response and response time. The results indicated that the photoconductive characteristic were the best for the samples annealed in Cu vapor compare with in Cd, Se, air and vacuum vapour. Then we obtained the sensitivity of 0.99, the value of pc/dc of 1.39 X 10^7, the MAPD of 335mW, and the rise and decay time of l0ms and 9.5ms, respectively

Chemical Bath Deposition 방법으로 제작한 CdSe 박마의 특성

신영진,홍광준,이상열,유상하,서상석,문종대,신현길,김택성,송정훈,유기수,정태수 한국센서학회 1993 센서학회지 Vol.2 No.1

Polycrystalline CdSe thin films were grown on ceramic substrate using a chemical bath deposition (CBD) method. They were annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometer in order to study CdSe polycrystal structure. Using extrapolation method of X-ray diffraction patterns for the CdSe samples annealed in N₂ gas at 450℃ it was found hexagonal structure whose lattice parameters a_o and c_o were 4.302 A and 7.014 A, respectively. Its grain size was about 0.3 ㎛. Hall effect on this sample was measured by Van der Pauw method and studied on carrier density and mobility depending on temperature. From Hall data, the mobility was likely to be decreased by piezo electric scattering at temperature range of 33 K and 200 K, and by polar optical scattering at temperature range of 200 K and 293 K. We measured also spectral response, sensitivity (γ), maximum allowable power dissipation and response time on these samples.

광전도체의 CdS 단결정 성장과 물리적 특성

신영진,신현길,김택성,유기수,정태수,유평열,정철훈,이훈,신영신,홍관준 한국센서학회 1993 센서학회지 Vol.2 No.1

A CdS single crystal was grown by using sublimation method. Lattice constants, a_o and c_o, obtained by using extrapolation were 4.1318 Å and 6.7122 Å, respectively. The carrier density was ∼10^(23) m^(-3) and the mobility was 2.93X10^(-2) ㎡/V-sec from measured Hall data at room temperature. The mobility has a increasing tendency in proportion to T^½ from 33 K to 150 K and a decreasing tendency in proportion to T^(-2) from 180 K to room temperature. The short wavelength band peak measured from photocurrent was due to intrinsic transition, and the energy value of this peak was equal to the energy band gap of CdS photoconductor.

운동후 측복통과 함께 발생한 급성 신부전 1 예

김종순,박영주,조종태,이정임,신민호,구천희,박태용,한승수,강진화 대한내과학회 1996 대한내과학회지 Vol.50 No.6

We report a case of acute renal failure with severe loin pain and patchy renal vasoconstriction after exercise. An immediate postcontrast computed tomogram of this case shows multiple patchy areas of poor contrast enhancement in the cortex of the both kidneys. A 24-hours delayed scan without further injection of contrast dye shows multiple wedge-shaped contrast enhancement in the coincident areas of poor enhancement in the immediate scan. The 2 and 5 days delayed scans show that wedge-shaped contrast enhancement becomes disappeared gradually to the renal cortex, and the 8 days delayed scan shows complete disappearance of contrast enhancement. The renal scintigrams with technetium-99m-methylene diphosphonate and dimercaptosuccinic acid show diffuse increased uptakes and multiple patchy photon deficient areas in the both kidneys respectively. The follow-up renal scintigrams show nearly normal findings, This patient had an uneventful hospital course and recovered completely without dialysis.

급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

CBD 방법에 의한 CdS1-xSex 박마의 열처리에 따른 광전기적 특성

문종대,정태수,신현길,김택성,신영진,홍광준,유상하,서상석,최승평,이상열,신용진,이관교,김혜숙,윤은희,김승욱,전승룡 한국센서학회 1995 센서학회지 Vol.4 No.1

Polycrystalline CdS_(1-x)Se_x, thin films were grown on ceramic substrate using a chemical bath deposition method. They ere annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometer in order to study CdS_(1-x)Se_x, polycrystal structure using extrapolation method of X-ray diffraction patterns for the CdS. CdSe samples annealed in gas at a 0 it was found hexagonal structure which had the lattice constant a_0=-4.1364Å, c_0=6.7129Å in CdS and a_0=4.3021Å, c_0=7.3021Å in CdSe. respectively. Hall effect on these samples was measured by Van der Pauw method and then studied on carrier density and mobility depending on temperature. We measured also spectral response, sensitivity(γ), maximum allowable power dissipation and response time on these samples.

Cd1-xZnzS 박막의 성장과 광전도 특성

문종대,정태수,신현길,김택성,이충일,홍광준,이상열,서상석,신용진,김혜숙,윤은희,김승욱,전승룡,유상하,이관교,박향숙,신영진 한국센서학회 1995 센서학회지 Vol.4 No.3

Polycrystalline Cd_(1-x)Zn_xS thin film were grown on slide glass(corning-2948) substrate using a chemical bath deposition (C.B.D) method. They were annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometor in order to study Cd_(1-x)Zn_xS polycrystal structure using extrapolation method of X-ray diffraction patterns for the CdS, ZnS sample annealed in N₂ gas at 550 ℃. It was found hexagonal structure which had the lattice constant a_o = 4.1364Å, c_o=6.7129Å in CdS and a_o = 3.8062Å, c_o = 6.2681 Å in ZnS, respectively. Hall effect on these sample was measured by Van der Pauw method and then studied on carrier density and mobility depending on temperature. We measured also spectral response, sensitivity maximum allowable power dissipation and response time on these sample

사료내 아미노산비가 흰쥐의 성장 , 도체성분 , 조직 유리아미노산 농도 및 뇨내 질소배설량에 미치는 영향

신종서,라창식,김창혁,김병완,송영한 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.4

본 논문에서는 아미노산 혼합사료를 이용하여 사료내 질소 수준을 1.6N%로 일정하게 조절한 후 ET%의 단계적 변화(30, 50, 70ET%)가 휜쥐의 성장, 체성분, 혈중요소태 질소, 조직내 유리아미노산 농도 및 뇨중 질소량 변화에 미치는 영향을 검토하였다. 그 결과는 다음과 같이 요약되었다. 1. 증체량은 30ET%구에서 유의적으로 낮게(P<0.05) 나타났으나 사료섭취량은 50ET%구에서 유의적으로 높게 나타났으며(P<0.05), 증체량과 사료섭취량간에는 높은 상관이 인정되었다. 2. 도체 및 간장의 성분은 사료내 ET%의 변화에 의한 영향이 없는 것으로 나타났다. 3. 혈중 유리아미노산의 농도는 사료내 ET%의 변화에 민감하게 반응하였으며 특히 threonine 농도는 30ET%구에 비하여 70ET%구가 약 35배 정도로 유의적으로 높게 나타났다(P<0.05). 또한 총 필수아미노산의 농도는 사료내 ET%의 증가에 따라 유의적으로 증가하였으나 비필수아미노산 농도는 유의적으로 감소하였다(P<0.05). 간장 및 근육내 총필수아미노산과 비필수아미노산의 농도도 혈중 아미노산의 농도 변화와 비슷한 경향을 보였다. 4. 사료내 ET%에 따른 질소 배설량은 저 ET%구에 비하여 고 ET%구에서 높게 나타났으며 사육초기 보다 사육후기에 높은 질소 배설량을 보였다. 이와 같은 결과로 미루어 사료내 아미노산 조성은 중체량과 사료섭취량에 영향을 미칠 뿐만 아니라 조직내 아미노산 농도 및 질소 배설량에도 영향을 주기 때문에 정제 아미노산을 사료에 첨가할 때에는 비필수아미노산의 함량도 고려함으로서 효율적으로 사료의 이용성을 중진시키는 방향을 모색하는 것이 바람직 할 것으로 사료된다. The objective of this study was to investigate the effect of ET(essential amino acid/total amino acid) ratio variations (30, 50, 70 ET%) in the feeds on growth, body composition, blood urinary nitrogen, concentration of free amino acids in tissues and urinary nitrogen of rats. The nitrogen level in feed was constantly maintained at 1.6% with a purified amino acid, despite the difference in ET ratios. The results obtained are summarized as follows; 1. Body weight gain and feed intake was significantly lower and higher in 30 and 50 ET% than in other groups, respectively(P<0.05), and body weight gain was highly correlated with feed intake. 2. No ET% ratio effects on composition of carcass and liver were observed. 3. The concentration of plasma free amino acids varied with ET% ratios in the feeds, especially the concentration of threonine in 70 ET% was 35 times higher than that in 30 ET%. The concentration of total essential amino acids was significantly elevated by increasing ET% ratios in the feeds. In liver and muscle, the patterns of total essential amino acids and nonessential amino acids were similar to that of plasma amino acids. 4. Urinary nitrogen concentration increased with higher ratios of ET% in the feeds, and was higher in early growth stage than in late growth stage. These results indicate that the amino acid composition in the feeds influence the concentration of amino acids in tissue and urinary nitrogen as well as body weight and feed intake.