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김영주,이명희,정성창 대한두개하악장애학회 1992 대한두개하악장애학회지 Vol.4 No.1
The authors examined the condylar movement in 28 patients with closed locking of the temporomandibular joint before and after treatment and 33 controls by transcranial radiography. The Treatment adminstered to the patients were noninvasive and conservative therapy such as patient education, home care, reductive manipulation, physical therapy and occlusal splint. The authors obtained the following results. 1. In patient group, the mean amount of condylar translation was 5.07±2.00㎜ in the affected side and was 7.39±3.22㎜ in the unaffected side before treatment, the mean amount of condylar translation in affected side was 12.77±2.75㎜ and in unaffected side was 15.52±2.53㎜ after treatment. And the condylar translation was significantly improved after treatment(P<0.001). 2. In patient group, the ranges of comfortable mouth opening were 27.04±4.12㎜ and maximum mouth opening were 29.96±3.69㎜ before treatment, the ranges of mouth opening were below 40㎜, And the ranges of comfortable mouth opening were 43.86±1.86㎜ and maximum mouth opening were 43.96±1.90㎜ after treatment. And the mouth opening was significantly improved after treatment(P<0.001). 3. In patient group, the mean amount of treatment time was 4.13 ±1.52 months when patients opened above 40㎜. 4. The mean amount of condylar translation was 17.23±2.75㎜ in control group and was 12.77±2.75㎜ in the affected side of patient group after treatment. There was a significant difference between the groups(P<0.001), And in the unaffected side of patient group, the mean amount was 15.52±2.53㎜ after treatment. There was a significant difference between the control group and the unaffected side of patient group(P<0.05). 5. The ranges of comfortable mouth opening were 43.86±1.86㎜ in patient group after treatment and 42.82±4.47㎜ in control group. There was no significant difference between the groups. But the ranges of maximum mouth opening were 43.96±1.90㎜ in patient group after treatment and 46.48±3.85㎜ in control group. There was a significant difference between the groups (P<0.05).
韓國産 납자루 亞科 魚類의 染色體와 ARM NUMBER
李金泳,蘇俊魯,金聖周 全北大學校 基礎科學硏究所 1982 基礎科學 Vol.5 No.1
Karyotypes of 12 species of the Acheilognathine fishes were studied using chromosomes of gill slit and kidney cells prepared by the flame drying technique. The results were as follows : 1. Numbers of chromosomes were classified into three patterns as 2n=48, 44, and 46. 2. In the 2n=48, No. of two-arm chromosome (TAC) and one-arm chromosome (OAC)were 12 or 14 pairs and 10 or 12 pairs, respectively. In the 2n=44, TAC and OAC were 14 or 12 and 8 or 10, severally, In the 2n=46, TAC was 2 pairs and OAC was 21 pairs. 3. Above results indicate that patterns of arm number(AN) were classified into four groups as AN=76, 72, 68, and 50. In the view of these results, we suggest that primitive chromosomal type of Acheilognathine fishes(cyprinidae) was 2n=46 and AN=50(R. notatus, R. suigensis).
Kim, Seong Kwang,Shim, Jae-Phil,Geum, Dae-Myeong,Kim, Jaewon,Kim, Chang Zoo,Kim, Han-Sung,Song, Jin Dong,Choi, Sung-Jin,Kim, Dae Hwan,Choi, Won Jun,Kim, Hyung-Jun,Kim, Dong Myong,Kim, Sanghyeon Institute of Electrical and Electronics Engineers 2018 IEEE transactions on electron devices Vol.65 No.5
<P>In this paper, we fabricated In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As-on insulator (OI) MOSFETs on Si substrates with different doping types to mimic ground plane doping using direct wafer bonding and epitaxial lift-off (ELO) techniques. We investigated the impact of doping types on the ground plane and the backgate biasing, which are important and preferable components in monolithic 3-D (M3D) integration, on the electrical properties of MOSFETs, such as the threshold voltage ( <TEX>${V} _{T}$</TEX>) and the effective mobility ( <TEX>$\mu _{\textsf {eff}}$</TEX>). It was found that <TEX>${V} _{T}$</TEX> and <TEX>$\mu _{\textsf {eff}}$</TEX> were significantly modulated by the backsubstrate doping and the backbiasing. These observations were explained by the change of carrier distributions, which were confirmed by technology computer-aided design simulation. Furthermore, we investigated the reusability of InP donor substrates for sequential epitaxial growth after ELO process toward a cost-effective M3D integration with the In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As channel.</P>
Developmental Modulation of Specific Receptor for Atrial Natriuretic Peptide in the Rat Heart
Kim, Yoon-Ah,Kim, Soo-Mi,Kim, Suhn-Hee,Kim, Sung-Zoo The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.3
Although cardiac distribution of specific receptors for atrial natriuretic peptide (ANP) was mainly observed in the ventricular endocardium, the modulation of ANP receptors in relation to cardiac development is not defined. The present study was undertaken to investigate ANP receptor modulation in rat during development. In the developmental stages examined (fetus, after postnatal 3-days, 1-, 2-, 3-, 4-, and 8-week-old Sprague Dawley rats) specific ANP binding sites were localized in the right and left ventricular endo-cardia by quantitative in vitro receptor autoradiography using (equation omitted)-rat ANP as labeled ligand. The specific bindings to endocardium were much higher in the right than the left ventricle. The binding affinities of ANP were much higher in the right than the left ventricular endocardium. The difference of these binding affinities among various developmental stages was not observed in the right ventricle, whereas the binding affinity in left ventricle was gradually increased with aging and reached the peak value at 8 weeks. No significant difference in maximal binding capacities of endocardial bindings was observed in the right and left ventricular endocardia during developmental stages. Also, cGMP production via activation of particulate guanylyl cyclase-coupled receptor subtypes in the ventricular membranes was gradually decreased with close relationship to aging. Therefore, the present study show that the endocardial ANP receptor is modulated with close relationship to cardiac development in the left ventricle rather than the right ventricle, and may be involved in regulating myocardial contractility in left heart.
Kim, Seong Kwang,Shim, Jae-Phil,Geum, Dae-Myeong,Kim, Chang Zoo,Kim, Han-Sung,Song, Jin Dong,Choi, Sung-Jin,Kim, Dae Hwan,Choi, Won Jun,Kim, Hyung-Jun,Kim, Dong Myong,Kim, Sanghyeon Institute of Electrical and Electronics Engineers 2017 IEEE transactions on electron devices Vol.64 No.9
<P>Defect less semiconductor-on-insulator (-OI) by a cost-effective and low-temperature process is strongly needed for monolithic 3-D integration. Toward this, in this paper, we present a cost-effective fabrication of the indium gallium arsenide-OI structure featuring the direct wafer bonding (DWB) and epitaxial lift-off (ELO) techniques as well as the reuse of the indium phosphide donor wafer. We systematically investigated the effects of the prepatterning of the III-V layer before DWB and surface reforming (hydrophilic) to speed up the ELO process for a fast and high-throughput process, which is essential for cost reduction. Thismethod provides an excellent crystal quality of In0.53Ga0.47As on Si. Crystal quality of the film was evaluated using Raman spectra, and transmission electron microscope. Finally, we achieved good electrical properties of In0.53Ga0.47As-OImetal-oxide-semiconductorfield-effect-transistors fabricated through the proposed DWB and ELO.</P>
Receptor Subtypes for Endothelin in the Kidney of the Freshwater Turtle (Amyda japonica)
Kim, Sung-Zoo The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.1
The distribution of receptor subtypes for endothelin (ET) in the kidney of the freshwater turtle, Amyda japonica, was examined by quantitative in vitro receptor autoradiography using iodinatd mammalian type ET-1 ($^125$/I-ET-1)as a radiolabeled ligand. Specific $^125$/I-ET-1 bindings were localized to renal tubules, renal arteries and ureter with binding densities of 111.21 $\pm$ 19.14, 182.13$\pm$10.57 and 219.46$\pm$12.83 amol/$mm^2$. respectively. Binding dissociation constants in renal tubules, renal arteries and ureter were 1.05 $\pm$ 0.63, 2.03 $\pm$0.56 and 1.70$\pm$0.47nM, respectively. Receptor subtypes for ET in the kidney were characterized by competition with BQ 123 and BQ 788 as specific antagonists for ET receptors, type A (ET$_A$ ), and type B (ET$_B$) subtypes, respectively. Specific $^125$/I-ET-1 bindings in renal arteries and ureter were potently inhibited by BQ 123 in a dose-dependent manner, whereas BQ 788 was not in competing for specific $^125$/I-ET-1 bindings in this structure. However, specific $^125$/I-ET-1 bindings in renal tubules were inhibited more potently by BQ 788. Therefore, these results indicate that specific ET receptors are localized in renal tubules, renal arteries and the ureter of the freshwater turtle. Results also suggest that the predominant ET receptor subtypes are like the ETA receptor in renal arteries and ureter, and like the ET/$_A$ receptor in the renal tubule.
( Boo Sung Kim ),( Youn Zoo Cho ),( Soon Koo Baik ),( Moon Young Kim ),( Won Ki Hong ),( Hye Won Hwang ),( Jin Hyung Lee ),( Myeong Hun Chae ),( Seung Yong Shin ),( Jung Min Kim ),( Mee Yon Cho ),( Sa 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Cirrhosis is a long-term consequence of chronic hepatic injury with fibrosis and no effective therapy except liver transplantation is currently available for decompensated cirrhosis. However, some practical limitations in liver transplantation lead us to a need for new therapeutic paradigm in this field. Recent reports have shown that the mesenchymal stem cells (MSCs) have the plasticity to differentiate into some kinds of tissue cells and improve organ function. Hence, we investigated the effect of direct inoculation of human bone marrow derived MSCs (BM-MSCs) in thioacetamide (TAA)-induced cirrhosis in a rat model. Methods: Adult Sprague-Dawley rats were allocated into three groups (each group, n = 15) as follows: G1, shame; G2, TAAcontrol; G3, TAA+BM-MSC. To induce cirrhosis, 200mg/kg TAA injection was done twice a week for 12weeks in G2 and G3. 2×106 cells of amplified human BM-MSCs were injected directly into the right liver lobe twice, at weeks 6 and 8 in G3. At 12 weeks, the effect of BM-MSCs on cirrhosis was analyzed histomorphologically using Laennec scores. α-Smooth muscle actin(α-SMA) expression by immunohistochemical staining, relative expression of collagen type 1, and transforming growth factor β (TGF-β) were also evaluated by real-time reverse transcriptase- polymerase chain reaction. Results: Laennec scores were 0, 5.4±0.7 and 3.7±1.06 in G1, G2 and G3, respectively. Histologically, BM-MSCs injected group (G3) showed significant suppression of hepatic fibrosis compared with TAA-control group (G2)(P<0.001). Expressions of α-SMA(%) were significantly lower in G3 than in G2 (3.08±1.26 vs. 7.00±4.12, P<0.05). Also, the relative expression of collagen type 1 and TGF-β1 in RT-PCR were 0.64±0.24, 2.06±0.51, 1.32±0.31 and 0.62±0.28, 5.89±3.05, 2.22±1.41 in G1, G2 and G3, respectively P<0.005). Conclusions: Our results showed that BM-MSCs could attenuate liver fibrosis in rats with TAA-induced cirrhosis, raising the possibility for clinical use of BM-MSCs in the treatment of cirrhosis.