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( Hee Jun Cho ),( Byung Moo Oh ),( Jong-tae Kim ),( Jeewon Lim ),( Sang Yoon Park ),( Yo Sep Hwang ),( Kyoung Eun Baek ),( Bo-yeon Kim ),( Inpyo Choi ),( Hee Gu Lee ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.2
Interleukin-21 is a common γ-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells. Targeting IL-21 to strengthen the immune system is promising for the development of vaccines as well as anti-infection and anti-tumor therapies. However, the practical application of IL-21 is limited by the high production cost. In this study, we improved IL-21 production by codon optimization and selection of appropriate signal peptide in CHO-K1 cells. Codon-optimized or non-optimized human IL-21 was stably transfected into CHO-K1 cells. IL-21 expression was 10-fold higher for codon-optimized than non-optimized IL-21. We fused five different signal peptides to codon-optimized mature IL-21 and evaluated their effect on IL-21 production. The best result (a 3-fold increase) was obtained using a signal peptide derived from human azurocidin. Furthermore, codon-optimized IL-21 containing the azurocidin signal peptide promoted IFN-γ secretion and STAT3 phosphorylation in NK-92 cells similar to codon-optimized IL-21 containing original signal peptide. Collectively, these results indicate that codon optimization and azurocidin signal peptides provide an efficient approach for the high-level production of IL-21 as a biopharmaceutical.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
慢性精神分裂病患者의 꿈에 관한 考察(Ⅰ) : 橫斷的 對照硏究 A Cross-sectional Control study
趙成俊,李符永 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1
정신분열병 환자의 꿈에 대하여 '정신분열병적 꿈'이 있는가 하는 것은 논란의 대상이 되어 왔다. 본 연구에서 통계적으로 유의한 결과는, 정서반응에서 정신분열병 환자군의 꿈에서 정상대조군과 비교하여 만족도가 떨어지고, 꿈 내용상으로는 꿈自我의 소극적 참여. 관망 또는 꿈自我缺如 등의 약화된 각성시의 자아기능이 꿈에도 지속되는 경향을 보였으며 괴기. 이상한 내용의 꿈이 많은 경향이 있었다. 또한 현재 망상수준과 非平常度 간의 관계에 있어 陰의 상관관계를 보였다. 결론적으로 정신분열병 환자에서는 특징적인 꿈이 나타나는 경향이 있지만, 이러한 것은 망상의 强度와는 일치하지 않는 것으로 간주된다. 즉, 망상정신분열병 환자들의 꿈은 파괴적인 보상을 띄는 경향이 있지만 망상이 극에 이르게 되면 反轉되어 오히려 平常한 내용의 꿈이 나타나는 경향이 있다 하겠다. 그리고, 본 연구대상에서 정신분열병 환자들의 꿈의 그림내용은 기술한 내용과 일치하지 않는 경우가 많았는데, 이 문제 및 꿈의 내용분석은 第2障에서 상세히 다룰 예정이다. 앞으로 측정체계 (scoring system)를 더욱 발전시켜 많고 다양한 환자군을 대상으로 연구할 필요가 있으리라 보며, 꿈의 橫的인 斷面的 硏究뿐 아니라 개인개인의 정신분열병 환자의 꿈의 縱的인 長期間의 追跡과 分析은 꿈의 기능의 연구상 필수적인 것임을 다시금 강조돼야 할 것이다. 본 연구를 도와주신 국립서울정신병원의 조성남선생님과 간호원여러분, 용인정신병원의 주치의선생님들과 간호원여러분, 그리고 서울대학교병원의 유명숙간호원, 임상심리 이영호선생님께 깊이 감사를 드린다. Whether the dream characteristic of schizophrenia does exist or not has been disputed until these days. This study aimed to seek the affect response of chronic schizophrenics and to test the general assumption that dream content would be consistent with waking psychopathology. Also, the authors tried to seek the relation between delusional level during waking state and novelty within the dream content, consequently testing that Jung's compensation theory of dreams is applicable to that relation. 'Yesterday dream' of 104 chronic schizophrenics and 110 normals were selected from mental hospital for chronics and general population. schizophrenic subjects were matched with normal subjects in age, sex, educations, socioeconomic status and religion. Collection of dreams was done by use of unstructured questionnaire and affect response was checked by structured questionnaire. For gathering the clinical information and scoring delusional level, chart was reviewed and patient was interviewed by the psychiatric senior residents. Normals were answered by semistructured questionnaire for personal information, in addition to the same questionnaire with patient. all questionaire were answered at the same time. Both sex-linked groups were compared and an analysed statistically. The statistically significant findings of this study were as follows: 1. Affect response; Satisfaction was less marked in schizophrenic dreams than was normals. And anger response was more marked in male schizophrenics than was in female schizophrenics. 2. Dream content; Passive participation, observation or absence of dream ego were more often in chronic schizophrenics than were in normals. And their dreams tended to display strange, uncanny and unusual themes. 3. Delusional level vs. Novely; Delusional level was negatively correlated with novelty in female chronic schizophrenics. In conclusion, the dream content of chronic schizophrenics is partially consistent with waking psychopathology. And the correlation between delusional level and novelty supports Jung's compensation theory of dreams.
전성재,조연상,김동호,박흥식 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1
It is known that fractal theory has recently been used as a useful in the characterization of surface texture and the understanding of tribological phenomena such as friction, wear and lubrication. The fractal-based method for describing the rubbed surface texture has roused great interest. In this paper, the fractal descriptors was applied to rubbed surface of hydraulic driving material with image processing system in order to describe morphology of the rubbed surface. The results showed that the fractal dimension can be determined by sum of intensity difference of surface pixel. The two step size to get fractal dimension is similar to surface roughness Ra. Fractal dimensions of the rubbed surfaces increase with an increase of applied load. Morphology of the rubbed surface driving in lubricant can be effectively obtained by fractal dimensions.
地方自治를 위한 選擧行態에 關한 調査硏究 : 濟州島를 中心으로 In Case of Cheju Do
趙文富,梁永哲,金性俊 제주대학교 1990 논문집 Vol.30 No.1
This thesis aims to analyse the election behavior of residents in Chejo Do. The results of this study reveals that the residents in Cheju Do hope the member of Local Assembly to be as follows : First, he should be fresh and conscientious. Second, he should accept their opinions in developing Cheju area and put them into practice with his responsibility. Third, he should display his ability, rising above the matters of money, power, and affinity bond. Fourth, he should create the future with vision. Finally, for our voters' part, we should also fulfil our missions as a judge and referee with cool reason, as the election is getting intense.
방사선치료 조사영역 내에 발생한 설암 환자에서 입체조형방사선치료 경험 : 증례보고
조문준,장지영,김기환,김병국,송창준,김준상,김재성 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.
Objectives : We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods : A 64-year-old male patient was diagnosed with T4NOMO supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2NOMO. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from 7×6.4 to 8×8㎠, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results : In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion : Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.
조규현,김제섭,전판근,김우재,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1
The purpose of this study is to improve the productivity and constructability of permanent forms. The permanent forms will cut down the cost of production and make easier to install in the field; hence increase the use of forms in the today's market. The permanent form is produced in the factory and built in field. So this study is in two parts. The one is the productivity in factory, the other is constructability in the field. This study is the designing a new mold system as a solution to existing mold system's problems.