한국어 판 WHO-CIDI(Composite International Diagnostic Interview)-Alcohol의 개발:신뢰도 및 타당도 검사

남궁기,유계준,조은영,송선미,이희상,길계선,조현상,우용일 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

CIDI-Alcohol의 한국어 판 개발을 위해 이를 우리말로 번역, 수정하고, 정신병원에 입원한 환자 90명과 일반인 50명에게 시행한 후 임상 진단과 비교하여 일치도를 봄으로써 그 신뢰도 및 타당도를 조사하였다. 결과는 다음과 같다. 1) 주정 사용 각 진단 범주에 대한 한국어 판 CIDI-Alcohol의 일반 면담자간 진단 일치도는 97%∼100%의 높은 일치도를 보였다. 2) 임상 진단을 기준으로 한 한국어 판CIDI-Alcohol의 주정 사용 장애의 진단 일치도는 각 진단 범주별로 kappa치가 0.43∼0.55로 기존의 연구에 비해 비교적 낮았다. 3) CIDI-Alcohol의 진단 기준을 변화시켜, 각 진단 범주에 대한 임상 진단과의 일치도를 알아본 결과 ICD-10/harmful use는 진단 기준 항목의 수를 2개 이상으로 하였을 때, DSM-Ⅲ-R/주정 의존은 진단 기준 항목의 수를 4개 이상으로 하였을 때 임상 진단과 가장 일치하였다. 이런 결과는 한국어 판 CIDI-Alcohol의 진단 기준이 대체적으로 민감도는 높으나, 특이도가 떨어지는 것으로 생각할 수 있으며, 따라서 본 연구자들에 의해 작성된 한국어 판 CIDI-Alcohol는 일반인구 집단을 대상으로 하는 역학 조사보다는 주정 사용 장애로 이루어진 순수한 실험군의 연구에 적합하다고 생각된다. he authors translated a CIDI-Alcohol, a highly structured diagnostic interview, into Korean and examined the validity and reliability of the Korean version of CIDI-Alcohol. In order to examine the validity and reliability of CIDI-Alcohol, the authors calculated the degree of agreement of CIDI-Alcohol diagnoses between the two lay interviewers and sensitivity, specificity, kappa coefficient between clinical and lay CIDI-Alcohol diagnoses. The results were as follows: 1) Agreement rates of CIDI-Alcohol diagnoses between the two lay interviewers ranged from 97% to 100%. The kappa coefficient for each diagnosis was quite high(0.96-1.0). 2) The kappa value of agreement between clinical and lay CIDI-Alcohol diagnoses ranged from 0.43 to 0.55, which was lower than those of other studies. 3) With canging the diagnostic criteria of CIDI-Alcohol, The highest agreement rate between clinical and CIDI-Alcohol diagnoses was acquired when the authors used two or more diagnostic criteria of ICD-10/harmful use and four or more diagnostic criteria of DSM-Ⅲ-R/ alcohol dependence.

치료저항 만성 정신분열증 환자에서 Clozapine과 Haloperidol의 치료효과에 대한 비교

이홍식,김찬형,이희상,남궁기,송동호,이영문,한은선 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.2

자궁내막암 수술시 임파절 전이의 예측인자로서 CA 125의 임상적 유용성

김진휘,이성종,임채춘,남궁성은 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.4

목적 : 자궁내막암 환자에 있어서 골반 임파절 전이의 예측인자로 수술 전 CA 125 값의 유용성을 알아보고자 하였다. 연구 방법 : 1992년 10월부터 2002년 10월까지 가톨릭대학교 의과대학 강남성모병원에서 자궁내막암 진단하에 수술받은 환자 100명을 대상으로 의무기록을 토대로 수술전 CA 125와 임파절 전이유무의 관계를 살펴보았다. 통계적 방법으로는 만-휘트니 유 테스트와 카이 제곱 피셔 테스트를 사용하였다. 결과 : 수술 전 CA 125 값은 병기가 증가함에 따라, 자궁근층을 1/2 이상 침범한 경우, 자궁경부나 부속기를 침범한 경우, 골반 임파절 전이가 있는 경우 유의하게 높게 측정되었다(p<0.05). 결론 : 수술 전 CA 125의 증가는 자궁내막암의 골반 임파절 전이를 예측하는데 있어 유용하다고 할 수 있다. Objective : The aim of this study is to evaluate the clinical usefulness of preoperative CA 125 levels in determining the need for lymphadenectomy in patients with endometrial carcinoma. Methods : CA 125 levels were measured in 100 patients diagnosed with endometrial carcinoma who underwent surgery at Kangnam St. Mary's Hospital between October 1992 and October 2002. Statistical analysis was performed using the Mann-whitney U test and x-Fisher's exact test. Results : Univariate analyses showed that elevated CA 125 levels were significantly correlated with an advanced stage, increasing depth of myometrial invasion, cervical invasion, adnexal involvement, high grade hystology and lymph node metastases (p<0.05). Conclusion : Our data provide an evidence that the elevation of preoperative CA 125 levels can be considered as a predictor for full pelvic lymphadenectomy in the surgical staging of endometrial cancer.

알코올 금단 섬망 발생의 예측

이충헌,이은,박성혁,정승용,박상진,석정호,남궁기 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Alcohol withdrawal delirium is a serious clinical condition with high mortality rate if not treated. This study was to examine whether readily available clinical variables can predict the development of alcohol withdrawal delirium. Methods : The authors performed a retrospective study by reviewing charts of 566 patients who had been admitted for alcohol dependence. The cases were divided into two groups: delirium group (n=40) and control group (n=40). We compared baseline characteristics and serum analysis data at admission between two groups. We used logistic regression to predict risk factors for alcohol withdrawal delirium among potential risk factors. Results : The delirium group had significantly lower hemoglobin, hematocht, platelet counts, and potassium level than countrol group, Presence of previous withdrawal delirium history, AST, GGTP, and bilimbin level of delirium group were significantly higher than those of control group. Among potential risk factors, past history of withdrawal delirium, decreased hemoglobin, elevated bilirubin level, and number of previous detoxification were predictable factors of the development of alcohol withdrawal delirium by 72.5%. Conclusion : Our results suggest that the infomation obtained at admission can be useful to predict the development of al-cobol withdrawal delirium. Also, it makes the individualization of detoxification strategies possible.

Precancerous Conditions of Uterine Cervix and its Relation to Trichomonal Infection

Namkoong, Sung Eun,Kim, Seung Jo,Lee, Yong Seon,Kim, Yoon Ho,Kim, Sun Moo CATHOLIC MEDICAL CENTER 1979 Bulletin of the Clinical Research Institute Vol.7 No.1

Trichomonas Vaginalis, first described by Donne, 1836, for many years has been associated with lesions of the female genital tract.

A real-time optoelectronic device in screening of cervical intraepithelial neoplasia

( Sung Jong Lee ),( Jeong Hoon Bae ),( Jin Hwi Kim ),( Sung Ha Lee ),( Sung Eun Namkoong ),( Jong Sup Park ) 대한산부인과학회 2009 Journal of Womens Medicine Vol.2 No.1

Objective: The purpose of the study was to evaluate the sensitivity and specificity of the TruScreen in the diagnosis of cervical intraepithelial neoplasia (CIN) and the benefit of an adjunct test to cervical cytology screening. Methods: Data were collected prospectively on 249 women who had undergone a loop electrosurgical excision procedure (LEEP) or hysterectomy at Kangnam St. Mary`s Hospital of Catholic University between March and December 2008. The TruScreen was performed on 249 patients and the sensitivity and specificity were determined. The accuracy of TruScreen and cervical cytology were also ascertained. Results: A remarkable improvement in the accuracy of the combined test for CIN 1 (sensitivity, 96.8%) and CIN2/3 (sensitivity, 92.4%) was noted. The sensitivity of TruScreen for CIN1 and CIN2/3 was 75.8% and 77.3%, respectively. The specificity of TruScreen for normal tissue was 85.1%. Conclusion: The present study suggests that the TruScreen is an excellent device as an adjunctive test for the detection of CIN. The instantaneous result of TruScreen in women with ASCUS or LSIL can provide rapid and reliable information.

The Effect of Picibanil on Cell-Immunity in Patients with Gynecological Malignant Tumor

Namkoong, Sung Eun,Lee, Joon Mo,Lee, Hun Young,Jung, Jae Keun,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1

Natural killer cell-mediated cytotoxicity(NKMC), total, helper and suppressor T-cells were measured before and 4 weeks after treatment with 0.5-3.0 KE of OK-432 in the patients with trophoblastic disease which were divided into 2 subgroups of low risk (n=10) and high risk (n=11), and compared with those in normal control group (n=9). In the group of low risk trophoblastic disease no change was noted in any of all parameters after treatment. However, in the group of high risk trophoblastic disease, NKMC as well as total and helper T-cells before treatment were significantly lower while suppressor T-cells were higher than those in normal control. And all above data before treatment were definitely reversed after treatment except NKMC that remained unchanged. Considering above results OK-432 may play an important role in host defense mechanism through lymphokine or humoral immune response by increasing the ratio of helper to suppressor T-cells rather than increasing NKMC.

Detection of c-K-ras Point Mutation in Ovarian Cancer

Namkoong, Sung Eun,Lee, Joon Mo,Kim, Jin Woo,Han, Sang Kyun,Kim, Heung Kee,Park, Jong Sup,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.1

To detect the point mutation of c-k-ras in ovarian cancer, GGT of codon 12 was replaced by GAT, AGT, TGT and GTT, then we performed polymerase chain reaction and agarose gel electrophoresis and confirmed it using Southern blot hybrization with digoxygenin detection system. The frequency of c-k-ras point mutation was compared with the clinico-pathological characteristics of 37 ovarian cancer patients. The incidences of four-typed point mutations of K-ras oncogene in 37 ovarian cancers were 35.1%(13/37) and distribution were 32.4%(12/37), 2.7%(1/37), 0%(O/37) and 0%(O/37) in GGT to GAT, GGT to AGT, GGT to TGT, and GGT to GTT, respectively. The incidence of K-ras point mutations on codon 12 among 37 patients with ovarian cancer according to histological type was 35.5%(8/22) with serous cystadenocarcinomns, 28.6%(2/7) with mucinous cystadenocarcinomas. Comparing the positive rate of K-ras point mutations on code 12 among 37 patients with ovarian cancer in different clinical stages, point mutation was detected in 14.3%(1/7) with stage Ⅰ, 28.6%(2/7) with stage Ⅱ, and 43.5%(10/23) with stage Ⅲ/Ⅳ and there was statistically significant increasement of point mutations of K-ras oncogene with advance of the clinical stage of ovarian cancer (P<0.05). The incidence of K-ras point mutntions on codon 12 among 33 patients with ovarian cancer who were performed pelvic lymph node dissection was 52.4%(l1/21) of the patients with positive pelvic lymph node metastases and 16.7%(2/12) of the patients without pelvic lymph node metastasis and the difference was statistically significant (P<0.05). The activation of ras oncogene seems to be a major implication of the multistep process of ovarian carcinogenesis and tumor progression. Furthermore, the point mutation of c-K-ras gene could occur more frequently in the patients of ovarian cancer in far advance stage, and the those with pelvic lymph node metastases than in those without pelvic lymph node metastases, suggesting the role in tumor invasion and metastases.

Polymorphisms of p53, p21 and IRF-1 and Cervical Cancer Susceptibility in Korean Women

Sung Jong Lee,Sung Eun Namkoong,Won Chul Lee,Jae Woong Sul,Sun Ha Jee,Youn Kyoung You,Jong Eun Lee,Jong Sup Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5

Purpose: The aim of this study was to identify genegeneand gene-environmental factor on cervical carcinogenesisin Korean women.Materials and Methods: We evaluated 185 womenpatients who had cervical cancer with 345 normal controlhealthy women. The single nucleotide polymorphisms(SNPs) of the p53 codon 72, the p21 codon 31 and theIRF-1 intron 6 were evaluated from extracted DNA ofperipheral blood with an automatic DNA sequencer. Thedifference of each SNP, gene-gene and gene-environmentalinteraction between normal controls and patients,were evaluated in an adjusted environmental background.Results: With regard to environmental factors, thecervical cancer increased in the women with a lower levelof education, a younger age at first sexual intercourseand with the increased number of children borne. Thewomen who had p53 (Arg/Arg), IRF-1 (T/T) and an educationof less than 6 years showed a 14.7 fold increasedrisk of cervical cancer than those women who had p53(~Pro), IRF-1 (~C) and an education of more than 15years. The women who had p53 (Arg/Arg), p21 (Ser/Ser)and more than 3 children showed a 6.4 fold increased riskof cervical cancer than those women who had p53 (~Pro),p21 (~Arg) and had borne no child. The women who hadp53 (Arg/Arg), IRF-1 (T/T) and had experience of firstsexual intercourse before the age of 22-years showed a5.5 fold increased risk of cervical cancer than thosewomen who had p53 (~Pro), IRF-1 (~C) and hadexperience of first sexual intercourse after the age of26-years.Conclusion: We found that the level of education, theage at first intercourse, and the number of children borne,were independent risk factors in cervical carcinogenesis.The specific combination of p53, p21 and IRF-1 gene-geneand gene-environmental interactions were significantlynoted in the cervical carcinogenesis of Korean women.(Cancer Res Treat. 2002;34:357-364)

Ovary-preserving treatment of adenosarcoma of an endometrial polyp in young woman

이성종 ( Sung Jong Lee ),( Hyun Jung Jo ),( Jae Eun Shin ),( Se Youn Lee ),( Sung Eun Namkoong ) 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-