황구침법(黃丘鍼法)을 이용한 고혈압 환자의 혈압강하 효과에 대한 증례보고

한창현 ( Chang Hyun Han ),황치원 ( Chi Won Hwang ),신미숙 ( Min Suk Shin ),신선화 ( Seon Hwa Shin ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.3

Objectives: The aim of the study was to investigate the antihypertensive effect of Hwang-gu Acupuncture in hypertensive patients. Methods: We measured the blood pressure of the patients who were admitted in the Oriental Medical Clinic of Brother from 25th November 2005 to 27th March 2006. We included the patients only in case of the systolic blood pressure was over 140mmHg or diastolic blood pressure was over 90mmHg, Twenty two patients were treated by Hwang-gu Acupuncture. In order to evaluate the effect of the Hwang-gu Acupuncture, the blood pressure was measured before and after Acupuncture procedure total 4 times, 10times. Results: There were a significant decrease in the systolic blood pressure and significant decrease in the diastolic blood pressure by Hwang-gu Acupuncture 4 times. The effect of Hwang-gu Acupuncture by measurement time on blood pressure were follows: In a systolic blood pressure was gradually deceased significantly from 1st to 4th but diastolic blood pressure was significantly decreased after 2nd and 4th only. Conclusions: These results suggest that Hwang-gu Acupuncture is effective in decreasing the systolic and diastolic blood pressure.

중학교 가정과 학습내용에 대한 예비중학생과 학부모의 인식

황선화,정영숙 한국 가정과 교육 학회 1995 한국가정과교육학회지 Vol.7 No.2

The purpose of this study was to investigate the recognition degrees of contents in Home Econimics textbook for middle school students among pre-middle school students and their parents. It is for developing better Home Econonmics textbook. Three objectives of this study were: 1) To find the recognition degrees of the fact that Home Economics subject is supposed to utilize for not only girls, but boys students in middle schools in 1996 among pre-middle shcool students and their parents. 2) To find the degrees of necesiity in each field of Home Economics subject among pre-middle school students and their parents. 3) To find the differences in recognition degrees of understandings, attitudes, and skill of Home Economics subject between pre-middle school students and their parents. Questionnaire survey metod was utilized to 1,205 sizth grade students and their parents in Pusan. The results of this study as follows; 1) It was low that the recognition degrees of the fact that Home Economics subject is supposed to utilize for both girls and boys in middle school among both pre-middle school students and their parents. This result implies that it is important to dissenminate the curriculum change in Home Economics practice to the public. 2) It was high that the recognition degrees of necessity in each field of Home Economics subject among pre-middle school students and their parents. Th recognition defree were different according to sociodemographic factors. That is, ① the recognition degrees of students were lower than their parents; ② the recognition degrees of parents who have high education were higher than those who have low education; ③ the recognition degree of an evirionmental field was highest. 3) There were little differences between pre-middle school students and their parents in the recognition degrees of understandings, attitudes, and skills of Home Economics subject: The recognition degrees of girls fathers showed higher scores than boys fathers those of in understandings and skills of Home Economics subject. The recognition degrees of girls fathers showed higher scores than those of girls in attitudes of Home Economics subject.

肢발생중 세포 증식성에 미치는 Etretinate의 영향에 관한 연구

황정연,김은영,박선화,전용혁 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.1

Cell proliferation in the developmental sequence of fore-limb in the DDY mouse with the adverse effect of single dose of etretinate (Tigason®) on it correlated to the drug-induced dysmorphogenesis was studied by measns of argyrophil technique for nucleolar organizer regions(AgNORs) and expression of proliferating cell nuclear antigen(PCNA). The number of AgNORs per nucleus displayed regional differences in the limb bud on day 11 of gestation, as higher values in apical ectodermal ridge(AER) and growing tip but decreased rapidly thereafter compared with those in the other parts of epithelia and subepithelial mesenchyme, while in core mesenchyme where the higest in its value on day 11, the numbers decreased depend not on the age but on the chondrified stage specific. Antibody reaction to PCNA expressed in almost all of the cells, stronger in mesenchyme than in epithelia on day 11 and then decreased gradually with the development proceed. Siver reactions to NORs as well as PCNA expression were decreased sharply by etretinate but recovered gradually from 24 hours after treatment except the value of AgNORs in the chondrified mesenchyme. The results Indicate that growth conducted by AER with subridge mesenchyme and chondrification in the core mesenchyme are two of major processes in the early development of limb, and the adverse effects of etretinate on proliferation and differentiation persist longer in the chondrified area but decreased expression of proliferative activities by the drug do not appear to be the result subsequent to the drug-induced cell death. The results suggest that temporal inhibition or interruption of the proliferation could deprive the programmed sequence of development of its appropriate timing with subsequent disturbance of the pace in growth which might be a role of limb dysmorphogensis but the drug's affinity to the chondrified cells remains a question.

알레르기 환자에서 특이알레르겐 항체 양성율과 관련요인

이선화,남해선,이성수,안현철,황규윤,박준수,,박춘식 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

Recently, allergic diseases are very prevalent in Korea, resulting in physical and economic losses during the life. It is well-known that the principle therapy is identification, eradication, and desensitization of allergens. There are many allergic diagnostic tools for identification of specific-allergens. However, none of them is satisfied with its efficiency due to lack of validity. Recently MAST-CLA has been widely used in the allergic clinical fields because of its simplicity and simultaneous identification of allergens. This study was designed to determine the positivity of allergen-specific antibodies using MAST-CLA in patients with allergic diseases, and evaluate the efficacy for allergen detection, compared to results of skin prick test. During June 2000 - September 2001, 325 study subjects visited Soonchunhyang University Chunan Hospital for the evaluation of allergic problems. Among them, 289 subjects were diagnosed with allergic disease and included for the study. Thirty four subjects visited children's allergic unit were evaluated specific allergens using a skin prick test at the same time. Our result as follows; 1. The positive rates of allergen-specific antibodies and total IgE were 51.2% and 73.4%, retrospectively. 2. There was significant difference in positive rate in age group, showing highest in teen ages(73.6%), but insignificant difference in sex in allergen-specific antibodies. 3. The positive rate was 60.4% in allergic rhinitis, 51.3% in allergic dermatitis, 46.9% in bronchial asthma, and 39.1% in urticaria in order(P=0.073). 4. Significant difference in month or season was observed, with highest rate in April(78.1%) and May(72.1%). The highest season was in spring(62.7%), and then summer(52.8%), fall(50.3%), and winter(41.4%) in order (P=0.04). 5. The three highest allergen-specific antibodies were D. pteronyssinus(39.3%), D. farinae(38.3%), and house dust(24.3%) in Korean inhalant pannel, However, in food pannel types of allergen-specific antibody were different as D. farinae(18.5%), Alternaria(18.5%), house dust(17.3%). 6. There were significant agreements between MAST-CLA and Skin prick test (D. farianae Kappa=0.636;D. pteronyssinus Kappa=0.78, both P<0.001) In conclusion, MAST-CLA could detect allergen-specific antibodies in patients with allergic diseases as a simple and valid tool of screening of allergy. Especially, it could be a useful measure of multiple allergens simultaneously in children However, more detailed allergens and valid assay for unmeasured allergens should be identified for Korean-specific allergens.

대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

Hwang, Sun-Young,Sun, Hwa-Young,Lee, Kwang-Hoon,Oh, Byung-Ha,Cha, Yu Jin,Kim, Byeang Hyean,Yoo, Joo-Yeon Oxford University Press 2012 Nucleic acids research Vol.40 No.6

<P>RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β production. In an attempt to identify novel tools that modulate IFNα/β production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the selected RIG-I aptamers contained polyU motifs in the second half regions that played critical roles in the activation of RIG-I-mediated IFNβ production. Unlike other known ligands, RIG-I aptamer bound and activated RIG-I in a 5′-triphosphate-independent manner. The helicase and RD domain of RIG-I were used for aptamer binding, but intact RIG-I protein was required to exert aptamer-mediated signaling activation. Furthermore, replication of NDV, VSV and influenza virus in infected host cells was efficiently blocked by pre- or post-treatment with RIG-I aptamer. Based on these data, we propose that RIG-I aptamer has strong potential to be an antiviral agent that specifically boosts the RIG-I-dependent signaling cascade.</P>

Transduced Tat-Annexin protein suppresses inflammation- associated gene expression in Lipopolysaccharide (LPS)-stimulated Raw 264.7 cells

( Sun Hwa Lee ),( Dae Won Kim ),( Su Sun Back ),( Hyun Sook Hwang ),( Eun Young Park ),( Tae Cheon Kang ),( Oh Shin Kwon ),( Jong Hoon Park ),( Sung Woo Cho ),( Kyu Hyung Han ),( Jin Seu Park ),( Won 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.7

Annexin-1 (ANX1) is an anti-inflammatory protein as well as an important modulator in inflammation. However, the precise action of ANX1 remains unclear. To elucidate the protective effects of ANX1 on lipopolysaccharide (LPS)-induced murine macrophage Raw 264.7 cells, we constructed a cell-permeable Tat-ANX1 protein. The transduced Tat-ANX1 protein markedly inhibited the expression of cyclooxygenase-2, production of prostaglandin E2, and generation of pro-inflammatory cytokines in the cells. Furthermore, transduced Tat-ANX1 protein caused a significant reduction in the activation of nuclear factor- kappa B (NF-kB) and mitogen-activated protein kinase (MAPK). The results indicate that Tat-ANX1 inhibits the production of inflammatory response cytokines and enzymes by blocking NF-kB and MAPK. Therefore, Tat-ANX1 protein may be useful as a therapeutic agent against various inflammatory diseases.

Poster Session 1 : Analytical biochemistry Biochemical pharmacology and natural product chemistry Biotechnology Carbohydrate chemistry and metabolism ; Identification and cloning of a bovine-associated protein from bovine urine

( Sun Il Hwang ),( Hwa Jin Lee ),( Ji Sun Oh ),( Jae Hoon Pyo ),( Jin Kyu Lim ) 한국생화학분자생물학회 (구 한국생화학회) 2001 생화학분자생물학회 춘계학술발표논문집 Vol.2001 No.-

Osteopetrosis Associated with Hydrocephalus and Rickets: A Case Report

황선미(Sun Mi Hwang),공영화(Young Hwa Kong),김선준(Sun Jun Kim) 대한소아신경학회 2014 대한소아신경학회지 Vol.22 No.3

Osteopetrosis or albers-Schonberg disease is extremely rare disease. It is characterized by osteoporosis, stunted growth, deformity, increased likelihood of fractures, also patients suffers anemia, recurrent infections and hepatosplenomegaly. However, we recently came upon a 14-month-old female as the 1st child of osteopetrosis with hydrocephalus and rickets. She has the typical symptoms such as nystagmus, osteosclerosis -especially in skull. Brain Magnetic Resonance Imaging (MRI), MRI shows hydrocephalus and x-ray finding are consistent with rickets. This is the first report of osteopetrosis with hydrocephalus and rickets in Korea by pediatrician.

공간구문론적 해석에 의한 컨벤션 공간구성에 대한 연구

황선화 ( Sun Hwa Hwang ),김경진 ( Kyung Jin Kim ),유진형 ( Jing Hung Yoo ) 한국공간디자인학회 2013 한국공간디자인학회논문집 Vol.8 No.4

(연구배경 및 목적)우리는 가장 본질적인 주체에 대한 변화가 공간에도 영향을 미친다는 것을 지각해야 한다. 이러한 변화 속에서 중요한 사회적 의미를 생산해내는 컨벤션 공간은 각 단위의 부스들만이 변화할뿐 관람자와의 관계성은 전혀 고려되지 않는다. 따라서 현재 컨벤션 전시공간의 주체의 의미를 정의내리고 그에 적합한 방법론으로 컨벤션 공간구성을 제안한다. (연구방법)본 연구에서는 관람자의 행태 특성에 대한 연구와 공간 안에서의 단위 공간들에 대한 관계성을 구성하는 공간구문론 방법론으로 현재 컨벤션 공간 구성을 분석하여 관람자와 공간과의 관계성을 위한 해결책을 찾는다. (결과)관람자가 전체 공간을 이해하기 위한 공간의 경계는 뚜렷해야 하며 전시 오브제에 대한 집중도를 높이는 환경 조성은 물론 심리적 지루함이나 부담감을 줄이기 위한 부스의 형태나 배치는 신중해야 한다. 또한 대공간 속에서 관람자가 기준으로 삼을 랜드마크적인 요소와 관람자의 신체성을 고려한 휴식 공간이 잘 고려된다면 관람자와 컨벤션 공간 간의 긴밀한 관계성을 유도하고 근대와 현대의 주체적 의미를 아우르는 공간 구성이 될 것이다. (Background and Purpose)We should know that changes for the most fundamental subject affect but also space. For instance, changes to a convention space produce important social meaning, which not only changes each of the booth units but also affects the users of the space. However, when these changes are made, the relationship with visitors is not considered at all. Therefore, I suggest approaching space configuration with a suitable methodology that defines meaning that is independent of current convention spaces. (Method) In this study, I will find a resolution that addresses the relationship between visitors and space by researching the behavior characteristics of visitors and analyzing the current space configuration of convention spaces using Space Syntax methodology, which indicates relationships between the unit spaces within the larger space. (Result)A paradigm of space that understands a whole space must be clear. In addition to the development of an environment that draws maximum attention to the exhibitions, consideration should also be given to shaping and arranging booths in a way that reduces psychological burdens and boredom. A landmark element that can orient visitors in large space and a rest area that considers the physicality of visitors will induce a more harmonious relationship between visitors and the convention space. As a result, the space configuration will encompass independent meanings of the concepts of “modern” and “contemporary.”