Effects of Exogenous Estrogen and TRH on the Pituitary Function in Hypogonadal Women

( Soon Beom Kang ),( Myon Woo Shin ) 대한산부인과학회 1983 대한산부인과학회 학술대회 Vol.51 No.-

Comparison of DNA hypermethylation patterns in different types of uterine cancer: Cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma

Kang, Sokbom,Kim, Jae Weon,Kang, Gyeong Hoon,Lee, Sun,Park, Noh Hyun,Song, Yong Sang,Park, Sang Yoon,Kang, Soon Beom,Lee, Hyo Pyo Alan R. Liss, Inc 2006 International journal of cancer Vol.118 No.9

<P>The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for the molecular diagnosis of CA and endometrial adenocarcinoma (EA). Using the bisulfite-modification technique and methylation-specific PCR, we examined the aberrant promoter hypermethylation patterns of 9 tumor suppressor genes (APC, DAPK, CDH1, HLTF, hMLH1, p16, RASSF1A, THBS1 and TIMP3) in 62 CSCCs, 30 CAs and 21 EAs. After Bonferroni correction adjustment (statistically significant at p < 0.0055), we found that the aberrant hypermethylations of CDH1 and DAPK were more frequent in CSCCs than in CAs (80.6% vs. 43.3%, p = 0.001; 77.4% vs. 46.7%, p = 0.005), whereas HLTF and TIMP3 were more frequently methylated in CAs (3.2% vs. 43.3%, p < 0.001; 8.1% vs. 53.3%, p = 0.001). The hypermethylations of RASSF1A and APC were more frequent in CAs than in CSCCs, but this was not significant (9.7% vs. 33.3%, p = 0.008; and 14.5% vs. 40.0%, respectively, p = 0.009). In addition, RASSF1A hypermethylation was significantly more frequent in EAs than in CAs (81.0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms. © 2005 Wiley-Liss, Inc.</P>

Learning curve for single-port-access Laparoscopic surgery in benign adnexal mass (초)

( Soon Beom Kang ),( Jae Weon Kim ),김윤환 ( Yun Hwan Kim ),( Hyun Hoon Chung ),( Noh Hyun Park ),( Yong Sang Song ) 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-

Predictive value of the serum Tissue Polypeptide Specific Antigen (TPS) for borderline epithelial ovarian cancer

( Soon Beom Kang ),( Sang Soo Seo ),( Seong Il Kim ),( Moon Hong Kim ),( Jae Won Kim ),( Noh Hyun Park ),( Yong Sang Song ),( Hyo Pyo Lee ) 대한산부인과학회 2001 대한산부인과학회 학술대회 Vol.87 No.-

Message from Chairman

( Soon Beom Kang ) 대한산부인과학회 2008 Journal of Womens Medicine Vol.1 No.1

최신임상강좌 : 다기관 공동연구의 수행과 그 필요성

강순범 ( Soon Beom Kang ),이택상 ( Taek Sang Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.6

현재 국내외 다기관 공동임상연구는 암질환을 중심으로 빠른 속도로 발전하고 있다. 우리나라에서의 질병 현황은 그 종류에 따른 발생 빈도 및 임상양상이 서양과는 많은 면에서 차이가 있어 미국이나 유럽에서 시행된 임상연구의 결과만으로는 국내현실에 맞는 치료법의 확립을 충족시킬 수 없다는 점을 고려할 때 우리나라 환자를 대상으로 다기관 공동연구 수행은 필수적이며 이러한 배경을 바탕으로 국제적으로 경쟁력 있는 체계적인 다기관 공동임상연구의 진행을 통해 새로운 치료 방법의 개발과 이를 임상에 응용키 위한 합리적 정책 제시 및 치료방법에 관련된 국제교류, 궁극적으로 질병 치료에 관한 의료 발전을 통한 국민보건 향상에 기여하는 거시적인 관점에서의 계획수립이 절실하다고 할 수 있다. Recently, multicenter clinical trials have been getting more popular inside and outside of the country. The disease pattern of our country is somewhat different from that of western countries in terms of its incidence, clinical feature. Therefore, the results of clinical studies in US or European countries cannot be properly applied without consideration of trial design features and intertrial comparisons. Therefore, the conduct of multicenter trial with our own population is necessary. Well organized multicenter trials having competitive power will make it possible to develop new treatment modalities, frame a reasonable policies for its clinical applications and ultimately contribute to improve national healthcare services.

아동 중기 남아의 애착유형별 분포 및 특성에 관한 연구

홍순범(Soon-beom Hong),김창대(Chang-dai Kim),이순형(Soon-hyung Yi),최은정(Eun-jung Choi),강수정(Sujeong Kang) 한국아동학회 2016 아동학회지 Vol.37 No.5

Objective: Sex differences in attachment types are absent during early childhood, but emerge in middle childhood. Prior research has shown that boys classify as more often avoidant than ambivalent. The purpose of this study was to investigate marked sex differences in the distribution of attachment types in middle childhood, especially in boys. Methods: Attachment was assessed with the Separation Anxiety Test in a sample of 208 boys in Grades 3 and 4. Their socioeconomic backgrounds and developmental histories were also collected. Results: The distribution of attachment types was differed from those in early childhood, with insecure boys more often avoidant (31.3%) than ambivalent (7.2%). Insecure-avoidant boys were rated as over 10% compared the global distribution. Conclusion: These results supported the hypothesis of adrenarche in middle childhood. Boys may be changed to have more avoidant types in attachment.

재발성 자궁경부암의 예후인자로서 SCC 항원의 유용성

강순범(Soon Beom Kang),이철민(Chul Min Lee),오수영(Su Young Oh),노주원(Ju Weon Roh),김용범(Yong Beom Kim),김재원(Jae Weon Kim),박노현(Noh Hyun Park),송용상(Yong Sang Song),이호표(Hyo Pyo Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9

연구목적: 재발성 자궁경부암 환자의 생존율에 영향을 미치는 예후 예측인자를 알아보기 위하여 본 연구를 시행하였다. 연구대상 및 방법: 1988년 1월부터 1998년 12월까지 서울대학교병원 산부인과에서 재발성 자궁경부암으로 진단된 68명의 환자를 대상으로 하였다. 6개월 이상의 무병기간 후 새로이 암이 발견된 경우를 재발암으로 정의하여 임상적 특징을 분석하였으며, 생존율에 영향을 미치는 인자를 알아보기 위하여 Cox 비례위험함수를 이용한 다변량분석을 시도하였다. 병리조직학적 분포는 편평상피암이 70.6%, 선암이 11.8%, 선상피암이 11.8%, 그리고 소세포암이 1.5%를 차지하였고, 병기별 분포는 FIGO 병기 제 1기가 25.0%, 제 2기가 66.2%, 그리고 제 3기가 4.4%를 차지하였다. 재발부위별로는 중심골반재발이 44.1%, 골반측벽재발이 11.8%, 그리고 원격재발이 44.1%를 차지하였으며, 가장 흔한 원격전이 장기는 골반외 림프절(29.4%)이었다. 재발의 29.4%가 일차치료 후 12개월 이내에 발생하였고, 50.0%가 2년, 그리고 64.7%가 3년내에 재발하였다. 결과: 처음 진단 당시 SCC 항원의 양성율(>2.0ng/ml)은 45.2%이었고, 재발당시 측정한 SCC 항원의 양성율은 60.0%이었다. 대상환자의 총누적생존율은 29.1%이었다. 중앙골반재발의 경우가 골반측벽재발 및 원격재발에 비하여 완전관해율이 높았고(P = 0.002), 재발 진단당시 SCC 항원의 농도가 정상이었던 경우 완전관해율이 높았다(P = 0.032). 재발후 1년의 총누적생존율은 66.8%, 2년 생존율은 36.7%, 그리고 5년 생존율은 18.7%이었다. 중심골반재발의 경우 골반측벽재발 및 원격재발에 비하여 누적생존율이 높았으며(P = 0.029), 재발당시 측정한 SCC 항원의 농도가 정상이었던 경우 누적생존율이 높았다(P < 0.001). Cox 비례위험함수 모형을 이용한 다변량분석 결과 재발당시 측정한 SCC 항원 농도는 재발성 자궁경부암 환자의 누적생존율을 예측하는 독립적인 예후인자이었다(OR = 2.56, 95% CI [1.22-5.39], P = 0.01). 결론: 본 연구에서 자궁경부암의 재발 당시 측정한 혈중 SCC 항원 농도가 재발성 자궁경부암 환자에 있어서 독립적인 예후 예측인자임을 다변량분석을 통하여 확인할 수 있었다. 따라서 자궁경부암 환자의 추적검사에 있어서 혈중 SCC 항원을 정기적으로 검사하여 보다 일찍 재발을 발견하고 적절한 치료를 시행하는 것이 재발성 자궁경부암 환자의 생존율을 높이는데 기여하리라고 사료된다. Objective: This study was performed to identify the prognostic factor for survival of patients with recurrent cervical cancer. Methods: Sixty-eight patients were diagnosed as recurrent cervical cancer at the Seoul National University Hospital from January, 1988 to December, 1998. Recurrence was defined as new evidence of tumor after 6 months of disease free survival. Retrospective analysis was done in terms of clinical features and the Cox proportional hazard model was used to identify independent variables associated with an improved survival rate. Histopathologic types were distributed as follows; squamous cell carcinoma in 70.6%, adenocarcinoma in 11.8%, adenosquamous cell carcinoma in 11.8%, and small cell carcinoma in 1.5%. Distribution of FIGO stage was as follows; stage I in 25.0%, stage II in 66.2%, and stage III in 4.4%. Sites of recurrence were as follows; central pelvic recurrence in 44.1%, pelvic side wall recurrence in 11.8%, and distant metastasis in 44.1% and the most common site of distant recurrence was extrapelvic lymph nodes (29.4%). 29.4% of recurrences were observed within the first 12 months after initial therapy, 50.0% within 2 years and 64.7% within 3 years. Results: Positive rate of SCC-Ag at initial diagnosis was 45.2% with cutoff value of 2.0 ng/ml. Positive rate of SCC-Ag at the diagnosis of recurrence was 60.0%. Overall response rate to the treatment was 29.1%. Complete response rate was higher in central pelvic recurrrence than pelvic side wall recurrence and distant metastasis (P = 0.002) and also higher in normal SCC-Ag level (≤ 2.0 ng/ml) at the diagnosis of recurrence than elevated level (P = 0.032). Cumulative survival rates of 1 year after recurrence was 66.8%, 2 year 36.7%, and 5 year 18.7%. Central recurrence showed higher cumulative survival rate than pelvic side wall or distant recurrence (P = 0.029). The patients with elevated SCC-Ag level at the time of diagnosis of recurrence showed lower cumulative survival rate than those with normal SCC-Ag level (P < 0.001). Cox proportional hazard model showed that SCC-Ag elevation at the time of diagnosis of recurrence retained significant values in predicting survival(OR = 2.56; 95% CI = [1.22-5.39]; P = 0.01). Conclusion: SCC-Ag elevation at the diagnosis of the recurrence is a strong independent prognostic indicator for survival of patients with recurrent cervical cancer.

부인종양의 진단과 치료에서 양전자단층촬영술의 역할

강순범 ( Soon Beom Kang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.4

도시부도로 제한속도 산정모형 개발 및 효과분석 연구

강순양 ( Soon Yang Kang ),이수범 ( Soo Beom Lee ),임준범 ( Joon Beom Lim ) 한국안전학회 2017 한국안전학회지 Vol.32 No.2

Appropriate speed limits at a reasonable level in urban roads are highly important factors for efficient and safe movement. Thus, it is greatly necessary to develop the objective models or methodology based on engineering study considering factors such as traffic accident rates, roadside development levels, and roadway geometry characteristics etc. The purpose of this study is to develop the estimate model of appropriate speed limits at each road sections in urban roads using traffic information big data and field specific data and to review the effects of accident decrease. In this study, the estimate method of appropriate speed limits in directional two or more lanes of urban roads is reflecting features of actual variables in a form of adjustment factor on the basis of the maximum statutory speed limits. As a result of investigating and testing influential variables, the main variables to affect the operating speed are the function of road, the existence of median, the width of lane, the number of traffic entrance/exit path and the number of traffic signal or nonsignal at intersection and crosswalk. As a result of testing this model, when the differences are bigger between the real operating speed and the recommended speed limits using model developed in this study, the accident rate generally turns out to be higher. In case of using the model proposed in this study, it means accident rate can be lower. When the result of this study is applied, the speed limits of directional two or more lane roads in Seoul appears about 11km/h lower than the current speed limits. The decrease of average operating speed caused by the decrease of speed limits is 2.8km/h, and the decrease effect of whole accidents according to the decrease of speed is 18% at research road. In case that accident severity is considered, the accident decrease effects are expected to 17~24% in fatalities, 11~17% in seriously injured road user, 6~9% in slightly injured road user, 5~6% in property damage only accidents.