백서의 우울모형에서의 칼슘통로 길항제 에타베린(Ethaverine)의 항우울효과

이상경,김선희,김록우,윤성환,김용관,김경태,김영훈 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 본 전임상연구에서는 우울증의 두가지 동물모형을 통해 에타베린이 단독 혹은 이미프라민과 병용처치 되었을 때의 효과를 알아보고자 하였다. 방법: 표준화된 검사법인 강제수영검사를 사용하여 옹성백서에게 에타베린(20mg/kg) 및 이미프라민 (20mg/kg)을 단독 혹은 병용 처치하였을 때의 부동시간의 변화를 관찰하였고, 경도의 만성 스트레스를 3주간 가한 후 4주간 에타베린과 이미프라민을 단독 혹은 병용 처치하였을때의 자당섭취량의 변화를 관찰하였다. 결과: 약물을 1회 단기처치 및 7일간 장기처치한 강제수영검사에서 이미프라민 및 에타베린 단독처치는 대조군에 비하여 부동시간의 단축을 보였고 에타베린은 이미프라민의 부동시간 감소에 대한 증강작용을보였다. 경도의 만성스트레스 실험에서도 3주간의 스트레스로 인하여 감소된 백서의 자당섭취량을 이미 프라민 및 에타베린이 회복시켰으며, 치료초기에 두 약물의 병용처치효과가 두드러졌다. 결론: 본 연구의 결과는 에타베린이 향우울 효과를 가지고 있음을 시사하며, 삼환계 항우울제인 이미프라민의 항우울효과를 증강시키므로 에타베린의 임상적 활용 가능성을 보여준다. Objectives: This pre-clinical study was performed to assess the effects of ethaverine in the two kinds of behavioral models of depression in rats. Methods: We observed the changes of the immobility time in the froced swimming test and the quantity of sucrose consumed in the chronic mild stress model, using ethaverine(20mg/kg) alone, imipramine(20mg/kg) alone, or ethaverine and imipramine concomitantly. Results: In the forced swimming test, both single treatment and chronic treatment(for 7days) with imipramine or ethaverine significantly reduced the immobility time, and concomitant chronic treatment with ethaverine potentiated the effect of imipramine. In the chronic mild stress model, both imipramine and ethaverine reversed the decreased sucrose consumption induced by 3-week stress and concomitantly treated ethaverine potentiated the effect of imi-pramine in the early phase of treatment. Conclusions: The data suggest that ethaverine can be used alone or concomitantly with other antidepressants in the clinical situation.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

말초혈액 내 백혈구수와 대사증후군과의 연관성

황상태,김범수,황상준,서정열,김병진,이원영,성기철,강진호,김선우,이만호,박정로 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

플레이트거더의 전단강도

최취경,김태영,서성연,김정석,김상섭,김규석 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

In the design of plate girder web panels, it is required to evaluate accurately the elastic buckling strength under pure shear. Whether or not the post-buckling strength is accounted for. Currently. Elastic shear buckling coefficients of web panels stiffened by transverse intermediate stiffeners are determined by assuming conservatively that web panels are simply supported at the juncture between the flange and the web. Although the notion of the real boundary condition at the juncture of the web and flanges to be somewhere between simple and fixed has been recognized from early days, the boundary condition has been conservatively assumed. Mainly due to lack of means to evaluate it in a rational manner. In this paper. A series of numerical analyses based on a three-dimensional finite element modeling is carried out to investigate the effects of the geometric parameters on the boundary conditions at the juncture between the flange and the web.

사용후핵연료 차세대관리공정 장비의 내방사선 요건 분석

김성영,송태길,윤지섭,정운관,여화연 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1

For hot operation of advanced spent fuel conditioning process(ACP), the analysis of radiation-resistant Requirements effect and the system design process are required to design equipment to operate to operate reliably in a gamma radiation environment such as hot cell. To analysis the effects of radiation for ACP, we used the SCALE codes which were certified by Nuclear Regulatory Commission(NRC). The source term was calculated which reflects the features of target nuclear fuels using ORIGEN-S, a module of the SCALE code, and the gamma dose rates were calculated by using the QADS modules, considering the geometry of process equipment respectively. the results are shows that the value was maximum 3.03 ㏉/h from the rod storage box in hot cell, maximum 0.6 ㏉/h from the metallizer, and maximum 72.0 ㏉/h from the vol-oxidizer. Considering those values, the design methods for shielding and repositioning the major equipments and components should be induced, and, the preventive maintenance for components before failure actually occurs should be minimized the effects of radiation.

韓國人에서 HumFIBRA/FGA와 D21S11 遺傳座의 對立遺傳子 頻度와 遺傳的 變異의 分析

김윤신,황적준,이혜린,구태완,한길로,김성민,이혜승 大韓法醫學會 1998 대한법의학회지 Vol.22 No.1

Allele-and genotype frequencies of the two short tandem repeat (STR) loci, HumFGA and D21S11, were determined in Korean population(n=196). DNA typing was accomplished by applying fluorescence-labeled PCR products and a differently labeled sequenced allelic ladders, followed by automated analysis using ABI 377 automatic sequencer and GeneScan 2.02 software. Prior to typing, allelic ladder of each locus was constructed with a combination of all alleles occuring from the population sample. A total of 15 alleles and 48 genotypes with the heterozygosity of 0.854 for HumFGA, and 12 alleles and 33 genotypes with the heterozygosity of 0.787 for D21S11 are observed in a population of 196 genetically unrelated individuals. No deviations from Hardy-Weinberg equilibrium were observed(p=0.753 for HumFGA, p=0.262 for D21S11). The data presented here (power of discrimination and average power of exclusion) show that both STR Loci, HumFGA and D21S11, are very informative for individualization from criminal evidences, and are also useful for parentage testing.

한국어판 지역사회 치매선별 검사도구[CSID-K]의 개발

김재민,김성완,신일선,정태길,윤진상 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : Community Screening Interview for Dementia (CSID) is a reliable screening instrument for dementia, irrespe-ctive of educational level and cultural differences among various populations. This study aimed to develop the Korean version of CSID (CSID-K) for screening of dementia in Korean community residing old people. Methods : Study sample consisted of a dementia patient group and three control groups (depression, education, no education), each of them was composed of 30 community residing elders. CSID-K was administered, and demographic characteristic, depression, and cognitive function were investigated. Results : Split half reliability (Guttmans'), internal consistency (Cronbach's α ), and inter-rater and test-retest (two weeks) reliabilities of the CSID-K were excellent. Scores on the CSID-K were significantly correlated with other measures for cognitive function, In addition, scores on the CSID-K were significantly different between the dementia patient group and three control groups. Conclusion : CSI-K was a reliable and valid instrument to screen dementia in Korean community residing old people, It could be used not only in community settings but also in clinical settings and for cross-cultural researches.

1972년 8월 서울시내 침수지역하수에서 대한 장내병원균 분리상태

김성희,김우식,고광균,이연태,이종훈 中央醫學社 1974 中央醫學 Vol.26 No.5

Bacteriological survey was performed with the 81 seweage specimens taken from the flooded areas in Seoul City (Young; dungpo-Ku, Yongsan-Ku, Mapo-Ku, Seongdong-Ku and Seodaemoon-Ku) during August, 1972. Thirteen strains of enteric pathogens were isolated. from their specimens of the 13' strains of isolates, 5 strains of Salmonella species, 6 strains of Shigella and 2 strains of Vibrio parahaemolyticus were confirmed by means of biological, biochemial and serological test, respectively.

상아질 결합제의 생체적합성에 관한 연구

김성훈,진태호 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.3

This study was investigated to evaluate the biocompatibility of dentin bonding agents. The 4th generation dentin bonding agents such as Scothbond Multi-Purpose(3M, USA), Clearfil Liner Bond 2(Kuraray, Japan), All Bond 2(Bisco, USA), and 5th generation dentin bonding agents such as Single bond(3M, USA) Prime & Bond NT(Dentsply, Germany), and One Step(Bisco, USA) were used in this study. The viability of normal human pulp cell, gingival fibroblast, immortalized gingival fibroblast and HaCaT cell was measured in vim for evaluation of cytotoxicity on dentin bonding agents, and the response of pulp tissue(organotypic tooth slice culture) was analyzed and evaluated with light microscope after application of dentin bonding agents at cutting incisor edge of rats. The results obtained from this study were as follows : I. The gingival fibroblast was the most sensitive to toxicity of dentin bonding and HaCaT cell was the least. 2. The cytotoxicity of One step was low and that of ScotchbondScotchbond Multi-purpose was high in pulp cell and immortalizedginggival fibroblast. 3. The cytotoxicity of the 5th generation dentin bonding agent was lower than that of 4th generation dentin bonding agent in gingival fibroblast 4. Scotchbond Multi-Purpose showed the highest cytotoxicity comparativelyn most cells including HaCaT cell. 5. At 2 days after cultivation of tooth slice organ, them was no significant change in alveolar bone and periodontal ligament according to dentin boading apts. Odntoblasts and pulp cell population was excellent in the 5th generation dentin bonding agents after 2 days cultivation, and the similar response of odntoblasts and pulp cell was revealedafter 10 days cultivation. Collectively, in vim, cell viability and tooth slice organ culture test revealed similar results. From this study, we find out the some tendency that Scotbond Milti-Purpose is relatively more cytotoxic and One-Step is less

2000학년도 입학관련 정책연구

김선형,남상인,엄태준,제갈욱,신현철,권준택 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.1

This paper presents an improved admission policy of 2000 academical year so that more promising students apply for the University. By analyzing the past admission data and the questioned report, a unique admission policy has been suggested as the University feature reflected. One of the major differences compared from the admission policy of the last year is that the entry number limit for the special admission is in creased or newly established such as the entry allocated for recommended students, perfectly attending students, and regionally apportioned students. Also established is the special admission for those licensed students and late educated students.