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충남 연기지역에서 발생한 쭈쭈가무시병 30예의 임상적 고찰
이종화,송민호,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
We experienced 30 Tsutsugamushi disease cases occuring in the Yongi area during late October t 1 early November 1992, diagnosed clinically and serologically by indirect immunofluorescent antibody test with the following results. 1. The disease was prevalent in adult female farmers and most of the patients had chances of exposure to grass fields or scrub. 2. Clinical findings were characterized by fever(100%), myalgia, abdominal pain, headache, rash(87%), eschar(50%), conjunctival injection, CVA tenderness and lymphadenopathy. 3. On laboratory findings, proteinuria(30%) and hematuria(17%) were observed and signs of interstitial pneumonia(7%) on chest X-ray film were noted. 4. All the patients showed mild clinical course and good response to antibiotics therapy with doxycycline or chloramphenicol.
이세훈,오민화 가톨릭 대학 산업의학 쎈타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.4
This study was designed to investigate the effect of styrene-7,8oxide(styrene oxide) on their potentialto induce of sister chromatid exchanges(SCE) in phytohaemagglutinin-stimulated human whole blood lymphocytes cultured for 72 hours. The treatment with styrene or styrene oxide diluted by acetone were carried out 48 hour before harvest. The concentration of styrene was 1.0,1.5 and 2.0 mM and that styrene oxide was 50 and 100 M, and control group was treated wiht acetone only. A dose-dependent increase of SCE was observed in lymphocytes treated with styrene or with styrene oxide. The toxictiy of styrene oxide was about 15times of that of styrene considering the ability of inducing SCE in the cultured human lymphocytes and cell replicationindex. This study result was on the line that the active metabolite formed from styrene through the action of the erythrocytes is styrene oxide.