장기입원 만성정신질환자의 실태에 관한 조사

김영미,조병만,장기용,정영인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 부산지역내 정신보건시설에 1년 이상 장기입원하고 있는 만성정신질환자의 실태를 조사하여, 인구사회학적 특성과 장기입원에 영향을 미치는 요인 가운데 직접적인 의료적 요인보다는 주로 간접적인 의료외적인 요인을 알아보고, 이를 바탕으로 향후 만성정신질환자의 효율적 관리를 위한 기초자료를 얻고자 본 연구를 시도하였다. 방 법 연구대상은 1998년 7월1일 현재 부산지역 정신보건시설에서 1년 이상 장기입원중인 3,477명의 만성 정신질환자들이었다. 조사대상기관으로는 10개의 정신병원, 8개의 정신질환자 요양시설이었다. 조사방법은 저자들이 사전에 작성한 자료조사표의 양식을 부산광역시 보건과의 협조를 받아 이들 정신병원과 정신질환자 요양시설에 보내 작성하게 한 다음, 부산광역시의 행정계통을 통해 회수하였다. 자료조사표에는 성별, 연령, 진단명, 정신보건시설의 종류(정신병원, 정신질환자 요양시설), 정신보건법에서 규정한 입원형태(동의입원, 시?? 도지사에 의한 입원, 자의입원). 결혼상태, 교육수준, 요양급여형태, 연고자 유무, 면회횟수 등의 10개의 독립변수가 포함되었다. 자료분석은 입원기간에 따른 대상환자의 분포가 정규분포를 나타내지 않아 독립변수항목들과 입원기간간 의 관련성을 검증하는데는 비모수 방법인 Spear-man 상관계수, Mann-Whitney 검증, Kruskal-Wallis 검증을 사용하였다. 결 과 1) 본 연구의 대상인 1년이상 장기입원중인 환자는 전체입원환자의 70.7%에 해당하였으며 이들 대상 환자의 입원기간의 중앙값은 5.5년이었다. 2) 정신보건시설별 전체환자에 대한 대상환자의 비율은 정신병원과 정신질환자 요양시설이 각각 46.3%, 95.1%로서 정신질환자 요양시설이 정신병원에 비해 장기입원환자의 비율이 높았다. 3) 본 연구에서 설정한 10개 항목의 독립변수 모두에서 입원기간의 유의한 차이를 보여, 이들 변수 모두가 장기입원에 영향을 미치는 것으로 나타났다. 결 론 : 만성정신질환자들의 장기입원에는 상당수의 의료외적인 간접적 요인들도 중요한 역할을 하고 있는 것으로 나타났고, 이는 국내 정신의료서비스의 후진성을 보여주는 것으로 판단되었다. Objectives : In an attempt to identify the demographic characteristics and the factors influencing long-term hospitalization of chronically mentally-ill patients, a survey on the chronically mentally-ill patients who had been staying longer than 1 year in mental health facilities was conducted. Methods : Checklist including some demographic data that were regarded as independent variables was applied to 3,477 subjects through administration system of Pusan Metropolitan City. Statistical analyse were done using distribution-free, non-parametric tests. Results : 1) Subjects who had been staying longer than 1 year were 70.7% of the total inpatients of mental health facilities, and median duration of their hospitalization was 5.5 years. 2) In mental hospitals and asylums, the ratio of chronically mentally-ill subjects to the total inpatients in each facilitiy was 46.3% and 95.1%, respectively. 3) All of the 10 independent variables had an influence on the hospitalization duration. Conclusions : These results indicated that many indirect, extramedical factors had an influence the long-term hospitalization of chronically mentally-ill patients, and it is likely to reflect the underdevelopment of mental health services in Korea.

6-Exomethylene penamsulfone 유도체의 β-lactamase 저해작용

김해종,여성현,임채욱,임철부,김미영 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

6-Exomethylene penam derivatives were tested as possible β-lactamase inhibitors. The in vitro β-lactamase inhibitory activities were determined by a spectrophotometric assay using Type Ⅰ, Ⅱ, Ⅲ, Ⅳ and TEM β-lactamase. Their activities were compared with sulbactam, tazobactam and clavulanic acid. The 6-exomethylene sulfone derivatives were more potent than clavulanic acid and sulbactam against Type Ⅳ β-lactamase. The Z-isomers showed stronger activities than the E-isomers against TEM and Type Ⅳ β-lactamase.

생체시료中 Morphine 및 Codeine의 분석

임미애,이종숙,김재균,박세연,성은연,구기서 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

소비자교육과 관련 변수가 초등학교 학생의 소비자능력에 미치는 영향

제미경,김영옥 한국 가정과 교육 학회 2002 한국가정과교육학회지 Vol.14 No.3

The objectives of this study are to investigate whether consumer education affects the consumer competency and to find out which factors including consumer education affect the consumer competency of elementary school children. The subjects of this study were 43 children at fifth grade to participate in consumer education(experimental group) and 37 children not to participate(control group). Consumer education program was executed for total 20 hours in a semester. Surveys were also conducted twice times to get data for consumer competency and the related factors. The findings are as follows : 1) Consumer education has a positive effect on consumer-role attitude and consumer skill according to the result of ANCOVA. 2) The variables affecting the consumer-role attitude are consumer education and consumer skill of mother in that order according to the result of multiple regression. The variables affecting the consumer skill are consumer skill of mother, consumer education, record of a cashbook and gender in that order. The only variable affecting the consumer knowledge is consumer education.

소비자교육이 유아의 소비자지식과 소비자행동에 미치는 영향

제미경,김영옥 대한가정학회 2004 Human Ecology Research(HER) Vol.42 No.2

The purpose of this study is to evaluate a practical consumer education program for kindergarten children and to investigate whether consumer education affects their consumer knowledge and consumer behavior. The subjects of thii study were 32 5-year-old kindergarten children who participated (experimental group) and 25 kindergarten children who did not participate (control group) in the consumer education program. Consumer education was held for 6 hours twice a week during October 8 to 29, 2002. Questionnaire surveys were conducted before and after the education program. Percentiles, frequencies, means, and ANCOVA were uwized for data analysis with SPSS program. The results of this study showed that consumer education had very positive and significant effects on consumer knowledge (pe.01) and consumer behavior (pc.05) among kindergarten children. Furthermore, consumer education for only three weeks had effectively enhanced kindergarten children's ability as consumers. These results imply that consumer education should be served periodically and systematically from an early age. Diverse subjects and teaching methods must be developed and utilized for consumer education of kindergarten children.

TRANCE, a TNF Family Cytokine, Promotes Angiogenesis : Its angiogenic Action and Signaling Mechanism in Human Endothelial cells

Kim, Young-Mi,Kim, Young-Myoung,Lee, You Mie,Kim, Hae-Sun,Choi, Yongwon,Kim, Kyu-Won,Lee, Soo-Young,Kwon, Young-Guen 이화여자대학교 세포신호전달연구센터 2001 고사리 세포신호전달 심포지움 Vol. No.3

TNF-related activation-induced cytokine(TRANCE), a member of the TNF family, is highly expressed on osteoblasts and plays a key role in the control of bone development. Because angiogenesis is the crucial first step in the processes of proper bone formation, we tested the hypothesis that TRANCE is able to induce the growth of new blood vessels. TRANCE evoked a time- and dose-dependent activation of the mitogen-activated protein kinases ERK1/2, AKT and NF-B in human umbilical vein endothelial cells(HUVECs). TRANCE stimulated in vitro DNA synthesis, chemotactic motility, and capillary-like tube formation of HUVECs. Both Matrigel plug assay in mice and chick chorioallantoic membrane(CAM) assay revealed that TRANCE potently induced neovascularization in vivo. These results indicate that TRANCE, presumably via activation of the endothelial TRANCE receptor, stimulates various angiogenic signaling pathways in endothelial cells. Thus, TRANCE may act as an important modulator of angiogenesis under the physiological and pathological conditions.

Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation.

Kim, Suhyun,Kim, Jun-Dae,Chung, Ah-Young,Kim, Hyung-Seok,Kim, Young-Seop,Kim, Myoung-Jin,Koun, Soonil,Lee, You Mie,Rhee, Myungchull,Park, Hae-Chul,Huh, Tae-Lin The Society 2012 The Journal of neuroscience Vol.32 No.24

<P>Oligodendrocytes are myelinating glial cells in the CNS and are essential for proper neuronal function. During development, oligodendrocyte progenitor cells (OPCs) are specified from the motor neuron precursor domain of the ventral spinal cord and differentiate into myelinating oligodendrocytes after migration to the white matter of the neural tube. Cell cycle control of OPCs influences the balance between immature OPCs and myelinating oligodendrocytes, but the precise mechanism regulating the differentiation of OPCs into myelinating oligodendrocytes is unclear. To understand the mechanisms underlying oligodendrocyte differentiation, an N-ethyl-N-nitrosourea-based mutagenesis screen was performed and a zebrafish leo1 mutant, dalmuri (dal(knu6)) was identified in the current study. Leo1 is a component of the evolutionarily conserved RNA polymerase II-associated factor 1 complex (PAF1C), which is a positive regulator of transcription elongation. The dal(knu6) mutant embryos specified motor neurons and OPCs normally, and at the appropriate time, but OPCs subsequently failed to differentiate into myelinating oligodendrocytes and were eliminated by apoptosis. A loss-of-function study of cdc73, another member of PAF1C, showed the same phenotype in the CNS, indicating that PAF1C function is required for oligodendrocyte differentiation. Interestingly, inhibition of positive transcription elongation factor b (p-TEFb), rescued downregulated gene expression and impaired oligodendrocyte differentiation in the dal(knu6) mutant and Cdc73-deficient embryos. Together, these results indicate that antagonistic regulation of gene expression by PAF1C and p-TEFb plays a crucial role in oligodendrocyte development in the CNS.</P>

반월형 사구체신염이 병발된 T 림프구 기원의 원발성 간림프종 1 예

김용일,정철원,이현순,김홍빈,박동영,이효석,김성권,소영,김노경,김병관,김선미,이기형,허대석 대한내과학회 1997 대한내과학회지 Vol.53 No.1

The primary lymphoma of the liver is a rare disease. We report a case of primary hepatic T-cell lymphoma associated with crescentic glomerulonephritis. The case, a 53-year-old male was presented with a 2-year history of hepatic mass and a 1-month history of foamy urine, rapidly progressive azotemia, and oliguria. The kidney biopsy revealed diffuse crescentic glomerulonephritis. The result of immunohistochemical study of liver biopsy specimen was consistent with non-Hodgkin's lymphoma in T-cell lineage. Because renal function was deteriorated rapidly and there were signs of volume overload, hemodialyses were performed. Although the patient received 2 cycles of combination chemotherapy with CHOP(cyclophosphamide, vincristine, prednisolone, and doxorubicin), he did not respond and died of sepsis.

Increased bone mineral density according to increase of skeletal muscle mass in 534 Korean women: A retrospective cohort study conducted over 2.7 years

( Sun Mie Kim ),( Seok Hyun Kim ),( Jin Ju Kim ),( Min Jeong Kim ),( Hyuk Tae Kwon ),( Chang Suk Suh ),( Young Min Choi ),( Jung Gu Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.2

Objective To determine the impact of the changes in the amount of abdominal fat, directly measured by computed tomography, body composition, and the metabolic syndrome (MetS) risk factors on the bone mineral density (BMD) of Korean women. Methods A retrospective cohort study involving 534 Korean women aged 29 to 78 years, who had undergone both dual-energy X-ray absorptiometry and abdominal adipose tissue analysis by computed tomography scan more than twice between January 2004 and December 2010. The changes in the BMD values were examined in association with the changes in fat amount, body composition parameters, and risk factors of MetS. Results On cross sectional analysis, there was a significant positive correlation between femoral BMD and total abdominal fat amount at the initial visit. However, the correlation disappeared when the impact of change of the fat amount on the change in BMD was analyzed over the study period. When the MetS and body composition parameters were analyzed, a significantly positive correlation was found between skeletal muscle mass and BMD. There was no significant relationship between the MetS risk factors or other body composition parameters and BMD throughout the study period after adjusting for age (time interval). Conclusion Among body composition parameters, only increased skeletal muscle mass had a positive correlation with increased BMD over the study period of 2.7 years.

항 Ro/SS-A 항체 양성인 일차성 쇼그렌 증후군 환자에서 침샘 초음파의 유용성

Young Wook Kim,Seong Ryul Kwon,Mie Jin Lim,Hwan Cheol Kim,Park Won 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-