의약분업 전후의 의약정보서비스의 질의응답과 질의자의 만족도 분석

신정인,김미애,허경희,김미정,신현택,오정미 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Drug Information Centers(DICs) are responsible for providing updated and relevant drug information on the efficacy, safety and quality of drugs to health-care practitioners and finally to patients. After the establishment of new prescription law(Bunup)' on August 2000, the future direction for DICs is strongly needed to provide specified, appropriate and rapid information to health-card practitioners and patients. This project was undertaken to provide a future direction of DICs via comparing differences of Q&A before and after Bunup, based on the analysis of Q&A worksheets that were conducted from August 1999 to July 2001 at Drug Information Research Institute(DIRI) of Sookmyung Women's University. In addition, feedback sheets were collected from the users of DIRI from April 2001 to August 2001, to evaluate the satisfaction scores by '5-point Likert scale' on the response. The number of inquiries responded by DIRI was increase from 201 to 574 and the most frequently asked inquirers were pharmacists, specifically community pharmacists. The mean time to respond before and after Bunup was 5.35 and 4.68 hours, respectively. The method of inquiry utilized the most was electronic mailing system followed by telephone both before and after Bunup(66.2% vs. 65.7% via e-mail, from 32.8% vs. 32.4% via telephone). The most frequently asked category of question was on the 'clinical drug' category both before and after Bunup (79% vs. 73.6%). The tertiary literature was the most frequently used reference to answer the inquiries. Mean feedback result via questionnaires was good. That included accuracy, quality of information, time to respond, attitude of provider, accessibility, etc. The most increased inquirer after Bunup was general person, compared with before. Therefore DICs should provide separate responds according to inquirers, develop the systemic program to improve the response for each request, have systemic Q&A worksheet, and develop the educational program for drug information providers. DICs should continuously provide more appropriate and rapid information to health-care practitioners and patients.

웹 기반환경에서의 종합금융시스템에 관한 사례연구

신미향,김갑수,서영희 한국세무회계학회 2003 세무회계연구 Vol.13 No.-

금융업은 정보집약산업이기에 정보통신기술의 급격한 발달로 인하여 급격한 변화를 맞이하고 있다. 특히 기업들과 금융기관에서는 웹 환경에 적합한 전자상거래나 인터넷 뱅킹을 추진하려고 한다. 본 연구에서는 이러한 시스템들을 자체 개발할 능력이 부족한 기업이나 금융기관들에게 지침을 제공하기 위해서 종합금융시스템 솔류션을 사례로 선정하여 분석하였다. 사례기업의 SOLBUS시스템은 전자상거래를 비즈니스 모델로 고려하고 있는 중소기업들로 하여금 전자상거래를 위한 포탈사이트 운영 및 관리, 결제시스템을 갖추고 있는 전자상거래 시스템을 쉽게 구축할 수 있도록 한다. 뿐만 아니라 SOLBUS는 제2금융권들에게 인터넷 뱅킹을 용이하게 구현할 수 있도록 설계되어 있다. 본 사례연구를 통해서 중소기업이나 제2금융권에 최근 많은 관심을 받고 있는 전자상거래나 인터넷 뱅킹을 구현할 수 있는 지침을 제공해줄 수 있다.

식사를 통한 N-Nitrosamine의 추정 섭취량 평가

신정혜,김연희,이수정,손미예,성낙주 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1

단체급식소 12개소의 식단을 수거하여 각 메뉴별 및 1인분 식단별 NA 함량을 분석하였고 인공소화 기법을 활용하여 체내에서 생성 가능한 NA의 함량을 예측하였다. 육류와 어패류를 주재료로 요리된 메뉴들의 인공소화 전·후 NA 함량을 분석한 결과 멸치볶음에서 NDMA 함량이 흔적량 ~ 4.8 ㎍/kg으로 가장 높았고, 채소류를 주재료로 한 메뉴들에서는 불검출에서 흔적량의 NDMA가 정량되었으며, 인공소화 후에도 흔적량 이하로 정량되었다. 1인 분량의 식사를 수거하여 인공소화 전·후의 NA를 분석한 결과 NDMA는 인공소화 전 0.20 ~ 0.78 ㎍/kg의 범위였으나 인공소화 후에는 0.43 ~ 0.80 ㎍/kg으로 약간 증가하였다. 상기의 분석 결과를 기초로 하여 성인 1일 NA 섭취량을 계산한 결과 0.60 ~ 2.34 ㎍/day/person이며, 인공소화를 통한 체내에서의 생성량을 고려하면 최대 5.15㎍/day/person으로 추정된다. N-nitrosamine (NA) contents depending on simulated gastric digestion were analyzed with 12 kinds of diets collected from institutional food service those diets were estimated the total NA amounts including both intake from food directly and its endogenous formation in human body from simulated gastric digestion. NA was determined in dishes of meats, fished and vegetables before and after simulated gastric digestion. N-nitrosodimethylamine (NDMA) contents were from not detected(ND) to 4.8 ㎍/kg in dishes of meats and fishes. After digestion, its contents increased and the highest level was 3.0 ㎍/kg in panbroiled dried anchovy. In vegetable dishes, NDMA was detected as ND ~ trace before and after digestion. The contents of NDMA in diets collected from institutional food service were 0.20 ~ 0.78 ㎍/kg, 0.43 ~ 0.80 ㎍/kg before and after digestion, respectively. The average intake of Na per day to Korean, based on the above data, was 0.60 ~ 2.34 ㎍/day/person. The maximum daily intake of NA was reduced to 5.15 ㎍/day/person when considering NA amounts formed endogenously by simulated gastric digestion.

교직원 중 비흡연자와 흡연자의 건강상태비교

신선미,이희우 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.2

Purpose:This study estimated the prevalence of smoking among male and female school employees. This study also correlated key indicators of health with the number of cigarettes consumed per day by the male smokers. The indicators of health included health behavior, blood pressure (mmHg), BMI (kg/m2), diabetes, total cholesterol, GOT, GPT and GTP. Methods:Subjects included 2,640 male and 2,747 female employees working at elementary, middle, and high schools who received a physical check-up at the Seoul School Health Center in 2002. Data was obtained from the physical examinations, questionnaires, and laboratory results. Results:39.7% of males and 0.4% of females were current smokers. 60% of the male smokers consumed between 10 and 19 cigarettes per day, and39.6% of male smokers had been smoking between 10 and 19 years. Smokers who consumed more than one pack per day had a relatively higher BMI than the non-smokers (24.7 24.1, respectively). However, smokers had lower blood pressure than non-smokers. The mean systolic and diastolic blood pressure of current-smokers were 128.2 and 82.8, respectively, while the values among non-smokers were 129 and 84.5, respectively. The proportion of current smokers with severe obesity (over BMI 30) was 5.0%. This was considerably higher than the 1.3% of severely obese non-smokers. Current-smokers also had mean and abnormal rate of fasting blood glucose, total cholesterol, GOT, GPT, and GTP that were higherthan those of non-smokers. The frequency of red meat consumption, alcohol use, perceived incidents of stress were alsomore frequent in current-smokers than in non-smokers. Exercise frequency was also lower among smokers. In multiple regression after adjusting all possible confounding factors including age, BMI, diet, and drink, the parameter value of fasting blood glucose, cholesterol, GOT, GPT, and GTP increased relative to the level of cigarette consumption. Conclusion: Among school employees, health behavior, and general health status including BMI, total cholesterol, GOT, GPT, GTP, and fasting blood glucose were worse in smokers than in non-smoker.

좌측 관동맥에서 시작된 관동정맥루에 동반된 거대 동맥류 1예

신미승,맹선희,이혜진,조홍근,정의모,신길자 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

카드뮴이 인간 단핵구 세포주(THP-1)에서 cytokine 유전자 발현에 미치는 영향

신동훈,박관규,강미정,서석권,정인성,양선희 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

Cadmium, a potent toxic metal, posses a serious environmental threat but the mechanism of its toxicity remains unclear. Also, cadmium is a known immunotoxic agent in animal studies and induces pathophysiological effects by modulating components of immune system. Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. Cells of mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. In the present study, we investigated the effect of cadmium cytotoxicity for the monocyte and expression of cytokine gene in the control and cadmium treated human monocytic cell lines using RT-PCR method. The results showed that cadmium inhibited cell proliferation at 0.1mM cadimium treated cells for 24 hours. The TNF-α mRNA was expressed in both control and cadmium treated cells but not IL-6 and IL-1β. The mRNA levels of TNF-αwere examined during 24 hours culture period, at different time points. The expression of TNF-αmRNA increased in both 0.01mM and 0.1mM cadmium treated cells, but did not show dose-response relationship. According to cadimium treated duration, expression of TNF-αmRNA was more decreased in 24 hours than 6 hours. The decreased levels of mRNA of TNF-α suggest that cadmium suppresses its production at the transcription level.

초등학교 아동의 비만지수와 신체활동에 관한 조사연구

신재신,김명희,박형숙,송미경 韓國學校保健學會 2000 韓國學校保健學會誌 Vol.13 No.1

This study researches an obesity inde( and the reaiities of physical activity of etementary school childrnl and pvide basic data to instruct correct physical activity for low weight md obese childraL The subject was 813 Elementary School Chiliherl of grade 4-6 in Krimgiu and data were collected with a Physical Activir Questionnaire from fTs, USA The collected data ware an3ly2ed with real number, pnfentagf avErge and standard deviation techniques. The rarlge was by SPSS WIN. Both of them were in the normal range, between -38.3 and 77.7, between low weight and obesity The results are as follows : 1. An Obesity index according to grade and sex: the average obesity index of 423 boys was 7.56 ± 15.7, for girls it was 2.56± 14.3. Both of them were in the nrnmal range, between -38.3 and 77.7. There were low weight(-38.85±0.9) students as well as obese, including extremely low weight children (-38.85 ±0.9) and extremely obese children. 2. On the whole, in the Freouency of the 25 item physical activities breakdown, children reported to watch TV 1.(2.7±0.6), or do homework(2.1 ±0.9), more than three-fourths of the week, male children, however, played more football(2.0 ±0.9). As male obese children do less MET5, MET8(highly active activity) than male normal children, it was also discovered that low weight children do mnre severe activity in MET8(high activity). In female cases, it was revealed that neither do highly intense activity. 3. In physical activitiy, male children received higher points than fonale children with 92.94±37.95 to 74.46 ±29.50. On the whole, male and female obese children had lower score than normal children. 4. As for attitude toward physical activiv, male children(31.9614.37) had a positive attitude than female children (29.57 ±3.89), but obese male children had a negative attitude regarding activity viewed as normal. ThaefgrE in peventing obesity in elementary school childrerl the treating of under-weight childrern. should be included in the obesity Fgram so as to Pevent mal-nutrition or denciency. It is needed to instruct obese childrul to carry out interlsive w[rk-outs at least 3 times a weft through systematic grams. It is also needed that parents and teachers educate elementary school chil(hell from an early age with iDcimation on the frequency and interlsity of work-outs to prevent obesity. It is also desirable that children be eddcated to cauy out physical activities that address thetr specific needs. As a result of this study, obesif management must be started from elementary school and children should be instructed to act in hiRh-interlsity actirities when they spend leisure time.

오존처리시 부식산의 흡광도 및 총유기탄소량 변화에 관한 연구

신성희,김계월,한미덕,이동석 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

Experiments were performed to evaluate UV/VIS absorbance and TOC of humic acid solutions which were ozonated at different pH values. The optimum conditions for ozonation of humic acid from this study are pH 9 (buffered) and 0.84(H?O?/HA, w/w) for H?O? dosage.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

서울시 교직원의 고혈압 실태파악과 그 요인에 관한 연구

신선미,김종희,한규종,이희우 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.1

Purpose : To describe epidemiological characteristics and related factors in school personnel with hypertension. Method : 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=l00 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results : Normotension was 20.13% in d e s and 48.65% in female, prehypertension 43.4% in males and 3.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a &her BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions : It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.