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Yoo, Dae Young,Kim, Woosuk,Yoo, Ki‐,Yeon,Nam, Sung Min,Chung, Jin Young,Yoon, Yeo Sung,Won, Moo‐,Ho,Hwang, In Koo Wiley Subscription Services, Inc., A Wiley Company 2012 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.90 No.8
<P><B>Abstract</B></P><P>In this study, we challenged pyridoxine to mice fed a high‐fat diet (HFD) and investigated the effects of pyridoxine on HFD‐induced phenotypes such as blood glucose, reduction of cell proliferation and neuroblast differentiation in the dentate gyrus using Ki67 and doublecortin (DCX), respectively. Mice were fed a commercially available low‐fat diet (LFD) as control diet or HFD (60% fat) for 8 weeks. After 5 weeks of LFD or HFD treatment, 350 mg/kg pyridoxine was administered for 3 weeks. The administration of pyridoxine significantly decreased body weight in the HFD‐treated group. In addition, there were no significant differences in hepatic histology and pancreatic insulin‐immunoreactive (‐ir) and glucagon‐ir cells of the HFD‐treated group after pyridoxine treatment. In the HFD‐fed group, Ki67‐positive nuclei and DCX‐ir neuroblasts were significantly decreased in the dentate gyrus compared with those in the LFD‐fed mice. However, the administration of pyridoxine significantly increased Ki67‐positive nuclei and DCX‐ir neuroblasts in the dentate gyrus in both LFD‐ and HFD‐fed mice. In addition, the administration of pyridoxine significantly increased the protein levels of glutamic acid decarboxylase 67 (GAD67) and brain‐derived neurotrophic factor (BDNF) and the immunoreactivity of phosphorylated cyclic AMP response element binding protein (pCREB) compared with the vehicle‐treated LFD‐ and HFD‐fed mice. In contrast, the administration of pyridoxine significantly decreased HFD‐induced malondialdehyde (MDA) levels in the hippocampus. These results showed that pyridoxine supplement reduced the HFD‐induced reduction of cell proliferation and neuroblast differentiation in the dentate gyrus via controlling the levels of GAD67, pCREB, BDNF, and MDA. © 2012 Wiley Periodicals, Inc.</P>
YOO, Dae Young,NAM, YoonYi,KIM, Woosuk,YOO, Ki-Yeon,PARK, Jaeil,LEE, Choong Hyun,CHOI, Jung Hoon,YOON, Yeo Sung,KIM, Dong-Woo,WON, Moo-Ho,HWANG, In Koo Japanese Society of Veterinary Science 2011 The Journal of veterinary medical science Vol.73 No.1
<P><I>Ginkgo biloba </I>leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.</P>
Yoo, Dae Young,Shin, Bich Na,Kim, In Hye,Kim, Woosuk,Kim, Dae Won,Yoo, Ki-Yeon,Choi, Jung Hoon,Lee, Choong Hyun,Yoon, Yeo Sung,Choi, Soo Young,Won, Moo-Ho,Hwang, In Koo Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.2
<P>Oxidative stress is one of the most important factors in reducing adult hippocampal neurogenesis in the adult brain. In this study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) on lipid peroxidation, cell proliferation, and neuroblast differentiation in the mouse dentate gyrus using malondialdehyde (MDA), Ki67, and doublecortin (DCX), respectively. We constructed an expression vector, PEP-1, fused PEP-1 with SOD1, and generated PEP-1-SOD1 fusion protein. We administered PEP-1 and 100 or 500 관g PEP-1-SOD1 intraperitoneally once a day for 3 weeks and sacrificed at 30 min after the last administrations. PEP-1 administration did not change the MDA levels compared to those in the vehicle-treated group, while PEP-1-SOD1 treatment significantly reduced MDA levels compared to the vehicle-treated group. In the PEP-1-treated group, the number of Ki67-positive nuclei was similar to that in the vehicle-treated group. In the 100 관g PEP-1-SOD1-treated group, the number of Ki67-positive nuclei was slightly decreased; however, in the 500 관g PEP-1-SOD1-treated group, Ki67-positive nuclei were decreased to 78.5% of the vehicle-treated group. The number of DCX-positive neuroblasts in the PEP-1-treated group was similar to that in the vehicle-treated group. However, the arborization of DCX-positive neuroblasts was significantly decreased in both the 100 and 500 관g PEP-1-SOD1-treated groups compared to that in the vehicle-treated group. The number of DCX-positive neuroblasts with tertiary dendrites was markedly decreased in the 500 관g PEP-1-SOD1-treated group. These results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus.</P>
농촌 Amenity 자원 활성화를 위한 조직리더 육성 방안
유덕기,이상영 동국대학교 사회과학연구원 2007 사회과학연구 Vol.14 No.1
마을발전을 위한 정책적 사업 개발은 필수적이다. 그러나 이를 추진하고 주민의 적극적인 참여와 자발적인 발전계획을 수립하고 운영할 수 있는 마을조직정비와 조직리더의 역할은 무엇보다 중요하다. 지역의 특성을 바탕으로 지역 내 산업간 유기적 관련성을 높이며 지역자원의 잠재력을 활성화하고 자원의 최대한 이용을 전제로 한 지역농업으로의 지방자치제의 기능강화와 자율성의 강화에 의한 성공적인 추진사례도 등장하고 있으나 대부분 조직과 리더의 미약으로 효과적인 추진이 어려운 실정이다. 1980년대 중반 이후 이농 및 농촌고령화로 인한 조직파괴와 리더의 감소는 심각한 현상이라고 하겠다. 이러한 농업 농촌의 현실에서 농업, 농촌발전의 핵심적 역할을 담당하는 것으로 그 중요성이 부각되고 있는 지역단위의 마을을 중심으로 잠재된 농촌의 어메니티(amenity)자원을 활성화하고 마을단위의 환경친화적 특화농업을 통하여 지역경쟁력을 강화하고 농가소득향상을 추구하며 그린투어와 연계된 농촌체험마을을 육성, 활성화하기 위하여 제기되고 있는 정책과 필수적으로 요구되고 있는 주민조직의 활성화와 조직리더 육성방안을 강구하고 기초지방자치단체(시/군/읍/면/마을)단위 중심의 지역농업 개발사업(지역농업 클러스터)에도 연계하는 방안을 제시하여 농촌지역과 생명농업발전에 기여하고자 한다. In the development of policies and projects for regional development, consolidating region's organization and organizational leadership that could establish and operate voluntary developmental plans along with active participations by regional people are important. There have been successful cases of regional agricultural products emphasizing regional characteristics by strengthening functions and autonomy of the local government based on the premise of increasing mealable relationship among local industries and maximizing the characteristics of local resources and local resource utilization. However, effective pursuing is difficult due to lack of organization and leadership. Centering around local units with their importance recognized playing the core role in the development of rural areas, other important issues are activating civic organizations essential for local development based on town units and agricultural amenity resources in rural areas by seeking methods of rearing organizational leadership, improving rural incomes by strengthening local competitiveness through environmentally -friendly agricultural products based on local units, and developing and activating farm experience related with green tour. The types of organization and leaders are analyzed by investigating approved cases of farm experience. According to the results of the analysis, we seek the methods of promoting organizations and leaders for promoting farm experiences in villages and methods of constructing support organizations for promoting farm experience centering around local government units (such as city, Kun, Eup, Myun and village).
한국인 모발과 내부장기조직간 Cd, Hg, Pb 및 Zn함량의 상호관련성
유영찬,이상기,양자열,김기욱,이수연,정규혁 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1
In order to study the relationships between trace element concentrations of hair and internal organs, autopsy samples of hair, liver, kidney cortex, kidney medulla, heart, lung, spleen, cerebrum, testis and bone from 162 Korean subjects were analyzed for Cd, Hg, Pb and Zn by inductively coupled plasma atomic emission spectrometry. High significant positive correlations were found between the Cd concentration in hair and bone and Pb in hair and lung. Hair Hg levels were highly significantly correlated with organ Hg levels in the liver, kidney cortex, kidney medulla, heart, lung, spleen, cerebrum, testis and bone. And hair Zn levels were highly significantly correlated with organ Zn levels in the kidney cortex, kidney medulla, spleen, testis and bone.