정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

황색포도구균의 균혈증에서 초기 항생제 치료가 예후에 미치는 영향

김성한,박완범,이기덕,강철인,최영주,김홍빈,박상원,김의석,오명돈,김의종,최강원 대한감염학회 2002 감염 Vol.34 No.5

알루미늄 합금과 고장력 강판 접합을 위한 헬리컬 SPR의 단조공정 설계

김원영, 김동범, 김기호, 김도훈, 이인환, 조해용 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

A self-piercing rivet(SPR) is a mechanical component for joining dissimilar materials. It is used for joining dissimilar material sheets such as aluminum alloy and steel. The self-piercing rivet directly pierces into sheets without drilling sheets beforehand unlike conventional rivets. However, the self-piercing rivet occurs buckling when piercing high strength steel. Therefore, a helical SPR which can pierce high strength steel sheet was designed. In this study, forging process was designed for manufacturing the helical SPR and simulated by using commercial FEM code DEFORM-3D. In the simulation of forging process for manufacturing rivet, process sequence, formability, forging load were investigated. The suitable forging process could be designed by comparisons of simulated results. Experimental trials have been carried out for same conditions as simulated ones. The simulated results agreed with the experimental ones. So, the analytic approach in this thesis is useful to save cost and time in the forging industry

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

분산시스템에서 Performance에 기반을 둔 Optimal Leader Election에 관한 연구

金漢雄,陳祈範 안성산업대학교 1992 論文集 Vol.24 No.-

This thesis proposed new in the optimal election model new performance measure in the optimal election model and new optimal leader election scheme. In this paper, we analyzed, experimented and tested the proposed scheme using the simulation method and non-parametric statistics test method.

단무지 공장에서 발생한 질식 사고의 원인과 방사선학적 소견: 중례보고 및 가스분석 결과

박충기,김만구,김흥철,안범규,박만수,황우철,최철순,강익원 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

목 적:단무지 공장에서 질식사고를 일으켰던 가스의 종류를 알아내고, 이러한 가스중독의 방서선학적 소견을 소개하기 위하여 본 연구를 하였다. 대상 및 방법:단무지 공장에서 발생한 질식 사고자 3예중 생존자 1예를 대상으로 단순흥부X-선검사와 CT 소견을 분석하였으며, 가스의 종류를 알아내기 위하여 단무지를 유리병에 넣어 발생된 가스를 가스크로마토그래픽을 이용하여 분석하였다. 결 과:단무지 공장에서 발생한 질식사고자중 생존한 1명의 방사선학적 검사에서 신속히 호전되는 폐경결(consolidation)을 볼 수 있었으며 이는 폐부종의 소견임을 알 수 있었다. 협기성 상태에서 단무지를 담은 유리병의 상층부 가스를 실험 분석한 결과 이산화탄소, 에칠알코올이 다량으로 검출되었으나 독성가스는 주로 황화수소이였다. 결 론:단무지 공장의 질식 사고자에서 폐방사선학적 소견은 폐경결을 보이는 폐부증으로서 이는 실험을 통해 단무지에서 발생되는 유독가스인 황화수소 때문임을 입증하였다. Purpose: To identify the main toxic gas released from salted radish in rice bran(Dan-M-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Materials and Methods: Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analized by using the gas chromatography. Results: The radiographlc examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consolidations in both lung. The headapace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Conclusion: Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.

니켈촉매를 이용한 메탄의 부분산화에 의한 합성가스 제조

김상범,신기석,박은석,곽윤철,천한진,함현식 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.1

메탄의 부분산화에 의하여 힙성가스를 제조하였다. 촉매는 니켈 담지 촉매를 사용하였으며, 담지된 니켈의 양은 10-15 wt%이었다. 담체로는 BaO, CaO, MgO를 사용하였다. 촉매는 함침법으로 제조하였으며, 반응은 CH_4:O_2의 비가 2:1, 1 atm, 750℃에서 수행하였다. 반응결과, MgO를 담체로 사용하였을때 가장 좋은 촉매활성을 보여주었으며, 니켈의 담지량이 13 wt%일때 촉매의 활성이 가장 좋았다. 이 13 wt% Ni/MgO 촉매의 경우 80%의 메탄 전화율과 93% 및 94%의 CO 및 H_2 선택도를 각각 얻을 수 있었다. 또한 이 촘매는 약 180시간 정도의 반응 후에도 촉매의 활성이 감소하지 않았다. 논란 중인 반을 기구에 대하여 조사해 보기 위하여 펄스방식으로 반응물을 투입하며 촉매 상 · 하층의 온도를 측정하였고, 반응시간에 따른 반응물과 생성물의 몰수 변화, 그리고 O_2-TPD 실험을 수행하였다. 그 결과 메탄으로부터 합성가스가 생성되는 경로는 2단계반응으로써 메탄이 완전 산화되어 CO_2와 H_2O가 생성되고, 이 생성된 CO_2 및 H_2O가 미반응 메탄과 각각 개질반응을 하여 합성가스가 생성됨을 알 수 있었다. Synthesis gas producution by partial oxidation of methane has been investigated using BaO, CaO and MgO supported Ni catalysts. The catalysts were prepared by the impregnation method. The reaction was carried out at I atm, 750℃, and CH_4:O_2=2:1. The highest catalytic activity was obtained with MgO support when Ni loading was 13 wt%. With the 13 wt% Ni/MgO catalyst, methane conversion was 80%, and CO and H_2 selectivities were 93% and 94%, respectively. The activity of the catalyst remained nearly constant after 180h of the reaction. To investigate the reaction mechanism of this reaction, the temperature of the actalyst bed at top and products were determined with time; and O_2-TPD experiment was carried out. From the results, it is deduced that the reaction takes place by a two-step reaction-first, total oxidation of methane to CO_2 and H_2O takes place, and then the produced CO_2 and H_2O are further reacted with CH_4 to give synthesis gas.

대상 포진 반흔 부위에 발생한 대상 편평 태선 1예

김지숙,김명화,최혜영,명기범 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.2

Many cutaneous reactions have been known to occur within resolved herpes zoster lesions. These include granuloma annulare, pseudolymphoma, lymphoma, granulomatous vasculitis, lichen planus and other dermatoses. The pathogenesis of these reactions remains unclear and it has been proposed that they may represent isotopic response. A dermatomal distribution in lichen planus is very rare. We report here a case of zosteriform lichen planus that was developed on the site previously affected by herpes zoster. (Korean J Dermatol 2004;42(2):217~219)

소아치과 영역에서 러버댐의 다양한 임상적 적용에 대한 증례보고

김종범,김종철,이성혁,장기택 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3

Usage of the rubber dam has been advocated by countless number of dentists. The advantages of the rubber dam such as the following are well-known 1. Moisture control. 2. Improved field of vision. 3. Ease of approach. 4. Soft tissue retraction and Injury prevention. 5. Prevention of aspiration of materials or instruments. 6. Shortened chair time. 7. Induction of nasal breathing during administration of N₂O-O₂sedation. Recent reports indicate the rubber dam can protect the dental staffs from the infection when treating HBV or HIV positive patients. Also, impreved moisture control and freeing of both handes allowed by the rubber dam makes it very useful when bonding orthodontic brackets. This case study presents the various clinial application of the rubber dam on patients visiting SNUDH dept. of pediatric dentistry to emphasize the importance of its use in pediatric dentistry.

인공타액에서 염소 및 황이온이 치과용 아말감의 전기화학적 부식에 주는 영향

김철위,김명국,백기석,임범순 대한치과기재학회 1996 대한치과재료학회지 Vol.23 No.2

The amalgam alloys contained the Ag, Sn, and Cu. Alloys containing Ag and Cu suffer sulfide tarnish and chloride corrosion. The purpose of this study was to evaluate the effect of Cl and S ions in artificial saliva on electrochemical corrosion dental amalgam and clarify the effect of sulfides on chlorides corrosion of dental amalgam. Eight types of dental amalgams were selected; four conventional dental amalgam alloys (BSA, CVX, HIA, and STF) and four high copper alloys (A21, LGA, LUX, and TYT). Fusayama's modified artificial saliva was used as standard electrolyte (concentrations of Cl and S ion were 12.22 mM/ℓ, 0.1mM/ℓ respectively). The concentration of Cl ions was modified to 1.22mM/ℓ, 12.22mM/ℓ, 24.44mM/ℓ, and 61.10mM/ℓ. As the Cl ions fixed at 12.22 mM/ℓ and 24.44mM/ℓ, the concentration of S ions in the artificial saliva was also modified to 0.1mM/ℓ, 0.5mM/ℓ, 1.0 mM/ℓ, and 5.0mM/ℓ. Specimens were tested by potentiostatic anodic polarization technique with scanning rate of 1 mV/sec. from -1200 mV to +800 mV at 37±2℃ From the experiment, the following results were obtained: 1. In the standard electrolyte, the corrosion resistance of the high-copper amalgams was higher than that of the conventional amalgams since the range of passivity for the high-copper amalgams was 200 mV wider than that of the conventional amalgams. 2. As the amount of chloride in the artificial saliva increased, the corrosion resistance of the conventional amalgams was decreased but the passivity of the high-copper amalgams was not changed. 3. When the concentraion of Cl was kept at 12.22 mM/ℓ, the increase of S had a little on the corrosion potential but caused increase of current density of the conventional amalgams. The corrosion resistance of the high-copper amalgams was decreased with similar trend to the conventional amalgams. 4. When the concentraion of Cl was kept at 61.10 mM/ℓ, the increase of S had a little on the corrosion behavior of the conventional amalgams. In case of high-copper amalgams, however, the corrosion resistance was decreased.