消積白朮散의 癌 轉移 抑制와 T 및 B 임파구의 증식에 미치는 영향

Jung, Chel-Jong,Son, Chang-Kyu,Cho, Chong-Kwan 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Chel-Jong Jung, Chang-Kyu Son, Chong-Kwan Cho. Department of Oriental Internal Medicine, Oriental Medical Hospital, Taejon University, Taejon, Korea. Studies on the effects of sojekbaekchoolsan on immune response & metstasis of B16-Fo melanoma cells. Proceedings of International Symposium on East-West Medicine, Seoul. 117-127, 1999.-This study was carried out to investigate the effect of Sojeokbaekchoolsan on immune response and metastasis of B16-Fo melanoma cells. The result were summarized as follows:1. Metastasisi of B16-Fo melanoma cell in C57BL/6 mice were decreased in the Sojeokbaekchoolsan treated group as compared with the control group. 2 Blastic response of lymphocyte to Con A were increased in the Sojeokbaekchoolsan teated group as compared with the control group. 3. Blastic response of lymphocyte to LPS were increased in the Sojeokbaekchoolsan treated group as compared with the control group. 4 Blastic response of lymphocyte to PWM were increased in the Sojeokbaekchoolasn treated group as compared with the control groupl From the above results, It is suggested that Sojeokbaekchoolsan enhanced as well cellula-mediated and humoral immune response as sojeokbaekchoolsan supressed the metastasis of tumor cells as compared with the control group.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

스포츠센터 헬스클럽 이용자의 선택요인과 구매후평가

조재기,정종윤,김경두 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

This research is to offer the managers of Health Club User's of sports centers a new perspective for sports marketing strategy by verifying what kind of factors most affect the sorts Users and let them use those facilities through Using a demonstrative analysis. For this purpose, this research for mulated a conceptual model by the related studies hitherto and has reached the suitable degree of this research model by using path analysis. Based on the model, 1 presented a hypothesis that "material service(X1), human service(X2, X3), and systematic service(X4, X5), would affect the post-purchase evaluation(Y)," and verified it by the path analysis. To verity the hypothesis mentioned above, I made a pilot study on the 100 users of "K" sports facilities which are thought to be one of the best facilities in Taegu, and made the main research with 200 questionaire sheets distributed among the sports facility users in every zone of Taegu. The 157 effective answers carefully chosen among the returned materials were analyzed by PC 'SAS' and 'LISREL 8W' package. The result of this answers is Cronbach 'α=.7093~.9026. Though this procedure and method, I gained the following results. 1) The study model is of great value. The independent variables including material service(fundamental facilities), human service(service of sports leaders and that of facility personnels) and systematic service(service by system-convenient accessibility to sports facilities) give a significant effect to the post-purchase evaluation. The value of each process is above the general standard, so all the hypothesis was adopted and the value of the model aptitude(GFI) is so high 0.93 that the model proved to be an excellent one. 2) The independent variables-fundamental facilities, services of sports leaders and facility personnels, the accessibility to facilities-make a remarkable on the subordinate variables in the study model of "the post-purchase evaluation".

자가 골수 중간엽줄기세포와 생분해성 고분자 스캐폴드를이용한 조직공학적 인공혈관 제조

조승우,김동익,박희정,임상현,전오주,김수현,김영하,최차용,이민재,김종성,장인성,김병수 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

'PRO/II with PROVISION' 범용성 화학공정 모사기를 이용한 원유정제공정의 모사에 관한 연구

조정호,전종기,한원희,고승태,노상균 동양대학교 2001 동양대학교 논문집 Vol.7 No.1

Crude refinery unit is the first step in refining crude oil.Crude refinery unit is divided into the following two parts.The first par is atmospheric crude distillation column and crude preheating train.Because of the massive furnace duty to heat crude oil for distillation most units have an elaborate preheat train, in which the crude oil is preheated by back exchange with hot pumparound liquids from the unit.The other part is composed of the vacuum distillation unit.In this study, a step-by-step procedure for simulating an atmospheric crude distillation column by using PRO/II with PROVISION as a general purpose chemical process simulator is introduced.

악성 혈액질환에서 성공적인 동종골수이식 후 숙주 기질 미세환경의 구축

조상희,이제중,남찬은,최경상,정익주,이일권,김진희,박종태,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

인체의 골수는 간엽모세포를 함유하고 있으며 이들은 골수미세환경의 주된 세포들로 분화가 가능하여 조혈기능을 지지한다. 본 연구에서는 성별이 다른 동종조혈모세포이식 환경에서 조혈모세포의 완전 생착을 보이고, 이식 후 1년에서 8년이 지난 11예의 재생불량성 빈혈 및 백혈병 환자들을 대상으로 하여 골수에서 MSC를 분리하고 체외 확장을 통해 배양된 MSC에서 X 염색체 탐식자를 이용한 FISH 및 microsatellite polymorphism PCR 기법으로 그 기원을 확인하였다. 그 결과 조혈모세포는 완전히 공여자 기원으로 대치되었음에도 불구하고 MSC는 모두 수여자 기원임을 알 수 있어, 동종조혈모세포이식에서 미세환경의 구축은 수여자의 자가 생산에 의한 골수 간질세포에 의한 것으로 생각된다. Background: Human bone marrow (BM) contains mesenchymal stem cells (MSC) that can differentiate into various cells of mesenchymal origin. It remains a matter of controversy whether donor-derived stromal cells are capable of engraftment following hematopoietic stem cell transplantation (HSCT) or not. Methods: To determine if donor-derived stromal cells are transferred to the recipients of allogeneic HSCT, we investigated the characterization of MSC in 11 patients 1 to 8 years after sex mis-matched allogeneic HSCT in severe aplastic anemia and leukemia. Results: All patients had complete engraftment with donor- derived stem cells as shown by detection of donor type DNA in peripheral blood mononuclear cells. Following culture, MSC showed the expression of SH2 and SH4, but none of the hematopoietic markers of CD14, CD34, or CD45. MSC which can be differentiated to osteogenic lineage showed the genotype of recipient completely using FISH or PCR analysis. Conclusion: This study confirmed that MSC isolated from recipients of allogeneic HSCT in severe aplastic anemia and leukemia are not of donor genotype despite of full hematopoietic engraftment with donor type. Donor cells did not contribute to reconstitute the marrow microenvironment.

압저항형 스마트 실리콘 압력 센서의 설계

정후민,신윤권,조상복,이종화 울산대학교 2001 공학연구논문집 Vol.32 No.2

압저항형 스마트 실리콘 압력 센서를 0.6 ㎛ 이중 폴리 실리콘 이중 금속 CMOS 공정으로 구현하기 위하여 설계하였다. 이 스마트 실리콘 압력 센서는 압저항형 저항기들로 된 휘스톤 브리지를 갖는 다이아프램과 op-amp, A/D 변환기, 및 UART 회로 등의 주변회로 들로 구성되어 있다. 브리지 회로의 출력 전압과 압력에 의한 기계적 응력 사이의 관계를 COSMOS-M 상용프로그램으로 다이아프램의 응력 분포를 모의실험하여, 압저항기의 최적의 위치와 크기에 대한 연구를 하였다. CMOS op-amp 회로는 규정된 출력 특성을 얻기 위하여 크기가 다른 트랜지스터들로 설계하여 HSPICE로 모의실험하여 최적화 시켰다. A/D 변화기 회로는 가능한 칩 면적을 줄이기 위하여 서브 레인징 기법과 신경 MOSFET 구조를 이용하여 설계하였다. UART회로는 VHDL 소스 코드와 셀 라이브러리를 이용하고 Synopsys로 합성하여 설계하였다. 회로의 물리적 레이아우트 설계는 Mentor 틀로 설계하였다. 그러나 온도보상회로와 출력오프셋 문제는 아직 해결하지 못하고 다음에 연구할 예정이다. A piezoresistive smart silicon pressure sensor is designed to implement with 0.6 ㎛ double-polysilicon double-metal CMOS precess. This smart pressure sensor is composed of a diaphragm with piezoresistive resistors' Wheatstone bridge and the peripheral circuitry of op-amp, A/D converter and UART. The relationship between the output voltage of the bridge circuit and the mechanical stress by applied pressure was studied by simulating the stress distribution on the diaphragm with COSMOS-M package program to optimize the size and position of piezoresistors. The CMOS op-amp circuit was designed with different CMOS transistor sizes to obtain the defined op-amp output characteristics and simulated with HSPICE. The A/D converter was designed using neuron MOSFET structure and sub-ranging method to minimize the chip area. The UART circuit was designed by using VHDL source code and cell library and by synthesizing with Synopses and the physical layout of the circuit was designed with Mentor tools. The problems for temperature compensation and the output voltage offset were not yet considered.

새로운 열방성 액정중합체의 합성과 PET와의 블렌드

조정대,김희종,최재곤,조병욱,유지강 조선대학교 생산기술연구소 1997 生産技術硏究 Vol.19 No.1

Blends of new thermotropic liquid crystalline polymer(TLCP) with poly(ethylene terephthalate)(PET) were prepared by the coprecipitation from a common solvent. The thermal, mechanical properties and morphology of the blends(2wt%, 5wt%, lOwt% and 20wt% TLCP/PET) were examined. In the blends, liquid crystalline phase did not reveal any significant macrophase separation and thermal degradation at the processing temperature. According to the scanning electron micrograps, the TLCP domains in matrix were found to be more or less finely dispersed with 0.2㎛ to 0.4㎛ in size and interfacial adhesion between the TLCP and matrix polymer was excellent. Results of mechanical property measurement show that modulus of TLCP/PET blend was enhanced with increasing TLCP content.

장기간 수영운동에 참가한 중년여성의 신체구성과 건강체력 특성에 대한 연구

전종귀,성민철,이창규,현광석,조병준 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1

The purpose of this study was to identify the effects of swimming exercise career on the middle-aged women. The number of sujects were 44 postmenopausal women(45-60 age group). The number of exercise group were 27(3 years average career) and that of control group were 17, Percent body fat physical development score, back strength, grip strength, trunk flexion, endurance were measured. The results were as followings; 1. The percent body fat, physical development score, back strength, grip strength, endurance of swimming exercise group was higher than that of control group. The difference showed the statistical significance. The trunk flexion and grip strength of swimming exercise group were lower than that of control group. The difference didn't showed the statistical significance. 2. The back strength, muscle endurance, endurance of swimming exercise 7 years average career group was higher than that of 3 years average career group. The difference showed the statistical significance. As the above, the regular participation of swimming exercise help the middle-aged women to promote their health-related fitness. Also the exercise prevent obesity, back pain.