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김태연 ( Tae Yoen Kim ),정경원 ( Kyoung Won Jung ),권준식 ( Jun Sik Kwon ),김지영 ( Ji Young Kim ),백숙자 ( Suk Ja Baek ),송서영 ( Seo Young Song ),강찬숙 ( Chan Suk Gang ),이국종 ( Kug Jong Lee ) 대한외상학회 2011 大韓外傷學會誌 Vol.24 No.1
Purpose: Recently, social interest in an organized trauma system for the treatment of patients has been increasing in government and academia and the establishment of trauma center is being considered across the country. However, establishing such a system has not been easy in Korea, because enormous experiences and resources are necessary. The objectives of this study were (1) to estimate a trauma patient`s demands during the course of treatment and (2) to provide appropriate direction for trauma centers to be established in Korea. Methods: The records of 207 patients who were admitted to the Department of Trauma Surgery in Ajou University Medical Center due to trauma were retrospectively reviewed for a 1 year period from March 2010 to February 2011. Patients were reviewed for general characteristics, number of hospital days, numbers and kinds of surgeries, numbers and kinds of consultations, ISS (Injury Severity Score) and number of patients with ISS more than 15. Results: All 207 patients were enrolled. The average number of hospital days was 36.7 days. The ICU stay was 15.9 days, and the general ward stay was 20.8 days. Admitted patients occupied 9.02 beds in ICU and 11.80 beds in the general ward per day. The average number of surgeries per patient was 1.4, and surgery at the Department of Trauma Surgery was most common. Number of consultations per patient was 14.23, and consultations with orthopedic surgeons were most common. The average ISS was 18.6. The number of patients with ISS more than 15 was 141 (61.8%) and the average number of patients treated per trauma surgeon as a major trauma patient was 94.3. The number of mortalities was 20, and the mortality rate was 9.7%. Conclusion: To reduce mortality and to provide proper treatment of patients with major trauma, hospitals need some number of beds, especially in the ICU, to treat patients and to prepare them for emergent surgery. An appropriate number of trauma surgeons and various specialists for consultation are also needed. (J Korean Soc Traumatol 2011;24:37-44)
PI3K款 is required for NMDA receptor??dependent long-term depression and behavioral flexibility
Kim, Jae-Ick,Lee, Hye-Ryeon,Sim, Su-eon,Baek, Jinhee,Yu, Nam-Kyung,Choi, Jun-Hyeok,Ko, Hyoung-Gon,Lee, Yong-Seok,Park, Soo-Won,Kwak, Chuljung,Ahn, Sung-Ji,Choi, So Yoen,Kim, Hyun,Kim, Kyoung-Han,Backx Nature Publishing Group, a division of Macmillan P 2011 NATURE NEUROSCIENCE Vol.14 No.11
<P>Phosphatidylinositol 3-kinase (PI3K) has been implicated in synaptic plasticity and other neural functions in the brain. However, the role of individual PI3K isoforms in the brain is unclear. We investigated the role of PI3K gamma in hippocampal-dependent synaptic plasticity and cognitive functions. We found that PI3K gamma has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral-commissural synapses. Both genetic deletion and pharmacological inhibition of PI3K gamma disrupted NMDAR long-term depression (LTD) while leaving other forms of synaptic plasticity intact. Accompanying this physiological deficit, the impairment of NMDAR LTD by PI3K gamma blockade was specifically correlated with deficits in behavioral flexibility. These findings suggest that a specific PI3K isoform, PI3K gamma, is critical for NMDAR LTD and some forms of cognitive function. Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior.</P>
서울 지역 고등학생들의 성격유형 및 창의성과의 상관관계 연구
임효희(Hyo Hee Lim),정승현(Seung Hyun Jung),김오연(Oh Yoen Kim),정지범(Ji-Bum Chung),백윤수(Yoon Su Baek) 한국창의력교육학회 2010 창의력교육연구 Vol.10 No.1
본 연구의 목적은 서울시내에 위치한 고등학교에 재학 중인 학생들을 대상으로 창의성 검사와 성격유형 검사를 실시하여, 전반적인 창의성 수준을 알아보고, 상관관계를 분석해 보고자 함이다. 본 연구에 참여한 학생은 남학생 269명, 여학생 199명으로 총 468명이었다. MBTI 성격유형 중 내향(I)-외향(E) 유형, 판단(J)-인식(P) 유형, 사고(T)-감정(F)형과 창의성과는 유의적인 관련성을 보이지는 않았다. 그러나 감각(S)-직관(N) 유형의 차이에 따라 비교해 보았을 때 직관형에서 추상성, 정교성, 종결에 대한 저항이 유의적으로 높게 나타났고, 이를 종합하여 평가한 창의지수도 유의적으로 높게 나타났다. This study aimed to investigate the relationship between the character type and the creativity of high school students in Seoul. It was performed in 468 high school students in Seoul. Five factors of creativity were tested and compared according to the each pair of MBTI character types[Introversion(I) - Extraversion(E), Judgement(J) - Perception(P), Thinking(T) - Feeling(F), Sensing(S) - Intuition(N)]. Creativity factors were not significantly different between I type and E type as well as J type and P type. On the other hand, a fluency index among the all 5 creativity factors was higher in F type than in T type. In addition, the abstract, the elaboration and the resistance for the end were significantly higher in N type in S type.
Protein Tyrosine Phosphatase 1B Inhibitors: Heterocyclic Carboxylic Acids
Cho, Sung-Yun,Ahn, Jin-Hee,Ha, Jae-Du,Kang, Seung-Kyu,Baek, Ji-Yoen,Han, Sang-Sub,Shin, Eun-Young,Kim, Sung-Soo,Kim, Kwang-Rok,Cheon, Hyae-Gyeong,Choi, Joong-Kwon Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.10
Several series of compounds (benzoic acids, pyrazolecarboxylic acids, phenoxyacetic acids, and quinolinoxyacetic acids) were prepared and evaluated for their inhibitory activity against PTP-1B. Several compounds showed submicromolar inhibitory activity.
최혜민 ( Hye-min Choi ),김인수 ( In-su Kim ),김세진 ( Se-jin Kim ),백가연 ( Ka-yoen Baek ),이지범 ( Ji-beom Lee ),김민주 ( Min-ju Kim ),문성옥 ( Sung-ok Moon ),이화동 ( Hwa-dong Lee ) 한약응용학회 2016 한약응용학회지 Vol.16 No.2
Objectives : Samchulkunbitang (SCKBT), an oriental herbal formula, has been used in Asian countries including Korea, China and Japan to treat the chronic gastritis, gastric ulcers and gastroptosis. However, there was not report on the anti-obesity-related diseases efficacy of SCKBT. we investigated the antioxidant effects of Samchulkunbitang soft extract (SCKBTSE). We also investigated the anti-obesity-related diseases effect of SCKBT-SE, on adipogenesis in 3T3-L1 cells and PDGF-BB-induced proliferation of rat aortic Vascular smooth muscle (VSMC, A-10). Methods : Preferentially, we analyzed the component of SCKBT-SE using high performance liquid chromatography (HPLC). In vitro, We investigated the anti-oxidant properties of SCKBT-SE on the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. 3T3-L1 cells were treated with SCKBT-SE (100 to 500 ㎍/㎖) during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining. And, To investigate the A-10 cells anti-proliferative effect of SCKBT-SE, we performed MTT assays. Results : SCKBT-SE showed inhibitory activity on adipocyte differentiation at 3T3-L1 preadipocytes without affect cell toxicity. In addition, The pre-incubation of SCKBT-SE (100 ㎍/㎖) significantly inhibited proliferation of PDGF-BB-induced VSMCs. Conclusions : The SCKBT-SE according to the present invention has excellent antihyperlipidemic and antiatherogenic effects as well as an antiobesity effect, has an effect of simultaneously treating obesity, hyperlipidemia, and arteriosclerosis, and is free from side effects by containing a traditional medicine as an active ingredient, and thus can be useful as an agent for preventing or treating obesity-related diseases