혈관모세포종의 임상 분석

김은성,강삼석,이정길,김태선,정신,김재휴,김수한,이제혁 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.5

혈관모세포종의 임상 분석

김은성,강삼석,이정길,김태선,정신,김재휴,김수한,이제혁 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.1

생약성분 항암제 Tianxian의 흡수동태에 관한 연구

양은정,김원배,심창구,이민화,정석재 서울대학교 1995 藥學論文集 Vol.20 No.-

뚜렷한 입체 선택성을 갖는 알릴 디올의 고리 카보네이트와 아세토니드의 Wacker 산화 반응 연구

강석구,정경윤,정재욱,남궁은영,김태현 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.1

Palldium(Ⅱ) 촉매 하에서의 말단 알릴 디올의 고리 카보네이트와 아세토니드의 산화반응은 anti-Markovnikov hydation에 의해 알데히드 또는 α,β-불포화 알데히드 만이 생성되었다. 치환된 알릴 디올의 분자내 이중 결합의 반응으로는 (E)-알릴 디올의 경우에 β-케토 생성물을, 반면에 (Z)-알릴디올의 경우엔 α-케토 생성물을 얻을 수 있었다. 치환된 알릴 디올의 고리 카보네이트와 아세토니드에서는 각각 β-케토 화합물과 α,β-케토 화합물 들이 생성되었다. Palladium(Ⅱ)-Catalyzed oxidation of acetonides or cyclic carbonates of terminal allylic diols afforded aldehydes or α,β-unsaturated aldehydes as the sole products, resulting of anti-Markovnikov hydation. For the internal olefins of the substituted allylic diols, (E)-allylic diol provied β-keto-product, whereas (Z)-allylic diol affored α-keto-product. The acetonides and cyclic carbonates of the substituted allylic diols yielded β-keto-products and α,β-unsaturated ketones, respectively.

고등학교 운동선수에서 최대하 Treadmill 운동시 심폐기능의 변화와 산소섭취량의 추산법

배옥석,김형진,박재식,주영은 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.3

고등학교 운동선수에서 최대하 treadmill 운동시험시 심폐기능의 변화를 구명하고 운동부하, 운동시간 및 심박수로부터 산소섭취량을 추산할 수 있는 회귀방정식을 유도하고자 15∼18세의 남자 고등학생 운동선수 14명과 비운동선수 16명을 대상으로 하여 Bruce법에 따라 treadmill 상에서 최대 운동능력의 80%에 해당하는 최대하운동을 실시하고 운동전, 운동중 및 운동후에 심박수, 혈압, 분시환기량, 탄산가스생산량 및 산소섭취량을 측정하였으며 운동 전후에 폐환기역학 검사를 시행하였다. 심박수는 선수군에서 안정시의 71.9±1.3회로부터 운동중 178.0±2.0회까지 증가하여 최대심박수의 81.2±2.3%에 달하였고 비선수군에서는 안정시의 81.8±2.4회로부터 182.6±1.1회까지 증가하여 최대심박수의 79.6±2.0%에 달하였다. 선수군의 심박수는 비선수군에 비해 전 실험기간에 걸쳐 유의(P<0.01)하게 낮은 값을 유지하였다. 분시환기량은 선수군에서 안정시의 5.1±0.6 L/min로부터 운동중 63.0 L/min까지 증가하였고 비선수군에서는 안정시의 5.2±0.5 L/min로부터 51.2 L/min 까지 증가하였으며 양군 사이에는 유의한 차이가 없었다. 산소섭취량은 선수군에서 안정시 1.0±0.4 ㎖/㎏/min로부터 운동중 32.6 ㎖/㎏/min까지 증가하여 최대산소섭취량의 72.9%에 달했으며 비선수군에서는 안정시 1.4±0.3 ㎖/㎏/min로부터 28.9 ㎖/㎏/min까지 증가하여 최대산소섭취량의 70.3%에 달하였다. 선수군의 산소섭취량은 비선수군에 비해 계속 낮은 경향을 보였다. Treadmill 속도 및 경사도와 산소섭취량 간의 중회귀분석 결과 중상관계수 0.9998로서 높은 상관관계를 나타내었다. Bruce법에 따른 운동시간과 산소섭취량 간의 회귀분석 결과 1차함수 회귀식에 대한 상관계수는 0.999였으나 3차함수 회귀식에 대한 상관계수는 0.99999로서 극히 높은 상관관계를 나타내었다. 심박수와 산소섭취량 간에는 상관계수 0.998 및 0.992로서 대체로 높은 직선적 상관관계를 나타내었다. 폐기능검사 결과 안정시 FVC, FEF_(0.2-1.2L), FEF_25% 및 MVV는 선수군에서 비선수군에 비해 유의(P<0.05)하게 높았다. 운동후 폐기능검사 성적은 비선수군에서는 안정시보다 저하된 경향을 보인데 비해 선수군에서는 향상된 경향을 보였다. The cardiorespiratory function was evaluated during and after a submaximal treadmill exercise and some regression equations were derived for estimation of oxygen uptake from exercise load, exercise time and the heart rate. A total of 30 high school boys, of whom 14 were athletic and 16 non-athletic, performed a submaximal treadmill exercise according to the Bruce protocol to the point when 80% of their maximum exercising capacity were reached. The heart rate, blood pressure, minute ventilation, CO_2 production and O_2 uptake were measured before, during and after exercise, and the pulmonary function test was performed before and after exercise. Heart rate was increased from 71.9±1.3 beats/min at rest to 178.0±2.0 during exercise which was 81.2±2.3% of the maximum heart rate in athletes, and from 81.8±2.4 beats/min at rest to 182.6±1.1 which was 79.6±2.0% of its maximum in non-athletes. Athletes showed significantly (P<0.01) lower heart rate than non-athletes throughout the experimental period. Minute ventilation was increased from 5.1±0.6 L/min at rest to 63.0 in athletes and from 5.2±0.5 L/min to 51.2 in non-athletes. Athletes and non-athletes showed no significant difference. Oxygen uptake was increased from 1.0±0.4 ㎖/㎏/min at rest to 32.6 which was 72.9% of maximum oxygen uptake in athletes, and from 1.4±0.3 ㎖/㎏/min to 28.9 which was 70.3% of the maximum in non-athletes. Athletes showed consistently lower oxygen uptake than non-athletes. Multiple regression analysis between treadmill speed and grade and the oxygen uptake showed a high correlation coefficient of 0.9998. A first order regression analysis between exercise time and oxygen uptake showed a correlation coefficient of 0.999, while a third order regression analysis showed an extremely high correlation coefficient of 0.99999. The heart rate and oxygen uptake showed a linear regression with a reasonably high correlation coefficient of 0.998 and 0.992. The pulmonary function test revealed significantly(P<0.05) higher FVC, FEF_(0.2-1.2L), FEF_25% and MVV at rest in athletes than in non-athletes. After exercise, athletes showed enhanced pulmonary function compared with the resting state while non-athletes showed more or less decreased.

로타리형 교차로의 역사와 미래

이용재,김석근 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.1

This paper deals with the history and development of the roundabout from its inception to the present day. The paper describes some early developments in Great Britain, much of which has not yet been introduced before in Korea. Starting with the early rule-of-thumb design, firstly, this paper reviews how experimental experience and research developed an efficient form of urban intersection control, constructing roundabouts by accommodating increasing traffic volumes with smaller spaces. Secondly, the rest of this paper is concerned with the introduction of new traffic operation rule offside priority rule to weaving operation and associated changes in roundabout design. Finally, the prospect of modern roundabouts in the future is briefly given, outlining expected usage and research needs.

대황황련해독탕의 항고지혈증 작용

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

Mg₂SiO₄: Tb, Nd, Dy 열형광선량계에서 활성제 농도가 Glow Curve에 미치는 영향

노경석,채근식,오재근,김영국,이은숙,설정식,손인호 慶南大學校 附設 基礎科學硏究所 1996 硏究論文集 Vol.8 No.-

The Mg₂SiO₄: Tb, Nd, Dy thermoluminescent phospher has been prepared by sintering Mg₂SiO₄after doping the transition elements Tb, Nd and Dy. The heating rate is 10℃/sec at this thermoluminescent phospher are heated. From the results of this study, the following conclusions were obtained. The maximum peaks are found in the measured Mg₂SiO₄: Tb, Nd, Dy, and TL glow curve at 289℃, 252℃ and 220℃ when the 1wt.% ∼ 5wt.%. Glow curve of TLD increased TL intensity and temperature of peak appears to the high temperature when the heating rate is 10℃/sec∼25℃/sec. The activation energy of the main peak has been estimated by the peak shape method. The estimated activation energies are 1.26 eV, 0.53 eV and 0.80 eV respectively. The thermoluminiscence process in Mg₂SiO₄: Tb, Nd, Dy are found to the 2nd order when the main peak of the glow curve is analyzed by peak shape method. The Mg₂SiO₄: Tb thermoluminescent phosphor is the most sensitive to X-rays among the other materials. The dose responses of Mg₂SiO₄: Tb, Dy TLD are linear up to intensity of X-ray.

정서 사진에 대한 정서 반응성 : 평가 공간에서의 분포

이은,강지인,박성혁,전종희,최재혁,김재진,안석균 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : To investigate the nature of emotional responsiveness in norma) adults, we exam the emotional responses to emotional pictures in an evaluative space defined by arousal and valence. Methods : Subjects were instructed to rate the arousal and valence that they experienced from the presentation of one of two sets of 60 emotional pictures. These two picture sets were comprised of 107 pictures : 101 selected from Intetnational Affective Pictures System and six pictures from our own collection. According to "evaluative space model", the authors set an evaluative space defined by the arousal scores as independent variable and the valence scores as dependent variable. In this evaluative space, one-hundred-and-seven pairs of coordinates representing respective emotional pictures were plotted. With regression analyses, the steepness of the regression lines on the plots with positive emotional responsiveness (n=51) and those with negative emotional responsiveness (n=56) were compared. Results : In the evaluative space, the regression line of negative emotional responsiveness was significantly different from that of positive responsiveness. The slope of negative responsiviveness was significantly steeper than that of positive responsiveness. At a low arousal level, the absolute valence of a positive stimuli was larger than that of a negative picture. Conclusion : This finding indicates that the function of the negative affective responsiveness might be different from that of the positive responsitiveness. IAPS also seems applicable to Korean subjects.

췌장암 환자에서 알코올 내장신경 신경파괴블럭 후 발생한 간염

이상은,최석환,김영환,임세훈,이정한,이근무,정순호,최영균,김영재,신치만 인제대학교 2008 仁濟醫學 Vol.29 No.-

Splanchnic neurolytic block(SNB) with alcohol improves the management of pancreatic cancer pain. Adverse effects of alcohol SNB which include regional pain, hypotension, diarrhea, and acute alcohol intoxication are common, but acute hepatitis caused by alcohol neurolytic block is rare. A 63-year-old patient with pancreatic head cancer and liver metastasis had complete pain relief after both retrocrural tansdiscal SNB with 100% alcohol 10 ml. But, 1 day later, liver function test showed a high elevation in the aspartate aminotransferase (AST, 2182 IU/L) and alanine aminotransferase (ALT, 1807 IU/L). The patient had slight jaundice, general weakness, chilling, nausea and vomiting after SNB. Both AST and ALT decreased to 46 and 119 IU/L within 10 days with only supportive therapy. But, 19 days later, the patient died due to pneumonia. Our case illustrates the importance of clinical surveillance especially in patient with hepatic disease after alcohol SNB.