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인슐린 비의존성 당뇨병환자에서 설포닐요소제와 Acarbose 병합요법의 임상적 효과
조정구 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1
The alpha glucosidase inhibitor, Acarbose (Glucobay^R, Bayer) inhibits carbohydrate digestion and suppresses or delays absorption of the final breakdown products, glucose and fructose when it is taken orally with meal. Therefore, clinical usefulness of acarbose is anticipated in NIDDM patients treated simultaneously by a sulfonylurea compound and acarbose. In the current study its ability to lower plasma glucose levels was studied in 12 placebo-treated NIDDM patients and in 12 patients with NIDDM, poorly controlled on diet plus sulfonylurea drugs. Patients were studied before and 16 weeks after the addition of acarbose to their treatment program, and there was a notable fall in fasting and postprandial plasma glucose concentrations. In addition to the improvement in glycemia, acarbose treatment also led to a notable reduction in Hb A_1c levels. The adverse effects during administration of acarbose was negligible. Only one patient complained of mild abdominal bloating. These data suggest that acarbose may be a useful additional method in the treatment of patients with NIDDM.
인슐린 비의존형 당뇨병환자에 있어서 Multitestⓚ Kit 를 이용한 면역반응에 관한 연구
조정구,이용구 圓光大學校 1987 論文集 Vol.21 No.2
인슐린 비의존형 당뇨병환자에서 세포성 면역반응 및 감염과의 관련성 유무를 알아 보고져 1986년 1월부터 1986년 6월까지 원광대학병원 내과에 입원한 당뇨병환자 25명을 대상으로 Multitest CMI 방법을 이용하여 지연성 피부과민 반응을 측정 비교한바 정상 대조군과 환자군에 있어서 면역반응의 평균 득점치는 대조군 16.9 ±8.41 ㎜, 환자군 7.7±4.24 ㎜로 환자군에서 대조군에 비해 현저히 저하된 면역반응 ( P < 0.005) 을 보였으며, 환자군에서 면역반응과 당화 혈색소치와의 관련성은 유의한 음의 상관관계 (r = -0.50, P < 0.05) 를 보였으며 환자군중 감염이 있는 군의 면역반응 평균 득점치는 5.5 ±3.55 ㎜ , 비감염군은 9.4 ±4.02 ㎜로 감염군에서 유의한 감소 ( P<0.01)를 보였다. 결론적으로 Multitest CMI 방법은 편리하게 환자의 세포성 면역반응을 알아볼 수 있었으며, 혈당을 정상으로 유지하므로서 면역능을 강화하고 감염을 방지할 수 있음을 시사하였다. To assess cell mediated immunity in NIDDM, 25 NIDDM patients were evaluated by Multitest device. Delayed cutaneous hypersensitivity (DCH) responsiveness is quantified by a score ( the sum of the diameters of induration)at 48 hours. The results were summarized as follows 1) Compaired to male, significantly lower DCH response were observed in female of the control group ( P < 0.005 ), for the average scores (22.0 ㎜ for male, 10.8 for female). 2) In all ages classes, the patients had an average score significantly lower than that of the control subject(16.9 ㎜ for controls, 7.7 ㎜ for patients. P<0.005). 3) In the oldest group of the control subjects, DCH responses were decreased (8.4 ㎜) 4) There were significant cerrelations between DCH responses and glycosylated hemoglobins in diabetics ( r = -0.50, P < 0.05). 5) Compaired to patients without infection, Patients with infection had significant reductions in response to skin test (9.4 ㎜ for patients without infection, 5.5 ㎜ for patients with infection. P<0.01) 6) As the complications, no adverse reation was observed in both groups. Local reactions such as itching sensation and vesicle formation particularly to the tuberculin antigen were obsered 7 cases for the control groups and 2 cases for the patients. But these reactions disappeared within 8 to days without secondary infection or scar formation. In conclusion, the Multitest system appears to be safe, rapid and reproducible means of evaluating DCH and it suggested that better diabetic control may have a role in bolstering or augmenting cell mediated immunity and protecting against infections.
인슐린 비의존형 당뇨병환자에서 씨-그린� 과립이 혈당 및 지질대사에 미치는 영향
조정구,김재백 圓光大學校 藥品硏究所 1989 藥品硏究所報 Vol.4 No.1
The study was carried out assess the clinical efficacy of SEA-GREEN?? granule administered with 6 packs daily for 12 weeks, in 30 patients with non-insulin dependent diabetes mellitus. the results obtained were as follows; 1. Mean blood glucose levels were significantly reduced at fasting state in the 2nd, 4th, 8th, 12md week of SEA-GREEN?? granule administration. 2. Serum cholesterol and triglyceride levels were significantly reduced at the 8th weeks of SEA-GREEN?? granule administration. 3. Serum HDL-cholesterol levels were significantly increased at the 12th weeks of SEA-GREEN?? granule administration.
부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로
김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.
기질성 뇌장애 환자의 구조적 뇌영상과 비교한 저해상 전자기 단층 촬영 영상
이승환,권구형,박영민,김 현,이강준,정영조 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3
Objectives : Patients with organic brain lesion can produce unique slow waves (delta and theta) in the EEG. Basic assumption of this study was that the low resolution electro magnetic tomography (LORETA), an inverse source localization program, can provide functional images representing increased slow wave activity in these patients compared to normal subjects. Methods : The current study was performed by 18 channels digital EEG for 10 patients whose organic deficit have been Visually confirmed by CT or MRI. The source images of slow wave (1-7 Hz) frequency were produced by LORETA-key program. Results : We found that in eight out of ten subjects, LORETA successfully found out the source regions which were very closely matched to their original brain lesions. However in two subjects whose organic brain lesions were too small (<1cm) and located out of gray matter, we failed to find any increased slow wave activity compared with normal control. Conclusion : We can conclude that LORETA could be a useful method to provide functional imaging in patients with gray matter deficits in their brain. Its usefulness and limitations were discussed.