Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway

ZHENG Jie,SON Dong Ju,LEE Hee Pom,GU Sun Mi,HAM Young Wan,HAN Sang Bae,HONG Jin Tae 한국특수교육학회 2014 한국특수교육학회 학술대회 Vol.2014 No.-

Towards an Ethical Subject: Mourning and Memory in John Banville`s The Sea

( Zheng Jie ) 한국영어영문학회 2016 영어 영문학 Vol.62 No.3

The article focuses on The Sea (2005) and attempts to investigate Banville’s articulation of the ethics of mourning in the self’s interaction with the world (the dead and the living). Compared with the critical attention on Banville’s narrators’ concerns with memory in their endeavors to construct and reconstruct identity, it is notable that the ethical implications involved in the discussion of selfhood are generally neglected. The essay departs from the existing criticism in two aspects. On one hand, subjective imaginations as fragmented and decentered are socio-historically located in the shifting ethical relationship between Self and Other. On the other hand, Banville’s narrators, who conceive of themselves as character and author, are primarily concerned with examining the ethical dimensions in a narrative of memories. I argue that Banville tells a broader morality tale about the narrative of the past, in which one can recollect and reconstruct memories of the dead, that has a salvationary effect on the narrator’s present relation with the living. The narrated episodes of the narrator’s struggle with the divided and shifty self(s) deal with his ethical concerns embodied in the act of mourning. The mourning of Anna, Chloe and Myles turns out to be an interminable process calling question of ethical responsibility to the Other, in which the relationship between self and other is examined and maintained and further, reconfigured. The act of mourning thus becomes a continued way of, in Jacques Derrida’s sense, “speaking to” the other who is gone because the dead are the ones that the narrators continue to address in reconciling with the examination of selfhood. Memories are transformative and it is through the reckoning of the dead that the self finds meaning in life.

Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats

Zheng Lin Zhao,김영우,Yi Yan Wu,Jie Zhang,이주희,XiaoHua Li,조일제,박상미,Dae Hwa Jung,양재하,김상찬,Rong Jie Zhao 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.4

Background: Korean Red Ginseng (KRG) is known to have antianxiety properties. This study was conductedto investigate the anxiolytic effects of KRG extract (KRGE) during ethanol withdrawal (EW) andthe involvement of the mesoamygdaloid dopamine (DA) system in it. Methods: Rats were treated with 3 g/kg/d of ethanol for 28 d, and subjected to 3 d of withdrawal. DuringEW, KRGE (20 mg/kg/d or 60 mg/kg/d, p.o.) was given to rats once/d for 3 d. Thirty min after the finaldose of KRGE, anxiety-like behavior was evaluated in an elevated plus maze (EPM), and plasma corticosterone(CORT) levels were determined by a radioimmunoassay (RIA). In addition, concentrations ofDA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the central nucleus of the amygdala (CeA) were alsomeasured by high performance liquid chromatography (HPLC). Results: The EPM test and RIA revealed KRGE inhibited anxiety-like behavior and the over secretion ofplasma CORT during EW. Furthermore, the behavioral effect was blocked by a selective DA D2 receptor(D2R) antagonist (eticlopride) but not by a selective DA D1 receptor (D1R) antagonist (SCH23390). HPLCanalyses showed KRGE reversed EW-induced decreases of DA and DOPAC in a dose-dependent way. Additionally, Western blotting and real-time polymerase chain reaction (PCR) assays showed that KRGEprevented the EW-induced reductions in tyrosine hydroxylase (TH) protein expression in the CeA and THmRNA expression in the ventral tegmental area (VTA). Conclusion: These results suggest that KRGE has anxiolytic effects during EW by improving the mesoamygdaloidDA system.

Hypothalamic Norepinephrine Mediates Acupunctural Effects on Hypothalamic–Pituitary–Adrenal Axis During Ethanol Withdrawal

Zheng Lin Zhao,김상찬,Jie Zhang,Hong Feng Liu,이봉효,장은영,이철원,조일제,안원근,양재하,김영우,Rong Jie Zhao,Yi Yan Wu 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.1

A previous study demonstrated that acupuncture at ST36 (Zu-San-Li) attenuates ethanol withdrawal (EW)-induced hyperactivation of the hypothalamic–pituitary–adrenal axis in rats. The current study investigated the involvement of hypothalamic norepinephrine (NE) in that process. Rats were intraperitoneally treated with 3 g/kg/d of ethanol or saline for 28 days. After 24 hours of EW, acupuncture was applied to rats at bilateral ST36 points or at nonacupoints (tail) for 1 minute. A high-performance liquid chromatography analysis showed that EW significantly increased both the NE and the 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels in the hypothalamic paraventricular nucleus (PVN). Western blot analysis also revealed that EW markedly elevated the phosphorylation rates of tyrosine hydroxylase (TH), but spared TH protein expression in the PVN. However, acupuncture at ST36, but not at nonacupoints, greatly inhibited the increase in the hypothalamic NE, MHPG, and phosphorylation rates of TH. Additionally, postacupuncture infusion of NE into the PVN significantly attenuated the inhibitory effects of acupuncture at ST36 on the oversecretion of plasma corticosterone during EW. These results suggest that acupuncture at ST36 inhibits EW-induced hyperactivation of the hypothalamic NEergic system to produce therapeutic effects on the hypothalamic–pituitary–adrenal axis.

Permanent Magnet Synchronous Motor Control Algorithm Based on Stability Margin and Lyapunov Stability Analysis

Jie, Hongyu,Xu, Hongbing,Zheng, Yanbing,Xin, Xiaoshuai,Zheng, Gang The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.6

The permanent magnet synchronous motor (PMSM) is widely used in various fields and the proportional-integral (PI) controller is popular in PMSM control systems. However, the motor parameters are usually unknown, which can lead to a complicated PI controller design and poor performance. In order to design a PI controller with good performance when the motor parameters are unknown, a control algorithm based on stability margin is proposed in this paper. First of all, based on the mathematical model of the PMSM and the least squares (LS) method, motor parameters are estimated offline. Then based on the estimation values of the motor parameters, natural angular frequency and phase margin, a PI controller is designed. Performance indices including the natural angular frequency and the phase margin are used directly to design the PI controller in this paper. Scalar functions of the d-loop and the q-loop are selected. It can be seen that the designed controller parameters satisfy Lyapunov large scale asymptotic stability theory if the natural angular frequencies of the d-loop and the q-loop are large than 0. Experimental results show that the parameter estimation method has good accuracy and the designed PI controller proposed in this paper has good static and dynamic performances.

Concomitant EGFR Inhibitors Combined with Radiation for Treatment of Non-small Cell Lung Carcinoma

Zheng, De-Jie,Yu, Guo-Hua,Gao, Jian-Feng,Gu, Jun-Dong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Epidermal growth factor receptor (EGFR) is considered to be one of the key driver genes in non-small cell lung cancer (NSCLC). Several clinical trials have shown great promise of EGFR tyrosine kinase inhibitors (TKIs) in the first-line treatment of NSCLC. Many advances have been made in the understanding of EGFR signal transduction network and the interaction between EGFR and tumor microenvironment in mediating cancer survival and development. The concomitant targeted therapy and radiation is a new strategy in the treatment of NSCLC. A number of preclinical studies have demonstrated synergistic anti-tumor activity in the combination of EGFR inhibitors and radiotherapy in vitro and in vivo. In the present review, we discuss the rationale of the combination of EGFR inhibitors and radiotherapy in the treatment of NSCLC.

Clinical and Histopathological Analysis of 66 Cases with Cardiac Myxoma

Zheng, Jian-Jie,Geng, Xi-Gang,Wang, Hai-Chen,Yan, Yang,Wang, Hong-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background and Purpose: Cardiac myxoma is a major primary heart tumor which often causes unexpected symptoms or sudden death. This present study was designed to investigate its clinical pathological features and biological behavior. Methods: A retrospective analysis of the clinical pathologic and immunohistochemical features of 66 cases with cardiac myxoma was conducted. Results: In 66 patients with cardiac myxoma, 61 cases had involvement of the left atrium, one case in both the right ventricular and left atria. The female: male ratio was 2.7:1. Patients had symptoms of blood flow obstruction and systemic alterations with performance of arterial embolization. Tumors were spherical, lobulated or irregular in shape, and soft and brittle. Immunohistochemical markers of vimentin and CD34 in tumor cells were positive. Conclusion: Cardiac myxoma always exists in the left atrium and is more common in women, with diverse clinical manifestations and pathomorphism. Although proliferative activity and the recurrence rate are low, in addition to thorough surgical resection, strengthened review is important for young patients.

Adsorption of Co(2), Ni(2), Pb(2) and U(7) from Aqueous Solutions using Polyaniline/Graphene Oxide Composites

( Zheng Jie Liu ),( Jian Wei Yang ),( Chang Zhen Li ),( Jia Xing Li ),( Ya Juan Jiang ),( Yun Hui Dong ),( Yue Yun Li ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.6

Polyaniline modified graphene oxide (PANI/GO) composites were synthesized by dilute polymerization technique and were characterized by Fourier transformed infrared spectroscopy (FTIR), Raman spectroscopy, and scanning electron microscopy (SEM). The characterization results indicated that polyaniline molecules were successfully grafted on GO surfaces. The application of PANI/GO composites to the adsorption of heavy metals from aqueous solutions was investigated under ambient conditions. The maximum adsorption capacities of Co(II), Ni(II), Pb(II) and U(VI) ions on PANI/GO composites calculated from Langmuir models are 22.28, 25.67, 65.40 and 1552.31 mg/g, respectively. The excellent adsorption capacity suggests that PANI/GO composites can be applied as a promising adsorbent in heavy metal pollution cleanup in environmental pollution management.

Prediction of Steady-state Creep Strain Rate and Rupture Life for SnAg-based Lead-free Solder Joints by SP Test

Zheng-Jie Yang,유효선,양성모,박소영,송준혁 한국정밀공학회 2013 International Journal of Precision Engineering and Vol.14 No.7

This is to predict the equation of steady-state creep strain rate and rupture life of Lead-free solder joints and to observed the fractographies of the surfaces of the fractured solder joints using the SP creep test method. In this research, Sn-4Ag, Sn-4Ag-0.5Cu, Sn-4Ag-1.0Cu and Sn-37Pb solders are used. So as to compare the Lead-free solder alloys with lead(Pb) containing solder alloys. In addition, SP creep tests are held at temperature of 30, 50 and 80¢™C. And the shear stresses used in the research are in the range of 3 to 22 MPa. The microstructure characterization and fractographic analysis of the fractured solder joints are conducted to fully describe the creep behavior of the solder joints. Increasing the testing temperature from 30 to 80oC has some effect on the fracture behavior of ternary SnAgCu solder joints during creep testing. The increased temperature made the joints more vulnerable to the brittle interfacial fracture. In addition, Sn-37Pb solder joint, dimples in the fractured surfaces are much smaller than that of the Lead-free solder joints. Also using the creep data, we obtained a prediction equation of steady-state creep strain rate and rupture life for Lead-free solder joint in this research.

중국 대학의 효과적인 사진 교육 발전을 위한 교수와 학생의 인식 차이에 관한 연구

Jie Zheng 사단법인 한국융합기술연구학회 2023 아시아태평양융합연구교류논문지 Vol.9 No.12

The purpose of this study is to discover differences in perception between professors and students in the impact of the Chinese university's international talent training model on the development of successful photography education. Moreover, another goal of the study on the impact of the photography internationalization talent training model on the successful growth of photography education. They were finding out if there is a mediating role between curriculum internationalization and faculty capacity building. First, it suggests that there are differences in respondents' perceptions about the impact of the photography department's global talent training model on curriculum internationalization, professors' internationalization capabilities, and the successful development of photography education. Second, continuous research is needed on allowing double majors, strengthening practical education, expanding overseas experience, and inviting excellent photographers. Furthermore, the mediating effect of internationalizing the curriculum and enhancing the professor's internationalization capabilities was confirmed, leading to the need for active efforts of the professor group. Unlike in the past, both professors and students were found to have various views on internationalization. The results of this study will serve as basic data for fostering successful internationalized photographic talents in Chinese universities. 본 연구는 중국 대학 사진학과의 글로벌 인재 양성 모델이 성공적인 사진교육 발전에 미치는 영향에 대하여 교수와 학생 간 인식 차이를 고찰하고 커리큘럼 국제화와 교수 역량 제고의 매개효과 유무를 파악하는 데 목적이 있다. 분석 결과, 첫째, 사진학과의 글로벌 인재 양성 모델이 커리큘럼 국제화, 교수의 국제화 역량제고, 성공적인 사진교육 발전에 미치는 영향에 대해 응답자의 인식 차이가 존재하고 있음을 시사한다. 둘째, 복수전공 허용, 실습교육 강화, 해외경험 확대, 우수한 사진작가 초빙에 대한 지속적인 연구가 필요하다. 그리고 커리큘럼 국제화와 교수의 국제화 역량 제고의 매개효과가 확인되어 교수 집단의 적극적인 노력이 필요하다는 결과를 도출하였다. 또한, 과거와 달리 교수와 학생 모두 국제화에 대한 다양한 견해를 가진 것으로 나타났다. 본 연구는 중국 대학 사진학과의 글로벌 인재 양성을 위한 객관적인 데이터를 제공한다는 점에서 그 의의가 있다.