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      • KCI등재

        Uniaxial Eccentric Load Behavior of L-CFSST Composite Column

        Zhen Wang,Zhe Liu,Xingbo Wang,Xuejun Zhou,Zhoutai Wang,Guodong Xian 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5

        This study presents the mechanical behavior of L-shaped concrete-filled square steel tube (L-CFSST) composite columns under uniaxial eccentric compression. Nine specimens were tested and the effects of eccentricity, steel tube thickness, steel yield strength, and slenderness ratio were investigated regarding failure modes, ultimate load, load-lateral displacement curves, and load-strain curves. Test results showed that, under uniaxial eccentric load, these columns showed favorable mechanical properties and steel tubes showed strong cooperative working performance. There were two types of failure modes for these columns: local buckling of the steel tube or overall bending of the specimen. ABAQUS was used to simulate the loading process and the accuracy of the numerical simulation results was verified by comparing failure characteristics, load-displacement curves, and ultimate bearing capacity with the test results. The N/Nu-M/Mu curves of the columns under uniaxial eccentric load with different parameters were simulated by the finite element method. A simplified formula for predicting the N/Nu-M/Mu relationship was established based on the finite element analysis results, which might be a workable approach for designing L-CFSST composite columns in engineering practice.

      • KCI등재SCOPUSSCIE
      • KCI등재

        Overexpression of a peroxiredoxin gene from Tamarix hispida, ThPrx1, confers tolerance to oxidative stress in yeast and Arabidopsis

        Liuqiang Wang,Zhen Li,Chao Wang,Deyin Wang,Yucheng Wang,Mengzhu Lu 한국식물학회 2017 Journal of Plant Biology Vol.60 No.6

        Peroxiredoxins (Prxs) are ubiquitous thiol-specificantioxidant enzymes that are critically involved in cell defenseand protect cells from oxidative damage. In this study, aputative Type II Prx (ThPrx1) was identified and characterizedfrom Tamarix hispida. The expression of ThPrx1 is highlyinduced in response to hydrogen peroxide (H2O2) and methylviologen (MV) stresses. When expressed ectopically, ThPrx1showed enhanced tolerance against oxidative stress in yeastand Arabidopsis. In addition, transgenic Arabidopsis plantsoverexpressing ThPrx1 displayed improved seedling survivalrates and increased root growth and fresh weight gain underH2O2 and MV treatments. Moreover, transgenic Arabidopsisplants showed decreased accumulation of H2O2, superoxide(O2•−) and malondialdehyde (MDA), increased superoxidedismutase (SOD) activity compared to wild-type (WT) plantsunder oxidative stress. Moreover, transgenic plants maintainedhigher photosynthesis efficiency and lower electrolyte leakagerates than that of WT plants under stress conditions. Theseresults clearly indicated that ThPrx1 plays an important rolein cellular redox homeostasis under stress conditions, leadingto the maintenance of membrane integrity and increasedtolerance to oxidative stress.

      • KCI등재

        Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro

        Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8

        Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.

      • KCI등재

        Robust Secure UAV Relay-Assisted Cognitive Communications with Resource Allocation and Cooperative Jamming

        Zhen Wang,Jichang Guo,Zhiqiong Chen,Zhiqiong Chen,Lisu Yu,Yuhao Wang,Hong Rao 한국통신학회 2022 Journal of communications and networks Vol.24 No.2

        This paper considers a novel scenario, where a physicallayer security issue is studied in unmanned aerial vehicles(UAVs)-assisted cognitive relay system. A secondary unmannedaerial vehicle (SUAV) relay delivers information from multiplesecondary Internet of things (IoT) devices to a secondary user(SU) under the spectrum sharing with primary users (PUs). Inthe processing of the information transmission of the SUAV relay,a secondary eavesdropper (SE) wiretaps the information transmittedby the UAV relay with imperfect location information. Inorder to confuse the SE, a friendly SUAV jammer is employedto transmit jamming signals to the SE. To prevent the SEwiretapping information as much as possible, we aim to maximizeaverage worst-case secrecy rate of the secondary relay networkby jointly optimizing robust trajectories and power of the SUAVrelay and jammer under the power, trajectories, informationcausality and multiple interference temperature (IT) thresholdconstraints. Thus, we formulate the original problem whichis a challenging non-convex problem. We propose an effectivealgorithm to solve the original problem and attain locally optimalsolution based on the successive convex approximation (SCA)technology and the alternate optimization method. Simulationsare offered to demonstrate that our proposed resource allocationscheme can effectively improve the security performance ofthe SUAV relay network in comparison with other benchmarkschemes.

      • Repeat Colonoscopy Every 10 Years or Single Colonoscopy for Colorectal Neoplasm Screening in Average-risk Chinese: A Cost-effectiveness Analysis

        Wang, Zhen-Hua,Gao, Qin-Yan,Fang, Jing-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

        Background: The appropriate interval between negative colonoscopy screenings is uncertain, but the numbers of advanced neoplasms 10 years after a negative result are generally low. We aimed to evaluate the cost-effectiveness of colorectal neoplasm screening and management based on repeat screening colonoscopy every 10 years or single colonoscopy, compared with no screening in the general population. Methods and materials: A state-transition Markov model simulated 100,000 individuals aged 50-80 years accepting repeat screening colonoscopy every 10 years or single colonoscopy, offered to every subject. Colorectal adenomas found during colonoscopy were removed by polypectomy, and the subjects were followed with surveillance every three years. For subjects with a normal result, colonoscopy was resumed within ten years in the repeat screening strategy. In single screening strategy, screening process was terminated. Direct costs such as screening tests, cancer treatment and costs of complications were included. Indirect costs were excluded from the model. The incremental cost-effectiveness ratio was used to evaluate the cost-effectiveness of the different screening strategies. Results: Assuming a first-time compliance rate of 90%, repeat screening colonoscopy and single colonoscopy can reduce the incidence of colorectal cancer by 65.8% and 67.2% respectively. The incremental cost-effectiveness ratio for single colonoscopy (49 Renminbi Yuan [RMB]) was much lower than that for repeat screening colonoscopy (474 RMB). Single colonoscopy was a more cost-effective strategy, which was not sensitive to the compliance rate of colonoscopy and the cost of advanced colorectal cancer. Conclusion: Single colonoscopy is suggested to be the more cost-effective strategy for screening and management of colorectal neoplasms and may be recommended in China clinical practice.

      • SCOPUSKCI등재

        Improvement of heat and drought photosynthetic tolerance in wheat by overaccumulation of glycinebetaine

        Wang, Gui-Ping,Hui, Zhen,Li, Feng,Zhao, Mei-Rong,Zhang, Jin,Wang, Wei The Korean Society of Plant Biotechnology 2010 Plant biotechnology reports Vol.4 No.3

        Within their natural habitat, crops are often subjected to drought and heat stress, which suppress crop growth and decrease crop production. Causing overaccumulation of glycinebetaine (GB) has been used to enhance the crop yield under stress. Here, we investigated the response of wheat (Triticum aestivum L.) photosynthesis to drought, heat stress and their combination with a transgenic wheat line (T6) overaccumulating GB and its wild-type (WT) Shi4185. Drought stress (DS) was imposed by controlling irrigation until the relative water content (RWC) of the flag leaves decreased to between 78 and 82%. Heat stress (HS) was applied by exposing wheat plants to $40^{\circ}C$ for 4 h. A combination of drought and heat stress was applied by subjecting the drought-stressed plants to a heat stress as above. The results indicated that all stresses decreased photosynthesis, but the combination of drought and heat stress exacerbated the negative effects on photosynthesis more than exposure to drought or heat stress alone. Drought stress decreased the transpiration rate (Tr), stomatal conductance (Gs) and intercellular $CO_2$ concentration (Ci), while heat stress increased all of these; the deprivation of water was greater under drought stress than heat stress, but heat stress decreased the antioxidant enzyme activity to a greater extent. Overaccumulated GB could alleviate the decrease of photosynthesis caused by all stresses tested. These suggest that GB induces an increase of osmotic adjustments for drought tolerance, while its improvement of the antioxidative defense system including antioxidative enzymes and antioxidants may be more important for heat tolerance.

      • KCI등재

        Magnetostrictive Characteristics of the Grain‑Oriented Electrical Steel in an Epstein Frame Magnetized with a DC Biased Magnetic Field

        Zhen Wang,Yanli Zhang,Dianhai Zhang,Ziyan Ren,고창섭 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.2

        The presence of direct current (dc) biased magnetic feld enhances the vibration and noise in the transformer cores due to magnetostrictive efect in the grain-oriented electrical steel laminations. Based on an Epstein frame, an experimental setup was built to measure the in-plane magnetostriction, the principal magnetostriction was computed under a dc bias, and the infuence of dc bias magnetic feld on the magnetostrictive property of electrical steel sheet was investigated. A model based on a back propagation neural network (BPNN) method assisted with the Levenberg–Marquardt algorithm was proposed to describe the magnetostrictive behaviour in the presence of dc bias. Finally, the BPNN model was verifed by comparing the measured magnetostriction and the computed one. This research is helpful to make an accurate estimation to deformation of iron core under a dc bias.

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