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Fault Detection for a Class of Closed-loop Hypersonic Vehicle System via Hypothesis Test Method
Xunhong Lv,Yifan Fang,Zehui Mao,Bin Jiang,Ruiyun Qi 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
This paper studies the fault detection problem for a class of hypersonic vehicle with actuator faults,disturbances and random noises. To handle the unknown disturbances, an unknown input Kalman filter (UIKF) ispresented to estimate the unknown system states and disturbances, simultaneously. Considering that the closed-loopstructure brings the robustness to the hypersonic vehicle, which could cover some faults, the Total Measurable FaultInformation Residual (ToMFIR) is employed as the fault detection residual. Moreover, to deal with the randomnoises, the hypothesis testing method is utilized to obtain the thresholds under some fault detection performances(false alarm rate and missing alarm rate). The fault detectability condition is also derived. Finally, the simulationsverify the effectiveness of the proposed fault detection method
Anqiu Liu,Bing Liu,Zehui Zhang,Zhongfeng Fang,Kecheng Huang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
In this study, we have developed a new method for the synthesis of EMF from HMF and fructose using mesoporous MCM-41 supported 12-tungstophosphoric acid (MCM-41-HPW) as the catalyst. The structure of 40 wt.% MCM-41-HPW was characterized by various techniques and its surface acidity was determined by potentiometric titration. A high EMF yield of 83.4% was obtained from HMF by the etherification reaction. Synthesis of EMF from fructose was also realized through one-pot reaction with a moderate yield of 42.9%. More importantly, the catalyst could be reused for several times without the loss of its catalytic activity.
( Zhiguo Wang ),( Hong Luo ),( Zehui Fang ),( Yanling Fan ),( Xiaojuan Liu ),( Yujing Zhang ),( Shuping Rui ),( Yafeng Chen ),( Luojia Hong ),( Jincheng Gao ),( Mei Zhang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9
Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204. Our results showed that miR-204 expression was significantly downregulated in AML tissues and cell lines. In addition, overexpression of miR-204 induced growth inhibition and apoptosis in AML cells, including AML5, HL-60, Kasumi-1 and U937 cells. Cell cycle analysis further confirmed an augmentation in theapoptotic subG1 population by miR-204 overexpression. Mechanistically, baculoviral inhibition of apoptosis protein repeat containing 6 (BIRC6) was identified as a direct target of miR-204. Enforcing miR-204 expression increased the luciferase activity and expression of BIRC6, as well as p53 and Bax expression. Moreover, restoration of BIRC6 reversed the pro-apoptotic effects of miR-204 overexpression in AML cells. Taken together, this study demonstrates that miR-204 causes AML cell apoptosis by targeting BIRC6, suggesting miR-204 may play an anti-carcinogenic role in AML and function as a novel biomarker and therapeutic target for the treatment of this disease. [BMB Reports 2018; 51(9): 444-449]
Research on the explosion release method and damage mechanism of titanium alloy fan blade
Yanan Zhang,Zekan He,Chuang Liu,Meng Wang,Haijun Xuan,Mingmin Qu,Zehui Fang 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8
The current advanced aero-engine fan rotors are usually integrally-bladed rotor discs, and the root of the fan blade has irregular curved surface, which brings technical difficulties and challenges to achieve the blade releasing. In this paper, the dynamic response and energy dissipation process of the titanium alloy blade under shaped charge jet explosion were analyzed by numerical model, and the explosion damage mechanism of titanium alloy fan blades was clarified. Finally, a FBO test was conducted to verify the blade explosion release method in rotating state. Through the energy dissipation analysis of the whole explosion process, it can be seen that the overall residual kinetic energy of the blade is about 15.7 J, which is only 0.02 % of the initial kinetic energy of the releasing blade in rotating. It is indicated that the explosion separation method will not generate additional kinetic energy to the released blade.