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RISS 인기검색어
- 검색키워드
- 저자 : ( Yunus Erdem ) (검색결과 3 건)
- 무료
- 기관 내 무료
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Demiroz, Serdar,Ur, Koray,Bengu, Aydin Sukru,Ulucan, Aykut,Atici, Yunus,Erdogan, Sinan,Cirakli, Alper,Erdem, Sevki The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.2
Objective : To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods : A total of 28 male wistar albino rats weighing 300-350 g were divided into four groups. In group I, the sciatic nerve exposed and the surgical wound was closed without injury; in group II, peripheral nerve injuries (PNI) was performed after dissection of the nerve; in group III, PNI was performed after dissection and lacosamide was administered, and in group IV, PNI was performed after dissection and physiological saline solution was administered. At 7 days after the injury all animals were sacrificed after walking track analysis. A 5 mL blood sample was drawn for biochemical analysis, and sciatic nerve tissues were removed for histopathological examination. Results : There is low tissue damage in lacosamide treated group and antioxidant anzymes and malondialdehyde levels were higher than non-treated and placebo treated group. However there was no improvement on clinical assessment. Conclusıon : The biochemical and histological analyses revealed that lacosamide has neuroprotective effect in PNI in rats. This neuroprotective capacity depends on its scavenger role for free oxygen radicals by increasing antioxidant enzyme activity.
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Ahmet A. Kiykim,Ahmet Camsari,Serkan Kahraman,Mustafa Arici,Bulent Altun,Dilek Cicek,Yunus Erdem,Unal Yasavul,Cetin Turgan,Sali Caglar,Aytekin Oto 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.2
Cardiovascular disease (CVD) is still the major cause of the morbidity and mortality in hemodialysis (HD) patients. The characteristics of major arterial changes, atherosclerosis and related risk factors in HD patients remain unclear. We aimed to evaluate the atherosclerotic process in asymptomatic HD patients and healthy volunteers, and to determine the association between the risk factor(s) and the atherosclerotic process in these groups. 92 HD patients (female: 43, male: 49) and 62 age and sex matched healthy volunteers (female: 27, male: 35) were enrolled in this study. Diabetics, smokers, and patients with symptomatic CVD were excluded. The right and left carotid intima-media thicknesses (CIMTs) were measured and plaque structures were studied by B-mode ultrasound. The mean CIMT in patients and control group were 0.79±0.16 mm and 0.54±0.09mm, respectively. Mean CIMT in HD patients was thicker (p<0.001) and the presence ratio of plaque was higher in patients group (n=38, %61.2 vs n=9, %17.3) (p<0.001). Calcified type of plaque was more frequent in HD patients than control group. Age (r=0.48, p<0.001), left ventricular mass (r=0.42, p<0.05), and homocysteine (r=0.46, p<0.01), mean hematocrit (r=-0.36, p<0.05), plasma CRP (r=0.50, p<0.001), ESR (r=0.43, p<0.01) and albumin (r= -0.34, p<0.05) levels were correlated with the CIMT measurements and plaque presence, significantly. -CIMT as an atherosclerotic process indicator is thicker in asymptomatic HD patients than healthy subjects. We concluded that in addition to various classical risk factors, uremic environment may also contribute to acceleration of the atherosclerotic process.
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( Tolga Yildirim ),( Hadim Akoglu ),( Rahmi Yilmaz ),( Gonca Eldem ),( Tuncay Hazirolan ),( Tuncay Aki ),( Mustafa Arici ),( Bulent Altun ),( Yunus Erdem ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Immunosuppressive protocols decreased the rates of acute rejection in kidney transplantation however long term graft survival has not changed signifi cantly. Nephron underdosing may be one of the factors affecting the long term prognosis of the transplanted kidney. Aim of this study was to determine the impact of volume of transplanted kidney on long term allograft functions. Methods: The study was conducted among sixty-two living renal transplant recipients (41 male, 21 female; mean age 30.6±10.2 years) who underwent transplantation between years 2003-2007 and their respective donors (22 male, 40 female; age 41.9±9.9 years). Patients that suffered graft loss due to any cause within fi ve years after transplantation were excluded. Volume of the transplanted kidneys had been measured preoperatively via 3-D helical computerized tomography. Transplanted kidney volume/ recipient weight (Vol/weight) was calculated for each donor-recipient pair. Subjects were divided into two groups according to the median value of Vol/weight (2.35 cm3/ kg). Glomerular fi ltration rates (GFR) of the recipients were calculated for fi ve years. Results: First and third year GFR`s of the patients was significantly higher in Vol/ weight>2.35 cm3/kg group compared to Vol/weight<2.35 cm3/kg group (73.7±17.6 vs. 61.6±19.3, p=0.01 and 72.3±20.7 vs. 60.0±17.3, p=0.01 respectively). However fi fth year GFR was similar in both groups (64.5±16.9 and 56.6±21.7, p=0.11). There was a signifi cant correlation between Vol/weight and both fi rst and third year GFR`s (r=0.409, p<0.001 and r=0.429, p<0.001; respectively). The correlation was not observed with the fi fth year GFR (r=0.133, p=0.303). Conclusions: Volume of transplanted kidney adjusted for recipient weight is a signifi - cant predictor of early but not late graft functions.
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