http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population
( Yun Sung Kim ),( Yunsuek Kim ),( Geon Park ),( Seong Kyu Kim ),( Jung Yoon Choe ),( Byung Lae Park ),( Hyun Sook Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6
Background/Aims: Gout is a common inflammatory arthritis triggered by the crystallization of uric acid in the joints. Serum uric acid levels are highly heritable, suggesting a strong genetic component. Independent studies to confirm the genetic associations with gout in various ethnic populations are warranted. We investigated the association of polymorphisms in the ABCG2 and SLC2A9 genes with gout in Korean patients and healthy individuals. Methods: We consecutively enrolled 109 patients with gout and 102 healthy controls. The diagnosis of gout was based on the preliminary criteria of the America College of Rheumatology. Genomic DNA was extracted from whole blood samples. We identified single nucleotide polymorphism (SNP) changes in the ABCG2 and SLC2A9 genes using a direct sequencing technique. rs2231142 in ABCG2 and rs6449213 and rs16890979 in SLC2A9 and nearby regions were amplified by polymerase chain reaction. Results: Patients with gout had significantly higher A/A genotype (29.3% vs. 4.9%, respectively) and A allele (52.8% vs. 26.5%, respectively) frequencies of rs2231142 in ABCG2 than did controls (χ2 = 29.42, p < 0.001; odds ratio, 3.32; 95% confidence interval, 2.11 to 5.20). We found novel polymorphisms (c.881A>G and c.1002+78G>A) in the SLC2A9 gene. The univariate logistic regression analysis revealed that the c.881A>G and c.1002+78G>A SNPs were significantly higher in patients than in controls. Conclusions: We demonstrated a significant association between rs2231142 in the ABCG2 gene and gout and identified novel SNPs, c.881A>G and c.1002+78G>A, in the SLC2A9 gene that may be associated with gout in a Korean population.
증례 : 순화기 ; 경요골 경피적 관상동맥 중재술 중 발생한 요골동맥 천공의 간편한 관리
김윤석 ( Yunsuek Kim ),정찬성 ( Chan Sung Jung ),김효식 ( Hyo Shik Kim ),이민호 ( Min Ho Lee ),박병원 ( Byoung Won Park ),방덕원 ( Duk Won Bang ),현민수 ( Min Su Hyon ) 대한내과학회 2016 대한내과학회지 Vol.90 No.2
Radial artery perforation is one of the major complications of transradial percutaneous coronary intervention (PCI). Previous reports have suggested that sealing the perforation with a smaller guiding catheter may be possible. In one such study, the perforated segment was sealed with a 0.014- or 0.021-inch guidewire, and PCI was successfully completed. In this study, we describe a radial artery perforation that occurred after diagnostic coronary angiography and during insertion of a 6 French (FR) guiding catheter. PCI and the perforation were successfully managed through the use of a 5 Fr guiding catheter and a 0.035-inch guidewire. (Korean J Med 2016;90:136-139)
Cardiac arrest caused by nafamostat mesilate
( Hyo Shik Kim ),( Kyung Eun Lee ),( Ji Hyun Oh ),( Chan Sung Jung ),( Dughyun Choi ),( Yunsuek Kim ),( Jin Seok Jeon ),( Dong Cheol Han ),( Hyunjin Noh ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.3
A 65-year-old man was transferred from the Department of Vascular Surgery to Nephrology because of cardiac arrest during hemodialysis. He underwent incision and drainage for treatment of a buttock abscess. Nafamostat mesilate was used as an anticoagulant for hemodialysis to address bleeding from the incision and drainage site. Sudden cardiac arrest occurred after 15 minutes of dialysis. The patient was treated in the intensive care unit for 5 days. Continuous veno-venous hemodiafiltration was started without any anticoagulant in the intensive care unit. Conventional hemodialysis was reinitiated, and nafamostat mesilate was used again because of a small amount of continued bleeding. Ten minutes after hemodialysis, the patient complained of anaphylactic signs and symptoms such as dyspnea, hypotension, and facial swelling. Epinephrine, dexamethasone, and pheniramin were injected under the suspicion of anaphylactic shock, and the patient recovered. Total immunoglobulin E titer was high, and skin prick test revealed weak positivity for nafamostat mesilate. We first report a case of anaphylactic shock caused by nafamostat mesilate in Korea.
증례 : 류마티스 ; 재발성 췌장염 및 신장 혈전성 미세혈관병증으로 나타난 항인지질증후군
이해경 ( Hae Kyung Lee ),정신옥 ( Shin Ok Jeong ),김윤석 ( Yunsuek Kim ),진소영 ( So Young Jin ),김현숙 ( Hyun Sook Kim ),조영덕 ( Young Deok Cho ) 대한내과학회 2015 대한내과학회지 Vol.89 No.5
저자들은 재발성 췌장염과 신장 혈전성 미세혈관병증을 동시에 진단받은 환자에서 LA 양성인 APS를 진단하였고 저용량 스테로이드 및 항응고제로 치료한 증례를 경험하여 문헌 고찰과 함께 보고하는 바이다. Antiphospholipid syndrome (APS) is characterized by vascular thrombosis or recurrent fetal loss in the presence of antiphospholipid antibodies. APS has various manifestations because it can involve any vessel in most organs and tissues. There are a few reports of acute pancreatitis or renal thrombotic microangiopathy accompanying APS, but none on concurrent acute pancreatitis and renal thrombotic microangiopathy in Korea. The clinical consequences can be devastating, so a high index of suspicion is necessary for early diagnosis and treatment. We report an unusual case of APS-associated recurrent pancreatitis and renal thrombotic microangiopathy. A 33-year-old woman was admitted for severe epigastric pain attributed to acute pancreatitis. She subsequently developed an acute kidney injury and the histology revealed thrombotic microangiopathy. Four weeks later, she was readmitted with recurrent pancreatitis. After treatment with anticoagulation and low-dose steroid, her abdominal pain subsided and the amylase and lipase levels normalized. (Korean J Med 2015,89:598-603)