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Association study of vitamin E content in rice using whole genome re-sequencing
Xiao-Qiang Wang,Qiang He,Wei Tong,Byung-Kook Yun,Young-Sang Lee,Tae-Sung Kim,Chang-Yong Lee,Yong-Jin Park 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Rice is the major food for half of the world population. The nutrition component in rice is critical for improvement of people’s health. Vitamin E serves as important antioxidant by quenching the free radical intermediates and thus protects the cell membrane. Because of the high nutritional value and the benefits of vitamin E in human health, increasing the tocochromanol content of major agricultural crops has long been in the focus of breeding programs and genetic engineering approaches. The key genes involved in tocopherol biosynthesis have been elucidated in Arabidopsis and other model organisms. Quantitative trait locus (QTL) study performed in Arabidopsis suggested that some of these key genes and a few additional loci contribute to natural tocopherol variations. Identifying such genetic variations in rice, enrich our understanding of the genetic mechanisms controlling tocopherol variation, which can be directly applied to rice breeding programs. In this study, we used genome-wide association mapping with high-resolution density SNPs of rice core set to identify natural allelic variations, which contribute to tocopherol increase in rice
Yun, Sang-Im,Choi, Yu-Jeong,Yu, Xiao-Fang,Song, Jae-Young,Shin, Young-Hak,Ju, Young-Ran,Kim, Seok-Yong,Lee, Young-Min Informa Healthcare 2007 Journal of neurovirology Vol.13 No.6
<P> Using the RNA replication machinery of Japanese encephalitis virus (JEV), the authors have established and characterized three strategies for the expression of foreign genes. Initially, ≈ 11 kb genomic RNA was engineered to express heterologous genes of various sizes by preferentially inserting a new cistron at the beginning of the 3' nontranslated variable region. RNA transfection yielded recombinant viruses that initiated foreign gene expression after infecting permissive cells. JEV was capable of packaging recombinant genomes as large as ≈ 15 kb. However, larger genome size was inversely correlated with RNA replication efficiency and cytopathogenicity, with no significant change in infectivity. Second, a variety of self-replicating propagation-deficient viral replicons were constructed by introducing one to three in-frame deletions into the ectodomains of all the structural proteins of JEV. These replicons displayed a spectrum of RNA replication efficiency upon transfection, suggesting that remnant transmembrane domains play a suppressive role in this process. Third, the authors generated a panel of stable packaging cell lines (PCLs) providing all three JEV structural proteins in trans. These PCLs efficiently packaged viral replicon RNAs into single-round infectious viral replicon particles. These JEV-based virus/vector systems may provide useful tools for a variety of biological applications, including foreign gene expression, antiviral compound screening, and genetic immunization.</P>
Xiao-Lin Wang,Shan Fei,Zhao Han-Lin,Lee Jae-Yun,Yoo Suchang,Ryu Heung Gyoon,Choi Seungkeun,Anvar Tukhtaev,Kim Sung-Jin 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.5
A high-performance indium oxide (In 2 O 3 )-based thin-film transistor (TFT) was prepared with aluminum oxide/fluorinated self-assembled monolayer (Al 2 O 3 /F-SAM) double-gate dielectric layer. The Al 2 O 3 /F-SAM double gate dielectric layer improved the performance of the In 2 O 3 -based TFT by reducing the device leakage current. In addition, devices with a double-gate dielectric layer show improved stability under negative bias stress testing compared to devices with a single gate dielectric layer (Al 2 O 3 ), shifting a threshold voltage by only 0.4 V. These results suggest that the Al 2 O 3 /F-SAM doublelayer gate dielectric layer can enhance the performance of In 2 O 3 -based TFTs. Furthermore, it can be used to improve the performance of other metal oxide-based devices by minimizing the leakage current at low operating voltages at low cost.
Deng, Xiao Long,Hong, Sahwan,Hwang, Inrok,Kim, Jin-Soo,Jeon, Ji Hoon,Park, Yun Chang,Lee, Jongjin,Kang, Sung-Oong,Kawai, Tomoji,Park, Bae Ho RSC Pub 2012 Nanoscale Vol.4 No.6
<P>By confining columnar grains of textured oxide film using anodized aluminum oxide template, we could obtain a grain-boundary-free (GB-free) cuprous oxide (Cu(2)O) nanowire arrays with a narrow diameter distribution and a high density under the same electrochemical deposition condition. A two-terminal device fabricated using an individual GB-free nanowire and Au/Cr electrodes exhibits bipolar resistive switching contrary to the unipolar one of a textured film, and Schottky-like conduction. On the other hand, a nanowire device with Pt electrodes reveals non-switching behavior and Ohmic conduction. Thus, we can propose that the bipolar switching of a nanowire device with Au/Cr electrodes may result from the modulation of Schottky barrier at the interface by migration of oxygen vacancies while the unipolar one of a textured film may be defined as the bulky filamentary switching along the GBs in the GB-embedded texture films.</P>
124I Labeled Arg-Gly-Asp (RGD) peptide: PET/MR fusion imaging of tumor expressing integrin v3
( Seon Young Yun ),( Xiao Yuan Chen ),( Jeong Chan Park ),( Seung Tae Woo ),( Seang Myung Han ),( Kyeong Min Kim ),( Ji Seub Lee ),( Tae Hyun Choi ),( Gi Jeong Cheon ),( Young Min Chang ),( Sang Woo L 대한핵의학회 2007 핵의학 분자영상 Vol.41 No.5
Tong Keun Lee,Cheon Yu,Xiao xu Dong,Yun Seop Hwang People&Global Business Association 2016 Global Business and Finance Review Vol.21 No.1
The marketing related literatures emphasize the key role of marketing for companies performances. However, not much attention has been paid to marketing innovations and their performances. Focusing on 2,149 Korean manu-facturing companies, this paper examines the factors that influence companies marketing innovation decisions and marketing performances by using the Heckman selection model for addressing the sample bias problem. Three key findings have been derived. First, by categorizing market orientation among the three components-customer orientation, competitor orientation, inter-functional coordination, the findings show that customer orientation enhan-ces marketing performance, but does not influence marketing innovation decision. On the other hand, both com-petitor orientation and inter-functional coordination have positive influences on the marketing innovation decision, but not on marketing performance. Second, marketing innovation activities such as product design, promotion, placement, and price help to enhance marketing performance. Third, the factors that influence marketing innovation decision and their performance are different depending on technological level of an industry. The results suggest that the marketing related activities are more important in high-tech rather than in low-tech industries.
Kim, Kiheung,Lee, Wonju,Chung, Kyungwha,Lee, Hongki,Son, Taehwang,Oh, Youngjin,Xiao, Yun-Feng,Ha Kim, Dong,Kim, Donghyun Elsevier Applied Science 2017 Biosensors & bioelectronics Vol. No.
<P><B>Abstract</B></P> <P>In this work, we investigate the detection sensitivity of surface plasmon resonance (SPR) biosensors by engineering spatial distribution of electromagnetic near-fields for colocalization with molecular distribution. The light-matter colocalization was based on plasmonic nanolithography, the concept of which was confirmed by detecting streptavidin biotin interactions on triangular nanoaperture arrays after the structure of the aperture arrays was optimized for colocalization efficiency. The colocalization was shown to amplify optical signature significantly and thereby to achieve detection on the order of 100 streptavidin molecules with a binding capacity below 1fg/mm<SUP>2</SUP>, an enhancement by more than three orders of magnitude over conventional SPR detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We describe plasmonic nanolithography for colocalization of fields and molecules. </LI> <LI> Experimental evaluation was performed by measuring streptavidin-biotin interactions. </LI> <LI> The results show enhanced sensitivity by 1000 times over traditional detection. </LI> </UL> </P>
Tang, Shu-Kun,Zhi, Xiao-Yang,Wang, Yun,Wu, Jin-Yuan,Lee, Jae-Chan,Kim, Chang-Jin,Lou, Kai,Xu, Li-Hua,Li, Wen-Jun Microbiology Society 2010 International journal of systematic and evolutiona Vol.60 No.9
<P>A Gram-staining-positive, facultatively anaerobic, non-motile and moderately halophilic actinobacterium, designated YIM 93306<SUP>T</SUP>, was isolated from a salt lake in Xinjiang province, north-west China, and subjected to a polyphasic taxonomic study. Strain YIM 93306<SUP>T</SUP> grew in the presence of 2-16 % (w/v) NaCl and did not grow without NaCl. The peptidoglycan type was A4<I>α</I> with an l-Lys-l-Glu interpeptide bridge. The whole-cell sugars were glucosamine, arabinose, mannose and two unknown sugars. The predominant menaquinone was MK-8(H4). The major fatty acids were iso-C15 : 0, anteiso-C15 : 0 and anteiso-C17 : 0. The polar lipids comprised diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, one unknown phosphoglycolipid and one unknown phospholipid. The DNA G+C content was 68.3 mol%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain YIM 93306<SUP>T</SUP> fell within the radius of the suborder <I>Micrococcineae</I>. Its closest phylogenetic neighbour was the type strain of <I>Ruania albidiflava</I> (AS 4.3142<SUP>T</SUP>; 96.2 % 16S rRNA gene sequence similarity), the sole recognized species of the genus <I>Ruania</I>. Sequence similarities between strain YIM 93306<SUP>T</SUP> and members of other genera of the suborder <I>Micrococcineae</I> were <95.2 %. On the basis of phylogenetic analysis, phenotypic characteristics and chemotaxonomic differences, a novel genus and species, <I>Haloactinobacterium album</I> gen. nov., sp. nov., is proposed. The type strain of the species is YIM 93306<SUP>T</SUP> (=DSM 21368<SUP>T</SUP> =KCTC 19413<SUP>T</SUP> =CCTCC AB 208069<SUP>T</SUP>). Based on phylogenetic characteristics and 16S rRNA gene signature nucleotide patterns, the genera <I>Ruania</I> and <I>Haloactinobacterium</I> gen. nov. are proposed to belong to a novel family, <I>Ruaniaceae</I> fam. nov.</P>
The Structural Design of Tianjin Goldin Finance 117 Tower
Liu, Peng,Ho, Goman,Lee, Alexis,Yin, Chao,Lee, Kevin,Liu, Guang-lei,Huang, Xiao-yun Council on Tall Building and Urban Habitat Korea 2012 International journal of high-rise buildings Vol.1 No.4
Tianjin Goldin Finance 117 tower has an architectural height of 597 m, total of 117 stories, and the coronation of having the highest structural roof of all the buildings under construction in China. Structural height-width ratio is approximately 9.5, exceeding the existing regulation code significantly. In order to satisfy earthquake and wind-resisting requirements, a structure consisting of a perimeter frame composed of mega composite columns, mega braces and transfer trusses and reinforced concrete core containing composite steel plate wall is adopted. Complemented by some of the new requirements from the latest Chinese building seismic design codes, design of the super high-rise building in high-intensity seismic area exhibits a number of new features and solutions to professional requirements in response spectrum selection, overall stiffness control, material and component type selection, seismic performance based design, mega-column design, anti-collapse and stability analysis as well as elastic-plastic time-history analysis. Furthermore, under the prerequisite of economic viability and a series of technical requirements prescribed by the expert review panel for high-rise buildings exceeding code limits, the design manages to overcome various structural challenges and realizes the intentions of the architect and the client.