청송도석의 구조해석

이희수,정윤중,신규연 연세대학교 산업기술연구소 1980 논문집 Vol.12 No.1

Mixed layer clay mineral among Chongsong pettery stones, which is important as raw material in ceramic manufactures, was investigated and then Al-chlorite(Sudoite)-Montmorillonite 1:1 regular interstratified clay mineral(Tosudite) was found to exist. X-ray diffraction, differential thermal analysis and infra-red absorption spectra were examined. The following results showed that the chief clay mineral of Chongsong pottery stone resembled to Al-chlorite(Sudoite)-Montmorillonite regular mixed layer. 1. Lattice spacing d(001) and d(002) after treatments showed as follows: d(001) d(002) untreated 29.4 17.7 ethylene glycol treatment 32.7 15.5 heat treatment - 14.2 2. DTA showed exothermal at 980 ℃ and endothermal at 70℃, 170℃, 550 ℃ and 570℃. 3. Infra-red absorption spectra showed OH absorption at wave number 3630cm??, 3650cm?? and 3530cm??.

배양한 NG-108 세포에서 Haloperidol에 의한 c-fos mRNA의 발현

이제욱,채영규,임은정,양병환,조연규 漢陽大學校 精神健康硏究 2000 精神健康硏究 Vol.19 No.-

아동기 학대 경험 유무에 따른 신경성 대식증의 임상특징 비교 : 증례분석에 의한 예비연구 Preliminary Study by Clinical Case Analysis

조연규,이준석 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

By comparing various clinical variables of 2 cases-one with the history of childhood abuse, the other without the history-of bulimia nervosa, the authors try to present basic materials for study of influence of childhood abuse to bulimia nervosa. Two cases of bulimia nervosa who were diagnosed according to the criteria of Diagnostic and Statistical Manual of Mental Disorders-Ⅳ were compared mainly by medical records. Clinical parameters which had been considered significant at previous studies such as main symptoms, age onset, severity of symptoms, and comorbid other psychiatric symptoms and personality disorders were compared. The patient who had a history of childhood abuse presented following characteristics ; largerer amount and lower frequency of binge eating, no use of laxatives, negative body image, presence of comorbid personality disorder(borderline personality disorder) and impulsive acting out such as excessive alcohol drinking, suicidal attempt, and emotional acting out, and finally poorer treatment response. Even though some overlap of clinical characteristics may be present, bulimia nervosa must be a separate clinical disease entity compared as one of diverse clinical manifestations of childhood abuse. Besides core eating disorder symptoms, diverse psychiatric symptoms which were commonly observed in bulimia nervosa patient may be rationally considered as results of childhood abuse.

광기능성 폴리머의 소산장 결합을 이용한 측면연마 광섬유형 자외선 센서

김상우,서규원,윤종국,장수원,유윤식,이승하,강신원 한국센서학회 2002 센서학회지 Vol.11 No.6

측면연마된 광섬유와 광기능성 색소가 분산된 평면도파로 결합기를 이용한 새로운 형태의 자외선센서를 제작하여 그 특성을 측정하였다. 자외선 조사에 의해 유효굴절률이 변화하는 광변색성 색소가 분산된 폴리머를 평면 도파로 재료로 사용하였다. 박막 광도파로는 광변색성 색소인 스파이록사진을 사용하였다. 자외선 조사시간을 20초, 30초, 40초로 증가시켰을 경우 센서의 파장응답은 1.44nm/mW, 1.64nm/mW, 1.78nm/mW였고 1550nm 파장에서 센서의 90% 복귀시간은 100초로 나타났다. In this paper, we investigated a novel UV sensor using evanescent field coupling between the side polished fiber and photo-functional polymer waveguide. It was found that resonant wavelength shifts occur due to variation in the refractive index of polymer planar waveguide for its photo-functional properties on exposed UV. Spiroxazine (photochromic dye) was used as the planar waveguide. The resonant wavelength response were exhibited at 1.44 nm/mW, 1.64 nm/mW, and 1.78 nm/mW when UV irradiations were exposed for 20 seconds, 30 seconds, and 40 seconds, respectively. The recovery time of sensor was independent of UV exposure power and 90% recovery time was 100 seconds.

2차원 저속절삭에 있어서 버어의 생성에 관한 연구

전태옥,박흥식,이광영,예규현,박윤식 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

Recently the development of CNC machine tools seems to bring about progressional high speed, precision, and automation in cutting processing, but is unlikely to avoid the generation of burr arising from plastic deformation, which may result in deterioration of improvement in the precision and productivity of products. This study conducted a comparative analysis of the sizes of burrs via two-dimensional low speed cutting experiments under varied different cutting conditions by taking as its materials of cutting A6061, A2014, STS304 and SM40C commonly used for precision machine paets, motor cars, aircrafts, and so on. When the depths of burrs increase, the size of the burrs are inclined to increase linearly at their final stage rather than the lateral sizes of the burrs. When cutting becomes fast in speed, the lateral sizes of burrs appear consistent, but from a relative perspective the sizes of the final burrs tend to be remarkably increased. An increase in the angle of inclination of α is seen as effective in reducing the thickness of burrs, and burrs were more decreased in size on coating tools rather than in uncoating tools.

Risk factors and prognostic impact of venous thromboembolism in Asian patients with non-small cell lung cancer.

Lee, Yun-Gyoo,Kim, Inho,Lee, Eunyoung,Bang, Soo-Mee,Kang, Chang Hyun,Kim, Young Tae,Kim, Hak Jae,Wu, Hong-Gyun,Kim, Young Whan,Kim, Tae Min,Lee, Keun-Wook,Lee, Se-Hoon,Kim, Dong-Wan,Heo, Dae Seog F. K. Schattauer 2014 Thrombosis and Haemostasis Vol.111 No.6

<P>Although the overall risk of venous thromboembolism (VTE) is high in patients with non-small cell lung cancer (NSCLC), risk identification is limited. The goal of this study was to estimate the incidence, risk factors and prognostic implications of VTE, and to evaluate a genetic link between oncogenes and the risk of VTE in Asian patients with NSCLC. A total of 1,998 consecutive patients with NSCLC were enrolled and analysed retrospectively. Since the effects of therapeutics on VTE development were modified by stage, stratified analyses were performed. When comparing overall survival in terms of VTE development, a propensity score-matching method was adopted to minimise potential confounding. The six-month and two-year cumulative incidences of VTE were 4.2% and 6.4%, respectively. The risk of VTE increased 2.45-fold with each advancing stage in NSCLC (p<0.001). The independent predictors of VTE were advanced age, pneumonectomy and palliative radiotherapy in localised NSCLC and ineligibility for surgery and palliative radiotherapy in locally advanced NSCLC. Adenocarcinoma histology (vs squamous cell) and former/current smoking status were significant predictors of VTE in metastatic NSCLC. A significant association between VTE and decreased survival was observed only among patients with localised NSCLC. EGFR mutations (p=0.170) and ALK rearrangements (p=0.159) were not associated with VTE development in lung adenocarcinoma. In conclusion, the two-year cumulative incidence of VTE is 6.4% in Asian patient with NSCLC. The significant predictors of VTE are different across stages of NSCLC. The prognostic impact of VTE on poor survival was limited to localised NSCLC.</P>

Comparative analysis between combination and single-agent chemotherapy for elderly patients with advanced non-small cell lung cancer: A nationwide population-based outcome study

Lee, Yun-Gyoo,Lee, Ju Hyun,Kim, Se-Hyun,Kim, Yu Jung,Lee, Heeyoung,Ahn, Soyeon,Jang, Joung-Soon,Lee, Jong-Seok,Kim, Jee Hyun Elsevier 2018 Lung cancer Vol.122 No.-

<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>To determine whether an upfront combination compared to single-agent therapy is beneficial for elderly patients with advanced non-small cell lung cancer (NSCLC) in the real world, a population-based epidemiologic study was conducted.</P> <P><B>Methods</B></P> <P>Patients ≥70 years with advanced NSCLC from 2007 to 2012 were identified in the National Health Insurance Service Database of Korea. A Cox proportional-hazards regression model and propensity score analysis were used to examine the effect of treatment modality on survival.</P> <P><B>Results</B></P> <P>Among 41,276 patients newly diagnosed with lung cancer, 8274 (20.0%) identified to be treated with upfront palliative chemotherapy were eligible for this study. After excluding 976 patients who received a first-line anti-epidermal growth factor receptor (EGFR) treatment, 7298 (88.2%) who received cytotoxic chemotherapy were included in further analyses: 5636 (77.2%) received doublet chemotherapy and 1662 (22.8%) received monotherapy. The most frequent regimen in combination group was gemcitabine and platinum doublet (44.7%), whereas that in monotherapy group was gemcitabine (46.7%). Multivariate analyses indicated lower use of combination chemotherapy with increasing age (odds ratio [OR] 0.73; 95% CI 0.67–0.79; <I>P</I> < 0.001) and female sex (OR 0.71; 95% CI 0.62–0.80; <I>P</I> < 0.001). Receipt of combination over single-agent chemotherapy was associated with a reduced risk of death (hazard ratio [HR] 0.91; 95% CI 0.86–0.96; <I>P</I> = 0.001) in overall population and (HR 0.89; 95% CI 0.80–0.98; <I>P</I> = 0.019) in the propensity-matched cohort.</P> <P><B>Conclusion</B></P> <P>In elderly patients with advanced NSCLC excluding those receiving frontline anti-EGFR targeted agents, receiving initial combination chemotherapy compared to single-agent was associated with improved survival.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This population-based study included all patients ≥70 years of advanced NSCLC. </LI> <LI> We examined if an upfront combination compared to singlet therapy is beneficial. </LI> <LI> Combination over singlet chemotherapy was associated with a reduced risk of death. </LI> <LI> Our results were consistent between overall and propensity score-matched cohort. </LI> </UL> </P>

Five-Year Follow-up Study of Monoclonal Gammopathy of Undetermined Significance in a Korean Elderly Urban Cohort

Lee, Yun-Gyoo,Bang, Soo-Mee,Lee, Jeong-Ok,Kim, Jin Won,Lee, Keun-Wook,Kim, Jee Hyun,Song, Jung Han,Kim, Tae-Hee,Kim, Ki Woong,Lee, Jong-Seok Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.2

<P><B>Purpose</B></P><P>We previously reported the prevalence of monoclonal gammopathy of undetermined significance (MGUS) to be 3.3% among an elderly Korean urban cohort recruited during 2005-2006. Here, we report a 5-year follow-up study of the previously identified MGUS cohort.</P><P><B>Materials and Methods</B></P><P>The 680 participants from the initial cohort were followed-up for a median of 5 years. Sera were collected between 2010 and 2011. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal-protein (M-protein).</P><P><B>Results</B></P><P>Of the 680 participants (21 with MGUS), 348 (51%) agreed to participate in the follow-up study and 10 were found to have MGUS. Among the 21 MGUS patients initially identified, nine were followed-up, six had persistent M-protein, and one patient had progressed to multiple myeloma (progression rate, 1.0%/yr). The M-protein disappeared in the remaining two individuals. Among the 339 participants without MGUS who were followed-up, four developed an M-protein. There was no significant difference in survival with respect to the presence of MGUS (p=0.66).</P><P><B>Conclusion</B></P><P>The 5-year follow-up data show that the natural clinical course of MGUS in Korea is similar to that in Western countries. MGUS was not associated with an increased risk of death over the 5-year study period.</P>

Port-wine stains confined to single cosmetic unit respond better to pulsed dye laser than lesions on multiple cosmetic units: A retrospective study

( Gyoo Huh ),( Jin Seop Kim ),( Yeon Gu Choi ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yun Ho Lee ),( Heun Joo Lee ),( Young-jun Choi ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Cosmetic units are designated based upon their similarity in topographic anatomy, texture and color, solar exposure, hair density, and sebaceous features. The difference in such features in facial Port-wine stain (PWS) may have an effect in response to pulsed dye laser (PDL) treatment. Objectives: To evaluate the response of facial PWS to PDL treatment based on the underlying cosmetic units. Methods: A retrospective study was performed of 18 patients with facial PWS treated with PDL. Clinical assessment was performed by 3 dermatologists who evaluated the photographs taken before each treatment sessions. Response grade were assigned according to quartile grading scale. The lesion was classified with respect to underlying cosmetic units. Results: The cheek was the area most involved (50 %). 100 % (6/6) of PWS confined to one cosmetic unit showed more than marked improvement compared with 16 % (2/12) on two or more units. (p < 0.05) The patients with PWS within one cosmetic unit required fewer treatment sessions to reach marked improvement. Conclusion: PWS confined to single cosmetic unit respond better to PDL than PWS located in the two or more units. When considering treatment for facial PWS with PDL, it is important to consider not only the age at the beginning of treatments or the initial size, but also underlying cosmetic units of the lesion.

A case of Dowling-Degos disease affecting the vulva

( Yun Ho Lee ),( Yeon Gu Choi ),( Gyoo Huh ),( Hyeon Jeong Park ),( Junghwa Yang ),( Jung Yup Kim ),( Sunmin Yim ),( Heun Joo Lee ),( Young Jun Choi ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Dowling-Degos disease is a rare autosomal dominant pigmented skin disorder, presenting clinically with reticular hyperpigmentation on flexor area, such as the neck, axilla, and groin. It is more common in women than in men and presents most frequently in the 4th decade. A 45-year-old female presented with a 5 years history of multiple, scattered, brownish to black colored macules on vulva area. There was no known family history of pigmentary disorder. The histologic examination of the lesion showed mild hyperkeratosis, epidermal rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation on tip of the rete ridges. And the S100 protein staining showed a few scattered intraepidermal dendritic cells. The based on the clinical and histological features, Dowling-Degos disease was diagnosed. Herein, we report a rare case of Dowling-Degos disease on the vulvar.