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스트릿 댄스 시장의 과제와 개선 방안 연구 : 전문가 인터뷰를 중심으로
이우재, 나윤빈,문병순 한국실용무용학회 2024 한국실용무용학회지 Vol.2 No.1
본 연구는 최근 미디어 등을 통해 주목받고 있는 스트릿 댄스의 주요 과제를 파악하고 이에 대한 개선방안을 모색하였다. 문헌조사와 더불어 관련 종사자 겸 전문가 10명을 대상으로 FGI를 실시하였다. 연구 결과, 국내 스트릿 댄스 시장은 아직까지 제도적 미비함이 많은 것으로 나타났고, 이를 계약, 일자리, 법제도 측면으로 나누어 보았을 때, 일자리 정보 공유, 의무적인 표준계약서 사용,법적 갈등에 대한 지원 등의 개선방안이 필요한 것으로 나타났다. 아울러 향후 지속가능한 형태의 발전을 위한 방안으로는 스트릿댄스의 허브 역할을 할 공적 협회의 설립 및 운영이 필요하다. This study looked at street dance, which has recently become popular through the media. The method was to identify major problems in the market and find ways to improve them. A literature survey was conducted, and then focus group interviews were conducted with 10 related workers and experts. As a result of the study, the domestic street dance market still had many institutional insufficiencies. This was divided by type into contracts, jobs, and legal system aspects. Here, improvement measures such as sharing job information, andatory use of standard contracts, and support for legal conflicts were found to be necessary. In addition, for future mid- to long-term evelopment, it is necessary to establish and operate a public association that will serve as a hub for street dance.
색상 측정 기기를 이용한 복합레진 적층 수복과 단일 수복의 색상 비교 분석
송영상,김자현,이빈나,장지현,장훈상,황윤찬,오원만,황인남 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.2
Objectives: This study analyzed the difference in color caused by different thickness in enamel layer of composite resins when applied with single and layering placement technique, and evaluated if the results agreed with the shade guide from the manufacturers to verify reliability of the color matching process of the manufacturers. Materials and Methods: For single composite resin samples, 6 mm diameter and 4 mm thickness cylindrical samples were fabricated using Ceram-X mono (DENTSPLY DeTrey) and CIE L*a*b* values were measured with spectrophotometer. Same process was done for layering compositie resin samples, making 3 dentinal shade samples, 4 mm thickness, for each shade using Ceram-X duo (DENTSPLY DeTrey) and enamel shade resins were layered in 2 mm thickness and CIE L*a*b* values were measured. These samples were ground to 0.2 mm thickness each time, and CIE L*a*b* values were measured to 1 mm thickness of enamel shade resin. Results: Color difference (△E*) between single and layering composite resin was 1.37 minimum and 10.53 maximum when layering thicknesses were between 1 mm and 2 mm and 6 out of 10 same shade groups suggested by manufacturer showed remarkable color difference at anythickness (△E* > 3.3). Conclusion: When using Ceram-X mono and duo for composite resin restoration, following the manufacturer's instructions for chossing the shade is not appropriate, and more accurate information for Ceram-X duo is needed on the variation and expression of the shades depending on the thickness of the enamel. (Restor Dent Endod 2012;37(2):84-89)
동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여
박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1
This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.
임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2
기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.
Glypican-3 Aptamer Has Potential as a New Targeted Therapy for Hepatocellular Carcinoma
( Yun Bin Lee ),( Jeong-hoon Lee ),( Dong Hyeon Lee ),( Yuri Cho ),( Jeong-ju Yoo ),( Young Youn Cho ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jong In Kim ),( Jong Hun Im ),( Jung Hwan Lee ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Aptamers are single-stranded synthetic oligonucleotides binding to overexpressed molecular targets on cancer cells. Glypican-3 (GPC3), a cell surface oncofetal protein that is highly expressed in hepatocellular carcinoma (HCC), has emerged as a novel therapeutic target. We developed aptamers targeting GPC3 and assessed those therapeutic potentials in the treatment of HCC by evaluating the binding affinity to HCC cells and anti-tumor efficacy. Methods: GPC3 expression on the surface of HCC cells (SNU-475, SNU-761, Huh7, and SNU-3058) was assessed by immunofluorescence staining. Flow cytometry was performed to determine the binding affinity of the GPC3 aptamers, which were generated through systematic evolution of ligands by exponential enrichment (SELEX) method, to HCC cells. Cell proliferation was studied using the MTS assay, and signaling pathways were explored by immunoblot analysis. Results: GPC3 was highly expressed in all HCC cell lines tested. Fourteen SELEX-derived GPC3 aptamers (representative aptamer; Kd, 4.5 ± 1.0 nM; Bmax, 0.45 fmol/mg protein) were evaluated using flow cytometry for selection of high-affinity aptamers to HCC cells. Among GPC3 aptamers analyzed, four GPC3 aptamers which showed high affinity to SNU-761 (~18.3%) or Huh7 cells (~37.0%) were selected for MTS assay. Treatment with GPC3 aptamers significantly suppressed HCC cell growth under normoxic (SNU-761 cells, P=0.038 and P=0.005; Huh7 cells, P=0.011 and P=0.013) and hypoxic (SNU-761 cells, P=0.019 and P=0.054; Huh7 cells, P=0.031 and P=0.011) conditions compared to control aptamers. Yes-associated protein (YAP), an oncogene which triggers cancer cell proliferation, was suggested to be down-stream signal of GPC3. GPC3 aptamers catalyzed inactivation of YAP by promoting its phosphorylation, leading to attenuation of HCC cell proliferation. Conclusions: We demonstrated that newly synthesized GPC3 aptamers can bind to HCC cells with high affinity and suppress HCC cell growth via inactivation of YAP. Further investigation of GPC3 aptamers as a novel targeted therapy for HCC is warranted.
Lee, Yun Bin,Jung, Eun Uk,Kim, Bo Hyun,Lee, Jeong-Hoon,Cho, Hyeki,Ahn, Hongkeun,Choi, Won-Mook,Cho, Young Youn,Lee, Minjong,Yoo, Jeong-Ju,Cho, Yuri,Lee, Dong Hyeon,Cho, Eun Ju,Yu, Su Jong,Park, Sung J American Society for Microbiology 2015 Antimicrobial Agents and Chemotherapy Vol.59 No.2
<P>Tenofovir disoproxil fumarate (TDF) monotherapy is a therapeutic option for chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV) variants resistant to lamivudine (LAM). We evaluated the antiviral efficacy and safety of TDF alone compared to those of TDF plus LAM or telbivudine (LdT) combination in patients harboring HBV variants with genotypic resistance to LAM. This multicenter retrospective study included consecutive patients who had LAM-resistant HBV variants and were treated with TDF alone (monotherapy group) or TDF combined with LAM or LdT (combination therapy group) for at least 6 months. Inverse probability of treatment weighting (IPTW) for the entire cohort was applied to control for treatment selection bias. Overall, 153 patients (33 in the monotherapy group and 120 in the combination therapy group) were analyzed. The overall probability of achieving complete virologic suppression at month 12 was 91.6%: 88.6% in the monotherapy group and 92.6% in the combination therapy group. Combination therapy was not superior to monotherapy in viral suppression before and after IPTW (<I>P</I> = 0.562 and <I>P</I> = 0.194, respectively). Hepatitis B e antigen (HBeAg) loss, biochemical response, and virologic breakthrough did not differ between treatment groups. The probabilities of complete virologic suppression were comparable between treatment groups in the subsets according to HBeAg status and HBV DNA levels at baseline. No patient experienced any significant renal dysfunction during the treatment period. In conclusion, TDF monotherapy has antiviral efficacy comparable to that of TDF plus LAM or LdT combination therapy, with a favorable safety profile in CHB patients with LAM-resistant HBV variants.</P>