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金光日,栗田廣,佐佐木雄司,崔美京,小野搏行,關根義夫 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.3
The aim of this study is to clarify factors determining illness behavior for Korean and Japanese depressed patients in relation to sociodemographic and illness variables and compare illness behavior patterns between the groups from the viewpoint of cultural value. Data regarding the illness behavior of 62 Japanese and 69 Korea depressed outpatients of university hospitals who were diagnosed by ICD-9 were used. All subjects were interviewed with semi-structured questionnaire. The first contact resuouces and time lag in approaching first mental health services and number of path until subjects' first contact mental health services were dependent variables, whereas sociodemographic and illness variables were independent variables. Analysis showed: 1) Korean subjects showed a tendency of first contact to non-mental health resources, of multiple help resources and delayed contact to mental health resources. Also, korean subjects relied more on traditional and folk medicine and drugstore than Japanese subjects. 2) Sociodemographic and illness variables did, inspite of sterotype, poorly impact on illness behavior except only one variable:Someatizing patients revealed a tendency of first contact to non-mental health resources, of multiple help resources and delayed contact to mental health resources. Such a pattern was similar in Japan and Korea. Subjective symptoms are thought be an important factor on illness behavior of depressed patients beyond medical systems. 3) In Japan, the higher in educational status,the more rapid in contact to mental health resources and the depressed who have early experience. In Korea, the depressed who have their spouse menifested delayed contact to mental health resources. Different support systems would be needed for the depressed patients in terms of utilization of mental health resources in different cultures.
Choi, Cheol Ho,Re, Suyong,Rashid, Mohammad H. O.,Li, Hui,Feig, Michael,Sugita, Yuji American Chemical Society 2013 The journal of physical chemistry. B, Condensed ma Vol.117 No.31
<P>The formation of like-ion pairs, Na<SUP>+</SUP>–Na<SUP>+</SUP> and Cl<SUP>–</SUP>–Cl<SUP>–</SUP>, in aqueous solution was studied by high-level ab initio methods, classical molecular dynamics (MD), QM/TIP5P, and QM/EFP MD (quantum mechanics/effective fragment potential molecular dynamics). Ab initio calculations on model clusters revealed that the Na<SUP>+</SUP>(H<SUB>2</SUB>O)<SUB><I>n</I></SUB>Na<SUP>+</SUP> (<I>n</I> = 2–4) clusters were significantly more stabilized by bridged waters than the corresponding Cl<SUP>–</SUP>(H<SUB>2</SUB>O)<SUB><I>n</I></SUB>Cl<SUP>–</SUP> clusters. QM/EFP MD simulations in solution also predicted a clear local minimum near 3.6 Å only for the Na<SUP>+</SUP>–Na<SUP>+</SUP> pair, suggesting that Na<SUP>+</SUP>–Na<SUP>+</SUP> pairs may be more likely to form than Cl<SUP>–</SUP>–Cl<SUP>–</SUP> pairs in solution. Analysis of the hydration structures further showed that two-water bridged Na<SUP>+</SUP>–Na<SUP>+</SUP> pairs were dominant at the local minimum. The preferred formation of Na<SUP>+</SUP> like-ion pairs in solution appeared to come from significant short-range effects, in particular, charge delocalization (polarization) between the bridged oxygen p and the vacant valence Na<SUP>+</SUP> orbitals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcbfk/2013/jpcbfk.2013.117.issue-31/jp4049346/production/images/medium/jp-2013-049346_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp4049346'>ACS Electronic Supporting Info</A></P>
Choi Baekgyu,Kang Chang Kyung,Park Seongwan,Lee Dohoon,Lee Andrew J.,Ko Yuji,Kang Suk-Jo,Kang Kyuho,Kim Sun,Koh Youngil,Jung Inkyung 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Clonal hematopoiesis of indeterminate potential (CHIP), a common aging-related process that predisposes individuals to various inflammatory responses, has been reported to be associated with COVID-19 severity. However, the immunological signature and the exact gene expression program by which the presence of CHIP exerts its clinical impact on COVID-19 remain to be elucidated. In this study, we generated a single-cell transcriptome landscape of severe COVID-19 according to the presence of CHIP using peripheral blood mononuclear cells. Patients with CHIP exhibited a potent IFN-γ response in exacerbating inflammation, particularly in classical monocytes, compared to patients without CHIP. To dissect the regulatory mechanism of CHIP (+)-specific IFN-γ response gene expression in severe COVID-19, we identified DNMT3A CHIP mutation-dependent differentially methylated regions (DMRs) and annotated their putative target genes based on long-range chromatin interactions. We revealed that CHIP mutant-driven hypo-DMRs at poised cis-regulatory elements appear to facilitate the CHIP (+)-specific IFN-γ-mediated inflammatory immune response. Our results highlight that the presence of CHIP may increase the susceptibility to hyperinflammation through the reorganization of chromatin architecture, establishing a novel subgroup of severe COVID-19 patients.
Choi, Hyeok-Jae,Ito, Takuya,Yokogawa, Masashi,Kaneko, Shingo,Suyama, Yoshihisa,Isagi, Yuji The Korean Society of Plant Taxonomists 2017 식물 분류학회지 Vol.47 No.1
The population status of Hydrangea luteovenosa Koidz. in Korea was investigated, with an emphasis on its genetic diversity. From field surveys, we obtained the only locality record for a wild population in Jeju Island, which contained 285 individuals in total. Genotyping was performed using five microsatellite markers for the all extant plants in Korea. Three Japanese populations were also genotyped for the comparative analyses. The genotyping result showed that the Jeju population consisted of only two multilocus genotypes, including identical heterozygous genotypes at two loci; it had been maintained mostly by vegetative reproduction; and although the Jeju population is geographically far from Japanese populations, all alleles observed in the Korean population were shared with Japanese populations, suggesting the possibility that H. luteovenosa in the Jeju Island had been recently migrated or introduced from Japan. Future ecological and genetic studies associated with negative effects of low genetic variation will be essential for determining the conservation direction of the threatened Korean population of this species.
Choi, Cheol Ho,Re, Suyong,Feig, Michael,Sugita, Yuji Elsevier 2012 Chemical physics letters Vol.539 No.-
<P><B>Graphical abstract</B></P><P><ce:figure id='f0025'></ce:figure></P><P><B>Highlights</B></P><P>► QM/EFP-MD: a new way of quantum mechanical molecular dynamics. ► It yielded accurate free energy change and reaction barrier of the <I>zwitterion</I>→<I>neutral</I> form conversion. ► Water rearrangements turned out to be the main driving force of the proton transfer.</P> <P><B>Abstract</B></P><P>We show that the hybrid quantum mechanical/effective fragment potential (QM/EFP) can be a very effective and practical quantum mechanical molecular dynamics method, when it is properly combined with well-developed traditional molecular dynamics (MD) techniques. QM/EFP-MD simulations on intra<I>-</I>molecular proton transfer of glycine with 290 EFP waters yielded accurate free energy change and reaction barrier of the <I>zwitterion</I>→<I>neutral</I> form conversion. Water rearrangements turned out to be the main driving force of the proton transfer.</P>
Choi, Hyang-Ki,Jung, Jin Ah,Fujita, Tomoe,Amano, Hideki,Ghim, Jong-Lyul,Lee, Dong-Hwan,Tabata, Kenichi,Song, Il-Dae,Maeda, Mika,Kumagai, Yuji,Mendzelevski, Boaz,Shin, Jae-Gook Elsevier 2016 Clinical therapeutics Vol.38 No.12
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>The goal of this study was to evaluate the moxifloxacin-induced QT interval prolongation in healthy male and female Korean and Japanese volunteers to investigate interethnic differences.</P> <P><B>Methods</B></P> <P>This multicenter, randomized, double-blind, placebo-controlled, 2-way crossover study was conducted in healthy male and female Korean and Japanese volunteers. In each period, a single dose of moxifloxacin or placebo 400 mg was administered orally under fasting conditions. Triplicate 12-lead ECGs were recorded at defined time points before, up to 24 hours after dosing, and at corresponding time points during baseline. Serial blood sampling was conducted for pharmacokinetic analysis of moxifloxacin. The pharmacokinetic–pharmacodynamic data between the 2 ethnic groups were compared by using a typical analysis based on the intersection-union test and a nonlinear mixed effects method.</P> <P><B>Findings</B></P> <P>A total of 39 healthy subjects (Korean, male: 10, female: 10; Japanese, male: 10, female: 9) were included in the analysis. The concentration–effect analysis revealed that there was no change in slope (and confirmed that the difference was caused by a change in the pharmacokinetic model of moxifloxacin). A 2-compartment model with first-order absorption provided the best description of moxifloxacin’s pharmacokinetic parameters. Weight and sex were selected as significant covariates for central volume of distribution and intercompartmental clearance, respectively. An E<SUB>max</SUB> model ( E [ C ] = [ <SUB> E max </SUB> ⋅ C ] / [ <SUB> EC 50 </SUB> + C ] ) described the QT interval data of this study well. However, ethnicity was not found to be a significant factor in a pharmacokinetic–pharmacodynamic link model.</P> <P><B>Implications</B></P> <P>The drug-induced QTc prolongations evaluated using moxifloxacin as the probe did not seem to be significantly different between these Korean and Japanese subjects. ClinicalTrials.gov identifier: NCT01876316.</P>