경영교육, 나눔경영을 위한 ‘기부’를 생각해보다!: Q방법론을 활용하여

유영설(Yu, Young-Seol),이도희(Lee, Doh-Hee) 한국경영교육학회 2021 경영교육연구 Vol.36 No.3

교내 수도꼭지형 냉온수기의 생수 배출 부위와 생수에 존재하는 미생물의 분포

박창은,김설아,임미소,이다은,박유진 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.1-1

The distributed species and number of viable microorganisms in drinking water were monitored according to water dispenser maintenance. our purpose was to investigate the distribution of bacteria in drinking water dispenser. To analyze possible dispenser contaminations sampling were performed from 14 locations in Namseoul University for 3 months from March to May, 2010. The isolated bacteria were identified by Gram stain and biochemical test using VITEKⅡ systems. The microorganism concentrations around the water discharge areas were measured and the average of total microorganisms was determined. The number of bacteria were measured by McFarland turbidity. The water and water discharge areas were separated and identified. The isolation rates of Gram positive cocci and Gram negative bacilli were 56.5%, 17.4% respectively. The frequently isolated bacteria were Staphylococcus epidermidis, Enterobacter aerogenes, Enterbacter sakazakii, Alcaligenes faecalis, Acinetobacter baumannii, Staphylococcus hominis, respectively. Further systematic studies are necessary with an emphasis on species identification. Key Words : Microorganisms, Water Discharge Areas, Drinking Water, McFarland

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

Sub-acute toxicity study in female ICR mice following repetitive intramuscular injection of cervical cancer vaccines

Seol-Hee Moon,Du-Yeol Kim,Jung-Min Lee,Hee-Won Park,Hye-Yeong Lee,Yong-Hoon Lee,Jaesung Lee,Jiwon Jung,Min-Ju Kim,Kyoung-Baek Choi,Yu-Kyoung Oh,Young-Bong Kim,Sujeong Kim,Seung Min Oh 환경독성보건학회 2014 환경독성보건학회지 Vol.29 No.-

Objectives : The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse-effect-level (NOAEL) of the cervical cancer vaccines was estimated. Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10<SUP>8</SUP>, 5×10<SUP>8</SUP>, and 2.5×10<SUP>9</SUP> copies/animal) of the cervical cancer vaccines. Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters. Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10<SUP>9</SUP> copies/animal.

특목고의 학교단위책임경영제에 대한 탐색적 진단 : 체육고등학교를 중심으로

유영설 ( Young Seol Yu ),이정흔 ( Jeong Hun Lee ),이도희 ( Do Hee Lee ) 한국스포츠산업경영학회 2009 한국스포츠산업경영학회지 Vol.14 No.4

이 연구는 학교단위 책임경영에 대한 진단과 향후 학교단위 책임경영제의 효율적 운영방안을 모색하고자 고등학교 교직원 및 교육기관 관계자를 대상으로 Q방법을 활용하여 학교단위 운영 현황에 대한 진단결과를 유형화하여 비교분석하였다. 분석과정은 문헌자료 및 고등학교 교직원 및 교육관계자를 대상으로 심층면접(depth interview)을 실시하여 학교단위 운영 현황에 대한 진술(statements)을 수집하고, 이들을 5개 영역의 총 29개 진술문(Q표본)으로 추출하였다. 진술문을 바탕으로 32명의 응답자(P표본)를 대상으로 Q분류를 실시한 결과 다음과 같이 두 가지의 유형으로 나타났다. 분석을 위한 응답자(P표본)는 체육고등학교 교직원과 일반고등학교 교사 및 장학사로 구성하였다. 첫째, <유형1>은 「평가체제진단형」이라 명명하였는데, 교사의 전문성 및 노력, 학교장 리더십의 중요성, 특목고와 일반고의 차별화 교육과정 등에 대하여 전반적으로 높은 긍정적인 현황을 나타냈다. 반면에 학교단위의 평가시스템에 대하여 부정적인 진단을 통하여 그 문제점을 제기하였다. <유형2>는 「인사체계진단형」으로 명명하였다. 이는 <유형1>과 같이 교사 및 학교장의 운영, 특목고와 일반고의 차별화된 교육과정에 대하여 긍정적인 반면에 학교인사시스템, 학교장의 구성원에 대한 의사결정 기회 부여, 특수교사에 대한 인센티브제도 등에 대하여 부정적으로 진단하였다. The aim of this study is to review the current ``school-based management,`` and suggest a more efficient plan for the school-based management. To achieve the goal, high school teachers and corresponding education institute officials were subjected to this study. The research result of the school-based management review was classified into pattern for a comparison analysis based on Q-Method. The analysis process was as follows. First, previous studies of this subject were reviewed and a depth interview was conducted with high school teachers and corresponding education institute officials. Second, statements on the current state of the school-based management were collected based on the interview, and they were processed into 29 statements(Q sample) under five categories. Based on the statements, 32 respondents(P sample) were subjected to Q sorting and the result yielded two patterns. The respondents for this analysis(P sample) were composed of the teachers in high school specializing in physical education, teachers in general high school, and school inspectors. The first pattern(Pattern 1) was named ``evaluation system diagnosis`` in which professionalism and committment of teachers, weight of the principal`s leadership, and distinctive curriculum of the specialized high school from that of the general high school were evaluated positively in general. On the other hand, a negative diagnosis on the evaluation system of the school-based management was made, hence addressing a problem. The second pattern(Pattern 2) was named ``personnel system diagnosis`` in which management of teachers and school principal, and distinctive curriculum of the specialized high school from that of the general high school were evaluated positively, as in the pattern I, whereas school personnel management system, teacher participation on a decision making granted by a school principal, and incentive system for a teacher with speciality were reviewed negatively.

The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity

( Da Hyun Lee ),( Jeong Su Park ),( Yu Seol Lee ),( Su Haeng Sung ),( Yong-ho Lee ),( Soo Han Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2

Nuclear factor erythroid 2-related factor 2 (Nrf2) provides a cellular defense against oxidative stress by inducing the expression of antioxidant and detoxification enzymes. The calcium antagonist, verapamil, is an FDA-approved drug prescribed for the treatment of hypertension. Here, we show that verapamil acts as a potent Nrf2 activator without causing cytotoxicity, through degradation of Kelch-like ECH-associated protein 1 (Keap1), a Nrf2 repressor. Furthermore, verapamilinduced Keap1 degradation is prominently mediated by a p62-dependent autophagic pathway. Correspondingly, verapamil protects cells from acetaminophen-induced oxidative damage through Nrf2 activation. These results demonstrated the underlying mechanisms for the protective role of verapamil against acetaminophen-induced cytotoxicity. [BMB Reports 2017; 50(2): 91-96]

Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation

( Da Hyun Lee ),( Buhyun Lee ),( Jeong Su Park ),( Yu Seol Lee ),( Jin Hee Kim ),( Yejin Cho ),( Yoonjung Jo ),( Hyun-seok Kim ),( Yong-ho Lee ),( Ki Taek Nam ),( Soo Han Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3

Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt2) is an NAD⁺-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesis, as well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries. [BMB Reports 2019; 52(3): 190-195]

폭발물탐지장비의 성능인증을 위한 최소 탐지용량 설정에 관한 연구

이상윤(Sangyoon Lee),박수홍(Soohong Park),김경훈(Kyunghoon Kim),설은숙(Eunsuk Seol),한수진(Soojin Han),강진구(Jingu Kang),김찬휘(Chanhwi Kim),이지수(Jisu Lee),박서하(Seoha Park),유상우(Sangwoo Yu),이원주(Wonjoo Lee) 한국신뢰성학회 2022 신뢰성응용연구 Vol.22 No.3

안쪽 눈꼬리점을 기준으로 한 한국인 눈확위구멍과 눈확아래구멍의 형태계측학적 분석

이명화(Myoung-Hwa Lee),정구수(Goosoo Jeong),유선경(Sun-Kyoung Yu),이광용(Kwang-Young Lee),김석(Seog Kim),이동설(Dong-Seol Lee),김흥중(Heung-Joong Kim) 대한체질인류학회 2012 대한체질인류학회지 Vol.25 No.4

악안면영역에서 해부학적 구조물의 위치에 관한 지식은 국소마취와 내시경을 이용한 수술과정에서 신경손상을 피하기 위해 필수적이다. 따라서 본 연구에서는 안쪽 눈꼬리점과 관련하여 눈확위구멍과 눈확아래구멍의 해부학적 위치를 계측하고 이들의 형태를 분석하고자 하였다. 해부학 교육용 시신 32구(64쪽; 평균 연령 64.1세)와 해부학 실습용 머리뼈 33개를 사용하였다. 눈확위구멍과 눈확아래구멍 주변의 연조직을 모두 제거한 후 디지털 캘리퍼를 사용하여 얼굴정중선으로부터 눈확위구멍, 안쪽 눈꼬리점, 눈확아래구멍까지의 거리를 각각 측정하였다. 이미지 분석 프로그램을 이용하여 디지털 카메라로 촬영한 사진 상에서 안쪽 눈꼬리점과 관련하여 눈확위구멍과 눈확아래구멍의 위치를 측정하였다. 각 머리뼈에서 눈확위구멍과 눈확아래구멍의 형태를 관찰하였으며 위턱 치아와 관련한 눈확아래구멍의 위치를 확인하였다. 모든 측정값은 SPSS 12.0프로그램을 이용하여 one-way ANOVA를 시행하였다. 얼굴정중선과 눈확위구멍, 안쪽 눈꼬리점, 눈확아래구멍 사이의 평균거리는 각각 24.13mm, 15.00mm, 29.11mm로 눈확아래구멍은 눈확위구멍과 안쪽 눈꼬리점보다 가쪽에 위치하고 있었다. 눈확위구멍은 안쪽 눈꼬리점에서 위쪽으로 18.99mm, 가쪽으로 9.05mm, 위가쪽으로 24.36˚ 지점에 위치하였다. 눈확아래구멍은 안쪽 눈꼬리점에서 아래쪽으로 26.69mm, 가쪽으로 13.53mm, 아래가쪽으로 26.59˚ 지점에 위치하였다. 눈확위구멍의 형태는 눈확위패임이 56.60%, 눈확위구멍이 43.40%로 패임이 더 많았다. 눈확아래구멍의 수직, 수평 직경은 각각 3.36mm, 3.45mm로 형태는 원형이 가장 많았으며, 눈확아래구멍은 대부분 위턱 둘째작은어금니 부위에 위치하고 있었다. 본 연구의 결과들은 국소마취, 얼굴성형수술, 그리고 이마와 준 주위의 외과적 시술 과정 시 눈확위구멍과 눈확아래구멍을 통과하는 신경혈관다발의 손상 방지를 위해 중요한 자료를 제공할 것이다. Knowledge of the location of the maxillo-facial foramina is essential for regional nerve blocks and endoscopic surgical procedures to avoid nerve injury passing through these foramina. The purposes of this study were to determine the locations of the supraorbital foramen (SOF) and the infraorbital foramen (IOF) related to medial canthus (MC), and to analyze the morphology of these foramina. Thirty-two embalmed cadavers (64 sides, mean age: 64.1 years) and 33 dry skulls (66 sides) were used. The distances from the SOF, IOF, and MC to facial midline were directly measured on the cadavers using digital Vernier caliper. The vertical and horizontal distances of the SOF and IOF relative to the medial canthus were indirectly measured on the digital photographs using image analyzer software. The vertical and horizontal diameters of the IOF, and its location in relation to maxillary tooth were evaluated on the dry skull. Statistical analysis was performed using one-way ANOVA with declaration of significant difference when P<0.05. The mean distances of SOF, MC, and IOF to the facial midline were 24.13mm, 15.00mm, and 29.11mm, respectively. The SOF was located 18.99mm superior and 9.05mm lateral to the medial canthus. The distance between the medial canthus and the SOF was 22.67mm, and the vertical angle(Angle 1) between these structures was 24.36˚ superolaterally. The IOF was located 26.69mm inferior and 13.53mm lateral to the medial canthus. The distance between the medial canthus and IOF was 30.82mm and the vertical angle(Angle 2) between these structures was 26.59˚ inferlaterally. In the this study, spraorbital notch(SON) was found more frequently than the SOF. The mean vertical and horizontal diameters of IOF were 3.36mm, 3.45mm, respectively. IOF was most commonly found in the same vertical plane with the second upper premolar. In conclusion, these results are important for performing local anesthetic, facial plastic surgery, and other invasive procedures in the forehead and periorbital region to prevent injury of neurovascular bundles passing through these foramina.

CTX-M and SHV-12 β-lactamases are the most common extended-spectrum enzymes in clinical isolates of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> collected from 3 university hospitals within Korea

Kim, Jungmin,Lim, Yu-Mi,Rheem, Insoo,Lee, Yeonhee,Lee, Je-Chul,Seol, Sung-Yong,Lee, Yu-Chul,Cho, Dong-Taek Elsevier 2005 FEMS microbiology letters Vol.245 No.1

<P><B>Abstract</B></P><P>Among the 443 clinical isolates of <I>Escherichia coli</I> and <I>Klebsiella</I> spp. collected between June and November 2003 from 3 university hospitals in Korea, 62 isolates were confirmed as extended-spectrum β-lactamase (ESBL)- or plasmid-mediated AmpC β-lactamase-producers by double disk synergy test, PCR and sequencing for β-lactamase genes. The most frequently identified ESBL gene among <I>E. coli</I> and <I>K. pneumoniae</I> isolates was <I>bla</I><SUB>SHV-12</SUB> and <I>bla</I><SUB>CTX-M</SUB> (<I>bla</I><SUB>CTX-M-9</SUB>, <I>bla</I><SUB>CTX-M-14</SUB>, <I>bla</I><SUB>CTX-M-3</SUB>, and <I>bla</I><SUB>CTX-M-15</SUB>). Four kinds of plasmid-mediated AmpC β-lactamases, ACT-1, CMY-1, CMY-2, and DHA-1, were detected. ESBL production was associated with high levels of resistance to tetracycline, sulfisoxazole, streptomycin, kanamycin, gentamicin and tobramycin when compared to non-ESBL producing isolates. Conclusively, this study suggests that the CTX-M β-lactamases are prevalent and various kinds of plasmid-mediated AmpC enzymes are distributed in clinical isolates of <I>E. coli</I> and <I>Klebsiella</I> spp. in Korea.</P>