NaOCL로 처리된 치수강 상아질에서 sodium ascorbate가 미세인장결합강도에 미치는 영향

전수연,이광원,유미경 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.6

본 연구의 목적은 NaOCl로 처리된 치수강 상아질에 total-etching adhesive system(single bond, 3M-ESPE, St Paul MN USA)을 적용할 때 미세인장결합강도에서 sodium ascorbate가 미치는 영향을 평가하는 것이다. 발치된 건전한 인간 대구치의 치수강 내면을 다음과 같이 처리하였다. 1군, 0.9% NaCl로 세척; 2군, 5.25% NaOCl로 세척; 3군 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 1분간 적용; 4군, 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 1분간 적용하고 다시 10ml 물로 수세 : 5군, 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 5분간 적용; 6군, 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 5분간 적용하고 다시 10ml 물로 수세 ; 7군, 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 10분간 적용; 8군, 5.25% NaOCl로 세척한 후 10% sodium ascorbate를 10분간 적용하고 다시 10ml 물로 수세. 처리된 시편들은 total-etching adhe-sive system(Single bond)으로 처리한 후 composite resin(Z250)으로 충전하고, 미세인장강도를 측정하기 전 24시간 동안 보관하였다. 분석 결과 NaOCl 처리 군(2군)은 다른 실험군들에 비해 유의성 있게 낮은 결합 강도를 보였다. NaCl 처리 군(1군)과 sodium ascorbate처리 군(3-8군)은 유의성 있는 차이가 없었다. 이번 연구 결과는 NaOCl로 처리한 치수강 상아질의 Single bond에 대한 미세인장결합강도는 감소되며 , 10% sodium ascorbate를 추가적으로 처리하였을 때 감소된 결합력이 회복됨을 보여주었다. Sodium ascorbate의 다양한 처리시간은 결합력에 영향을 미치지 않았다. The purpose of this study was to evaluate the influence of sodium ascorbate on microtensile bond strengths of total-etching adhesive system to pulp chamber dentin treated with NaOCl. Pulp chambers of extracted human non-caries permanent molars were treated as follows: group 1, with 0.9% NaCl; group 2, with 5.25% NaOCl; group 3, with 5.25% NaOCl and 10% sodium ascorbate for 1min; group 4, with 5.25% NaOCl and 10% sodium ascorbate for 1 min and 10ml of water; group 5, with 5.25% NaOCl and 10% sodium ascorbate for 5 min; group 6, with 5.25% NaOCl and 10% sodium ascorbate for 5 min and 10ml of water; group 7, with 5.25% NaOCl and 10% sodium ascorbate for 10 min; group 8, with 5.25% NaOCl and 10% sodium ascorbate for 10 min and 10ml of water. Treated specimens were dried, bonded with a total-etching adhe-give system (Single bond), restored with a composite resin(Z250) and kept for 24h at 100% humidity to measure the microtensile bond strength. NaOCl-treated group (group 2) demonstrated significantly lower strength than the other groups. No significant difference in microtensile bond strengths was found between NaCl-treated group (group 1) and sodium ascorbate-treated groups (group 3-8). The results of this study indicated that dentin treated with NaOCl reduced the microtensile bond strength of Single bond. Application of 10% sodium ascorbate restored the bond strength of Single bond on NaOCI-treated dentin. Application time of sodium ascorbate did not have a significant effect.

충수돌기에 발생한 비호지킨 림프종 1예

정유경,이미숙,김윤식,이미자,전호종 조선의대 1995 The Medical Journal of Chosun University Vol.20 No.2

Self-etching primer/adhesive를 사용한 교정용 브라켓의 접착시 오염이 전단결합강도에 미치는 영향

김유신,이형순,이현정,전영미,김정기 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.5

이 연구는 self-etching primer와 adhesive를 사용하여 법랑질 표면에 교정용 브라켓을 접착할 때 수분과 타액, 그리고 혈액에 의한 오염이 브라켓의 전단결합강도에 어떤 영향을 미치는지 알아보고자 시행되었다. 96개의 발거된 치아를 4개의 군으로 나누어서 self-etching primer와 adhesive를 사용하여 다음의 4가지 방법에 따라 교정용 브라켓을 접착하였다. 첫 번째 군은 치면을 건조시킨 상태에서 부착하였고, 두 번째, 세 번째, 네 번째 군은 각각 증류수, 인공타액, 혈액을 적용한 후 브라켓을 접착하였다. 각 시편의 전단결합강도를 측정하였고 debonding 후에 브라켓과 치아 표면은 stereomicroscope을 사용하여 관찰하였다. 각 군에서 4개씩의 시편을 선택하여 표면처리된 법랑질 표면과 접착계면을 주사전자 현미경으로 관찰하여 다음과 같은 결과를 얻었다. 건조군과 증류수군의 전단결합강도는 각각 15.22 ± 2.86 MPa과 16.20±3.85 MPa로 혈액군의 전단결합강도(12.56 ± 2.94 MPa)보다 높았다(p<0.05). 건조군과 증류수군, 그리고 인공타액군간에는 전단결합강도에 통계적 차이가 없었다(p>0.05). 혈액군은 다른군에 비해서 debonding 후 법랑질 표면에 잔류한 레진의 양이 더 적었다(p<0.05). self-etching primer로 처리된 치면의 주사전자현미경 소견에서 건조군과 증류수군의 치면에서는 인공타액군과 혈액군에 비해서 더욱 뚜렷한 산부식 구조를 볼수 있었다. 이상의 결과로서 self-etching primer/adhesive를 사용한 교정용 브라켓의 접착시 수분이나 타액의 오염은 결합력에 거의 영향을 미치지 않음을 알수 있으며, 혈액으로 오염시에는 결합력에 영향을 미치지만, 임상적으로 유용한 최소 결합강도(5.9-7.8 MPa) 이상을 보이고 있음을 알 수 있었다. The purpose of this study was to investigate the influence of water, saliva, and blood contamination on the bonding strenght of metal brackets with a self-etching primer/adhesive to enamel. Ninety-six extracted human teeth were divided into four groups. The brackets were bonded to enamel with a self- etching primer (3M/Unitek Dental Products, Monorovia, California) according to one of four protocols. The teeth were bonded in a dry condition (group D) or in contamination with distilled water (group W), artificial saliva (group S), or fresh human blood (group B). Shear bond strengths were tested using an Instron Universal testing machine. After debonding, bracket and tooth surfaces were examined with a stereomicroscope. In each group, four samples were selected and examined with a Scanning electron microscope of the prepared enamel surface and resin-enamel interface. The results obtained were summarized as follows: Shear bond strength in group D (15.22 ± 2.86 MPa) and W (16.20 ± 3.85 MPa) were higher than in group B (12.56 ± 2.94 MPa) (p<0.05). There were no statistical differences in the shear bond strengths between groups D, W and S (p>0.05). There was a tendency to have less residual adhesive remaining on the enamel surfaces of group B than group D. The SEM morphology of group D and W showed a more roughened etching pattern than group S and B. Water or saliva contamination on bonding of orthodontic brackets with Transbond plus self etching primer had almost no influence on bond strength. In this study, the blood contaminated group showed the lowest bond strength, but it was above the clinically acceptable bond strength (5.9-7.8 MPa, Reynold, 1975). The results of this study suggest that acceptable clinical bond strengths can be obtained in wet conditions when self-etching adhesives are used.

비호지킨 림프종의 REAL 분류와 cyclin D1, bcl-2, p53및 bcl-6 단백발현

이미자,전호종,정종달,박유환,김민 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives : There has been a continuous evolution of the lymphoma classification and recently a Revised European-American Lymphoma (REAL) classification was proposed by the International Lymphoma Study Group. This new classification requires information on immunophenotypic and molecular biologic markers in addition to the usual histologic findings. The distinction between mantle cell lymphoma (MCL) and other low grade B cell lymphomas is important because MCL has a more aggressive clinical course. The aim of this study is to determine the clinical characteristics and the relative frequency of malignant non-Hodgkin’s lymphomas (NHL) and analyze the expression of the cyclin D1, bcl-2, p53 and the bcl-6 protein. Materials and Methods : One hundred and twelve cases of NHL were recategorized by the newly described REAL classification categories and investigated for the expression of the cyclin D1, bcl-2, p53 and bcl-6 protein by the immunohistochemical method. Results : There were higher rates of extranodal lymphoma, diffuse large B cell lymphoma, and angiocentric lymphoma and lower rates of T cell lymphoma and follicular center lymphoma compared with Western countries. Cyclin D1 is expressed in all cases of MCL. But no cases except for MCL showed positive for cyclin D1. The expression of bcl-2 had decreased in high-grade lymphomas. Conclusion : It suggests that the cyclin D1 expression in mantle cell lymphoma could be reliably distinguished from its expression in other non-Hodgkin’ s lymphomas. In addition, bcl-2 may be useful for the differentiation of the low grade lymphoma from the high grade lymphoma.

대학생의 수면양상과 수면장애요인에 관한 연구

김유진,박미경,박이랑,이보람,이혜림,전선미,양난영,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38

The results of this Study are as follows:33.6% of all participants have insomnia; 22.5% of those who have insomnia are DIS(difficulty in initiating sleep), 17.3% are DMS(difficulty returning to sleep once awakened) and 7.0% awakened too early. 3 4.8% experience sleepiness during daytime. Type 1, experiencing insomnia and sleepi ness during daytime together, is 12.0%, Type 2, with insomnia only, is 21.6%, Type 3, with sleepiness during daytime only, is 22.8% and 43.5% experience no sleeping disturbances. After studying only those with 3 types of sleeping disturbances, it is found that the most common cause of such disturbance is stress 88.4%, anxiety 56.0%, no apparent reason 33.8%, anxiety/fear/terror 29.3%, hurry 23.6%, alcohol/caffeine 16.9%, bedroom tem perature 11.1%, urination during nighttime and persons living together 10.7%, noise from inside 8.9%, illumination 8.0%, and pain/itch 5.8%. The one group revealed significant differences in residential environment(p=0.003). Sex, age, education level, medicine, monthly earning revealed no meaningful differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), whether taking enough sleep(p=0.029), whether taking regular sleep(p=0.005) showed significant differences depending on whether or not having insomnia, and mean duration of sleep time, time to sleep, time of rising, whether taking naps did not reveal significant differences. Of sleep behavior, time to sleep(p=0.000), whether taking naps(p=0.000), indicated significant differences. Of sleeping behavior, mean duration of sleep latency(p=0.000), whether or not feeling freshness(p=0.000), and whether taking enough sleep(p=0.000), time of going to bed (p=0.002), whether or not taking nap(p=0.000), whether or not taking regular sleep(p=0.010) indicated significant differences among the sleeping disturbance types.

여성 간호직 근로자의 노인부양의식

이미정,전만중,유병철,이용환 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Background : The purpose of this study was to provide the fundamental data for developing appropriate policies and programs for the elderly and reducing relevant problems through the analysis of female nurses' awareness of supporting the elderly. Method : We conducted a questionnaire survey during the period from August 2007 till October 2007. The data was collected from questionnaires filled out by 220 female nurses working at three hospitals located in Busan City. Collected data were analyzed descriptive analysis, t-test, one-way ANOVA and dummy variable regression analysis using SPSS Win(ver 12.0k) program. Result : The mean score for awareness of supporting the elderly in female nurses was 3.56 ± 0.51. Awareness of supporting the elderly was high in groups of 20-29 years group, experience of voluntary service, living together with their parents, lived with progressive home education environment and lived with harmonic family, respectively. Awareness of supporting the elderly female nurses was influenced by experience of voluntary service, living together with parents, type of parent's education, family harmony and age. Conclusion : This study showed that the level of supports displayed by female nurses was influenced by the factors such as the educational environment, the experience of living with parents and volunteer works, and harmony of family. In order to provide substantial assistance for the elderly, we need national-wide welfare system for the elderly, cultural backgrounds for volunteer work and social programs for family harmony.

구절산과 인근산지(충남)의 식물상 : Chungcheongnam-do

이웅빈,전유미 용인대학교 자연과학연구소 2004 自然科學硏究所論文誌 Vol.8 No.2

The flora of Mt. Gujeolsan (329m) and neighbor areas such as Mt. Noseongsan (348m) was surveyed in this study from the middle of February till the middle of October, 2001. The vascular plants collected from these areas are as following: 123 taxa those are 16 varieties, 107 species, 92 genera, 48 families, 24 orders and 5 phyla. There are 4 taxa from southern plant in these areas. And there are two taxa of special protected plants which was designated from Ministry Environment of Korea, those are one taxon 3rd, and one taxon of 1st grade.

<디자인과 마케팅>융합을 통한 출판사 협동조합 'POOM' 개발 -그래픽 디자인, 제품 디자인, 공간 디자인을 중심으로-

주서역,오연수,유로운,이진민,장미정,전찬희,정인희 숙명여자대학교 디자인연구소 2017 숙명디자인학 연구 Vol.23 No.-

본 연구는 한국인의 독서 장려와 보다 효율적인 독서문화 전하를 위해 출판협동조합 브랜드 'POOM'을 개발하는 일련의 과정들을 밝히는데 그 목적이 있다. 연구의 대상은 2016년 3-6월 15주간 숙명여대 환경디자인학과 <브랜드스페이스마케팅> 수업에서 진행도니 수업의 결과물로써 4개 팀 중 1개 팀의 작업물을 정리한 것이다. 연구 범위는 4개의 주제 중 물의 'product'로 한정하였다. 연구 결과, '늘 내 품에 지닐 수 있는 책' 이라는 상징 개념으로 '품(POOM)'이라고 브랜드 네이밍하였다. 그래픽 디자인은 심플함과 속도감을 나타내는 레드 컬러로 얇은 책을 형상화한 형태를 로고에 적용, 제품 디장니은 휴대하기 편한 패키지디자인 개발, 공간디자인은 지하철 2,3,9호선으로 선정하고 각 호선의 특성을 기반으로 브랜드 컬러로 하여, 각 호선에 맞는 공간과 경유하는 지역의 특성을 통합적으로 브랜딩 하였다. 끝으로 본 연구는 출판협동조합의 아이덴티티를 개발함에 있어서 디자인과 마케팅을 융합하여 좀 더 체계화된 GI, PI, SI의 통합 브랜드 메뉴얼을 만드는 것에 의의가 있으며, 향후 협동조합의 통합 브랜드 디자인 개발에 있어서 그 자료로 활용될 것으로 기대한다.

Proteomic Analysis of Hepatotoxicity Induced by Titanium Nanoparticles in Mouse Liver

( Yu Mi Jeon ),( Seul Ki Park ),( Mi Young Lee ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.6

Differentially expressed proteins in mouse liver caused by toxicity of titanium nanoparticles (TiO2 NPs) were screened. More than 1,400 protein spots in mouse liver were detected by twodimensional gel electrophoresis, and 15 proteins that showed greater than 2-fold expressional changes in response to TiO2 NPs were identified by liquid chromatography-tandem mass spectrometry. Of these, 12 proteins were down-regulated and 3 proteins were up-regulated upon treatment with TiO2 NPs. The 15 differentially expressed proteins could be used for detection of inflammation, apoptosis, and antioxidative reaction for treatment of acute hepatic damage by TiO2 NPs.

Neuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity

Jeon, Yu-Mi,Lee, Shinrye,Kim, Seyeon,Kwon, Younghwi,Kim, Kiyoung,Chung, Chang Geon,Lee, Seongsoo,Lee, Sung Bae,Kim, Hyung-Jun Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.4

Several lines of evidence suggest that endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Protein tyrosine phosphatase 1B (PTP1B) is known to regulate the ER stress signaling pathway, but its role in neuronal systems in terms of ER stress remains largely unknown. Here, we showed that rotenone-induced toxicity in human neuroblastoma cell lines and mouse primary cortical neurons was ameliorated by PTP1B inhibition. Moreover, the increase in the level of ER stress markers ($eIF2{\alpha}$ phosphorylation and PERK phosphorylation) induced by rotenone treatment was obviously suppressed by concomitant PTP1B inhibition. However, the rotenone-induced production of reactive oxygen species (ROS) was not affected by PTP1B inhibition, suggesting that the neuroprotective effect of the PTP1B inhibitor is not associated with ROS production. Moreover, we found that MG132-induced toxicity involving proteasome inhibition was also ameliorated by PTP1B inhibition in a human neuroblastoma cell line and mouse primary cortical neurons. Consistently, downregulation of the PTP1B homologue gene in Drosophila mitigated rotenone- and MG132-induced toxicity. Taken together, these findings indicate that PTP1B inhibition may represent a novel therapeutic approach for ER stress-mediated neurodegenerative diseases.