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김윤신,이호,정유경,정익조,한백희 대한법의학회 2000 대한법의학회지 Vol.24 No.1
Paraquat is a bipyridilium nonselective contact herbicide and well-known pulmonary toxicants. Concentrated solution of paraquat may causes severe corrosive injury and multiple system organ failure. It is poorly absorbed from GI tract, but is extremely toxic and so one swallowed mouthful of Gramoxone(about 5ml) will be fatal. We experienced 3 cases of paraquat poisoning through injection and examined pathologic findings, medical records and concentration of paraquat in blood and tissues. We reviewed the mechanism of action of paraquat. pathologic changes of organ system, concentration of compound in the various organ and cause of death in autopsy cases.
Yu Jin Choi,Hee Sun Yang,Jun Hee Jo,Sang Cheon Lee,Tae Young Park,Bong Suk Choi,Kyoung Sun Seo,Chang Ki Huh 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.2
This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine-induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.
Development of High Energy Particle Detector for the Study of Space Radiation Storm
Jo, Gyeong-Bok,Sohn, Jongdae,Choi, Cheong Rim,Yi, Yu,Min, Kyoung-Wook,Kang, Suk-Bin,Na, Go Woon,Shin, Goo-Hwan The Korean Space Science Society 2014 Journal of Astronomy and Space Sciences Vol.31 No.3
Next Generation Small Satellite-1 (NEXTSat-1) is scheduled to launch in 2017 and Instruments for the Study of Space Storm (ISSS) is planned to be onboard the NEXTSat-1. High Energy Particle Detector (HEPD) is one of the equipment comprising ISSS and the main objective of HEPD is to measure the high energy particles streaming into the Earth radiation belt during the event of a space storm, especially, electrons and protons, to obtain the flux information of those particles. For the design of HEPD, the Geometrical Factor was calculated to be 0.05 to be consistent with the targets of measurement and the structure of telescope with field of view of $33.4^{\circ}$ was designed using this factor. In order to decide the thickness of the detector sensor and the classification of the detection channels, a simulation was performed using GEANT4. Based on the simulation results, two silicon detectors with 1 mm thickness were selected and the aluminum foil of 0.05 mm is placed right in front of the silicon detectors to shield low energy particles. The detection channels are divided into an electron channel and two proton channels based on the measured LET of the particle. If the measured LET is less than 0.8 MeV, the particle belongs to the electron channel, otherwise it belongs to proton channels. HEPD is installed in the direction of $0^{\circ}$, $45^{\circ}$, $90^{\circ}$ against the along-track of a satellite to enable the efficient measurement of high energy particles. HEPD detects electrons with the energy of 0.1 MeV to several MeV and protons with the energy of more than a few MeV. Thus, the study on the dynamic mechanism of these particles in the Earth radiation belt will be performed.
Lymph node metastasis of Vaginal primary neuroendocrine carcinoma: A case report
( Yu Jin Lee ),( Min Ji Kang ),( Hyun Kyoung Seo ),( Jae Yoon Jo ),( In Ae Cho ),( Won Jun Choi ),( Jeong Kyu Shin ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Neuroendocrine tumor of female genital tract is rare, and it is even rarer at vagina. We present the case of Primary small cell neuroendocrine carcinoma of vagina with Lt. inguinal lymph node metastasis. A 42-year-old hysterectomy state woman visited outpatient department with perineal palpable mass. Mass excisional biopsy diagnosed her with neuroendocrine carcinoma and Abdomen ECT revealed the presence of enlarged lymph node in Lt. inguinal area. We performed Lt. vaginal mass excisional biopsy and General surgeon performed Lt. inguinal lymph node excisional biopsy. Histopathological examination revealed small cell neuroendocrine carcinoma.
Yu, Chang-Yeon,Lim, Jeong-Dae,Kim, Myong-Jo,Kang, Won-Hee,Hyun, Tae-Kyoung The Korean Society of Medicinal Crop Science 2002 韓國藥用作物學會誌 Vol.10 No.4
Acifluorfen-tolerant callus lines of Solanum ptycanthum were isolated by stepwise selection. Growth of the unselected line was completely inhibited at 0.5 uM. while some selected lines grew at 8 uM acifluorfen. Twenty-two of twenty-five acifluorfen-tolerant callus lines regenerated shoots. Many of the regenerated somaclones were variants, differing in leaf shape, leaf color, number of flower parts, flower color, and fertility. The acifluorfen tolerant S. ptycanthum callus lines differed.
Choi, Yu Jin,Yang, Hee Sun,Jo, Jun Hee,Lee, Sang Cheon,Park, Tae Young,Choi, Bong Suk,Seo, Kyoung Sun,Huh, Chang Ki The Korean Society of Food Science and Nutrition 2015 Preventive Nutrition and Food Science Vol.20 No.2
This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.