Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the <i>KRAS</i> mutation

Kim, Kyu-Rae,Choi, Jene,Hwang, Jeong-Eun,Baik, Young-Ae,Shim, Jeong Yeon,Kim, Yong Man,Robboy, Stanley J Blackwell Publishing Ltd 2010 Histopathology Vol.57 No.4

<P>Kim K-R, Choi J, Hwang J-E, Baik Y-A, Shim J Y, Kim Y M & Robboy S J(2010) <I>Histopathology</I><B>57</B>, 587–596<B>Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the <I>KRAS</I> mutation</B></P><P>Aims: </P><P>Clinicopathological aspects of the endocervical-like mucinous borderline tumour of the ovary (EMBT), including higher frequencies of bilaterality, endometriosis and hormone receptor reactivity, and often admixtures of various Müllerian-type epithelia, closely resembles endometrioid tumour more than mucinous borderline tumour of the intestinal type (IMBT). Thus, the aims of this study were to determine whether EMBT is really a subtype of mucinous borderline tumours, as shown in the current classification system, and to determine the best classification for EMBT.</P><P>Methods and results: </P><P>The clinicopathological and immunohistochemical features of 17 EMBTs were analysed, including oestrogen receptor (ER), progesterone receptor (PR), <I>PTEN</I>, cytokeratins (CK) 7 and 20, and <I>&bgr;-catenin</I>. Additionally, mutational analyses of the <I>KRAS</I> (exon 1) and <I>PTEN</I> genes (all nine exons) were performed in all cases, and the results were compared with literature findings for IMBT and endometrioid tumours. Twelve patients (71%) were confirmed histologically to have endometriosis in one or both ovaries. In seven cases, gradual transitions from endometriotic foci to the EMBT were identified. Immunohistochemically, all cases were reactive for ER and PR, with no nuclear expression of &bgr;-catenin. CK7 positivity was strong in all patients, whereas there was no reactivity for CK20. <I>PTEN</I> reactivity was diffuse in the nuclei of epithelial and underlying stromal cells. Sixty-nine per cent showed <I>KRAS</I> mutations in exon 1 and codon 12, but no <I>PTEN</I> mutation was identified in any of the nine exons.</P><P>Conclusion: </P><P>Our study suggests that EMBT has features of both mucinous and endometrioid tumours and is an additional tumour type arising in endometriosis. While clinicopathological features of EMBTs are closer to endometrioid tumours, they still have molecular characteristics closer to IMBTs.</P>

증기발생기 세관에 대한 유도 초음파의 실험적 연구

김영환,송성진,엄흥섭,김재희,김준영 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

증기발생기 세관 비파괴 검사에 유도초음파를 적용하기 위한 예비 실험을 수행하였다. 이를 위하여 증기 발생기 세관을 실험 대상으로 하여 분산 선도 및 특정 모드에 대응하는 초음파 입사각의 계산을 수행하였고 short time Fourier transform을 이용한 시간-주파수 분석을 통하여 유도초음파 모드를 확인하였으며, 유도 초음파가 증기발생기 세관의 곡관 부분을 통과할 때 모드 변환이 발생하지 않는 것을 실험적으로 확인하였다. 탐촉자 사이의 거리를 바꾸면서 수신한 초음파 신호에 대한 시간-주파수분석으로부터 군속도를 계산하였다. 유도 초음파를 이용한 증기발생기 세관의 최적 검사 모드를 제안하고 실험에 의하여 이를 확인하였다.

Effect of Cooling Rate on Mechanical and Electrical Properties of Cu-TiB₂ by Turbulent In-Situ Mixing Process

Park, J.S.,Yun, J.H,Park, Young Do,Park, Yong Ho,Cho, Kyung Mok,Park, Ik Min Scitec Publications Ltd. 2007 Solid State Phenomena Vol.119 No.-

<P>A copper matrix composite reinforced with in situ TiB2 nanoparticle was successfully fabricated by tubulent in-situ mixing process. The microstructure, mechanical and electrical properties of the in situ composite were investigated. The results showed that the in situ formed TiB2 particles, in which size varying from about 50nm to 200nm, exhibited a homogenous dispersion in the copper matrix. It is shown that the interface between the nanoscale particles and the matrix was clean without a transitional layer. Because of the reinforcement, the hardness and Young’s Modulus of the composite improved with increment of cooling rate. Moreover, the in situ Cu-TiB2 composite exhibited higher electrical conductivity with increasing of cooling rate.</P>

Assessment of Phase Transformations in Binary Fe–Mn Alloys: Effects of Composition and of Plastic Strain

R. Young,J. Fuller‑Thomson,H. Zurob,O. Bouaziz,A. Arlazarov 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

A simple, first order description of the formation of ε- and α′-martensite in meta-stable austenitic Fe–Mn alloys containing12–35 wt% Mn was developed. Given the initial volume fractions of ε- and α′-martensite in the non-deformed material, itis possible to calculate the evolution of phase fractions as a function of applied strain. An accurate estimate of the initialamounts of ε- and α′-martensite based solely on the Mn content of the alloy, could not be obtained due to the important roleof microstructure features and processing conditions on the martensitic transformations.

한국인에서 심바스타틴의 효과와 부작용 분석을 위한 다기관 공동 임상 연구

박영배 ( Young-Bae Park ),서정돈 ( Jung-Don Seo ),배종화 ( Jong-Hwa Bae ),노영무 ( Young-Moo Rho ),이원로 ( Won-Ro Lee ),손민수 ( Min Soo Son ),채성철 ( Shung-Chull Chae ),김권삼 ( Kwon-Sam Kim ),김권배 ( Kwon Bae Kim ),안정천 ( J 대한내과학회 1999 대한내과학회지 Vol.57 No.5

The aim of this study was to investigate the efficacy of simvastatin to improved lipid profiles in hypercholesterolemic Korean patients. Methods : From 25 hospitals in Korea, 478 hypercholesterolemic patients were enrolled from November 1996 to April 1998. The inclusion criteria was hypercholesterolemia over 240 mg/dl after diet therapy for 1 month or hypercholesterolemia over 220 mg/dl in patients with definite evidence of ischemic heart disease. Simvastatin 10mg was started and doubled up to 40mg if total cholesterol level remained higher than 200 mg/dl at monthly check. Of 478 subjects, 344 patients in whom study protocol was not violated were analyzed. Results : Male to female ratio was 27:73 and 47% of the subjects were in 6th decade. Hypertension, coronary artery disease, and diabetes mellitus were present in 30, 10, and 4% of the subjects. Baseline lipid profile (mean of total cholesterol-LDL-HDL-triglyceride mg/dl) was 274-185-52-188. The dose of simvastatin for 3 months was 10/10/10mg in 61% of subjects, 10/20/20mg in 21%, 10/10/20mg in 7%, and 10/20/40mg in 12%. The change of total cholesterol level(before-4wk-8wk-12wk-withdrawal 4wk) was 274-209- 205-198-250, and the maximal reduction rate was 27%. The change of LDL-cholesterol was 185-123-116-110-159, with maximal reduction rate 39%. The change of HDL-cholesterol was 52-54-56-55-54, with maximal increase rate 9%. The change of tryglyceride was 188-161- 164-162-189, with maximal reduction rate 15%. The value before/after treatment of ApoA1, ApoB, and Lp(a) was 129/129, 138/83, and 9.3/10.7, respectively. The level of LDL-cholesterol at the end of treatment was below 100mg/dl in 36% of subjects, 100-130 in 45%, 130-160 in 16%, and over 160mg/dl in 4%. The reduction rate of LDL-cholesterol was different between subjects whose LDL decreased below 100 and those whose LDL did not decrease below 130mg/dl, which suggests the existence of the individual difference of responsiveness to simvastatin. There were only 3 subjects (0.9%) who showed increase of liver enzyme over 3 times as the upper normal limit. Conclusion: Simvastatin is effective in improving lipid profiles in hypercholesterolemic Korean patients without serious side effects. (Korean. J. Med 57:906-915, 1999)

얼굴 실인증으로 발현된 우측 우성의 의미치매 환자 : 증례보고 A Case Report

권재철,안선영,박영진,최미영,강수진,나덕렬 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Semantic dementia (SD) is a temporal variant of frontotemporal lobar degeneration (FTLD). Clinical manifestation depends on which hemisphere is predominantly involved Left side predominant group presents with naming difficulty and decreased auditory comprehension of words, whereas the right side predominant group presents with prosopagnosia. We report a 61-year-old right-handed woman presented with a 6-month history of impaired ability to recognize familiar faces of her acquaintances she used to know well She scored 25/30 on Mini-Mental State Examination. Neuropsychological tests showed impairments in visuospatial, memory, and naming function When presented with photographs of 25 famous people in Korea such as politicians, sports star, actors or actress, the patient could not tell their name at all and identify occupation only 7 of 25 people. But 6age/education matched controls showed correct responses of names in 12.3±4.1 and occupation in 20.8±3.2 of 25 people. Her brain MRI showed atrophy in both anterior temporal areas, more marked on the right side. We consider this patient as the first case of right side dominant SD reported in Korea

구기자 및 구기엽 추출물의 피부과색소 조절효과

김동희 ( Dong Hee Kim ),이수연 ( Soo Yeon Lee ),김남경 ( Nam Kyung Kim ),윤보경 ( Bo Kyung Youn ),정다솜 ( Da Som Jung ),최은영 ( Eun Young Choi ),홍소리 ( So Ri Hong ),윤지영 ( Ji Young Yoon ),강명화 ( Myung Hwa Kang ),이진영 ( J 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.4

구기자, 건조구기엽, 생구기엽 추출물의 미백효과를 검증하였다. Tyrosinase 저해활성 측정결과 건조구기엽 에탄올추출물 500 μg/mL에서 44%의 저해활성을 나타내었으며, melanoma cell (B16F10)에서의 melanin 생합성 저해율 측정결과 건조구기엽 에탄올 추출물 50 μg/mL에서 14%의 저해효과를 나타내었다. 구기자, 건조구기엽, 생구기엽 추출물을 처리한 B16F10군 에서는 tyrosinase protein의 발현이 처리하지 않은 군보다 감소 하였다. 특히, 건조구기엽 추출물의 경우 tyrosinase의 단백질 발현량을 많이 저해하였다. 결과적으로 건조구기엽 추출물의 미백활성이 가장 우수하였으며, 식품 및 화장품의 기능성 소재로 이용이 가능할 것으로 판단된다. The objective of the present study was to evaluate the skin whitening effect of the extracts, Lycii fructus (LF), Dry-L. foilum (DLF) and Fresh-L. folium (FLF). Tyrosinase inhibition activities was 44% in DLF ethanol extracts at a 500 μg/mL. When the tyrosinase activities in B16F10 murine melanoma cell were tested, the activities in DLF ethanol extracts was 14% at a 50 μg/mL concentration. The protein expression of microphthalmia-associated transcription factor, tyrosinase related protein 1 (TRP-1), TRP-2, and tyrosinase, which are all melanin related factors, showed that LF, DLF and FLF extracts inhibited the protein bio-synthesis in B16F10 melanoma cell. Especially the DLF extract showed greater decrease of protein expressions. Results indicate that the DLF extract tested in the present study had skin whitening activity and can be used as a function a ingredients for food and cosmetic compositions.

Suppression of cooling by strong magnetic fields in white dwarf stars

Valyavin, G.,Shulyak, D.,Wade, G. A.,Antonyuk, K.,Zharikov, S. V.,Galazutdinov, G. A.,Plachinda, S.,Bagnulo, S.,Machado, L. Fox,Alvarez, M.,Clark, D. M.,Lopez, J. M.,Hiriart, D.,Han, Inwoo,Jeon, Young Nature Publishing Group, a division of Macmillan P 2014 Nature Vol.515 No.7525

Isolated cool white dwarf stars more often have strong magnetic fields than young, hotter white dwarfs, which has been a puzzle because magnetic fields are expected to decay with time but a cool surface suggests that the star is old. In addition, some white dwarfs with strong fields vary in brightness as they rotate, which has been variously attributed to surface brightness inhomogeneities similar to sunspots, chemical inhomogeneities and other magneto-optical effects. Here we describe optical observations of the brightness and magnetic field of the cool white dwarf WD 1953-011 taken over about eight years, and the results of an analysis of its surface temperature and magnetic field distribution. We find that the magnetic field suppresses atmospheric convection, leading to dark spots in the most magnetized areas. We also find that strong fields are sufficient to suppress convection over the entire surface in cool magnetic white dwarfs, which inhibits their cooling evolution relative to weakly magnetic and non-magnetic white dwarfs, making them appear younger than they truly are. This explains the long-standing mystery of why magnetic fields are more common amongst cool white dwarfs, and implies that the currently accepted ages of strongly magnetic white dwarfs are systematically too young.

Isolation and Characterization of a Rhodococcus Species Strain Able to Grow on ortho- and para-Xylene

Jang Jung Yeon,Kim Dockyu,Bae Hyun Won,Choi Ki Young,Chae Jong-Chan,Zylstra Gerben J.,Kim Young Min,Kim Eungbin The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.4

Rhodococcus sp. strain YU6 was isolated from soil for the ability to grow on o-xylene as the sole carbon and energy source. Unlike most other o-xylene-degrading bacteria, YU6 is able to grow on p-xylene. Numerous growth substrate range experiments, in addition to the ring-cleavage enzyme assay data, suggest that YU6 initially metabolizes 0- and p-xylene by direct aromatic ring oxidation. This leads to the formation of dimethylcatechols, which was further degraded largely through meta-cleavage path-way. The gene encoding meta-cleavage dioxygenase enzyme was PCR cloned from genomic YU6 DNA using previously known gene sequence data from the o-xylene-degrading Rhodococcus sp. strain DK17. Subsequent sequencing of the 918-bp PCR product revealed a $98\%$ identity to the gene, encoding meth-ylcatechol 2,3-dioxygenase from DK17. PFGE analysis followed by Southern hybridization with the catechol 2,3-dioxygenase gene demonstrated that the gene is located on an approximately 560-kb megaplasmid, designated pJY J1

방광의 MALT 림프종 1예

이지연,김원석,송서영,이순일,박준오,김기현,고영혜,정철원,임영혁,강원기,이홍기,이희정,박찬형,박근칠 대한내과학회 2002 대한내과학회지 Vol.63 No.1

Primary lymphoma of the urinary bladder is a rare non-epithelial bladder tumor accounting for less than 1% of all bladder tumors. Approximately 17 cases of MALT lymphomas of bladder have been reported in the literature. Most reported MALT lymphomas of bladder have a female sexual preponderance with a mean age of 58 years with common presenting symptoms of hematuria, dysuria and urinary frequency. The reported prognosis of MALT lymphoma of the urinary bladder is excellent. We report a case of MALT lymphoma of urinary bladder in a 57-year-old woman patient who presented with a two-year history of persistent dysuria and urinary frequency. An intravenous pyelogram and cystoscopy revealed a 1 cm focal elevated lesion at the base of urinary bladder. The tissue obtained by transurethral resection (TUR) showed plasma cell infiltration consistent with low grade marginal zone B cell lymphoma. The immunohistochemical studies showed an immunoglobulin restriction to lambda light chain while the nested polymerase chain reaction analysis of the tissue showed a monoclonal Ig heavy-chain gene rearrangement. The clinical staging protocol revealed that the tumor was primarily arising from the urinary bladder with no evidence of other site involvements. The patient received radiation therapy of 3060 cGy in 17 fractions.