서울 서초동 지역의 산성비에 대한 조사

고영신,최영재,최홍관 서울교육대학교 과학교육연구소 1996 科學과 數學敎育 論文集 Vol.22 No.-

Pilot plant와 Jar test를 이용한 응집제 LAS와 PAC의 수처리 효과 비교

김운중,고창옥,조영관 朝鮮大學校 建設技術硏究所 2001 建設技術硏究 Vol.21 No.1

Juam raw water was used to investigated water treatment efficiency in terms of coagulants and experiment types as jar-test and lab-scale pilot plant. pH of treated water was about 0.1~0.2 high when pilot plant was used than when jar-test was used in all of coagulants as liquid aluminium sulfate(LAS) and poly aluminium chloride(PAC). In comparing pH of surface water between in actual precipitation process with in pilot plant precipitation process when LAS was used, variation range of pH was 0.16 in pilot plant process whereas 0.04 in actual process. In comparing color, turbidity, zeta-potential, aluminium of precipitated surface water, it showed same results in all of coagulants as PAC and LAS and all of processes. In comparing alkalinity of the water, PAC showed alkalinity was 2∼3ppm higher than when LAS was used because of coagulants' characteristics as Al2O3 contents. Langarier indices as Corrosive index were -2.95 in LAS and -2.66 in PAG, which means PAC has less corrosive than LAS. In, comparing the removal of algae using LAS and PAC in jar-test and pilot plant, the removal rates were 80% in jar-test and 75% in pilot plant. The rate was improved to 90% after when incline baffles were used. Therefore, PAC is appropriate in considering prevention of corrosion, on the other side, LAS is appropriate in considering economy.

Pacemaker-mediated Tachycardia 증례 보고 1례

안효용,고영관 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Pacemaker-mediated tachycardia(PMT) is a circus movement tachycardia that can occur in patients with dual chamber pacemaker with atrial sensing(VDD or DDD), when a ventricular depolarization, either spontaneous or paced, causes retrograde activation of the atrium. Recently, a number of pacemaker manufactures have incorporated in their devices a variety of relatively complex algorithms to prevent PMT. Despite these measures, PMT may still occur because of inappropriate programming or unpredictable variations of ventriculoatrial conduction. We report one case of PMT in a 78-year-old male who received DDD type pacemaker due to sick sinus syndrome. In this case, PMT was disappeared after reprogramming parameters of pacemaker and the application of PMT protection algorithm.

Cerivastatin과 Gemfibrozil 병합요법 후에 발생한 횡문근 융해증 : 1예보고

김신철,김명천,고영관 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Most currently available statins are associated with an increase with risk of myositis, including rhabdomyolysis. Myopathy is believed to be caused by interference in the cytochrome P450 3A4 enzyme system, which results in a marked increase in reductase activity. Cerivastatin, a new synthetic HMG-CoA reductase inhibitor, is a safe, well-tolerated effective drug for the treatment of patients with dyslipidemia. The drug is metabolized by the cytochrome P450 3A4 and cytochrome P450 2C8 hepatic isoenzymes. Because of this dual metabolic pathway, it has been suggested that cerivastatin is less subject to drug-to-drug interactions. We describe a 60-year-old woman with rhabdomyolysis and localized myositis, after she had taken cerivastatin(lipobay, 0.3 mg/day) and gemfibrozil(lopid, 500 mg/day) for 1month.

장루 보유자의 생활 만족도 조사

서현석,이석환,고영관,오수명,윤충,주흥재,이기형 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

패혈증과 피부 감염증 의증으로 오진된 스티븐스 존슨 증후군 1예

정성구,김명천,고영관 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Stevens-Johnson syndrome(SJS) is a rare, life-threatening, drug-induced cutaneous reaction which presents dramatic, unforgettable manifestations. While the characteristic features of the disease are well known universally, many physicians have not seen a case of SJS which may result in delay in recognition and treatment. We report a rare case of SJS, which was initially misiagnosed as sepsis with skin infection and atypical pneumonia on emergency department presentation, and we give a brief review of the literature.

Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

Kim, Sung Eun,Ko, Il Gyu,Shin, Mal Soon,Kim, Chang Ju,Ko, Young Gwan,Cho, Hanjin Medknow PublicationsMedia Pvt Ltd 2012 Neural regeneration research Vol.7 No.22

<P>Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.</P>

급성 허혈성 뇌졸중에 대한 동맥내 혈전 용해술 후 발생한 혈복증 1예

정성구,김명천,고영관 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Although thrombolytic therapy is one of the most effective therapeutic option for acute ischemic stroke, hemorrhagic complication still remains major concern about its application. A patient with hemoperitoneum, who previously underwent thrombolytic therapy(intraarterial urokinase infusion, IAUK) for acute ischemic stroke was treated successfully with emergency transarterial embolization for rupture of hepatocellular carcinoma. We present a rare case of rupture of hepatocellular carcinoma after intraarterial urokinase infusion for acute ischemic stroke with brief review of the literature.

외상성 비장 손상 5 2예의 임상적 고찰

홍성화,이상목,고영관,오수명,장연수 대한외상학회 1999 大韓外傷學會誌 Vol.12 No.2

Backgrounds : A total splenectomy was considered as the standard method to management of splenic injury. However, recently, splenic preservation has been emphasized because of the spleen ’s important immunologic function, especially in the young. This study was conducted to evaluate the safety and the indications of non-operative management of traumatic splenic injury. Methods : The medical records of 52 patients who were managed for traumatic splenic injury between Jan. 1, 1990, and Jun. 30, 1999, were evaluated. The clinical manifestations, the mecha-nism of injury, the diagnostic method, the grade of injury, the initial management, the initial treatment mode, treatment course, and complications were investigated. Results : Thirty(30) patients were initially treated medically with transfusions and intensive monitoring. A delayed operation was required in 9 patients (30%) who suffered a severe splenic injury more than grade III. Twenty-one(21) of the 30 patients (70%) who suffered a splenic injury less than grade III were successfully managed non-operatively. Nineteen(19) of the 22 patients (86%) who required an initial operation suffered a severe splenic injury more than grade III. There were differences between the non-operative and the operative groups in transfusion amount (1.1 vs 6.5 pints) and in hospital stay (14.8 vs 30.9 days). Conclusions : Non-opeartive management of traumatic splenic injury will be successful in patients who are hemodynamically stable with adequate resuscitation and a small amount of transfusion and who have suffered injuries below grade III.

H9c2 심근 세포주에서 외인성 nitric oxide가 허혈에 의한 세포 독성에 미치는 영향

정성구,장현용,김명천,고영관,정주호,배영미,박원서,김대중,유영민,김성수,임성빈 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Nitric oxide(NO) is known to have protective effects on an ischemic heart and to exert triggering effects on ischemic preconditioning. However, the effects of NO during the ischemic period have not been investigated. To investigate the role of exogenous nitric oxide in a model of ischemic heart cell death, we studied the effects of ischemic preconditioning and ischemia in a normal and an ischemic buffer. Methods: Rat cardiac myoblast cells(H9c2) were cultured in a normal and an ischemic buffered medium. For the ischemic culture of heart cells, the cells were cultured in a dessicator with GasPak for 5 hrs. In ischemic preconditioning, the cells were pretreated with ischemic buffer for 5 min and then perfused with normal medium for 30 min. For the measurement of the cytotoxicity, a MTT(3-4-Sdimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide) assay was performed. A DAPI(4',6-diamidino-2-phenylindole dihydrochloride) staining procedure and a flow cytometry analysis were performed to confirm apoptotic cell death by ischemia. Results: Cell viability, as determined by using a MTT assay, showed that the preconditioned group treated with NO showed more cell death than with the not-preconditioned groups in both normal and ischemic buffers. But, In normal medium and not-preconditioned groups, NO showed protective effect according to the concentrations(100,1000μM) . No treatment with NO produced the different results. In normal medium, the protective effect of ischemic preconditioning was demonstrated, but no protective effect of ischemic preconditioning could be seen in the case of the ischemic buffer. The DAPI staining and flow cytometry analysis of heart cells showed characteristic apoptotic features. Conclusion: NO added in the ischemic phase had deterious effects on heart cells. Ischemic preconditioning was more harmful than ischemia alone. The toxicity of the cells was characteristic apoptosis.