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Glucose Oxidase가 척수지각신경절세포에 미치는 영향과 천마의 효과에 관한 연구
송호준,이용석,손영우,이강창,정종길,신민교,홍기연 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2
Objectives : To clarify the cytotoxic effect of glucose oxidase(GO) and protective effect of gastrodiae Rhizoma (GR) on spinal sensory ganglion(DRG) neurons, neurotoxicity mediated by GO was measured by MTT assay and neurofilament enzymeimmuno assay(EIA). Methods : DRG neurons were cultured in the media containing various concentrations of GO for 3 hours. In addition, neuroprotective effects of GR, on GO-induced neurotoxicity in DRG neurons were examined after DRG neurons were preincubated with various concentrations of GR for 2 hours before 15mU/ml GO for 3 hours. Results : GO decreased remarkably cell viability in dependently in these cultures, and also RG increased cell viability and amount of neurofilament in DRG neurons damaged by GO. Conclusion : It is suggested that GO has toxic effect in cultured mouse DRG neurons, and also RG was effective in the protection of GO-induced neurotoxicity in these cultures.
이진호,최선웅,강길선,노승무,민병무,김용백,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
"Biomaterials" are nonviable materials used in medical devices, intended to interact with biological systems. They should have "biocompativility", which is defined as the ability of materials to perform with an appropriate host response in a specific application. It includes many materials that are often classified as biomaterials. Metals, ceramics, polymers, glasses, carbons, and composite materials are some examples. Among them, biodegradable polymers are discussed in this revies article. Since a biodegradable polymeric implant does not have to be removed surgically once it is no longer needed, biodegradable polymers are of value in short-term applications that require only the temporary presence of a polymeric implant. Main short-term medical applications of biodegradable polymers include the temporary tissue scaffold, the temporary adhesion barrier, the drug delivery device, and the multifunctional implant. In this article, the properties, processing methods, and medical applications of the biodegradable polymers are reviewed.
손영준(Young Jun Son) · 조한길(Han Gil Jo) · 김영옥(Young Ok Kim) · 우영종(Young Jong Woo) 대한소아신경학회 2010 대한소아신경학회지 Vol.18 No.1
기저세포모반증후군은 상염색체 우성 방식으로 유전되는 드문 질환으로 가족력과 특징적인 임상 및 방사선학적 소견으로 진단하며, 이에 대한 가족력이 없는 경우 질환을 조기 진단하는 데 어려움이 있다. 또한, 환아의 나이가 증가함에 따라 동반된 여러 이상을 가져올 수 있으므로 이에 대한 추적 관찰이 필요할 것으로 생각한다.저자들은 12세 여아에서 우연히 발견된 치성 각화낭으로 인해 기저세포모반증후군으로 진단된 환아를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Basal cell nevus syndrome(BCNS) is a rare autosomal dominant disorder characterized by variable developmental anomalies and predisposition to cancers. The main manifestations include multiple basal cell carcinomas of skins, odontogenic keratocysts, facial dysmorphism, skeletal abnormalities including scoliosis and bifid ribs, palmar and plantar pits, calcification of the falx cerebri, and biparietal frontal bossing. We experienced a case of 12-year-old girl with the clinical features of basal cell nevus syndrome.
위부 갑상선 기능저하증 3예 - Type Ia 및 II
이영길,강성구,이광우,손호영,강무일,윤건호,손현식,유순집,홍관수,박영부,김범생 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.2
Pseudohypoparathyroidism (PHP) is a rare clinical state of hypoparathyroidism that results from target tissue resistance to parathyroid hormone, associated with a secondary, hypocalcemia-induced increase in parathyroid gland function. Classically PHP have clinical (tetany and seizures) and biochemical (hypocalcemia and hyperphosphatemia) features of hypoparathyroidism and AHO (Albright's hereditary osteodystrophy), characterized by several distinctive skeletal and developmental defects. But other variants were reported according to clinical and biochemical manifestation. The biochemical hallmark of PHP is PTH resistance. In some patients with PHP, the guanyl nucleotide regulatory protein (G-protein) is decreased by 50 percent in red blood cells in such patients. This defect appears to produce resistance to several other hormones that apparently exert their actions by stimulating the increased production of cellular cyclic AMP. Pseudohypoparathyroidism is classified to Type Ia, Type Ib and Type Ⅱ according to clinical and biochemical manifestations. We experienced recently three pseudohypoparathyroidism patients admitted to St. Mary's Hospital. One was classic PHP (type Ia), manifestated by tetany, hypocalcemia, hyperphosphatemia and AHO.The others were PHP without AHO (PHP type Ⅱ). Here we confirmed these patients to specific PHP subtype with the urinary cAMP response to PTH (J Kor Soc Endocrinol 6:170~178, 1991).