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한국인 심부전증 환자 심근에서의 인형 거대 세포 바이러스 감염
이명용,이무용,김영권,한성식,최성준,김효수,이영우,서정돈 단국대학교 1998 論文集 Vol.33 No.-
Objectives: In order to evaluated the prevalence and the site of infection of cytomegalovirus in terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. Methods: DNA extractions were performed from explanted failing hearts(N=22) and normal hearts(N=5) and polymerase cain reactions(PCRs) were done for detection of late gene sequence coding pp150 glycoprotein. The products were confirmed by electrophoresis on the 1% agarose gel. n order to improve the detectability of cytomegaloviral genome, nested PCRs were executed with the primers designed for the original 607 bp products. In situ PCRs also were done with the samples which were confirmed as positive for CMV viral genome by nested PCRs. Results: All patients had IgG anti-cytomegalovirus antibody and did not have IgM anti-cytomegalovirus antibody. Cytomegaloviral genomes in myocardium were detected by polymerase chain reaction. The 607bp products by PCRs were found in both explanted failing heart(3 cases/22. 13.5%) and normal hearts( 1 case/5, 20.0%). In nested PCRs, 186bp products were found in both failing hearts(LV 4/22, LA 3/2, RV 4/22, RA 0/17) and normal hearts(LV 2/5, LA 1/4, RV 2/5, RA 2/5). These was no significant change in positivity of cytomegaloviral DNA genome between failing and normal hearts. Total positivity of cytomegaloviral genome in explanted hearts was 44.4% according to the nested PCR results. The positivity of cytomegaloviral DNA by n situ PCR was 33.3%(4/12), and the site of positive reaction was the nuclei of the myocardial cells. Conclusion: Cytomegalovirus was rarely observed in explanted hearts of terminal heart failure and nested PCR could enhance the sensitivity of cytomegaloviral genome detection. The result of the in situ PCR showed the site of the cytomegaloviral infection was nuclei of the myocardial cells. Cytomegalovirus, however, might have no direct causal relationship in the development of terminal heart failure.
Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례
김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-
Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).
Trigger point를 利用한 口眼괘斜 患者 10例에 대한 臨床的 考察
鄭榮敦,李浚龜,金永一,朴泰均,辛泳一,黃載然,李賢,李秉烈 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2
From July 1th 2001 to October 31th 2001, the Clinical investigation studies were carried out 10 cases of patient with Bell's palsy using Trigger point treatment group, who had been treated in Han-seung Oriental Medical Clinic. The results were like below : 1. The distribution of sex : Male were 4cases, female were 6case and the female to male ratio was 1.5 : 1. 2. The distribution of contributing factor : Unknown reason was most predominant 4 cases, and then were revealed to labor too hard, menttal stress(3 cases), trauma·common cold(1 case) in turn. 3. The distribution of perid to fall ill : Under a week was the most number 6cases, and then were revealed a week under two weeks(3 cases), over two weeks(1 case) in turn. 4. About period of treatment : The Trigger point treatment group is shorter than the Acupuncture treatment group. 5. The distribution of grade on admission in descending order : GrⅠ was the most number and then GrⅡ, GrⅢ in turn. 6. The distribution of clinical symptoms on adimission : Mastoid pain was the most number 9 cases and then lacrimal gland disorder 8 cases, dysgeusia 4 cases, hyperacusis 2 cases, the others 2 cases in turn. 7. About effect of treatment : The Trigger point treatment group is more excellent than the Acupuncture treatment group. 8. The more patient age is young, the more effect of treatment was excellent, had nothing to do with both groups. 9. The more perid to fall ill is short, the more effect of treatment was excellent, had nothing to do with both groups. 10. About period of improved frontal belly : The Trigger point treatment group is more excellent than the Acupuncture treatment group.
진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-
Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.
야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로
조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6
Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.
급성 백혈병 관해유도요법후 발생한 다발성 비장농양 1예
이홍기,김선운,박경동,이현성,주영돈,손창학 인제대학교 2000 仁濟醫學 Vol.21 No.1
Splenic abscess is a rare illness. Its incidence has ranged from 0.14 to 0.7 % in various autopsies conducted in the US. Even in the most recently published articles, diagnosis was made only in autopsies in 37 % of the cases. While splenic abscess may arise occasionally from contiguous spread of infection or direct trauma to the spleen, usually it develops with hematogenous spread or infection. But, bacterial endocarditis is the most common cause. RUQ pain of abdomen developed in only half of series. Splenomegaly, fever and leucocytosis was also present. When splenic abscesses are being considered in a differential diagnosis, CT scan of the abdomen has been the most sensitive diagnostic tool. Streptococcal species are the most common bacterial isolates from splenic abscesses, S. aureus is the next most common. Salmonella species are seen commonly in patients with sickle cell hemoglobinopathy. Because of the high mortality related for splenic abscess, the treatment of choice is splenectomy with adjunctive antibiotics. However, percutaneous drainage has been successful alternative. We reported a 19-years old female patient who had splenic abscess after remission induction chemotherapy of acute leukemia, successfully treated with splenectomy.
Helicobacter Pylori 감염의 유병률과 위험요인에 관한 연구
이후락,김영욱,김돈균 대한보건협회 1999 대한보건연구 Vol.25 No.1
H. pylori 감염은 만성위염과 소화성 궤양의 원인인지로 작용하며 위암발생과도 밀접한 관련성이 있는 것으로 증명되어 기존의 위·십이지장 질환의 치료와 관리에 많은 변화를 가져오고 있다. 저자는 H. pylori 감염의 유병률을 추정하고 감염과 관련되는 위험요인을 조사할 목적으로 부산광역시와 경상남도에 거주하는 소아, 청소년 및 성인 1,466명을 대상으로 1996년 4월부터 8월에 걸쳐 본 연구를 시행했다. 연구대상자들의 혈청에 존재하는 H. pylori IgG 항체는 Enzyme Linked immunosorbent Assay(ELISA) 방법으로 측정했으며 설문조사를 통해 기본적인 인구학적 특성, H. pylori 감염과 관련되는 요인에 관한 정보를 얻었다. 연구대상자들의 총 H. pylori 감염률은 33.1%였고 이를 1996년 한국표준인구로 환산한 연령보정 표준화 유병률은 51.5%로 우리나라 사람의 반 이상이 H. pylori에 감염되어 있는 것으로 추정된다. 성별 연령보전 표준화 유병률은 남자49.8%, 여자 53.7%로 여성이 남성보다 약간 높았다. 연령군별 H. pylori 감염률은 1∼9세군의 10.0%에서 60세 이상군의 76.1%까지 연령이 증가함에 따라 유병률도 비례해 증가하는 양상을 보였다(x2 for trend=460, p<0.0001). 특히, 1∼3세 연령군에서 학동기전 연령인 4∼6세군간에 유병률의 차이가 없으나 초등학교 1, 2, 3 학년 연령인 7~9세군 간에 갑작스런 유병률의 상승이 관찰되어 이 시기부터 H. pylori 감염이 본격적으로 시작되는 것으로 추측된다. 소아 및 청소년의 경우, 다변량 로짓 희귀 모델에서 연령과 가족수가 H. pylori 감염과 유의한 상관관계를 보였으며 특히, 연령은 1∼3세에 비해 16∼19세 군의 교차비(95% 신뢰구간)가 7.1(1.9-26.3)로 H. pylori 감염의 가장 강력한 예측인자인 것으로 나타났다. 가족수 1∼3명을 기준으로 4∼5명의 교차비는 2.0(1.0-4.0), 6명 이상의 교차비는 2.8(1.3-6.0)이었다. 성인의 경우 소아 및 청소년에서와 마찬가지로 연령과 가족수가 H. pylori 감염의 유의한 위험요인 이었다. Helicobacter pylori is now recognized as a causative agent of chronic gastritis and peptic ulcer, and strongly associated with the development of gastric carcinoma, by the sensitive and specific serologic ests to indentify the individuals infected with Helicobacter pylori, the epidemiologic features of this diseases have been investigated. But its transmission route is not established, yet. The purposes of this study is to estimate the prevalence of Helicobacter pylori infection in health children and adults and to evaluate the risk factors for Helicobacter pylori infection in Korea. The observed overall seropositivity rate, as determined by detecting IgG antibodies to Helicobacter pylori by using ELISA. was 33.1% and the age adjusted standardized prevalence rate was 51.5%. Also, age adjusted sex-specific standardized prevalence rates were 49.8% in male and 53.7% in female. The prevalence rate was increased progressively from 10.0% in the age group 1~9 years to 76.1% in the age group above 60 years(x2 for trend=460, p<0.001). Especially, the rate increased abruptly from 6.3% in the age group 4~6 years to 13.8% in the age group 7~9 years, and this suggested that elementary school age would be the beginning time of Helicobacter pylori infection in good earnest. In case of age group 1~19 years, age and the numbers of family member in the house were statistically significant risk factors for Helicobacter pylori infection in multivariate logistic regression model. Especially, adjusted odds ratio(95% CI) for Helicobacter pylori infection in the age group 16~19 years referent to age group 1~3 years was 7.1(1.9-26.3), so age was the strongest predictive factor for Helicobacter pylori infection. In case of age group more than 20 years, age and number of family members were statistically significant risk factors for Helicobacter pylori infection in multivarite logistic regression model.
꼬리줄나비고기, Chaetodon wiebeli의 초기발생
이치훈,김병호,노섬,이영돈 제주대학교 해양과환경연구소 2004 해양과환경연구소 연구논문집 Vol.28 No.2
The development of eggs and larvae of the butterflyfish. Chaetodon wiebili were observed. Fertilized eggs were spherical. colorless. and driven into gelatinous masses. They measured 0.75±0.18 in diameter and not contain an oil globule. Hatching taken place 61.0 hours after two celled stage at water temperature 25.6-27.7℃. Newly hatched larvae measured 0.91 nm in total length and had an ovoid yolk of 0.65 nm in longest diameter. In 72 hours after hatching. the larvae grew 1.72 nm in total length. The mouth and anus were open and the melanophore pigments appeared above the eyes. The pectoral fins are formed and the larvae began to swim actively.
Phenylephrine이 토끼 유두근의 수축력과 활동전압에 미치는 영향
이영배,고인송,박종완,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.1
In order to clarify the receptor types and mechanisms underlying the positive inotropic effect of phenylephrie on the mammalian ventricular myocardium, the action potential, its first derivatives and isometric contraction of the rabbit papillary muscle were recorded using a free transducer and glass capillary microelectronics filled with 3M KCI, and results were analyzed. The results were as follows; l. In normal Tyrode solution, the contractile force was increased with increments of phenylephrine concentration and maximum effect was reached at the stimulation frequency of 1 Hz in 10^-5 M phenylephrine. 2. In 22 mM K^+-Tyrode solution, the maximum rate of rise (Vmax) of action potential, overshoot and the duration oction potential were significantly increased with increments of phenylephrine concentration (10^-6 ~ 10^-4 M). 3. The negative inotropic effect induced by verapamil was reversed by phenylephrine. 4. Phentolamine (3x10^-6 M) shifted the dose response curve for phenylephrine to the right more than propranolol (10^-6 M) did. The above results may be interpreted as follow; The positive inotropic effect of phenylephrine is caused by increase in slow inward current (Ca^2+influx into the myocardial cell), and is mediated through α- and β-adrengergic receptors in the rabbit pailary muscle