스트레칭과 심부강찰마사지가 척추신전근 신장성에 미치는 영향

김영빈,전동혁,윤영복 圓光大學校 附設 體力科學硏究所 2002 體力科學硏究 Vol.25 No.1

The purpose of this study was to determined the effects of stretching and deep friction massage of back extensors in healthy subjects. The study was conducted on forty-two healthy volunteers(male=21, female=21) who were randomly divided into three groups. All of group was rested for 10 minute before a performance. Group 1(n=14) rested as control, Group 2(n=14) performed an active trunk stretching, Group 3(n=14) was received deep friction massage. Back extensors extensibility was measured immediately before and after application or rest by modified fingertip-to floor(MFTF) test. Back extensors extensibility significantly increased in Group 2(p<.05) and Group 3(p<.05). The Group 1 demonstrated no statistically significant changes in MFTF distance. In result of ANOVA of difference of MFTF between pre and post applied in 3 Groups, significant difference from group 2 to group 1 and from group 3 to group 1 and no significant difference from group 3 to group 2. The result indicate that the deep friction massage and stretching application increase to extensibility of back extensor extensibility.

유형별 스포츠 마사지 처치가 심폐기능에 미치는 영향

김영빈,김용남,윤영복 圓光大學校 附設 體力科學硏究所 2001 體力科學硏究 Vol.24 No.-

The purpose of this study is to review and analyze the effects of sports massage treatments by kinds on the function of cardiac and lung system, on the maximum performance capacity during the stable period. In order to confirm the effects of sports massage on the function of cardiac and lung system. The objects of the test were 18 male students enrolled at W university, divided in 3 groups ; guoup A(effleurage), group B(petrissage), and group C(friction), each assigned with 6 students. The outcomes of this test are as follows. First, during the stable period, the function of cardiac and lung system was improved by the treatment of sports massage by kind. Among the groups, friction showed mere signficant(p< .05) improvement than effleurage and petrissage Second, the treatment of sports massage by kind enhanced the maximum performance capacity. The friction increased significantly(p<.05) in the maximum performance capacity of all groups. Form the outcomes summed up as above, it may be concluded that the treatment of sports massage is expected to bring warming up effect to increasing the function of cardiac and lung system as well as the maximum performance capacity during the stable period. As to the types of sports massage, friction may be most effective among other groups. It is, therefore, thought desirable to employ much more diverse and systematic approaches than before to detect thoroughly the effects of the sports massage treatment.

원자력 발전소 저압 터빈 동익 자동 초음파 검사 기술 개발

양승한,이정빈,김영호,윤병식,김용식 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

원자력 발전소의 터빈에서 운전 연수 증가에 따라 pin finger형 블레이드 루트부에 균열이 발생하는 문제점이 발생되었다. 블레이드 루트부에 대한 비파괴검사는 매 계획 예방 정비기간 동안 수동 초음파 검사를 통하여 수행되어 왔으나, 검사의 신뢰성을 확보하기 위해 해당 설비에 대한 자동 초음파 검사 기술 개발의 필요성이 대두되었으며, 이에 따라 자동 초음파 검사 장비 및 검사 기술을 개발하였다. 개발된 검사 장비의 적용성을 확인하기 위해 계획 예방 정비 기간 중 저압터빈 2,3단 블레이드 루트부에 대한 자동 초음파 검사를 수행하고, 다양한 형태의 터빈 검사에 확대 적용 가능성을 확인하였다. As the turbine running duration in nuclear power plants increases, cracks have been found in the pin finger type blade root area. The nondestructive examination for the blade root area has been carried out by manual ultrasonic examination during the overhaul period, but because of necessity to improve the reliability, we developed an automatic ultrasonic examination system and technique. To demonstrate the performance of the developed automatic ultrasonic examination system, low pressure turbine blades in the 2nd and 3rd stages of nuclear power plants were examined using developed system. Its applicability nuclear power plant turbine roots of various types was also confirmed.

유산소성 운동이 혈중지질 및 체지방률에 미치는 영향

홍성찬,김영빈,윤영복,박병근,김유성 圓光大學校 附設 體力科學硏究所 2007 體力科學硏究 Vol.29 No.-

This study is aimed at investigating the effects of aerobic exercise of female college students on blood lipids and body fat percentage. Twelve female students were selected for this study and each 6 of them were alloted into the control group and experiment group. The experiment group underwent jogging for 12 weeks and its effects on blood lipids and body fat percentage were measured at the 4th, 8th and final week of the jogging program. The outcomes of the experiment could be summarized as follows: 1. As for HDL-C due to jogging, the experiment group showed an eminent increase with statistical significance(p<.05). 2. In case of LDL-C following jogging, there was a great amount of decrease in the experiment group after the exercise with statistical significance(p<.05). In sum, it is revealed from the present study that the prescribed magnitude and length of exercise can be of help for HDL-C and LDL-C that have been recognized as indicators for diseases of adult people.

대량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별

이숭덕,김기범,이윤성,최영태,신창호,이정빈 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

The mitochondrial DNA(mtDNA) is a small extranuclear DNA molecule that has been sequenced in man. the mtDNA has distinct characteristics over nuclear DNA. First, the evolutionary rate of nucleotide substitution appears to be larger compared with the nuclear DNA. Second, mtDNA is maternally inherited, so the determination of the various haplotype is unequivocal and no recombination has to be involved. Third, there is a 1.1 kb long control region, which shows severe polymorphism. These characteristics have been applied for several evolutionary study. Furthermore, they exist in cytoplasm with numerous copy number and their size, 16,569 bp is small relative to nuclear DNA, so they are more resistant to degradation or can be types in samples with only cytoplasm such as hair shaft without hair root. These presented the possibility of mtDNA as a tool in individual identification, especially when the nuclear DNA be unavailable. Actually, polymorphism in control region has been applied to individual identification for the skeletal remain found in Vietnam war. So we decided to apply the polymorphism of mtDNA in control region for the individual identification in case of mass disaster-"Downfall of Sampoong Department". Human remains from total 27 different individuals and 178 control persons were submitted for the individual identification. As the mtDNA comparison could be done through maternal lineage, 12 individual from 9 families from the control group were ruled out, because these families were consisted of father or were seeking for their father. Sequencing for the mtDNA control region was done using ABI automatic sequencer and DyeDeoxy Terminator Cycle Sequencing Kit. For convenience, sequencing reaction was done for two separate control region, region I from 16016-16401 in Anderson sequence, and regionⅡ from 048-388. First, sequences in regionⅡ of all samples and control persons were compared, and 20 samples were ruled out with no identical sequences in control group. Remaining 7 samples showed identical sequences with some of the control persons in three groups, and these identical pairs underwent mtDNA region I study. After region I study all samples except two dropped out in blood relationship. For the confirmation, STR and VNTR study such as MCT118, apoB, YNZ22, vWF, MBP, D21S11, TC-11 were done for remaining the two samples. The result denied the blood relationship between these two samples and any of the control group.

다량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별 : 삼풍백화점 사건에 대하여

이숭덕,신창호,김기범,최영태,이윤성,이정빈 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

Breakup Characteristics of Impinging and Swirl Type Injectors

( Young Bin Yoon ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-

The breakup characteristics of liquid sheets formed by the impinging and swirl type injectors were studied as increasing the Weber number (or injection condition) and the ambient gas pressure up to 4.0MPa. In the case of impinging type injector, we compared the changes of breakup lengths between laminar and turbulent sheets, which are formed by the impingement of laminar and turbulent jets, respectively. The results showed that both sheets expand as increasing the injection velocity irrespective of the ambient gas density when the gas based Weber number is low. When the Weber number is high, however, the breakup of turbulent sheet depends on the hydraulic force of jets as well as the aerodynamic force of ambient gas which determines the breakup of laminar sheet. Using the experimental results, we could suggest empirical models on the breakup lengths of laminar and turbulent sheets. In the case of swirl type injector, as Wel and ambient gas density increased, the disturbances on the annular liquid sheet surface were amplified by the increase of the aerodynamic forces, and thus the liquid sheet disintegrated near from the injector exit. Finally, the measured breakup length of swirl type injector according to the ambient gas density and Wel was compared with the result by the linear instability theory. We found that the corrected breakup length relation derived from linear instability theory considering the attenuation of sheet thickness agrees well with our experimental results

Optimal conditions for in vitro maturation of marmoset oocytes

( Yoon Young Kim ),( Ji Won Lim ),( Bo Bin Choi ),( Young Jae Ryu ),( Byeong-cheol Kang ),( Hoon Kim ),( Seung-yup Ku ),( Chang Suk Suh ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Non-human primate, common marmoset, has many advantages as an animal model for studying reproductive biomedicine because of its short gestation period and similar reproductive physiology to human. The investigators attempted to search for the optimal conditions of in vitro maturation for marmoset oocytes. Methods: Ovaries of 34-month-old female common marmoset (Callithrix jacchus) were excised and oocytes were retrieved. The oocytes were in vitro matured either in MEM (Invitrogen) universal or IVF media (Orgio) in the presence of epidermal growth factor and human chorionic gonadotropin (hCG) for up to 48 hours. Maturity of oocytes was graded and analyzed among the groups of various concentrations. RNAs were extracted from matured oocytes, and oocyte-specific gene expression was assessed by single cell qRT-PCR. Results: The maturation rate was highest in the universal media group treated with 100 IU/L hCG. Quantitative RT-PCR profiling demonstrated that the expression of bmp15 and zp1 gene was regulated in this group (P<0.05). Conclusion: In conclusion, the investigators elucidated the optimal conditions for in vitro maturation of marmoset monkey oocytes (2016R1E1A1A01943455).

Differential Effect of Hepatitis B Viral Suppression on Hepatocellular Carcinoma Development According to the Phase of Initial Antiviral Treatment: A Multicenter Study

( Young Chang ),( Jeong-hoon Lee ),( Sung Won Chung ),( Minseok Albert Kim ),( Sun Woong Kim ),( Hyo Young Lee ),( Junsik Yoon ),( Yun Bin Lee ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-h 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Although antiviral therapy for chronic hepatitis B virus (HBV) infection reduces risk of hepatocellular carcinoma (HCC), the risk is reportedly higher in the antiviral-induced viral suppression than inactive carriers. In this study, we aimed to compare the effect of the phases when the antiviral treatment started on the HCC development Methods: This retrospective study included chronic hepatitis B patients with suppressed HBV DNA (<2,000 IU/mL) and normal alanine aminotransferase levels and without evidence of cirrhosis from eight referral hospitals in Korea. Study subjects were categorized into four groups: patients underwent antiviral treatment from immune-tolerant phase (IT group), HBeAg-positive hepatitis phase (HBeAg+ group), or HBeAg-negative hepatitis phase (HBeAg- group); or inactive carriers without any antiviral treatment (IC group). Primary endpoint was an HCC development. Kaplan-Meier survival analysis and Cox proportional hazard model were used for statistical analysis. Results: A total of 887 patients were included: 63 in IT group, 151 in HBeAg+ group, 365 in HBeAg- group, and 308 in IC group. In univariate analyses, there was no significant difference in the risk of HCC development between IT group and IC group (hazard ratio [HR]=0.85, 95% confidence interval [CI]=0.10-7.15, P=0.98). However, both HBeAg+ (HR=4.01, 95% CI=1.57-10.28, P=0.001) and HBeAg- (HR=3.04, 95% CI=1.29-7.07, P=0.007) groups showed significantly higher risk of HCC occurrence. The 5-year risk of HCC occurrence was 5.6% in IT group, 10.9% in HBeAg+ group, 8.3% in HBeAg- group, and 1.9% in IC group (Figure 1). In multivariate analyses, IT group consistently showed similar risk of HCC development compared to IC group (adjusted HR [aHR]=0.85, 95% CI=0.10-7.15, P=0.88). Both HBeAg+ (aHR=2.91, 95% CI=1.13-7.42, P=0.03) and HBeAg- (aHR=2.48, 95% CI=1.05- 5.85, P=0.04) groups showed significantly higher risk of HCC development than IC group. Conclusions: Even if HBV DNA suppression has equally achieved, the risk of HCC development varies depending on the phase of initial antiviral therapy. Early antiviral therapy from immune-tolerant phase is associated with low risk of HCC similar to that of natural inactive carriers which is significantly lower than the risk of patients treated from immune-active phases.

Characterization of the aminopyridine derivative KRC-180 as a JAK2 inhibitor

Yoon, Kyoung Bin,Cho, Sung Yun,An, Su Jin,Park, Kyeong Ryang,Lee, Hyo Jeong,Yoon, Hae Sung,Lee, Sun-Mi,Kim, Yong-Chul,Han, Sun-Young D.A. Spandidos 2017 Oncology letters Vol.14 No.2

<P>Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that regulates the signal transducer and activator of transcription (STAT) signaling pathway. Deregulation of JAK2 signaling has previously been observed in hematologic malignancies, including erythroleukemia. In the present study, an aminopyridine derivative compound, KRC-180, exhibited direct inhibition of the JAK2 protein at the catalytic site, as demonstrated using <I>in vitro</I> kinase activity assays and docking analyses. In addition, KRC-180 reduced the phosphorylation of STAT3 and STAT5, downstream signaling molecules of JAK2. The growth of HEL92.1.7 erythroleukemia cells harboring a constitutively activated form of JAK2 was suppressed by KRC-180 treatment; KRC-180 induced apoptotic cell death and cell cycle arrest. The results of the present study indicate that KRC-180 is a JAK2 inhibitor with anti-leukemic properties.</P>