본태성 고혈압환자의 순응도에 관한 연구 IV : 의사개입과 제도개선의 합동효과 Effect of Combined Strategies Provided by Physician and Insurance

유원상,김용균,김준희,최석구,전영빈 인제대학교 1991 仁濟醫學 Vol.12 No.1

본태성 고혈압환자의 순응도 제고를 위하여 채택한 방책중 의사의 단독개입만으로는 13%의 통원탈락율의 개선, 보험급여 제도의 일부개선만으로는 3%의 악화에 비하여 양자 합동으로는 17%의 개선효과를 보았다. 따라서 진료의사의 좀 더 적극적인 개입과 보험급여의 진료일수제한 철폐가 요망된다. One hundred patients with essential hypertension, consecutively and newly diagnosed, were followed up at hypertension clinic of Paik Hospital to evaluate their compliance for 12 months with combination strategies provided by physician's intervention and extended insurance coverage. Rate of drop-out from reserved visit to clinic were 23% at the end of 3 months, 52% at the end of 12 month, which showed decrease, compared with 26%, and 63% respectively of ordinary management. In conclusion, in order to improve patient's compliance, a positive intervention by physician as well as lifting of insurance limitation should be intensified drastically.

점증부하운동후 휴식 유형에 따른 혈중젖산농도의 변화

박병근,이정윤,유영창,김영빈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose or the this study is to explore the relationship between the excess post-exercise blood lactate during the restoration stage after an incremental loading exercise. Subjects of this study are 14 students enrolled in W University who do not exercise regularly, Seven of them were assigned to the group of dynamic resting and remaining 7 to that of static resting, From the analysis into the measurement, following conclusions could be drawn: The lactic acid concentration in blood after the incremental loading exercise show a significant difference depending on the types of resting and restoration stages(p<.01). That is, the lactic acid concentration appeared to be significantly low in the dynamic resting method compared to the static one from 15 minutes after the end of exercise(p<.01), Whereas, the dynamic resting method proved to be significantly faster in resting lactic acid in blood(46.85%) than the static one (29.87%)(p<.01). In summary, there was a significant difference of response in physiological variants depending on the types of resting after an incremental Loading exercise, Accordingly, more attention should be paid to the importance of cool down after exercise.

스페로이드 조합자극치료 적용 후 만성요통의 통증 감소 효과

홍성찬,김영빈,박병근,김유성,이성진,정동혁 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1

The aim of the present study is to evaluate effects of Spheroid 9000NS applied to 10 elderly patients with Chronic Low Back Pain. The effects were measured and analyzed by means of MPQWL, VRS, VAS-I and VAS-U after 4, 8 and 12 weeks, respectively, during the 12-week application of the Spheroid 9000NS. From the findings of the measurement and analysis, following conclusion could be drawn: 1. Significant reductions in MPQWL were confirmed at each period of measurement since the use of Spheroid 9000NS(p<.001). 2. Significant reductions were also revealed in VRS at each period of the measurement(p<.001). 3. Significant reductions were also revealed in VAS-I at each period of the measurement(p<.001). 4. The same reductions were found as well in VAS-U 4, 8 and 12 weeks after the application of the Spheroid 9000NS(p<.001). In sum, it may be concluded from the outcomes that the use of Spheroid 9000NS may help reduce drastically Chronic Low Back Pain, mostly effective to remove them speedily and safely. Patients, rehabilitation therapists and health experts are, therefore, recommended to employ the products as safe and effective means to control pains. Continued researches and experiments should further be conducted to collect more data from the larger population of patients with particular diseases in clinical situation, though.

의료용 조합자극기(HAPPY DREAM HM-206DB) 적용이 동결견 환자의 통증과 관절가동범위에 미치는 영향

홍성찬,김영빈,박병근,김유성,이성진,정동혁 원광대학교 체력과학연구소 2008 體力科學硏究 Vol.30 No.1

The purpose of this study is to find out the effectiveness of the HAPPY DREAM HM-206DB applied to the patients with Frozen Shoulder by measuring, assessing and analyzing the changes in pain and range of motion(ROM). Surveyed from Mar. 2007 to Dec. 2007 were 10 patients suffering from Frozen Shoulder. After HAPPY DREAM HM-206DB, the pain were measured and analyzed by means of MPQWL, VAS-I and VAS-U, while ROM was measured and analyzed by using Goniometer. The major findings from this study are as follows; 1. There was significant decrease in the MPQWL after HAPPY DREAM HM-206DB applied(p<.001). 2. There was significant decrease in the VAS-I(intensity of pain) after HAPPY DREAM HM-206DB applied(p<.001). 3. There was significant decrease in the VAS-U(unpleasantness of pain) after HAPPY DREAM HM-206DB applied(p<.001). 4. There appeared, however, significant increase in ROM(abduction, external and internal rotation) after HAPPY DREAM HM-206DB applied(p<.001). From the above outcomes, it was revealed that HAPPY DREAM HM-206DB application has proven to reduce the pains, exercising huge influence to increase ROM. It is, therefore, suggested to continue and expand the study on the cure of Frozen Shoulder and to motivate patients, rehabilitation specialists, and health management specialists etc. to consider HAPPY DREAM HM-206DB application as safest and most efficient pain remedy.

유산소성 운동이 심폐기능과 체지방에 미치는 영향

홍성찬,김영빈,박병근,정동혁,이정윤,김유성 圓光大學校 附設 體力科學硏究所 2005 體力科學硏究 Vol.28 No.-

The Purpose of this research is to examine the effect of the aerobic exercise duration on cardiorespiratory function and body fat. Total 14 divided into two groups 7, for the control group and the other for the experimental group 7. The subjects of experimental group had 8 weeks aerobic program in the given intensity, during which the changes in cardorespiratory function and body fat were measured three times, at each end of 0th, 8th week. The research is comcluded as follows. 1. After 8 Weeks, aerobic exercise brought the decrease of maximum HR and the increase of VE with statistically significant(p<.05). 2. Aerobic exercise brought along the change of fat, especially the decline of the rate of fat and the amount of fat. In conclusion, aerobic exercise helps overweight women to reduce their weights and the amount of fat and to get rid of elements that cause various geriatric diseases. Therefore, overweight women as well as common adults are advised to take aerobic exercises

유산소성 운동이 혈중지질 및 체지방률에 미치는 영향

홍성찬,김영빈,윤영복,박병근,김유성 圓光大學校 附設 體力科學硏究所 2007 體力科學硏究 Vol.29 No.-

This study is aimed at investigating the effects of aerobic exercise of female college students on blood lipids and body fat percentage. Twelve female students were selected for this study and each 6 of them were alloted into the control group and experiment group. The experiment group underwent jogging for 12 weeks and its effects on blood lipids and body fat percentage were measured at the 4th, 8th and final week of the jogging program. The outcomes of the experiment could be summarized as follows: 1. As for HDL-C due to jogging, the experiment group showed an eminent increase with statistical significance(p<.05). 2. In case of LDL-C following jogging, there was a great amount of decrease in the experiment group after the exercise with statistical significance(p<.05). In sum, it is revealed from the present study that the prescribed magnitude and length of exercise can be of help for HDL-C and LDL-C that have been recognized as indicators for diseases of adult people.

홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.

약년자 폐암의 임상적 관찰

유빈(Bin Yoo),정희순(Hee Soon Chung),한성구(Sung Koo Han),심영수(Young Soo Shim),김건열(Keun Youl Kim),한용철(Yong Chol Han) 대한내과학회 1987 대한내과학회지 Vol.32 No.5

N/A Carcinoma of the lung is generally considered as a disease of middle age and elderly. But lung cancer is now so prevalent that patients below the age of 40 years must be increaseing. We reviewed the records of 483 lung cancer patients who had been diagnosed in the department of internal medicine of Seoul National University Hospital from March 1984 to February 1986, and the clinical features of the young patients under 40 years were compared with those of the control group patients over 40 years. The results are summarized as follows; 1) Seven percent of 34 cases of 483 patients were belong to the young age group patients (less than 40 years). The youngest patient was 22 years old. 2) Male to female ratios of young group and the control group were 3.25:1, 5.9:1 respectively (p>0.05). 3) The mean duration of symptoms from the onset to the definite diagnosis was 2.7 months in young group and 2.3 months in the control group (p>0.3). 4) The most common initial symptoms in the young group were dyspnea (26.5%), hemoptysis (20.5%), cough or sputum (20.5/), chest pain (8.8%) which were also the most common initial symptoms in the control group. (p>0.25) The incidence of superior vena cava syndrome was significantly higher in the young age group (23.5%) than in the control group (7.1%) (p<0.05). 5) In the young group, the proportion of adenocarcinoma (35%) was significantly higher than that of the control group (18%) (p<0.05). 6) The proportion of smoker was significantly lower in the young age group (13 cases, 38.2%) than in the control group (77.7%). The histological type of 13 smokers of the young group was squamous cell carcinoma in 12 cases and adenocarcinoma in 1 case. 7) All non-small cell lung cancer patients in young group were belong to stage III. 8) Distant metastasis rate of the young group (74%) was significantly higher than that of the control group (54.8%) (p<0.05).

Analysis of Immune Responses against Five Brucella abortus Proteins in Experimentally Infected Cattle

Young Bin Im,Woo bin Park,Myung hwan Jung,Hong Tae Park,Min Kyoung Shin,Suk Kim,Han Sang Yoo 대한수의학회 2014 대한수의학회 학술대회발표집 Vol.2014 No.-

Evaluation of immune responses in RAW 264.7 cells stimulated with Brucella abortus mutants

( Young Bin Im ),( Soojin Shim ),( Woo Bin Park ),( Han Sang Yoo ) 대한인수공통전염병학회 2017 창립총회 및 학술대회 초록집 Vol.2017 No.1

Introduction: Immune response in host cells is initiated with the production of cytokines by infection of bacterial pathogens. In case of B. abortus, intracellular introduction of bacterial components induce differential expression of the genes in chromosome which triggers the activation of the host immune system. B. abortus mutants were generated based on transposon mutation to investigate the immune responses. Of the mutants, four were selected based on different growth rates: faster (C1, C10) and slower (C27, C32) groups, compared to the wild type. In this study, we investigated the immune responses after stimulation with the B. abortus mutants in RAW 264.7 cells via identifying the disrupted loci in the mutant chromosomes, productions of inflammatory mediator (cytokines) and activation of toll-like receptors (TLR1 to TLR9). Methods: Four mutants were selected based on the growth rates: faster (C1, C10) and slower (C27, C32) groups, compared to the wild type. Genomic DNA of the mutants was analyzed for finding insertion site in the chromosomes. Using high-throughput sequencing (Illumina HiSeq 2500 genetic analysis system). Culture supernatants were collected from RAW 264.7 cells after stimulation with the B. abortus mutants at multiplicity of infection (MOI 100:1). Production levels of nitric oxide (NO) and the cytokines, IL-1β, IL-6, IL-12p40, IFN-γ, and TNF-α, were quantified with NO assay and ELISA. Expressions of TLRs were analyzed by real-time PCR. Results: Four mutants showed different insertion sites in the chromosome. The mutants were observed defect of 4-hydrobenzoate 3-monooxygenase, Heme exporter protein (CcmC), Exopolyphosphatase (ppx), and peptidase M24 from each mutant C1, C10, C27 and C32. Production of NO was highly increased in time dependent manner by stimulation with B. abortus mutants. Production of TNF-α and IL-6 were highly increased compared to the wild type after stimulation with C27 and C32. Stimulation with C1 and C10 induced the increased production of IL-1β at 24h. The productions of IL-12p40 and IFN-□were not detected after the stimulation with the B. abortus mutants. C32 mutant induced significantly high production of IL-6 at 12h and 24h after stimulation. However, C1 mutant showed decrease in production level in NO and TNF-α at 12h compared to the wild type. On the contrary, increase of production levels in NO and TNF-α were observed in C27 and C32 at 12h. In TLR analysis, the expression level of TLR2 due to the stimulation with C1 was increased at 24h while the rest of the mutant (C10, C27, C32) showed lower expression level of TLR2 compared to the wild type. With C1 stimulation, higher expression levels of both TLR5 and TLR6 were observed at 12h against the wild type. In contrast, C27 stimulation showed lower expression levels of TLR5, TLR6 and TLR8 than that of the wild type at 24h. Conclusion: Our results suggest that immune responses were related to the growth rates and disrupted loci of the mutants. Especially, a defected 4-hydrobenzoate 3-monooxygenase was identified in C1, in which the role of the particular gene is not yet fully understood. C1 showed low production of NO and TNF-α compared to the wild type at 12h after stimulation in RAW 264.7 cells. On the contrary, a defected exopolyphosphatase (ppx) was discovered in C27 in which it relates to the control of growth and survival of bacteria. C27 showed high production of NO and TNF-α. Of the TLRs, different expression levels of TLR2 was observed at 24h after the stimulation with B. abortus mutants with C1 and C27. Therefore, further characterization of the role of TLR2 may be a key step in the Brucella pathogenesis. Acknowledgement: This study was supported by NRF (No. 2014R1A2A2A01007291), KHIDI (HI16C2130), the BK21 PLUS program for Creative Veterinary Science Research, and the Research Institute of Veterinary Science, Seoul National University, Republic of Korea.