Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

데드링크 시각화에 관한 연구

김완규,김현주,김일,정연홍 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

Web mining is to extract useful information for homepage management by analyzing the structures, contents and usages of web pages. The web mining is classified into structure mining, content mining and usage mining. Web crawler is a representative tool that has been used in the structure mining. Not only the web crawler has a function to analyze the link structures among webpages and accumulate information, but also it is used to resolve problems by finding out link errors on homepages. But this web crawler uses a way of analyzing based on texts, so it takes so much time and costs a lot to find out locations of errors. As a result, most of homepages just leave these link errors unsettled. In this paper, we design and implement an analyzing system of link errors on hyperlinked environment in order to improve defects and increase efficiency of links on homepages. In addition, this system which we propose analyzes the location and size of hyperlinks, and provides visual information whether a link is successfully connected or not.

뇌혈관 질환에 대한 임상적 고찰

김윤,이주한 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

One hundred and thirty three cases of cerebrovascular disease, which were diagnosed by brain CT scan and angiography, were analysed. The results of analysis were summerized as follows: 1. Anatomical sites of hemorrhage were ICH(47.3%), SAH(33.8%), combined(12%) primary IVH(6.8%) in order of frequency. 2. The main causes of cerebrovascular disease were aneurysm, hypertension, AVM, and Moya Moya disease. 3. In cases of hypertensive hemorrhage, peak age incidence was above 5th decades and the hemorrhagic anatomical sites were basal ganglia, thalamus, cerebellum in order of frequency. 4. In cases of aneurysm, peak age incidence was above 5th decades and occured more frequently in females. The anatomical sites aneurysm were A-com, P-com, MCA in order of frequency. 5. The mortality of cerebrovascular disease was 13.5%.

전자선 증착장치 및 ITO 박막의 제작과 그 특성에 관한 연구

김수길,최범식,우정주,고년규,황정남,정원모,이철주 연세대학교 자연과학연구소 1982 學術論文集 Vol.9 No.-

태양 전지의 제작시 투명 전극막으로 쓰이는 ITO 박막을 제조하기 위하여 cathode 접지 방식의 전자총을 가진 정전 편향 집속형의 전자선 증착 장치를 제작하였다. 가속전압이 0∼15kV, 필라멘트 전류가 0∼28A, 두 전극판 사이의 간격이 11mm, anode와 deflector 사이의 간격이 30mm인 최적 실험조건하에서 생성된 전자선 spot의 크기는 길이가 20mm 폭이 1mm였으며, 전자선의 출력은 약 400W였다. 이 전자선 증착 장치를 이용하여 1600℃까지의 증발 온도를 가진 도체와 절연체 등을 쉽게 증착시킬 수 있었으며, 만드어진 ITO 박막은 약 5000Å의 두께에서 10^-1∼10^-2Ω·㎝의 비저항과 95%의 광투과율을 갖는다. An electron beam evaporator with a cathode grounded type electron gun was designed and constructed in order to deposit ITO thin films for photovoltaic applications. The optimum condition was observed with electode spacing of 11mm, 30mm between anode and deflector, a cathode inner diameter of 3mm and an anode inner diameter of 5mm. As the accelerating voltage varies from 0 to 15kV and ghe filament current from 0 to 28 A, the minimum electron beam spot has a 20mm length, and 1mm width and the output power ranges from 0 to 400W under the above optimum conditions. We can deposit materials whose evaporation temperature is over 1600℃ using this evaporator. And as a result ITO thin film showed a low resistivity of 10^-1∼10^-2Ω·㎝ and the transmittance of 95%.

EFFECT OF EUGENOL AND CAPSAICIN ON THE VOLTAGE-DEPENDENT ION CHANNELS OF TRIGEMINAL AFFERENTS

김주연,박상진,최기운,최호영 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.3

삼차신경절의 뉴런이 구강악안면영역에서의 촉각, 압각,온도각 및 통각 등 다양한 감각을 중추신경계로 전달하는 역할을 하는 것은 주지의 사실이다. 이러한 신경전달에 있어서 이온통로는 감각정보를 전달하는데 핵심적인 역할을 수행하며 특히 소디움 통로는 활동전위의 발생에 중요하다. 소디움 통로는 tetrodotoxin-sensitive(TTX-5) 및 tetrodotox-in-resistant(TTX-r) 통로로 나누어지는 데 이 중 TTX-r 통로에 발생되는 tetrodotoxin-resistant sodium cur-rent(TTX-r INa.)는 capsaicin에 민감한 일차구심신경세포에서 유해자극에 의해 통각신호를 발생시키고 전달하는데 중요하다. 또한 칼슘 통로는 시냅스 전토에 있어서 필수적인 역할을 수행하고 있다. 한편 치과영역에서 치수의 진정 목적으로 eugenol이 흔히 사용되고 있다. 그러나eugenol의 그 작용 기전에 대해서 현재까지 이온통로에 대한 상세한 결과가 없는 실정이며 최근의 보고에 의하면 eugenol이 capsaicin수용기를 통하여 감각신경에 대한 억제작용을 나타낸다고 한다. 따라서 본 실험은 eugenol과 capsaicin이 흰쥐의 삼차신경절의 TTX-r INa와 칼슘통로에 어떠한 영향을 미치는지를 알아보고 eugenol이 capsaicin 수용기를 통하여 작용하는지를 검증하고자 시행되었다 삼차신경절 뉴런은 100-150g의 흰쥐의 삼차신경절로부터 외과적으로 절제하여 통법의 화학적 및 기계적 처리를 통해 단일세포로 분리하였고 이를 Whole-cell patch clamp 방법을 이용하여 시행한 바 다음과 같은 결론을 얻었다. 1.1mM의 dugenol은 흰쥐 삼차신경절 뉴런의 TTX-r INa.와 HVA INa.를 억제하였다. 2.1㎛의 capsaicin은 흰쥐 삼차신경절 뉴런의 TTX-r INa 와 HVA INa 를 억제하였다 3.Capsazepine은 capsaicin의 HVA ICa 에 대한 억제작용을 차단하였다. 4.Capsazepine은 capsaicin의 HVA ICa .에 대한 억제작용을 차단하지 못하였다. 결론적 으로 eugenol과 capsaicin은 tetrodotoxin-resistant sodium current(TTX-r INa )와 high voltage-activated calcium current(HVA ICa )를 모두 억제하는 것으로 나타났으며 , 이러한 작용이 통각의 발생과 시냅스 전달과정을 차단하여 치수 진정 목적으로 많이 사용하는 eugenol의 작용기전으로 판단된다. 한편 capsaicin의 길항제인 capsazepine을 전처치하였을 때에도 eugenol의 HVA ICa 에 대한 억제효과는 변화가 없었다. 이와같은 결과로 보아 HVA ICa 에 관한한 eugenol은 capsaicin 수용기를 통하여 나타나지 않는 것으로 사료된다.

월경전증후군 여대생의 영양소 섭취량 및 식품선호도와 혈액성상 조사

김주연,안홍석 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study was performed to investigate nutritional intakes and preference food and blood composition of female college students of premenstrual syndrome. Based on physical measurement test results, both groups showed no noticeable difference and both groups were within the normal range according to body composition analysis. In terms of nutrients consumption, results showed nutritional intakes more than EAR (estimated average requirements) included phosphorus > vitamin B6>vitamin B1, while nutritional intakes less than EAR were vitamin A > vitamin B2> calcium > folic acid. A significant difference was observed for vitamin C intake (p < 0.05). The overall mean values of basic blood (WBC, RBC, Hct, and Hb), sex hormone (Estrogen, Progesterone), aldosterone, cortisol, Cu, Zn, and Ca, Mg indices in female college students were within the normal range and there was no significant difference between the PMS group and the Normal group. In conclusion, vitamin C intake of the PMS group showed a level of 84.8% EAR. Therefore vitamin C supplement can be beneficial to relieve the PMS Syndrome.

초등학교에서 홀리스틱 교육 방법의 적용 탐색

김현재,김윤주 仁川敎育大學校 科學敎育硏究所 2000 과학교육논총 Vol.12 No.-

본 연구는 초등과학교육에서 홀리스틱 교육방법을 적용했을 때 전통적인 교육 방법과 비교하여 인지적인 면과 정의적인 면의 차이점과 영향력을 찾아내기 위한 연구에 그 목적이 있는 바, 그 연구 결과에 따르면 아래의 결론을 얻는다. 초등과학교육에서의 홀리스틱학습에 적용한 영향에 따른 검사를 통한 학습 성취도 조사에 의하면 분명한 변화는 없으나 창의적 사고 증진과 과학적 태도에는 의미 있는 영향이 있고 긍정적인 변화를 보여주고 있다. 따라서 학생들은 다양한 경험을 통한 홀리스틱 학습에 의해 과학교육에 흥미와 새로운 욕구를 가지게 되고 이것은 정의적인 목적에 도달하는데 매우 영향력이 있음을 보여준다. The purpose of this study is to find out the difference and effectiveness on cognitive and affective aspect comparing with traditional education method when the holistic education method is applied in the elementary science. As the result of the study, following conclusion is obtained. There was no evident change in learning accomplishment investigation through test paper in the holistic learning application effect in primary school, but it showed effective and positive change in creative spirit improvement and scientific attitude. Therefore let the student have interest and new desire on science education by the holistic learning through various experience and it is very effective to reach affective goals.

저염도 음식물 쓰레기를 이용한 퇴비시여가 배추의 생육에 미치는 영향

전윤태,박길환,조경철,김희경,지연태,정순주 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study was conducted to investigate the changes of physico-chemical properties of soil applied with compost made by food wastes and its effect on the growth and yield of Chinese cabbage. Chinese cabbage was grown in the soil treated with food waste compst(FWC) of 0, 0.625, 1.25, 2.5, 5 and 10㎏/3.3㎡. As the amount of FWC increased, number of leaves, leaf area and fresh weight increased where application of 5㎏ and 10㎏/3.3㎡ showed vigorous plant growth in the late growing period. The pH of soil by application of FWC was not raised, which was similar to the soil before treatment. Organic matter increased in soil by increasing the amount of FWC. However, concentration of Cu and Pb in the soil reduced. The concentration of available phosphate(P) was lower in the soil treated with FWC than in the soil before treatment, which means that a large amount of P may be uptaken by plant. This study suggested that FWC should be an alternative to chemical fertilizer for vegetable production.

인터넷 상의 다중공격에 대비한 침입탐지시스템 모델 설계

최주영,최은정,이지윤,윤세안,김명주 서울여자대학교 자연과학연구소 2000 자연과학연구논문집 Vol.12 No.-

Since modern attacks against information system utilize large-scale and distributed network, they become more versatile and complicated. We propose a new model of intrusion detection system, IDSS that can effectively detect multiple resource attack from to the inter-system and intra-system. IDSS (Intrusion Detection System for Seoul women's university) is optimized in agent unit to detect multiple attacks on network effectively and designed to and respond to them in real time.

바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.