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A case of linear nevus sebaceous associated with syringocystadenoma papilliferum
( You Bum Song ),( Jun Gyu Song ),( Moo Kyu Suh ),( Jong Im Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Nevus sebaceous is a benign hamartoma with epidermal, follicular, and apocrine elements and has a well-documented neoplastic potential. Several appendageal tumors have been described presenting within a nevus sebaceous. Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal neoplasm that presented hamartomatous malformation of apocrine and eccrine sweat glands, and occur often in conjunction with a nevus sebaceous. The patient was a 31-year-old female who presented with 6.0 x 1.0 cm sized normal skin colored to yellowish linear verrucous plaques, nodule on the left forehead since childhood. Histopathological examination of a skin biopsy specimen from the lesion revealed 2 distinctly different findings. The nodular portion of lesion showed cystic invaginations extending into the dermis, with numerous papillary projections. The plaque portion of lesion showed papillomatosis, acanthosis in the epidermis, and consisted of many mature sebaceous glands, several ectopic apocrine gland in the dermis. We diagnosed this case as linear nevus sebaceous associated with SCAP on the basis of above clinical and histopathological examination. The patient was treated with surgical excision. The recurrence has not been observed during 3 months of follow up.
( You Bum Song ),( Moo Kyu Suh ),( Gyoung Yim Ha ),( Heesoo Kim ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.6
Background: The necessity of performing antifungal susceptibility tests is recently increasing because of frequent cases of oral candidiasis caused by antifungal-resistant Candida species. The Etest (BioMerieux, Marcy l`Etoile, France) is a rapid and easy-to-perform in vitro antifungal susceptibility test. Objective: The purpose of this study was to determine the minimal inhibitory concentrations (MICs) of antifungal agents by using the Etest for Candida species isolated from patients with oral candidiasis. Methods: Forty-seven clinical isolates of Candida species (39 isolates of Candida albicans, 5 isolates of C. glabrata, and 3 isolates of C. tropicalis) were tested along with a reference strain (C. albicans ATCC 90028). The MIC end points of the Etest for fluconazole, itraconazole, voriconazole, and amphotericin B susceptibility were read after the 24-hour incubation of each isolate on RPMI 1640 agar. Results: All Candida isolates were found susceptible to voriconazole and amphotericin B. However, all five isolates of C. glabrata were resistant to itraconazole, among which two isolates were also resistant to fluconazole. Conclusion: This study revealed that the Etest represented a simple and efficacious method for antifungal susceptibility testing of Candida species isolated from oral candidiasis patients. Therefore, voriconazole and amphotericin B should be recommended as effective alternatives for the treatment of oral candidiasis. (Ann Dermatol 27(6) 715∼720, 2015)
A case of linear IgA bullous dermatosis
( You Bum Song ),( Ji Young Yoo ),( Moo Kyu Suh ),( Jong Im Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Linear immunoglobulin A (IgA) bullous dermatosis is a rare vesiculobullous eruption that has an pattern of homogeneous linear IgA deposits at the epidermal basement membrane. Clinical presentations may heterogeneous and often indistinguishable from dermatitisherpetiformis and bullous pemphigoid. It is characterized by combinations of symmetrically presenting papules, bullae and vesicles on the extensor surfaces, including elbows, knees, and buttocks. The patient was a 15-year-old boy who presented with bullous eruptions on the whole face, chest, trunk, back, both arm and hand dorsum for 3 months. Other bullous eruption and mucosal involvement were not observed. Histopathological examination of a skin biopsy specimen from the lesion revealed subepidermal blister and infiltration of neutrophils and lymphocytes in the upper dermis. Direct immunofluorescence revealed linear deposits of IgA and C3 at the basement membrane zone. We diagnosed this case as linear IgA bullous dermatosis on the basis of above clinical and histopathological examination. The patient was treated with dapsone(100mg/day) and topical tarcrolimus. The lesions improved within 1 week and no bullous eruption was observed during 3 months of follow up
( You Bum Song ),( Jun Gyu Song ),( Sang Youl Yun ),( Moo Kyu Suh ),( Gyoung Yim Ha ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The necessity of performing antifungal susceptibility tests is recently increasing, because of frequent cases of oral candidiasis caused by antifungal-resistant Candida species. The Etest (BioMeriux, Marcy l``Etoile, France) is a rapid, easy-to-perform in-vitro antifungal susceptibility test. Objectives: The purpose of this study was to determine the minimal inhibitory concentrations (MICs) of antifungal agents using the Etest for Candida species isolated from patients with oral candidiasis Methods: Forty-seven clinical isolates of Candida species were tested along with a reference strain. MIC endpoints of Etest for fluconazole, itraconazole, voriconazole, amphotericin B susceptibility were read after 24 hour incubation of each isolate on RPMI 1640 agar. Results: MICs of fluconazole were 0.064-0.75 レg/mL for C. albicans, 16-64 レg/mL for C. glabrata, and 0.25-0.75レg/mL for C. tropicalis. MICs of itraconazole were 0.002-0.094 レg/mL for C. albicans, over 32レg/mL for C. glabrata, and 0.012-0.25 レg/mL for C. tropicalis. MICs of voriconazole were 0.002-0.016 レg/mL for C. albicans, 0.38-1.0 レg/mL for C. glabrata, and 0.008-0.094 レg/mL for C. tropicalis. MICs of amphotericin B were 0.012-0.19レg/mL for C. albicans, 0.064-0.19 レg/mL for C. glabrata, and 0.094-0.25 レg/mL for C. tropicalis. Conclusion: This study revealed that the Etest represented a simple and efficacious method for antifungal susceptibility testing of Candida species isolated from oral candidiasis patients.
Nipple eczema in 15-year-old boy with atopic dermatitis
( You Bum Song ),( Ji Young Yoo ),( Moo Kyu Suh ),( Jae Hong Kim ),( Jong Im Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Atopic dermatitis (AD) is a chronically relapsing skin disorder which is most common in childhiood. The common manifestations of AD is vary according to patient’s age and disease activity. The nipple involvement in AD is rare, but Hanifin and Raika indicated that it is specific indicator of AD. And nipple eczema predominated in girl. Nipple eczema in male with AD has been reported only 3 cases by Korean dermatological literature. We report a case of nipple eczema in 15-year-old boy with AD. He presented with localized pruritic lichenified eythematous patches with exudative erosions on the both nipples and areolas. He was diagnosed with AD at age of 4, but there are no other lesions or signs of scratching. Histopathologic examination revealed marked acanthosis with patial erosion, spongiosis, exocytosis of small lymphocytes and some eosinophils, and infiltrate of small lymphocytes and some eosinophils around dilated dermal vessels. The patient was treated with antihistamine and steroid. The skin lesions improved 1 months after treatment, and relapse has not been observed 3 months of follow up.