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A Bioactive Depsidone from Lachnum virgineum (Hyaloscyphaceae)
Yoshihito Shiono,Takuya Koseki,Hiromasa Koyama 한국생약학회 2018 Natural Product Sciences Vol.24 No.2
Norcolensoic acid (1) was isolated from both the fruiting bodies and the liquid culture of Lachnum virgineum. The structures of 1 was determined using spectroscopic methods. Compound 1 was isolated for the first time from this fungus. Compound 1 showed moderate antibacterial and phytotoxic activities.
Lilis Siti Aisyah,Yenny Febriani Yun,Tati Herlina,Euis Julaeha,Achmad Zainuddin,Ida Nurfarida,Ace Tatang Hidayat,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.2
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-b-D-glucopyranoside (3), kaempferol-3-O-b-D-glucopyranoside (4), kaempferol-3-O-a-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC50 values of 4.45 ? 0.05 and 6.28 ? 0.02 mg/mL, respectively.
Ace Tatang Hidayat,Kindi Farabi,Desi Harneti,Rani Maharani,Darwati,Nurlelasari,Tri Mayanti,Arlette Suzy Setiawan,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.4
Six dammarane-type triterpenoids, dammar-24-en-3b-ol (1), 3b-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3b,20-diol (3), dammar-24-en-3b,20-diol (4), 3b-acetyl-20S,24S-epoxy-25-hydroxy- dammarane (5), and 3b-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3b-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC50 value of 8.02 ? 0.06 mM.
A new havanensin-type limonoid from Chisocheton macrophyllus
Nurlelasari,Rahmayanti Intan,Salam Supriatno,Safari Agus,Harneti Desi,Maharani Rani,Hidayat Ace Tatang,Tanjung Mulyadi,Retnowati Rurini,Shiono Yoshihito,Supratman Unang 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.2
A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic efects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no signifcant activity.