예방적 lamivudine 투여로 성공적인 동종골수이식술을 시행한 HBV 양성 중증 재생불량빈혈 환자 1예

성윤경,안명주,오호석,최정혜,이영열,김인순,최일영 대한내과학회 2004 대한내과학회지 Vol.66 No.1

저자들은 만성 B형 감염을 동반한 중증 재생불량빈혈 환자에게 lamivudine을 예방적으로 투여하여 HBV의 재활성 없이 성공적으로 동종골수이식술을 시행하였기에 문헌고찰과 함께 보고하는 바이다. Reactivation of hepatitis B virus (HBV) infection has been known to be a serious complication of immunosuppressive or cytotoxic chemotherapy in HBV carriers or chronic hepatitis B patients. We report here a 25-year-old woman who has severe aplastic anemia and chronic hepatitis B underwent successful allogeneic bone marrow transplantation (BMT) with prophylactic lamivudine treatment and showed no evidence of reactivation of hepatitis B, HBV DNA elevation, or liver dysfunction. This result suggests that prophylactic administration of lamivudine to a BMT recipient of chronic hepatitis B might be a safe and promising measure to prevent fatal liver dysfunction.

제2형 당뇨병 환자에서 QUICKI법을 이용하여 측정한 인슐린 저항성과 비만도와의 관계

성윤경,최웅환,이창범,박용수 대한비만학회 2003 The Korean journal of obesity Vol.12 No.3

연구배경: 인슐린 저항성은 제2형 당뇨병의 중요한 병인으로서 비만과 밀접한 관계가 있으며, 이와 연관된 고지혈증. 고혈압의 발생은 결과적으로 혈관 합병증의 빈도를 높이는 것으로 알려져 있다. 본 연구에서는 한국인 제2형 당뇨병 환자를 대상으로 하여 새로운 인슐린 저항성 평가법인 QUICKI법을 이용하여 인슐린 저항성을 측정하고, 이와 비만도 및 체지방 분포, 지질 등의 대사성 인자들과의 상관 관계를 평가하고자 하였다. 방법: 연구 대상은 2000년 5월부터 2002년 10월까지 한양대학병원 내분비대사내과에서 당뇨병으로 치료 받은 환자 중 인슐린과 경구혈당 강하차를 투여하지 않은 103명을 차상으로 하였으며, 인슐린 저항성은 공복시 측정한 인슬린치와 포도당치를 이용하여 계산하는 QUICKI법을 이용하였다. 비만도는 입원시 키와 몸무게를 통하여 체질량지수를 측정하였으며, 체지방의 정량화와 분포를 알아보기 위하여QDR4500의 DEXA system (Hlologic, USA)을 이용하여 지방량과 건체중. 총 체지방률, 복부 지방률 등을 측정하였다. 측정 결과는 평균, 표준편차, 백분율 등으로 제시하였고 남녀간평균값의 비교 분석은 independent t-test를 시행하였다. 인슐린 저항성과 각 변수들과의 상관 관차는Pearson 상관 차수를 통해 비교하였고, 단계별 다중회귀분석을 통하여 인슐린 저항성에 가장 영향을 미치는 인자를 평가하였다. 이상의 모든 통계 분석은 SPSS (version 11.0)를 사용하였으며, 통계학적 유의 수준은 p값을 0.05 이하로 하였다. 결과: (1) 평균 연령은 55.7±12.8세, HbA_(IC)는 9.9±2.7%로 측정되었고, 체질량지수는 23.8±3.7kg/㎡', QUICKI값은 0.38±0.07로 계산되었다. (2) 남녀간에 체질량지수. EHA_(IC), 연령 등에서는 유의한 차이가 없었던 반면 QUICKI값. 총 체지방량 및 복부 지방량. 총 체지방률과 복부 지방률, 그리고 각각의 지질치에 있어서 유의한 차이가 있었다. (3) QUICKl법으로 측정된 인슐린 저항성은 HDL 콜레스테롤과 양호한 양의 상관 관계(r=0.456, p<0.01)를 보인 반면, 체질량지수(r=0.407, p<0.001), 총 체지방량(r=0.458, p<0.001), 복부 지방량((r=0.475, p<0.001), 총 체지방률(r=0.438, p<.0.01), 복부 지방률(r=0.457, p<0.01) 그리고 건체중과 대비한 총 체지방량(r=0.392, p<0.01)과 복부 지방량(r=0.423, p<0.01)과도 양호한 음의 상관 관계를 보였으며, 총 콜레스테롤(r=0.281, p<0.01), TG (r=0.333, p<0.01), LBL 콜레스테롤(r=0.326, p<0.01)과도 음의 상관 관계를 보였다. 그러나 수축기 및 이완기 혈압, HbA_(IC)와는 유의한 상판 관차를 보이지 않았다. 한편, 이러한 대사성 인자들과 QUICKI값과의 상관 관계의 정도는 HOMA_(IR)값과의 상관 관계에 비해 약간 높은 것으로 나타났다 (4) 단계별 다중회귀분석을 통하여 인슐린 저항성에 가장 영향을 미치는 인자를 분석한 결과 복부 지방률(R²=0.209, p<0.001), HDL 콜레스테롤(R²=0.135, p<0.001), 총 콜레스테롤 (R²=0.056, p<0.01) 등의 기여율이 가장 높은 것으로 나타났다. 결론: 한국인 제2형 당뇨병 환자의 인슐린 저항성을 QUICKI법을 이용하여 측정하였으며, 단순한 체질량지수나 전체 및 복부의 절대적인 지방량 보다는 복부를 구성하는 체성분중 지방이 차지하는 비율인 복부 지방률과 혈중HDL 콜레스테롤 및 총 콜레스테롤 수치가 인슐린 저항성을 가장 잘 설명하는 것으로 나타났다 따라서 이러한 인자들에 대한 개선 노력은 인슐린 저항성의 개선 및 제2형 당뇨병 발현의 억제에 기여할 것으로 판단된다. Background : Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and cardiovascular disease. The aim of this study was to investigate the relationships between insulin resistance generated by quantitative insulin sensitivity check index(QUICKI) and regional adiposity, body mass index (BMI), and serum lipid profile in Korean type 2 diabetic patients. Method: Study subjects included fat mass and lean body mass by dual energy x-ray absorptiometry(DEXA) system. Insulin resistance was estimated by the QUICKI. Result :50 were women and 53 were men, with a mean (±SD) age of 54.2 years(±12.8). The mean(±SD) score of QUICKI was 0.38(±0.07). Insulin resistance was positively correlated with total body fat percent, abdominal fat percent, BMI, total cholesterol, LDL-cholesterol, and triglyceride, and negatively correlated with the HDL-cholesterol. In multivariate model, the predicting variables on insulin resistance were abdominal fat percent, HDL cholesterol, and total cholesterol. Conclusion: In this study, we observed that the abdominal fat percent, HDL cholesterol and total cholesterol were meaningful variables correlated with insulin resistance among variables. Therefore, to improve insulin sensitivity in Korean type 2 diabetic patients, we should reduce the abdominal fat percent and total cholesterol and increase the level of HDL-cholesterol.

특발성 자발성 신장 파열 1예

윤재철,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Primary aldosteronism is a syndrome characterized by hypertension, hypokalemia, suppressed plasma renin activity, and elevated serum aldosterone levels. Conn first described it 1955 in association with adrenal cortical adenoma(Conn's syndrome). Today, it can be divided into at least six distinctive sub-groups. The diagnosis of primary aldosteronism is usually suspected when the patient presents with poorly controlled hypertension with hypokalemia. The main issues in the evaluation of primary aldosteronism are to differentiate an adenoma from hyperplasia and to localize the adenoma. Basic hormonal studies and computed tomographic(CT) scanning can be used effectively for that differentiation. An adenoma is one of a few potentially curable forms of hypertension, and it is best treated by removing the adrenal tumor. We experienced a case of a typical adrenal adenoma. The patient was a 37-year-old male who had experienced in both his legs over a period of several days a weakness due to hypokalemia. He was diagnosed using basic hormonal studies and adrenal CT scanning. After, he received laparoscopic adrenalectomy and was discharged with improved condition.

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

有機農業의 實態와 發展에 관한 事例 硏究 : 忠南 洪城郡 洪東面 有機農家를 中心으로

尹英相,洪性贊,金成敏,具漢謨,申東一,金昌護,姜熙慶 公州大學校 資源科學硏究所 1997 資源科學硏究論文集 Vol.5 No.-

This study was carried out to improve the organic farming system about crop cultivation, compost production and application, plant diseases & pest control, weed control and marketing system of organic farming products to the case study in Chungnam Hongdong area. Agricultural technologies concerning pest & diseases control, weed control and compost production are not established due to lacks of systemized researches by the agricultural scientist, and agricultural machines profitable to this works had not developed yet. In cropping system, reasonable crop rotation had not conducted. The related cultivation of vegetables on the same ground for a long time cause a various plant disease easily. So crop rotation is a reasonable method about soil nutrient utility and soil disease control. It is a good method that introduce the barley and wheat in this field crop system. Those crop have a long root, so can use the other nutrient against the vegetable. In organic farming products, the safety and quality of products by the National Agricultural Products Inspection Center had not inspected except rice, lettus and apple. Inspection is needed for the development of organic farming and mutual confidence between producer and consumer, because the mutual confidence is a major thing to sustain the organic farming. In products marketing, it is more need for the information of organic farming products. Nowaday most products are marketed in Seoul region, but it is not a good method. To search the consumer in near region is a good method for decrease the cost of conveyance and maintain the quality of products. The varieties of distribution structure of organic farming products are required. The products are sold to department store in large city and the prices are about 30% higher than normal products. But when those are supplied in near region, the prices of those are similar to normal products. Direct transactions in near regions is a good method for decrease the cost of conveyance and strength the mutual confidence between producer and consumer.

열가소성 Wood-Plastic Composites의 기계적 물성에 미치는 커플링제의 영향

윤태호,신경섭,황택성,이존태 공주대학교 자원재활용 신소재 연구센터 1999 1차년도 센터 성과집 Vol.1999 No.-

목분 충진제의 함량을 달리 하고 PE수지를 매티릭스로 하여 wood plastic composites(WPC)를 제조하였다. 또한 매트릭스와 충진제간의 계면결합력을 증가시키기 위하여 커플링제로 phthalic anhydride(PA)를 사용하였으며, 충진제의 충진률과 커플링제 처리가 복합재의 기계적 물성에 미치는 영향과 계면현상을 관찰하였다. 목분의 충진률 30wt%, PA커플링제농도 3wt%일 때 인장강도는 26.37MPa로 최대값을 나타내었으며, 이때 충격강도는 46.24J/m의 최대값을 나타냈다. 또한 WPC는 주사전자현미경 관찰을 통해서 커플링제의 처리농도의 증가에 따라 목분과 PE 수지와의 분산과 결합이 잘 이루어졌으을 확인할 수 있었다. Wood powder as reinforcing fillers and polyethylene as a matrix have been used for wood plastic composites(WPC). In preparing WPC, the coupling agent, phthalic anhy dride(PA) was used in order to increase the interfacial bonding force between matrix and fillers. In this study, the effect of wood powder, PA concentration on the mechanical properties and interfcial phenomena on the composites was eveluated. The tensile strength of 3wt% PA-treated composites reached its maximum value of 25.91 MPa when the wood powder content was 30wt%, and the mximum impact strength of PA-treated composites was 46.24H/m. SEM observation showed that wood powder was well dispersed and bonded well with PE matrix by increasing the coupling agent concentration.

Shield Disk 상의 Ag-Cu 공정계 합금 도금기술 개발

윤경도,차동관,심기종,민봉기,최순돈,이상기 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.1

The composition and the microstructure of the Ag-Cu alloy electrodeposits electroplated in Succinimide bath were investigated varying the electrolysis conditions such as bath composition, current density and additive agents etc. The cathode overpotential increased with the increase of Succinimide concentration and current density ratio in the bath. The Ag content of the alloy deposits decreased with the increase of current density and pH and temperature in the bath. The optimum condition for 78wt.%Ag-22wt.%Cu code position alloy is an follows : pH10(adjusted by NH_4OH), 0.03M AgNO_3, 0.27M Cu(NO_3)_2 3H_2O, 0.5M Succinimide in bath and 3.5A/dm^2∼5.5A/dm^2 current density.

iTECH 바닥 슬래브의 시공단계별 진동특성에 관한 연구

이윤경,주영규,윤성원,김도현,김상대 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.3

The story height of the tall buildings is the significant factor due to the limited construction area within the central city such as Seoul. Therefore we developed iTECH(Innovative Technical Economical & Convenient Hybrid) system to reduce story height. Since the top flange of the proposed beam is within the slab, the vibrational characteristics have to be verified by the test. The purpose of this paper is to study on vibration characteristics of floor with iTECH composite system and to evaluate the serviceability. In this research, natural frequency, damping ratio and peak acceleration were measured at experiments for each construction step such as steel erection stage, concrete casting stage and finishing stage. The test results are compared with that of the code. As a result, the proposed composite slab showed enough vibrational characteristics.

국내 민간투자(SOC)사업의 효율화 방안에 대한 연구

이호경,김상철,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study is to examine the theoretical concept and practical example of Social Overhead Capital(SOC) project based on development of nation the world. Also, the critical access is to find the way we can develop domestic SOC project underway in private and nationwide. Furthermore, anther access is to propose clearly how to utilize BOT, BTO in financial, technical, CM method focusing on more systematic and effective result.

폐흡충에 의한 무균성 노흉에 대한 돼지꼬리형 도관(pig-tail catheter)을 이용한 치료의 효과

한경택,권세훈,김형호,하재화,선길홍,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Pulmonary paragonimiasis is caused by consumption of raw or improperlycooked crustacea infected with the laval stage (metacercaria) of Paragonimus westermani. The most characteristic symptoms were rust-colored sputum and cough. Paragonimiasis causes pleural thickening or effusion in 48% of the patients. Pleuro-pulmonary paragonimiasis can be easily overlooked by physicians who do not suspect this disease in the differential diagnosis. Method: We compared the outcomes of 11 patients with paragonimus empyema managed either through thoracotomy or pig-tail catheter drain. These patients were confirmed by food history, clinical and radiological findings, and laboratory data. Results: The male and female ratio was 1.75 : 1, and mean age was 40.0 ± 13.5 years. AII patients had pulmonary symptoms such as cough or chest pain. Serum-ELISA for paragonimiasis were all positive (mean titer was 0.57). AII patients had pleural effusion in radiological findings( 2 patients had bilateral pleural effusion). All patients received praziquantel (75 ㎎/㎏/day for 3days). Two patients were treated with thoracotomy and nine patients were treated with pig-tail drain. Hospital stay were 14.5 days in thoracotomy group and 5.6 days in pig-tail group respectively, Conclusion: Compared to the conventional thoracotomy grouP, the patients with paragonimus empyema who received pig-tail catheters had a significantly-decreased period of drain in situ, were clinically improved earlier, and were discharged earlier.