2차원 및 3차원 초음파를 이용한 태아표면의 해부학적 선별 검사에 관한 연구

윤석범,이해혁,이정재,최경훈,이순곤,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

Objective : Our purpose of this study was to determine the clarity and consuming time of fetal surface screening in thirty-eight fetuses from 24 to 32 weeks of gestation by use of two and three-dimensional ultrasonography. Methods : From May 1998 to July 1998, we performed the fetal surface screening of the fetal face, extremities, and spine. Thirty-eight fetuses of 24-32 weeks of gestation (thirty-seven normal fetuses and one abnormal fetus) were studied by use two-dimensional (AI 5200S, 3.5-5.0MHz; Acoustic Imaging Technologic Cooperation, U.S.A.) and three-dimensional ultrasonography (Volusion 530D, 3.5-5.0 MHz ; Kretz-Medicine, Korea). On the fetal face, we evaluated both orbits, nose, lips and brow. Both hands and feet, five digits and toes should be seen in this study. We evaluated cervical spine and lumbosacral junction of the spine. Results : The maternal average age of 38 patients was 29.9 years and the average gestational age was 29.7 weeks. The results of fetal surface screening were as follows : face (both orbits 89.5%, lips 92.1%, nose 92.1%, and brow 89.5%), extremities (both hands 68.4% and feet 73.7%), and spine (cervical spine 94.7% and lumbosacral junction 97.4%) by use of two-dimensional ultrasonography. By use of three-dimensional ultrasonography, results were as follows : face (both orbits 76.3%, lips 81.6%, nose 81.6%, and brow 78.9%), extremities (both hands 76.3% and feet 78.9%), and spine (cervical spine 71.1% and lumbosacral junction 73.7%). Consuming time for two-dimensional ultrasonography were 4.7 minutes for face, 11.6 minutes for extremities, and 5.7 minutes for spine. Using three-dimensional ultrasonography results were 12.8 minutes for face, 17.9 minutes for extremities, and 11.7 minutes for spine. Average consuming time of all fetal anatomic screening was 22.0 and 42.4 minutes by use of two and three dimensional ultrasonography. In one abnormal fetus had cleft lip and polydactyly of right foot which were detected all by three-dimensional ultrasonography, but we couldn't detect the polydactyly by two-dimensional ultrasonography. Conclusion : Three-dimensional ultrasonography was more time-consuming method, but we suggested that three-dimensional ultrasonography was superior than two-dimensional ultrasonography in fetal surface screening.

한인진 추출물의 간장보호 작용에 관한 연구

이순복,조태순,윤기욱,이종찬,이선미,심성보 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

Special Issue of Professor Kiehwa Lee`s Retirement: Geophysical Environments of the Korean Peninsula : Articles ; Geoelectrical Structure of the Kyongsang Basin from Magnetotelluric Sounding

( Choon Ki Lee ),( Heui Soon Lee ),( Byung Doo Kwon ),( In Ky Cho ),( Seok Hoon Oh ),( Yoon Ho Song ),( Tae Jong Lee ) 대한지구물리학회 2006 지구물리 Vol.9 No.3

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

외상후 발작의 위험인자에 대한 조사

이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.

일방성 GFRP 복합재료에서 음향방출 신호의 위치표정

이종오,원순호,윤운하,이종규,소철호 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.3

General source location method that use an arrival time differences among sensor is restricted to the composite material and the complex-shaped material. In this study, a bundle-type acoustic sensor composed of 6 pinducers was utilized to determine wave propagation direction and then to estimate source location of the unidirectional GFRP. For the purpose of the study, slowness curve for the material was obtained and made an assumption that the incident waves on pinducers are propagated as a plane wave. According to the results, measured propagation directions of the wave was coincide with theoretical background, however, it was a hassle to determine the source location exactly. But, it is expected that bundle-type sensor gives more accurate results for zone location than generally used acoustic sensors.

TGF-β가 HPV-16의 인체 세포 발암화에 미치는 영향

이윤순,양재호,박일수 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Human epithelial cell line immortalized with Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 gene. Among these clones, clone-3 and clone-6 showed neoplastic transformation properties of contact inhibition, anchorage independence and cellular adhesion after 7 subcultures. The results suggest that SV40 gene in the immortalized human cell system be in concert with HPV-16 in the process of neoplastic transformation of human cells. While TGF-β₁( 5ng/㎖) inhibited growth of control cells and clone-1 cells which did not show transformation, there was no significant change on the growth of clone-3 cell with transformation properties. When transcriptional level of fibronectin on control cells and clone-3 cells were higher, as compared with control cells. RNA hybridization techniques were performed to compare trasncriptional levels of TGF-β₁ between control cellls and clone-3 cells. Rna level on clone-3 cells with transformation properties was higher than on control cells. These studies indicate that TGF-β₁ is associated with increases of fibronectin, which may lend to changes of TGF-β receptor and loss of its inhibitory action on the transformed cells. Thus, it seems that loss of inhibitory action of TGF-β which is mediated by changes of fibronectin may account for a possible mechanism of action in the HPV-16 induced transformation of human cells.

자두와인에 대한 마케팅 전략 연구

이수원 ; 윤옥현 ; 김순희 김천대학교 2003 김천대학교 논문집 Vol.24 No.-

Marketing strategy is marketing logic by which the business unit expects to achieve its marketing objectives. Marketing strategy consists of making decisions on the business's marketing expenditures, marketing mix, and marketing allocations in relation to expected environmental and competitive conditions. On the other hand, this study was taken on develop the marketing strategies for plum wine by the research institute of indigenous food at Gimcheon College. Accordingly, this study examines for the analysis, planning and con-trol of market involved plum wine through SWOT analysis and 4Ps. It is expected to provide the marketing managers of plum wine with some knowledge and insight in this area. Furthermore, this study can contribute to the establishment of the marketing strategies for plum wine.

開途國의 人口成長과 敎育計劃 : 學齡人口를 中心으로 In the Center of the School-age Population

李潤樹,金淳彦 경북대학교 1983 새마을 硏究論叢 Vol.3 No.-

The problem of population is a matter not in future but today. The advanced nations show only 0.8 percent in the low growth rate of population due to the high level of their lives and the ladies' advanced position, not directly concerned in the government, whereas the developing countries are considered difficult to succeed in the problem of population without practicing the strong will of government leaders, the financial punishment to many Children's family, the ladies' advanced position, the consistent population education in a primary school, a secondary school, and a college, and setting up the curriculum of population in a college of education and teachers' college. It is really required to set up valuable views of the nation on and world at from school-age pupils through the education of population, and it is also really important for them to understand the basic principle of eugenics in conformity to physiological process. I conclude that the population growth of educationally less advanced countries and the tendency of the school-age population will be how to operate on a plan of educational development. 1. The educationally less advanced countries have high birth rates and a much larger proportion of their population in the school-age groups. This unfavourable age-structure delays the plan of educational development and constitutes a formidable barrier to the early attainable quality of education. 2. The quality of education throughout most of the developing world leaves a great deal to be desired, and improvements in quality are being hampered by the drive to broaden the coverage of education, so the government should invest a lot of educational expenditure in raising P.T.Rs to he level of educationally advanced countries. 3. The growth-rate of the school-age population in developing countries indicates that it will be relaxed in the 1980s. The decline of the birth rate will lessen the eduational costs necessary to attain defined educational goals in a given period, and contribute towards the advance of educational quality. 4. The expansion of higher educational institutions will solve a problem of the continuous increase in labor population and gain the average level of an academic career. 5. Among the factors of increasing educational expenditures in developing countries, the factor of population growth is highly placed and only the decline in the birth rate will accomplish the highly educational quality of the school-age population. 6. The educational system will have an influence on the advance of educational quality in accordance with the growth of population and the increase in enrollment rates, and have necessity of an educational system for the elite-school-age population. 7. It is feared that the short-term plan of education will miss the implication of population trends, and the long-term plan of education is essential in reflecting the role of population, occurring in a problem for changing the plan of population and it can influence future population trends by incorporating population and family life education into the school curriculum and adult education activities.

유아평화교육을 위한 이론적 연구

윤혜원,이순영 한국영유아보육학회 2002 한국영유아보육학 Vol.0 No.29

The purpose of this study is to examine the concept, objective, content and preceding researches of peace educations, and to review the historical changes and the prospects for the early childhood peace educations. First, early childhood peace education has the conceptual objective of achieving eternal peace of humanity, with the basic principle of having children understand relationship, cooperation, dispute resolution and violence, to enhance a child's self-efficacy feeling. Second, the purpose of early childhood peace education is to nurture inquisitive minds, learn knowledge and technique, increase respect for humanity and religions, broaden understanding of the world, or learn knowledge, technique and attitude of peace education. Third, transition of early childhood peace education through our country's preceding researches of peace education is changing from concept and philosophy to practical application program development. Fourth, early childhood peace education's historical change is begin from ancient times' Plato to Comenius, Rousseau, Pestalozzi, Froebel, the UNESCO's Charter, a critical peace education thought, and come to modern changing from passitive concept anti-war, anti-nuclear to active concept through social bonds and behavior not individual dimension. According to above the prospects for early childhood peace education is peace education in human beings' the greatest subject emphasis must begin from early childhood in important period of life.