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김윤철,이정우,김보영,강정아,임대승,이민수,김정희,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1
Coronary stent implacement is known as an effective treatment in the intimal dissection after percutaneous transluminal coronary angioplasty and the prevention of restenosis. However, In-stent restenosis still remains a major concern in clinical stenting. The stents were placed in 103 patients from July 1996 to March 1999 and performed follow-up coronary angiograms in 59(57.3%) patients. To identify the clinical, angiographic and procedurerelated variables 'which predict late restenosis within the stented artery, 59 patients(58.3±9.9, M:F= 41:18) were studied. The clinical characteristics of the patients were stable angina in 23(39.0%), unstable angina in 14(23.7%), acute myocardial infarction in 21(35.6%) and old myocardial infarction in 1(1.7%). Coronary stenting was performed in 1 patient(1.7%) for primary lesion, 50 patients(84.7%) for suboptimal results after PTCA, 6 patients(10.2%) for bail-out procedure, and 2 patients(3.4%) for restenotic lesions. All patients were treated with aspirin and ticlopidinc. The follow-up angiograms were obtained at 7±4 months. The overall in-stent restenosis rate was 27.1%. The coronary angiographic findings were 32 single vessel(54.2%), 19 two vessel(32.2%) and 8 three vessel disease(13.6%). The angiographic morphological characteristics were type A in 33(55.9%), type B in 14(23.7%), type C in 12(20. 3%) cases. Variables of 16 patients with restenosis were compared with those of 43 patients without restenosis. Previously known predictors for in-stent restenosis were multiple stenting, stenting for restenotic lesions, residual stenosis after stenting, stenting for total occlusion lesions, reference diameter, balloon to vessel ratio, acute gain and minimal luminal diameter after procedure, design and characteristics of stents, ostial lesion of aorta, high pressure method for stenting, lesion length, diabetes mellitus, size of artheroma, saphenous vein grafts, ulcerlating lesions and calcified lesions. In this study, Reference diameter before stenting(2.43±0.54mm vs. 2.88±0.65mm, p=0.016) and balloon-to-artery ratio(1.28±0.26 vs. 1.11±0.18, p=0.006) were predictors for in-stent restenosis. 1) The overall in-stent restenosis rate was 27.1%. 2) In the analysis of predictors for in-stent restenosis, there was no significant differences in clinical, angiographic factors between group with restenosis and without restenosis. But, Only reference diameter before stenting and balloon-toartery ratio were predictors of late in-stent restenosis. In conclusion, stenting is effective revascularisation method for selected patients with ischemic heart disease, and to minimize in-stent restenosis rate, stent implanting is achieved in a large vessel on the basis of an artery-to-stnet ration of 1:1, if possible.
한국인에서 혈소판 당단백 Ⅱb/Ⅲa 유전자 다형성과 관동맥 성형술 후 재 협착과의 관계
이민수,이정우,김보영,임대승,강정아,김정희,김윤철,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2
Platelet aggregation is the final pathway of acute coronary syndrome such as acute myocardial infarction and unstable angina. Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and yon Willebrand factor and it plays an important role in platelet aggregation and in the pathogenesis of acute coronary syndrome. It is known that polymorphism of the gene that encoding platelet glycoprotein IIb/IIIa(PI^A1/A2) is strongly related to acute coronary syndrome in Caucasian, but not in Koreans. We investigated relationship between platelet glycoprotein llb/Illa gene polymorphism and restenosis of coronary artery after angioplasty in Koreans. Total 371 patients(M=251. F=120) were enrolled. Angioplasty group comprised 143 patients who underwent coronary angioplasty, and in the angioplasty group, restenosis group comprised with the 65 patients who had restenotic lesion over 50% of luminal diameter in follow-up coronary angiography. Normal group comprised 153 patients who had no significant angiographic lesion and variant angina group comprised 75 patients who were positive in ergonovine test. Genomic DNA was extracted from peripheral arterial blood. To determine the frequency of P1^A1/A2 genotype, polymerase chain reaction(PCR) was done and the product was restricted with Mspl. 3%. agarrose gel electrophoresis showed restriction fragment length polymorphism. Clinical profile and risk factor were also reviewed. Among all 371 patients of study group, genotype of only one patients in restenosis group if is proven to be PI^A1/A2 heterozygote. All patients of normal study group, no restenosis group, and the other patients in restenosis group have an PI^A1 homozygote genotype. In our study, platelet glycoprotein IIb/Illa polymorphism has no relationship with restenosis of the coronary artery after angioplasty in Koreans. But the genotypic frequency of platelet glycoprotein IIb/IIIa gene polymorphism in Koreans is concordant with that of previous studies.
Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling
Nam, Yoon Seok,Kim, Yoojung,Joung, Hosouk,Kwon, Duk-Hwa,Choe, Nakwon,Min, Hyun-Ki,Kim, Yong Sook,Kim, Hyung-Seok,Kim, Don-Kyu,Cho, Young Kuk,Kim, Yong-Hoon,Nam, Kwang-Il,Choi, Hyoung Chul,Park, Dong H American Heart Association, Inc. 2014 Circulation research Vol.115 No.5
<P><B><U>Rationale</U>:</B></P><P>Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a conventional DNA-binding domain. Through interactions with other transcription factors, SHP regulates diverse biological events, including glucose metabolism in liver. However, the role of SHP in adult heart diseases has not yet been demonstrated.</P><P><B><U>Objective</U>:</B></P><P>We aimed to investigate the role of SHP in adult heart in association with cardiac hypertrophy.</P><P><B><U>Methods and Results</U>:</B></P><P>The roles of SHP in cardiac hypertrophy were tested in primary cultured cardiomyocytes and in animal models. SHP-null mice showed a hypertrophic phenotype. Hypertrophic stresses repressed the expression of SHP, whereas forced expression of SHP blocked the development of hypertrophy in cardiomyocytes. SHP reduced the protein amount of Gata6 and, by direct physical interaction with Gata6, interfered with the binding of Gata6 to GATA-binding elements in the promoter regions of natriuretic peptide precursor type A. Metformin, an antidiabetic agent, induced SHP and suppressed cardiac hypertrophy. The metformin-induced antihypertrophic effect was attenuated either by SHP small interfering RNA in cardiomyocytes or in SHP-null mice.</P><P><B><U>Conclusions</U>:</B></P><P>These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling. SHP may participate in the metformin-induced antihypertrophic response.</P>
Pyoderma-Pyostomatitis Vegetans
최윤석 ( Yoon Seok Choe ),이재철 ( Jae Chul Lee ),박병철 ( Byung Cheol Park ),나건연 ( Gun Yoen Na ),이원주 ( Woen Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.8
Pyoderma-pyostomatitis vegetans (PD-PSV) is a rare, benign, eosinophilic pustular and vegetating mucocutaneous disease characterized by skin lesions which typically involve the axillary and genital regions, the face and the scalp. PD-PSV was at first regarded as a subtype of bullous disease. However, due to the lack of abnormality under a immunofluorescent microscope, it could be diffentiated from bullous disease. A 48-year woman presented with a 6-month history of sharply-outlined, exudative, papillomatous and vesiculopustular vegetating plaques on the perioral, umbilicus and nasal mucosa, tips of her fingers and toes and perianal region. A skin biopsy taken from the lip and umbilicus showed papillary dermal edema and focal inflammatory cell infiltration composed of many eosinophils, intraepithelial microabscesses, focal spongiosis, and exocytosis. No abnormalities were found during an immunofluorescence study. The lesions were almost cleared with 20㎎ of triamcinolone and 200㎎ of cyclosporine medication during a 3-month treatment period. (Korean J Dermatol 2006;44(8):991~994)
Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease
Yoon, Seung Yong,Choi, Jung Eun,Kweon, Hee-Seok,Choe, Han,Kim, Seong Who,Hwang, Onyou,Lee, Heuiran,Lee, Joo-Yong,Kim, Dong Hou Wiley Subscription Services, Inc., A Wiley Company 2008 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.86 No.14
<P>Autophagosomes are accumulated in Alzheimer's disease (AD), but the regulatory pathway of autophagy in AD remains largely unknown. By using electron microscopy, Western blotting, and immunocytochemistry, here we show that autophagosomes are accumulated in rat neurons by okadaic acid (OA), a protein phosphatase-2A inhibitor known to enhance tau phosphorylation, β-amyloid (Aβ) deposition, and neuronal death, which are the pathological hallmarks of AD. Autophagy can be generally induced via several distinct pathways, such as inhibition of mTOR or activation of beclin-1. Interestingly, OA increased both mTOR and beclin-1 pathways simultaneously, which suggests that autophagy in OA-treated neurons is induced mainly via the beclin-1 pathway, and less so via mTOR inhibition. Finally, inhibition of autophagy by 3MA reduced cytotoxicity in OA-treated neurons. Our novel findings provide new insights into the pathology of and therapeutic intervention for AD. © 2008 Wiley-Liss, Inc.</P>
Two Cases of Monckeberg`s Medial Sclerosis on the Face
( Seok Jong Lee ),( Yoon Seok Choe ),( Jae Chul Lee ),( Byung Cheol Park ),( Woen Ju Lee ),( Do Won Kim ) 대한피부과학회 2007 Annals of Dermatology Vol.19 No.1
Monckeberg`s medial sclerosis is a degenerative process related to age, and is particularly associated with long-standing diabetes mellitus. The media of small and medium-sized muscular arteries are usually involved. Although its pathogenesis is still unknown, its presence can predict the risk of cardiovascular events and leg amputation in diabetic patients. In our two cases, Monckeberg`s medial sclerosis was shown as a bean-sized, pulsatile mass which occurred from an inferior labial branch of the facial artery. Neither paient had a history of diabetes mellitus or calcification in any part of the body, nor an abnormality with their calcium metabolism. Herein, we report a case of a man and a woman with Monckeberg`s medial sclerosis. This condition is so rare that it has not been reported in the Korean dermatologic literature before. Moreover, Monckeberg`s medial sclerosis is very rarely found without diabetes mellitus. (Ann Dermatol (Seoul) 19(1) 31~34, 2007)
Yoon, Ho-Young,Lee, Hyeon-Seok,Ham, Seok-Hyeong,Choe, Hyung-Jin,Kang, Bongkoo Institute of Electrical and Electronics Engineers 2018 IEEE transactions on power electronics Vol.33 No.10
<P>This paper presents a control method that can prevent audible noise generation in an <I>LLC</I> resonant half-bridge dc–dc converter under a light-load condition, while achieving the same input voltage range and power-conversion efficiency <I>η<SUB>e</SUB></I> as the burst-control method that generates an audible noise. The proposed method reduces switching and conduction losses at light load by skipping several pairs of switch-control pulses, while varying the switching frequency less than the normal-control method does. This skip-control method enables the <I>LLC</I> resonant converter to have a large magnetizing inductance, and to have high <I>η<SUB>e</SUB></I> over a wide range of load variation. At an input voltage of 385 V, an output voltage of 24 V, and a resonant frequency of 180 kHz, the proposed method achieved <I>η <SUB>e</SUB></I> ≥ 85.46% for an output power range of 7.2–360 W; the highest <I>η<SUB>e </SUB></I> was 96.08% at <TEX>$P_o$</TEX> = 336 W.</P>