경희의료원 제3 중환자실(동서협진중환자실)에 입원한 89명의 중증 급성기 뇌경색 환자에 대한 임상적 고찰

허홍,소형진,임주혁,조인영,이혜영,민경윤,류재환,이범준,Heo, Hong,So, Hyung-Jin,Im, Ju-Hyuk,Cho, In-Young,Lee, Hae-Yong,Min, Kyoung-Yoon,Ryu, Jae-Hwan,Lee, Beom-Jun 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4

Objects : To gain better insights of East-west integrated treatment of ischemic stroke. We analyzed 89 patients with severe acute ischemic stroke who were admitted to the East-west integrated intensive care unit. Methods : Subjects enrollment was from the East-west integrated intensive care unit of Kyung Hee Medical Center from March 2006 to February 2007. Patients were admitted within 14 days after the onset of ischemic stroke. We assessed the subjects' general characteristics, risk factors, admitting routes and periods, diagnostic imaging, process of western treatment and Korean traditional treatment, complication and consequence. Results : The proportion of males was 50.6%, of females 49.4%, average age was male 66.0$\pm$10.3 and female 71.1$\pm$10.5. Average length of hospital stays was 19.5 days. Monthly admissions were highest in November and December. The admission route was through emergency room (61.8%) or ward (34.8%). Mean Glasgow coma scale score was 10.0$\pm$2.5, average time from symptom of onset to hospital admission was 2.3$\pm$2.2 days. Dominant ischemic vascular territory was middle cerebral artery (66.3%). Initial western treatment was argatroban (22.5%), urokinase (28.1%), and heparinization (38.2%). Distribution of Sasang constitution of So-yang to Tae-eum to So-eum was equal to 5.4 to 2.9 to 1.5. Major complications were observed in 40 (42.7%) patients. In hospital mortality was 12.4% (11 deaths), all of them caused by aggravation of neurological deficit and only 3 of them with major complications. There appears to be a significant positive relationship between length of hospital stay and occurrence of complications (P<0.05). After discharge from the ICU, 64 (71.9%) patients were improved, 11 (12.4%) patients had expired, and 14 (15.8%) patients were transferred. Conclusions : From this study, we suggest that patients with severe acute ischemic stroke should be treated with East-west integrated therapy for more favorable consequences and decreased mortality.

An Optimization of AAV-82Q-Delivered Rat Model of Huntington's Disease

So, Kyoung-Ha,Choi, Jai Ho,Islam, Jaisan,KC, Elina,Moon, Hyeong Cheol,Won, So Yoon,Kim, Hyong Kyu,Kim, Soochong,Hyun, Sang-Hwan,Park, Young Seok The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.5

Objective : No optimum genetic rat Huntington model both neuropathological using an adeno-associated virus (AAV-2) vector vector has been reported to date. We investigated whether direct infection of an AAV2 encoding a fragment of mutant huntingtin (AV2-82Q) into the rat striatum was useful for optimizing the Huntington rat model. Methods : We prepared ten unilateral models by injecting AAV2-82Q into the right striatum, as well as ten bilateral models. In each group, five rats were assigned to either the 2×10¹² genome copies (GC)/mL of AAV2-82Q (×1, low dose) or 2×10¹³ GC/mL of AAV2-82Q (×10, high dose) injection model. Ten unilateral and ten bilateral models injected with AAV-empty were also prepared as control groups. We performed cylinder and stepping tests 2, 4, 6, and 8 weeks after injection, tested EM48 positive mutant huntingtin aggregates. Results : The high dose of unilateral and bilateral AAV2-82Q model showed a greater decrease in performance on the stepping and cylinder tests. We also observed more prominent EM48-positive mutant huntingtin aggregates in the medium spiny neurons of the high dose of AAV2-82Q injected group. Conclusion : Based on the results from the present study, high dose of AAV2-82Q is the optimum titer for establishing a Huntington rat model. Delivery of high dose of human AAV2-82Q resulted in the manifestation of Huntington behaviors and optimum expression of the huntingtin protein in vivo.

경정맥 사구종 2예

소윤경(Yoon-Kyoung So),조양선(Yang-Sun Cho),정한신(Han-Sin Jeong),정수찬(Soo-Chan Jung) 대한두개저학회 2006 대한두개저학회지 Vol.1 No.2

Glomus jugulotympanicum is a slow growing tumor originating at the dome of jugular bulb. It is histologically benign, but can have an aggressive clinical course with involving neurovascular structures at the skull base and extending through dural barrier. The primary treatment of glomus jugulotympanicum is total surgical extirpation. However, it can cause injury of cranial nerves and major vessels at the cranial base. We present two cases of glomus jugulotympanicum and reviewed the surgical techniques with special emphasis on the manipulation of facial nerve and postoperative cranial nerve palsy.

Long-term Outcome of Fontan-Associated Protein-Losing Enteropathy: Treatment Modality and Predictive Factor of Mortality

Ja-Kyoung Yoon,Gi Beom Kim,Mi Kyoung Song,Sang Yun Lee,Seong Ho Kim,So Ick Jang,Woong Han Kim,Chang-Ha Lee,Kyung Jin Ahn,Eun Jung Bae 대한심장학회 2022 Korean Circulation Journal Vol.52 No.8

Background and Objectives: Protein-losing enteropathy (PLE) is a devastating complication after the Fontan operation. This study aimed to investigate the clinical characteristics, treatment response, and outcomes of Fontan-associated PLE. Methods: We reviewed the medical records of 38 patients with Fontan-associated PLE from 1992 to 2018 in 2 institutions in Korea. Results: PLE occurred in 4.6% of the total 832 patients after the Fontan operation. After a mean period of 7.7 years after Fontan operation, PLE was diagnosed at a mean age of 11.6 years. The mean follow-up period was 8.9 years. The survival rates were 81.6% at 5 years and 76.5% at 10 years. In the multivariate analysis, New York Heart Association Functional classification III or IV (p=0.002), low aortic oxygen saturation (<90%) (p=0.003), and ventricular dysfunction (p=0.032) at the time of PLE diagnosis were found as predictors of mortality. PLE was resolved in 10 of the 38 patients after treatment. Among medical managements, an initial heparin response was associated with survival (p=0.043). Heparin treatment resulted in resolution in 4 patients. We found no evidence on pulmonary vasodilator therapy alone. PLE was also resolved after surgical Fontan fenestration (2/6), aortopulmonary collateral ligation (1/1), and transplantation (1/1). Conclusions: The survival rate of patients with Fontan-associated PLE has improved with the advancement of conservative care. Although there is no definitive method, some treatments led to the resolution of PLE in one-fourth of the patients. Further investigations are needed to develop the best prevention and therapeutic strategies for PLE.

한국적 문화상품으로서의 한옥민박시설의 활성화방안

박경옥(Park Kyoung-Ok),배영화(Bae Young-Wha),김소연(Kim So-Yon),윤명희(Yoon Myung-Hee) 충북대학교 생활과학연구소 2003 생활과학연구논총 Vol.7 No.2

  The purpose of this study is to suggest the ways to make Hanoks, Korean traditional houses, more preferred sites for private lodging, consequently to make them as national cultural goods. For the purpose, present private lodging Hanoks" physical characteristics and management programs were studied, and the needs of tourists were also analyzed. The study surveyed 5 private lodging sites, whose managers were interviewed with questionnaires, and 180 tourists or others answered the questionnaires.   The conclusions are as follows. 1) Hanoks currently used as private lodging adopted several facilities in harmony with traditionality, so that not so much inconveniences were answered. 2) The cultural pride of the managers decided the quality of the facilities and services of private lodging Hanoks. 3) Tourists answered physical aspects, distance to urban area and quality of food as priorities when choosing their lodging. The classification of private lodging Hanoks according to their facilities and services is needed for tourist information. The development of cultural programs along with personal services would make tourists visit more frequently. And for an active approach towards tourists from home or abroad, regional management bureaus and internet homepages would be helpful.

A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea

Yong Sung Choi,정성훈,김은선,Eun Sun Kim,Eunhee Lee,Euiseok Jung,So-Yeon Lee,이우령,Hye Sun Yoon,Yong Joo Kim,Ji Kyoung Park,Son Moon Shin,Ellen Ai-Rhan Kim 대한신생아학회 2022 Neonatal medicine Vol.29 No.1

Purpose: Pediatricians have a significant responsibility to educate mothers about the importance of breastfeeding. However, there have been minimal efforts in the courses of resident training in Korea. The purpose of this study is to evaluate the change in knowledge and attitude before and after a 4-week breastfeeding educational intervention among multicenter residents. Methods: Prospective interventional educational research was designed for residents at eight training hospitals in Korea. Institutional reviews were obtained in each hospital. The education curriculum consisted of 14 courses regarding breastfeeding theory and practice. These materials were used to teach pediatric residents for 4 weeks. Knowledge-based tests were administered before the course, and re-tests were administered after the course using different test items of similar levels. Test scores and survey responses were compared before and after the intervention. Results: A total of 73 residents (1st year 20, 2nd year 23, 3rd year 16, and 4th year residents 14) from eight training hospitals completed the intervention. Their average age was 30.3±2.9 years, 17 (23.3%) were male, 22 (30.1%) were married, and eight had more than one child of their own. The mean pre-test score was 61.8±13.4 and the mean post-test score was 78.3±7.5 (P<0.001). The inter-grade difference in the score was significant in the pre-test (P=0.005), but not significant in the post-test (P=0.155). There were more responses of obtaining confidence after the intervention (P<0.001). Conclusion: In our study, pediatric residents showed improvement in their knowledge and confidence level after 4 weeks of the breastfeeding curriculum. This will provide a basis for future policymaking in the training of pediatric residents regarding breastfeedReceived: 6 January 2022 Revised: 15 February 2022 Accepted: 15 February 2022 Correspondence to: Ellen Ai-Rhan Kim, MD Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: +82-2-3010-3390 Fax: +82-2-3010-6978 E-mail: arkim@amc.seoul.kr A Multi-Center Educational Research Regarding Breastfeeding for Pediatrics Residents in Korea Yong-Sung Choi, MD,PhD1, Sung-Hoon Chung, MD, PhD2, Eun Sun Kim, MD, PhD3, Eun Hee Lee, MD4, Euiseok Jung, MD5, So Yeon Lee, MD, PhD5, Wooryoung Lee, MD6, Hye Sun Yoon, MD, PhD7, Yong Joo Kim, MD, PhD8, Ji Kyoung Park, MD, PhD9, Son Moon Shin, MD, PhD9, and Ellen Ai-Rhan Kim, MD, PhD5 1Department of Pediatrics, Kyung Hee University Hospital, Seoul, Korea 2Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea 3Department of Pediatrics, Kangwon National University Hospital, Chuncheon, Korea 4Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea 5Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 6Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea 7Department of Pediatrics, Nowon Eulji Medical Center, Eulji University, Seoul, Korea 8Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Korea 9Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 pISSN 2287-9412 . eISSN 2287-9803 Copyright(c) 2022 By Korean Society of Neonatology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Original Article 29 Neonatal Med 2022 February;29(1):28-35 https://doi.org/10.5385/nm.2022.29.1.28 ing in Korea.

Duplication of genes encoding non - clathrin coat protein γ - COP in vertebrate , insect and plant evolution

(Yoon So Hahn),(Young Jae Lee),(Ji Hye Yun),(Seung Kyoung Yang),(Chang Won Park),(Kazuei Mita),(Tae Lin Huh),(Myung Chull Rhee),(Jae Hoon Chung) 경북대학교 유전공학연구소 2000 遺傳工學硏究所報 Vol.14 No.-

Slide Session : OS-ALG-01 ; Allergy : Progranulin Level Correlates with Degree of Airway Obstruction in Asthma Patients

( So Young Park ),( You Sook Cho ),( Bomi Shin ),( Hyo Jung Kim ),( So Young Park ),( Sun Young Yoon ),( Gyong Hwa Hong ),( Kyoung Young Lee ),( Mi Young Park ),( Sun Joo Park ),( Hyouk Soo Kwon ),( T 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Progranulin is a pleiotrophic protein known to function in various physiological and disease processes. Progranulin concentration negatively correlated with mediators of neutrophilic inflammation in COPD and it was implicated to have an anti-in. ammatory role. However, it has not been studied in asthma and speci. cally through what mechanistic pathway progranulin exerts its anti-in. ammatory effect. As a pilot study, we aimed to identify the presence of progranulin in asthma in order to relate with mechanism study in the future, which is another typical chronic airway in. ammatory disease. Methods: Progranulin levels in serum were measured by ELISA in asthma patients (n=475) and normal subjects (n=43) and was compared with pulmonary function and other various clinical parameters. Results: Progranulin concentration was significantly lower in asthmatics than in healthy subjects (25.51±6.72 vs 33.92±10.99, p<0.001). Progranulin level was compared within asthma patients according to their degree of airway obstruction, and the level showed positive correlation with FEV1% predicted. (R=0.400, p<0.001) Patients diagnosed with asthma/COPD overlap syndrome(n=39) showed lower progranulin level (21.88±5.96 vs 25.84±6.70, p<0.001) and poor lung function (FEV1% predicted, 57.00±17.63 vs 77.20±18.81, p<0.001) compared with patients with asthma(n=436) when subgroup analysis was performed. Conclusions: The results demonstrate progranulin concentration is lower in asthmatics and the level correlates with the degree of airway obstruction. Progranulin may be associated with pathogenesis of severe asthma with fixed airway obstruction.

한국인 글루코코르티코이드 유발 골다공증 진료지침

( So Young Park ),( Hyun Sik Gong ),( Kyoung Min Kim ),( Dam Kim ),( Hayoung Kim ),( Chan Hong Jeon ),( Ji Hyeon Ju ),( Shin-seok Lee ),( Dong Ah Park ),( Yoon-kyoung Sung ),( Sang Wan Kim ) 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.4

목적. 한국인의 글루코코르티코이드 유발 골다공증의 예방과 치료를 위한 진료 지침과 권고안을 개발하고자 하였다. 방법. 대한골대사학회와 대한류마티스학회는 한국보건의료연구원에서 작성한 임상진료지침 개발 매뉴얼에 따라 공동으로 진료지침을 개발하였다. 국내 연구 결과가 제한적인 점을 고려하여, 기존에 개발된 근거 중심 진료지침을 수용 개작하였다. 핵심 질문 선정과 진료지침의 체계적 고찰이 수행되었으며 질평가를 통해 선정된 진료지침을 대상으로 핵심 질문에 대한 대답과 권고안이 동료 검토를 통해 도출되었다. 결과. 본 진료지침의 적용 대상은 글루코코르티코이드를 사용하거나 사용할 계획인 19세 이상의 성인이며 소아 및 청소년은 포함하지 않았다. 골절 위험도의 초기 평가는 글루코코르티코이드 사용시작 6개월 내에 이루어져야 하며 장기간 사용시 12개월마다 골절 위험도를 평가해야 한다. 골절위험도는 글루코코르티코 이드의 용량을 보정한 FRAX, 과거 골다공증에 의한 골절력, 골밀도 결과 등으로 평가한다. 매일 프레드니솔론 2.5 mg 을 3개월 이상 복용하는 경우 적절한 칼슘과 비타민 D를 투여할 것을 권고한다. 중등도 이상의 골절 위험이 있는 환자들의 경우 골다공증 약제를 투여해야 한다. 가장 권고 수준이 높은 1차 약제는 경구 비스포스포네이트, 테리파라티드, 데노수맙이다. 가임기 여성은 골다공증 약제 사용에 주의가 필요하다. 글루코코르티코이드을 지속적으로 투여받는 환자들에 대해 매년 골밀도, FRAX를 이용한 골절위험도 평가 및 척추 단순 엑스선 검사를 시행할 것을 권고한다. 결론. 임상의들을 위한 글루코 코르티코이드 유발 골다공증의 예방과 치료에 대한 진료지침이 개발되었다. Objective. To develop guidelines and recommendations to prevent and treat glucocorticoid-induced osteoporosis (GIOP) in Korea. Methods. The Korean Society for Bone and Mineral Research and the Korean College of Rheumatology developed this guideline based on Guidance for the Development of Clinical Practice Guidelines version 1.0 established by the National Evidence-Based Healthcare Collaborating Agency. This guideline was developed by adapting previously-published guidelines, and a systematic review and quality assessment were conducted. Results. This guideline applies to adults aged 19 years or older who are using or plan to use glucocorticoids (GCs), but does not include children and adolescents. An initial assessment of fracture risk should be performed within 6 months of initial GC use. Fracture risk should be estimated using FRAX (Fracture Risk Assessment Tool) with adjustments for GC dose, previous osteoporotic fracture history, and bone mineral density (BMD) results. All patients taking more than 2.5 mg/day prednisolone or equivalent for more than 3 months are recommended to take adequate calcium and vitamin D. Patients at moderate to high fracture risk should be treated with additional osteoporosis medication. All patients continuing GC therapy should receive an annual BMD measurement, vertebral X-ray, and fracture risk assessment using FRAX. When a treatment failure is suspected, switching to another drug should be considered. Conclusion. This guideline is intended to provide guidance for clinicians in prevention and treatment of GIOP. (J Rheum Dis 2018;25:263-295)

Anti-Inflammatory and Whitening Activity Evaluation of 70% Ethanol Extract of Sea Urchin

So Hyeon Lee,Chang Ho Lee,Jong-Yi Park,Won Seok Choi,Kyoung Mi Yoon,Ki-Hyun Kim 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10