서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

위치검출기가 없는 브러쉬리스 직류전동기의 자기제어 시스템

尹炳道,金倫鎬,金一煥,金石根 중앙대학교 기술과학연구소 1990 기술과학연구소 논문집 Vol.20 No.-

The microcomputer control of a brushless do motor without a shaft position sensor is implemented. The motor produces a trapezoidal back EMF voltage. The control system is operated by two phase feeding. In the two phase feeding mode, it is possible to obtain the rotor position data from the terminal votage which is not conducting. Microcomputer reads the positon data from the terminal voltage and output the data to the inverter control module. Experimental results show that this system is application to the low power drives of less than one hp for low performance such as fan, pumps and fome appliances.

유도 허벅다리걸기 기술발휘 시 받기의 자세와 저항수준에 따른 운동학적 특성 분석 사례연구[Ⅰ]

김의환,윤현,김성섭 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

E. H. KIM, H. YOON, S. S. KIM. A Case Study on Kinematical Traits Analysis when Performing of Uchimata(inner thigh reaping throw) by Posture and Voluntary Resistance Levels(VRL) of Like in Judo[ I ]. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 235-257, 2004. The purpose of this study was to analyze the kinematical traits variables when performing Uchimata(inner thigh reaping throw) by Voluntary Resistance Levels(VRL) and two postures of Like in Judo. The subjects, who were one male judoka(YH) for 1992 Barcelona Olympic Games, and one male trainee Y. I. University representative member(SDK) and were filmed on two S-VHS 16 mm video cameras(60fields/sec.),that posture of Like were Shizenhontai(straight defensive posture) and Jigohontai(straight natural posture), VRL of like were 0% and 100%. The kinematical variables were temporal(total time-required:TR), potures and COG variables etc., The data of this study collection were digitized by SIMI Motion Program computed the mean values and the standard deviation calculated for each variables. When performing according to each posture and VRL, from the data analysis and discussion, the conclusions were as follows : 1. Temporal variables : total time-required(TR) when performing Uchimata was shown the shortest time YH than SDK by each posture and VRL. TR of each posture were shown the shorten trends or equal in DP by lower than NP, In existence and / or nonexistence of VRL was shown the shorten trends in VRL 0% than 100% of Like. 2. Posture variables : In attacking right knee angle, YH was performing flexion(147→103degree) from Tsukuri(set-up) to Kake(execution) in regardless of postures and VRLs, SDK was performing not exchange extension and flexion in VRL 100%, and extension(120i142degree) in VRL 0%, respectively. In supporting left knee angle, YH was perfoinring extension(1194163degree) from Tsukuri(set-up) to Kake(execution) in regardless of postures and VRLs, SDK extension(934 139degree), respectively. In attacking right hip angle, from Tsukuri to Kake, YH was performing extension(1334 169degree), except in VRL 0%(156 i137degree) NP, SDK was performing flexion(159i126degree) accept in VRL 100%(149 i152degree) NP, In left hip angle, from Tsukuri to Kake, YH was performing flexion NP(70, 50degree) more than DP(27, 57degree), SDK was performing flexion DP(73, 52degree) more than NP(34, 20degree). 3. COG variables : When performing Uchimata, vertical COG variables was shown YH(:2-8cm), SDK(:15-24cm) lower than Uke's COG level position, in existence and / or nonexistence of postures and VRL, during Kake as maximum force point of throwing techniques in Judo.

배자와 태아에서 하악골의 형태발생 및 교원질 발현에 관한 면역조직화학적 연구

국윤아,김상철,김은철,김오환,김정기 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.2

치아 위치에 영향을 미치는 악안면의 성장 발육에서 Meckel 연골발생전 후의 하악골 형성과정과 교원 단백질 분포 및 발현정도를 알아보고자 좌고를 측정하여 태령을 결정한 후 4주부터 38주까지 50례의 배자와 태아를 대상으로 통법에 따른 조직절편을 제작하였으며 Hematoxylin과 Eosin, Alcian blue-pas와 Goldner의 Masson Trichrome 염색, 그리고 제1형과 제2형 교원 단백질에 대한 면역조직화학 염색을 시행하였다. 좌고 20.5 MM 배자에서 Meckel 연골이 출현하였으며, 좌고 22mm에서 38mm까지 하악골 외방에 신생골을 형성하고, 좌고 60mm태아에서 Meckel 연골이 점유하던 공간이 신생골로 채워져 연골내골화가 뚜렸하게 관찰되었으나, 좌고 240mm에서 Meckel 연골이 거의 소실되었다. 교원질에 대한 면역 염색결과에서 Mackel 연골 출현전 제1형 교원질 발현은 주로 상, 하악돌기의 구강상피에 국한되어 관찰되었고 제2형교원질 발현은 상대적으로 약간 적었다. Meckel 연골 출현 및 신생골 형성시기는 제1형교원질이 주로 치제상피와 신생골에서 약양성의 발현을 보였으며, Meckel 연골 및 신생골에서는 제1형보다 제2형의 교원질이 많이 발현되었다. 막내골화시기에는 제1형 교원질이 골아세포 및 골기질에서 중등도로 발현되었으나, 제2형에서는 경미하게 나타나 Meckel 연골형성전 후 제2형에서 제1형으로 발현전환이 있었다. Underlying malocclusions and dentofacial deformities are often related to variations in the craniofacial development. Type I and type Ⅱcollagens are considered the major collagens of bone and cartilage respectively. Monitoring the patterns of those protein expressions during development will provide a basis for the understanding of normal and abnormal growths. This study was undertaken to investigate the morphogenetic changes and the expression patterns of type I and Ⅱcollagen proteins involved in the developing mandible of human embryos and fetuses. 50 embryos and fetuses were studied with Hematoxylin and Eosin, Alcian blue-PAS, Masson Trichrome, and Immunohistochemical stains. The results were as follows: 1. A 13.5mm embryo showed the stomatodeum with dental lamina, maxillary and mandibular processes. Meckel's cartilage appeared in the mandibular arch of a 20.5mm embryo. New bone formation was bilaterally initiated at the outer side of middle portion of Meckel's cartilage of 22-38 mm embryos. 2. Meckel' cartilage was resorbed at the 15th week fetus. The endochondral ossification was observed where there was direct replacement of cartilage by bone. Meckel' cartilage disappeared and membraneous ossification were observed at the 25th week. 3. Before the appearance of Meckel's cartilage, the expression of type I collagen was moderate at the odontogenic epithelium of maxillary & mandibular process, but mild for the expression of type Ⅱ collagen. 4. During the appearance of Meckel's cartilage and new bone formation, the immunoactivity of type Ⅱ collagen was more expressed than type I collagen at the Meckel's cartilage and new bone. 5. During intramembranous bone formation, the expression of type Ⅱcollagen was rare in the bony trabeculae. There was a switch for the expression of collagens from type Ⅱto type I during the appearance of Meckel's cartilage.

새로운 isoquinoline 유도체, AQ44의 혈관평활근 수축에 미치는 영향

김보경,김윤선,용준환,장병준,박태규,조성일,장기철,이상목 한국노화학회 1998 한국노화학회지 Vol.8 No.3

항정신병 약물이 Cyclooxygenase-2 유전자 발현과 Prostaglandin E_2 농도에 미치는 영향

김종우,조성욱,범재명,윤도준,장환일,송지영 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : Cyclooxygenase(COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acids. The action mechanism of nonsteroidal anti-inflammatory drugs is through inhibition of COX activity and prostanoid biosynthesis including prostaglandin E_2(PGE_2). The antipsychotic drugs are known having an analgesic effects, however its mechanisms of actions of action to pain control was not still clearly proved. In the present study, the effects of antipsychotic drugs(chlorpromazie and clozapine) on the production of PGE_2 and the expression of COX-2mRNA and protein in P815 cell line were studied. Methods : For that purpose, the methods of RT-PCR, western blot and prostagalndin E_2 enzymeimmunoassay were applied. Results : The results showed tha tin P815 cells treated with chlorpromazine, the level of COX2 mRNA was significantly decreased compared to the control cells. And total cellular PGE_2 levels were significantly decreased after treatment with chlorpromazine and clozapine. Conclusion : These results suggest that antipsychotic drugs have revealed their analgesic effect through the inhibition of COX-2 activity and PGE_2 production. And also, these results partly supports the excess theory of prostaglangdins in the pathogenesis of schizophrenia.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

수종 교정용 Band의 세포독성에 관한 실험적 연구

김상철,국윤아,유동환 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.2

The purpose of this study was to investigate the cytotoxicity of orthodontic bands in vitro and in vivo.4 types of orthodontic bands were applied to cultured fibroblast and the supernatants were injected into dorsal subcutaneous tissue of mice. In vitro, the cytotoxixity was evaluated by an MTT assay after 2 and 6days. IN vivo, the histopathologic observation was performed 2 days after injection. The results were: 1. The cell viability was significantly decreased in the group added phosphoric acid in comparison to control group, but there was not any significance among the experimental group after 2 days. 2. Cell viability decreased in the high Ni containing group after 6 days. 3. The histopathological finding was that the Cr-containing group showed severe infiltration of inflammatory cells and muscular destruction.

대장암에서 Glucose Transporter Gene의 발현

이석환,박재훈,김윤화,오수명,윤충,주흥재,이기형 대한대장항문학회 2000 Annals of Coloproctolgy Vol.16 No.2

電流 制御形 共振形 컨버터를 위한 大信號 및 小信號 모델

金倫鎬,尹炳道,尙枓換 중앙대학교 기술과학연구소 1990 기술과학연구소 논문집 Vol.20 No.-

Recently resonant converter is being widely used and studied throughout the industrial applications. However, it is too difficult to understand the general conception of resonant converter because of the analysis of power circuits and various output control methods. This paper gives the general conception of resonant converter power circuits and describes the various output control methods. In this paper the pulse width modulation using discontinuous conduction mode is applied to a fullbridge series resonant converter to regulate the output from no load to full load with low switching loss and with a narrow range of frequency variation. Finally, a simple nonlinear discrete-time dynamic model for this converter is derived using approximation. This discrete time model is linearized and a general input - output transfer function for the converter is derived.