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Characterization of a Constitutive β-Lactamase from a Pseudomonas aeruginosa
유진홍,허동호,최정현,김양리,신원식,강문원 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2
Objective : We analyzed some physicochermical chracteristics of a constitutive β-lactamase from a clinical isolate of a Pseudomonas aeruginosa which resistant to various β-lactams except imipenem and susceptible to aminoglycosides the proportion of its contribution to such resistance profile. Method : 1. Antimicrobial susceptibility test was done by the broth dilution method. 2. In hibition profile was done using EDTA, HgCl₂ and p-chloromercuribenzoate (pCMB). We also measured 50% inhibitory concentration(IC??) using β-lactamase inhibitors, such as clavulanic acid, sulbactam. 3. Kinetics study for substrate profile was performed by spectrophotometric assay using crude extracts and various antimicrobial agents. Relative hydropysis rates were determined. 4. The isoelectric point(pI) was determined by isoelectric focusing. The molecular weight was estimated by SDS-polycrylamide gel electrophoresis. Results : 1. The strain was resistant to ceftriaxone, sulperazon, piperacillin, ceftazidime, and aztreonam, while it was susceptible to gontamicin, tobramycin, amikacin and imipenem. 2. The β-lactamase was not inhibited by EDTA, and pCMB, whereas it was inhibited by HgCI₂. The IC?? of clavulanic acid was over 100μM and that of sulbactam was 22μM. 3. The relative maximal hydrolysis rate was calculated by setting V_(max) for cephaloridine at 100. The enzyme hydrolyzed cephalosporins more rapidly than penicillins. 4. The pI was 9.3 by isoelectric focusing. The molecular weight was estimated to be 40kDa. Conclusion : According to its substrate profile, pI and molecular weight, the β-lactamase from a clinical isolate of P. aeruginosa was a cephalosporinase belonging to group 1 in the Bush-Jacoby-Medeiros classification scheme.
Poly(ρ-phenylenesulfide)와 Poly(ρ-phenylene)으로부터 제조된 탄소의 리튬 이온 2차전지 anode 재료로서의 전기화학적 특성
유덕영,이주성,박수길,변지형,류신환,정윤이 한양대학교 에너지·환경기술연구소 1998 에너지·環境技術論文集 Vol.4 No.-
Poly(p-phenylenesulfide)와 poly(p-phenylene)으로부터 제조된 탄소를 리튬이온 2차전지용 음극재료로 사용하여 전기화학적특성을 연구하였다. 이들 고분자들을 질소 분위기하에서 승온속도 2℃/min로 1000℃까지 상승시킨 후, 1시간 동안 탄화시켜 탄소를 제조하였다. Poly(p-phenylene)으로부터 제조된 탄소가 보다 더 규칙적인 구조를 가지기 때문에 Poly(p-phenylenesulfide)으로부터 제조된 탄소보다 더 많은 용량과 충방전 효율을 나타내었다. 수산화리튬과 염화주석(Ⅱ)을 첨가하여 용량의 증가와 충방전 효율의 증가를 가져올 수 있었다. 이중에서 poly(p-phenylene)에 염화주석(Ⅱ)을 첨가시켜 제조된 탄소가 가장 큰 충방전 용량과 충방전 효율의 향상을 가져왔다. Carbon inaterials manufactured from poly(p-phenylene sulfide) and poly(p-phenylene), were studied on electrochemical characteristics as anode materials for lithium ion secondary battery. These polymer precursors were heat treated for 1hr at 1000℃ with the rate 2℃/min under nitrogen atmosphere. Carbon manufactured from poly(p-phenylene) showed higher capacity and coulomb efficiency of charge/discharge than carbon from poly(p-phenylene sulfide) because the former has better ordered structure. Carbon manufactured from polymer precursors adding stannous chloride or lithium hydroxide showed higher capacity and better efficiency of charge/discharge. Also, carbon manufactured by adding stannous chloride to poly(p-phenylene) showed the highest capacity and efficiency of charge/discharge.
유일근,신정태 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-
Since the technology is one of the most important factors for national and cooperate competition, the development of new and profitable technologies is highly emphasized. Then the question occurs for the new technology as how much it would be profitable and valuable. To solve such a problem the Point assessment system(PAS) is developed in this paper. The PAS would provide sales price and mortgage value for technology assets. For this purpose, this paper include the analysis of existing PA methodologies throughout the world to find the differences and features to make new and improved assessment factors. In order to enhance objectivity of qualitative characteristics of technology, PAS suggests 10 factors for assessment. The 10 factors were divided into three groups that consist of technology feature, technology environment and economic environment. Various pointing questionnaires are provided for each 10 assessment factor in order to calculate the total grade and value of the given technology.
아로마 요법이 뇌졸중환자의 자율신경계와 스트레스에 대한 신체 저항도에 미치는 효과
신유선,조영숙,정유진 대한기초간호자연과학회 2004 Journal of korean biological nursing science Vol.6 No.2
Purpose : The purpose of this study is to determine effects of aromatherapy on the activity and balance of autonomic nervous system and on physical resistance to stress. Methods : This research is a primitive experimental design which attempts to analyze aromatherapy EKG monitoring on real-time basis. Lavender & Chamomile, each 30 drops, were blended with 100ml Sweet Almond oil. Subjects was laid relaxed, and had insides of his wrists and ankles attached with electrodes for EKG. Right after applied with essential oil onto his philtrum and parotid, started on EKG monitoring. Results : The activities of parasympathetic and sympathetic nerve were changed as time elapsed, with significant differences(p=.000). In multiple comparison, the value was significantly different (p<.05).The balance of autonomic nerve was changed, becoming close to the normal level in accord with applicable international standards(1.5)(p=.011). In multiple comparison, the value showed a significant difference(p<.05). Physical resistance to stress increased with the passage of time, but not statistically significant. Conclusions : This suggests that aromatherapy can be used as a nursing intervention which aims at alleviating symptoms related to the imbalance of autonomic nerve system such as headache, hot flashes, irregular heartbeat, nervousness, depression and anxiety.
Al-Mg합금(Al-5wt%Mg-3wt%Zn-1wt%Mn)의 T6 열처리에 따른 미세조직 및 기계적 특성변화
유정훈,신기삼,허성강,김정민 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-
Al-Mg base alloys are attractive for aircraft. automobile and leisure applications because of their properties of low density, high intensity and wear resistance. The effect of Zn and Mn on the properties was studied in an Al-Mg base alloy. After T6 heat-treatment, the change of the microstructure and mechanical property was examined. Our investigations show that after T6 heat-treatment, the elongation was improved. The microstructures are investigated by TEM, which shows that the size of Al6Mn, Al57Mn12 phase is 100~500nm, and it also appears presence of the very small size MgZn₂ phase about 30nm.
혈액질환 환자에서 조혈모세포 이식과 화학요법 후의 침습성 진균감염의 분석
유진홍,최정현,이동건,최수미,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.1
목적 : 조혈모세포 이식이나 화학요법을 받은 혈액질환 환자에서 침습성 진균감염의 양상을 분석하고 예후 인자를 정하기 위하여 이 연구를 실시하였다. 방법 : 2000년 3월부터 2001년 2월까지 가톨릭 조혈모세포이식센터에 입원한 318명의 환자들 중 진균 감염으로 의심되어 항진균제를 투여받은 122명의 환자를 대상으로 후향적 분석을 실시하였다. 결과 : 74명의 환자가 EORTC/MSG 기준에 의해 침습성 진균증으로 판정되었다. 이들 중 6명이 확진이었고, 46명이 추정, 22명이 가능 증례이었다. 가장 많이 침습된 장기는 하부 호흡기이었다(72/74). 사망률은 32.4%이었다. 단변량 분석으로 예후 인자를 도출한 결과 입원 기간, 진단까지 걸린 시일, 그리고 amphotericin B의 총 투여량이 유의한 인자로 나왔다. 그러나 다변량 분석을 시행한 결과 입원 기간만이 독립적으로 유의하게 영향을 미치는 예후 인자로 산출되었다. 결론 : 침습성 진균 감염은 현재도 조혈모세포 이식이나 화학요법 후의 중요한 합병증으로 작용하고 있음을 알 수 있었다. 진균 감염 합병증의 예후에 영향을 미치는 요소로 입원 기간이외에 진단의 신속성과 항진균제의 투여도 유의한지에 대해서는 후속 연구를 통해 재치 규명해야 할 것으로 생각된다. Background : Invasive fungal infections (IFI) are one type of representing total infections in compromised patients. To analyze the characteristics and to determine the prognostic factors of IFI in patients with hematologic diseases undergoing hematopoietic stem cell transplantation (HSCT) and/or chemotherapy. Methods : We retrospectively reviewed consecutive patients (n=122) who received antifungal treatment with the impression of fungal infection complicating post-HSCT or chemotherapy from March-2000 to February-2001. Results : Seventy-four out of 122 registered patients belonged to the IFI on the basis of EORTC/MSG criteria. Six patients were proven IFI, 46 were probable, and 22 were in the category of possible one. The most commonly involved organ was lower respiratory tract (72/74). The mortality was 32.4%. Univariate analysis revealed duration of hospitalization, days to diagnosis of IFI, and total amount of amphotericin B as significant prognostic factors. But multivariate analysis determined only duration of hospitalization from these variables as an independently influencing factor on the prognosis. Conclusion : Invasive fungal infection is still the major threatening complication of HSCT and chemotherapy. Further follow-up and extension of this study is necessary to elucidate more prognostic factors.
Modified 9Cr-1Mo 강의 항온변태처리에 따른 미세조직 및 경도변화
유정훈,주성욱,허성강,신기삼,이수,정연길 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-
Evolution of microstructure and its relation with hardness in the modified 9%Cr-1%Mo steel which was isothermally heat-treated has been investigated in various heat-treatment temperatures and time of duration. For microstructural and crystallographic analyses, optical microscope, scanning and transmission electron microscopes, energy dispersive spectrometer, and X-ray diffractometer were used. Vickers microhardness tester were used for the measurement of hardness. Precipitates of the complex M23C6, M(C,N) formed at grain boundaries and interiors of grains had led to the secondary hardening. Normalized specimen and all of the isothermally heat-treated ones showed no evidence of retained austenite.