중장년층에서의 외상성 견관절 탈구

이광원,류창수,김하용,안재훈,염진섭,김환정,최원식 대한견.주관절학회 2000 大韓肩.주關節學會誌 Vol.3 No.2

Polyester에 대한 Methacrylic acid 의 방사선에 의한 Graft Copolymerization.

박용성,이진국,안원재 서울산업대학교 1977 논문집 Vol.10 No.1

The grafting of methacrylic acid to polyester fiber with high dose rate of electromagneic radiation techniques has been studied. The polyester fiber which had been impregnated by the monomer mixture solution was made constant to pickup % and allowed to mutual dosage under the air. The apparent graft %, conversion %, and graft efficiency were improved as the dose rate increase. The graft polymerization reaction was greatly affected by the variation of the concentration of swelling agents and solvent.

알콜성 간질환 및 스테로이드를 장기 복용한 환자에서 내시경하 위조직 검사상 발견된 분선충 감염 1예

김영호,김남훈,이영희,김영관,조연희,김진범,곽재영,이명기,황이숙,김규식,이영록,용태순 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5

Strongyloides stercoralis is distinguished by a capacity, unusual among helminths to replicate within the human host, thereby permitting on going cycle of autoinfection due to internal production of internal larvae. It has a worldwide distribution but is much more common in tropical climates where the warm, moist soil offers an environment suited to the development of the larvae. In immunocompromised hosts who receiving corticosteroids, immunosupressive drugs, or radiotherapy in these with AIDS, large numbers of invasive strongyloides larvae can disseminate widely and be fatal. The presents case is a 76 year-old-woman presenting with vomiting and epigastric pain. The patient had a long history of adminstration of steroid and alcohol. A gastrofibroscopic biopsy and stool examination revealed rhabditoid larvae. The patient seems to have suffered from autoinfection with S. stercoralis. We report this case with the review of literatures.

Increase in the Biocompatibility of the Neutralized Chitosan Dermal Scaffold by Reconstruction of Wound Healing Microenvironment: In Vitro Study

Youn, Yong Ha,Kim, Chun Ho,Choi, Young Ju,Gin, Yong Jae,Son, Young Sook Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342-343 No.-

<P>The porous neutralized chitosan scaffold (NCS) was prepared by freeze-dry method. Its poor cell binding capacity was improved approximately five folds by mixing or coating of atelomeric type I collagen. In order to recreate wound-healing microenvironment within the NCS for the better wound healing effect, various concentrations of bFGF and fibronectin (FN) were supplied in the secondary freeze-dry process of the scaffold. NCS+ bFGF and NCS+FN improved the cell binding capacity by four folds and three folds respectively. Therefore supplementation of collagen, b-FGF and/or fibronectin in the NCS can improve the biocompatibility of the chitosanbased scaffold which itself revealed poor cell binding capacity.</P>

부지특성 자료 및 평가 결과의 관리 체계

김수진(Soo-Gin Kim),정재열(Jae-Yeol Cheong),조현진(Hyun-Jin Cho),하창용(Chang-Yong Ha) 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10

방사성폐기물처분시설(이하 ‘처분시설’)은 방사성폐기물을 인간 생활권으로부터 영구히 격리하기 위해 허가된 시설이며, 국내에는 경북 경주시 문무대왕면 일대에 중·저준위방사성폐기물을 수용할 수 있는 처분시설이 운영되고 있다. 처분시설은 방사성핵종의 이동을 지연시키거나 제한할 수 있는 인공구조물인 공학적방벽과 공학적방벽을 둘러싼 토양 및 암반 등을 포함하여 누출된 방사성핵종의 이동을 지연시킬 수 있는 천연방벽으로 구성된다. 처분시설을 운영하려면 정상적인 자연현상이나 자연적 또는 인위적 요인으로 비롯된 예상하기 어려운 현상으로 인한 방사선적 위험이 성능목표치 이하임을 규명해야 한다. 성능목표치 만족을 위한 공학적방벽의 설계 또는 인수기준 등을 수립하기 위해서는 천연방벽의 특성을 확인하는 것이 매우 중요하다. 처분시설 인허가 취득을 위해서는 부지안전성평가 결과를 제시해야 하며, 정확한 결과를 도출하기 위해서는 기상, 수문, 지질, 지진, 지질공학, 지구화학 등 부지 조사 결과의 품질이 매우 중요하다. 처분시설 운영 중에는 부지안전성평가를 통해 예측한대로 수리지질학적 환경이 진화하는지 여부를 확인하는 목적의 부지감시 활동을 수행하며, 지진 등의 이벤트 발생 또는 일정 주기로 처분시설 성능목표에 영향을 줄 수 있는 부지안전성을 재평가한다. 처분시설은 처분된 방사성폐기물로 인한 방사선적 위험도가 낮아질 때까지 매우 장기간 운영하며, 초기 개발단계부터 운영, 폐쇄까지 수많은 종류의 부지특성 자료 및 평가 결과가 생성된다. 본 연구에서는 국내·외 사례를 바탕으로 장기간 대량으로 발생하는 처분시시설의 부지특성 자료 및 평가결과를 어떻게 체계적으로 관리하는지에 대한 방안을 도출하고자 한다.

지열을 이용한 온실용 냉난방시스템 개발

이용범(Lee, Yong-Beom),조성인(Cho, Seon-Gin),이재한(Lee, Jae-Han),김태원(Kim, Tae-Won) 한국신재생에너지학회 2005 한국신재생에너지학회 학술대회논문집 Vol.2005 No.06

Importance of substitute energy has been increasing due to environmental issues and lack of fossil fuels. In addition, heating cost that occupies from 30 to 40% of the total production cost in Korean protected cultivation needs to be reduced for profitability and global competition. But, studying on substitute energy to solve these problems has not been activated for Korean protected cultivation. Therefore, this study was conducted to develop a geothermal heat pump system for cool ing and heat ing of greenhouses at a lower cost than conventional hot air heater and air conditioner. Fundamental test of heat transfer characteristics in soil was conducted by computer simulation and controlled tests for its verification. Based on the results of the theoretical and empirical investigations, an optimum heat pump system was developed and the performance was evaluated for practical use in a greenhouse at the Pusan Horticultural Experiment Station. The system was compared with a conventional hot air heating system through a cucumber growing test and economic feasibility analysis. Results of the application test of the geothermal heat pump showed that with an initial setting of 15?C the inside temperature of the greenhouse could be maintained between 15 and 17?C. Results of the cucumber growing test showed that there were no significant differences in average height, leaf length, leaf width, number of nods, leaf area, dry weight and yield between the plots wi th the geothermal heat pump system and a conventional hot air heater. Economic feasibility analysis indicated that the variable cost of the hot air heater could be saved 81.2% using the geothermal heat pump system. It was concluded that the geothermal heat pump system might be a pertinent heating and cooling system for greenhouses because of the low operating cost and the use of environment-friendly geothermal energy.

Clinicopathologic Characteristics of Barrett`s Cancer in Korea

( Jun Won Chung ),( Gin Hyug Lee ),( Hwoon Yong Jung ),( Kee Don Choi ),( Ho June Song ),( Kwi Sook Choi ),( Hyung Chul Oh ),( Kee Wook Jung ),( Jae Won Choe ),( Jeong Won Kim ),( Eun Sil Yu ),( Jin H 대한소화기학회 2008 Gut and Liver Vol.2 No.3

Background/Aims: The incidence of Barrett`s cancer is increasing in Western countries, but there have been only a few case reports of this condition in Korea. The aim of this study was to elucidate the endoscopic and pathologic characteristics of Barrett`s cancer in a single center in Korea. Methods: We retrospectively reviewed the demographic, endoscopic, and pathologic characteristics of six patients with Barrett`s cancer, defined as a tumor centered above the esophagogastric junction and surrounded by Barrett`s esophagus. Results: All six patients were male, and three (50%) were symptomatic. Barrett`s cancer had developed from short-segment Barrett`s esophagus in all patients. All tumors were located on the right side of the lower esophagus and showed hyperemic mucosal changes. Three patients were treated surgically and three by endoscopic resection. All cases had pathologic evidence of Barrett`s cancer. Conclusions: Early detection of Barrett`s cancer requires meticulous endoscopic observations of subtle mucosal color and morphological changes around the esophagogastric junction. (Gut and Liver 2008;2:193-198)

무증상 한국인에서 대장 종양의 유병률 및 대장암 선별검사로서 대장내시경 검사의 역할

장혜숙 ( Hye Sook Chang ),최재원 ( Jae Won Choe ),양석균 ( Suk Kyun Yang ),명승재 ( Seung Jae Myung ),정훈용 ( Hwoon Yong Jung ),이진혁 ( Gin Hyug Lee ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( Young Il Min ) 대한장연구학회 2003 Intestinal Research Vol.1 No.2

목적: 최근 대장암의 선별검사로서 대장내시경 검사의 중요성이 강조되고 있으나, 이에 대한 국내 연구는 미비하다. 저자들은 무증상 한국인에서 대장 종양의 유병률을 알아보고, 대장암의 선별검사로서 대장내시경 검사의 역할에 대해 알아보고자 하였다. 대상 및 방법: 1998년 3월부터 2002년 7월까지 서울아산병원 건강증진센터에서 대장내시경 검사를 시행받은 3,325명의 검진자 중 직장 출혈, 최근 배변 습관의 변화, 대장암 또는 용종의 가족력이나 과거력, 염증성 장질환이나 대장 수술의 과거력 및 지난 10년 이내에 대장 내시경 검사나 대장조영술을 시행받은 적이 있는 환자 1,106명 및 대장내시경 검사가 불완전하게 시행된 11명을 제외한 2,208명을 대상으로 대장 종양의 빈도와 특성을 분석하였다. 결과: 대상군의 평균 나이는 49.2±10.1세였으며, 남자가 1,564명(70.8%)이었다. 대장 종양의 유병률은 선종 18.3%, 진행성 선종 2.0%, 대장암 0.3%이었으며, 50세 이상의 경우에는 각각 25.8%, 3.0%, 0.5%이었다. 남녀 모두 연령이 증가할수록 대장 선종, 진행성 선종 및 대장암의 빈도가 증가하였으며(p for trend<0.05), 여자보다 남자에서 대장 선종의 유병률이 유의하게 높았다(21.0% vs 12.0%, p<0.001). 한편 근위부 대장에서 종양이 발견될 확률은 원위부 대장에 종양이 있는 경우 26.0% (53/2004)로서 원위부 대장에 종양이 없는 경우의 10.3% (207/2004)보다 유의하게 높았다(p<0.001). 그러나 근위부 대장에서 관찰되는 진행성 종양의 69.2% (18/26)가 원위부 대장에 이상이 없이 고립성으로 존재한 경우였다. 결론: 무증상 한국인에서 대장 종양의 유병률은 서양에 비해 다소 낮은 경향이 있으며 또한 남녀 사이에 차이를 보인다. 따라서 한국에서의 대장암 선별검사의 지침을 마련하는데 있어 이러한 점들이 고려되어야 할 것이다. 한편 원위부 대장에 종양이 있는 경우에는 그렇지 않은 경우에 비해 근위부 대장에서 종양이 발견될 확률이 높아지지만, 원위부 대장에 종양이 있는 경우에만 대장내시경 검사를 할 경우 근위부 진행성 종양의 약 2/3를 놓치게 된다. 따라서 대장암 선별 검사로서 대장내시경 검사는 매우 유용한 것으로 생각된다. Background/Aims: Recent studies have reported the importance of screening colonoscopy for colorectal cancer. However, the prevalence of colorectal neoplasms in asymptomatic Korean population has not been determined until now. The purpose of this study was to evaluate the prevalence of colorectal neoplasms in asymptomatic Korean population and to assess the role of colonoscopy in colorectal cancer screening. Methods: We reviewed the endoscopic and pathologic reports of 3,325 patients who underwent colonoscopy at the Health Promotion Center, Asan Medical Center, from 1998 to 2002. Of them, 2,208 asymptomatic patients who underwent colonoscopy for the purpose of colorectal cancer screening were enrolled. Results: The mean age was 49.2 years and 70.8% were men. The overall prevalence of colorectal neoplasms was 18.6% and the prevalence among patients 50 years of age or older was 26.3%. The prevalence of neoplasms increased with age and was higher in the male. Patients with distal neoplasms were more likely to have proximal neoplasms than those without distal neoplasms. However, 69.2% of the patients with advanced proximal neolplasms had no synchronous distal neoplasms. Conclusions: The prevalence of colorectal neoplasms in asymptomatic average-risk Koreans seems to be lower than that in corresponding Westerns and shows a gender-difference. These results should be considered when establishing a guideline for colorectal cancer screening in Korea. Over half of the patients with advanced proximal neoplasms will not be detected if only those with distal neoplasms undergo colonoscopic screening. Therefore, colonoscopy may be useful as a screening test for colorectal cancer. (Intestinal Research 2003;2:179-185)

Improvement of the Biocompatibility of Chitosan Dermal Scaffold by Rigorous Dry Heat Treatment

Kim, Chun-Ho,Park, Hyun-Sook,Gin, Yong-Jae,Son, Young-Sook,Lim, Sae-Hwan,Park, Young-Ju,Park, Ki-Sook,Park, Chan-Woong The Polymer Society of Korea 2004 Macromolecular Research Vol.12 No.4

We have developed a rigorous heat treatment method to improve the biocompatibility of chitosan as a tissue-engineered scaffold. The chitosan scaffold was prepared by the controlled freezing and lyophilizing method using dilute acetic acid and then it was heat-treated at 110$^{\circ}C$ in vacuo for 1-3 days. To explore changes in the physicochemical properties of the heat-treated scaffold, we analyzed the degree of deacetylation by colloid titration with poly(vinyl potassium sulfate) and the structural changes were analyzed by scanning electron microscopy, Fourier transform infrared (FT-IR) spectroscopy, wide-angle X-ray diffractometry (WAXD), and lysozyme susceptibility. The degree of deacetylation of chitosan scaffolds decreased significantly from 85 to 30% as the heat treatment time increased. FT-IR spectroscopic and WAXD data indicated the formation of amide bonds between the amino groups of chitosan and acetic acids carbonyl group, and of interchain hydrogen bonding between the carbonyl groups in the C-6 residues of chitosan and the N-acetyl groups. Our rigorous heat treatment method causes the scaffold to become more susceptible to lysozyme treatment. We performed further examinations of the changes in the biocompatibility of the chitosan scaffold after rigorous heat treatment by measuring the initial cell binding capacity and cell growth rate. Human dermal fibroblasts (HDFs) adhere and spread more effectively to the heat-treated chitosan than to the untreated sample. When the cell growth of the HDFs on the film or the scaffold was analyzed by an MTT assay, we found that rigorous heat treatment stimulated cell growth by 1.5∼1.95-fold relative to that of the untreated chitosan. We conclude that the rigorous dry heat treatment process increases the biocompatibility of the chitosan scaffold by decreasing the degree of deacetylation and by increasing cell attachment and growth.

Novel Endoscopic Criteria for Predicting Tumor Invasion Depth in Superficial Esophageal Squamous Carcinoma

최지영,Suh Eun Bae,Ji Yong Ahn,이정훈,Young Soo Park,Do Hoon Kim,Kee Don Choi,Hye-Sook Chang,Ho June Song,Gin Hyug Lee,Jae Won Choe,Se Jin Jang,정훈영 대한의학회 2020 Journal of Korean medical science Vol.35 No.41

Background: Accurate prediction of tumor invasion depth in superficial esophageal squamous carcinoma (SESC) is essential for deciding the appropriate treatment strategy. We proposed novel endoscopic criteria to differentiate between mucosal and submucosal esophageal cancers and to evaluate the diagnostic accuracy and usefulness of the criteria. Methods: A total of 352 patients who underwent endoscopic or surgical resection for SESC between 1991 and 2010 were included. First, the novel endoscopic criteria were created based on the endoscopic features of 60 randomly selected patients as follows: for T1m cancers, I. flat or slightly elevated or depressed lesion with smooth/even surface of any size, II. slightly elevated lesion of ≤ 1 cm with granular or uneven surface, III. hyperemic flat lesion of ≤ 3 cm with granular or uneven surface, IV. slightly depressed lesion of ≤ 2 cm with uneven surface and for T1sm cancers, I. irregularly (unevenly) nodular or protruded lesion of any size, II. slightly elevated lesion of > 1 cm with granular or uneven surface, III. hyperemic flat lesion of > 3 cm with granular or uneven surface, IV. irregularly (unevenly) depressed lesion of > 2 cm, and V. ulcerative lesion of any size. Next, the endoscopic findings of the remaining 292 patients were reviewed according to the criteria. Results: The accuracy of novel endoscopic criteria was 79.5% (232/292). The sensitivity and specificity of mucosal cancers were 78.4% and 81.0%, respectively, whereas those for submucosal cancers were 81.0% and 78.4%, respectively. The accuracy for mucosal cancers was high (97.3%, 72/74) when the lesions were flat or slightly elevated/depressed with smooth/even surface regardless of size, whereas that for submucosal cancers was high (85.7%, 18/21) when the lesions were irregular/nodular protrusions regardless of size. In multivariate analysis, macroscopic type IIb lesion was identified as an independent factor affecting accuracy (P < 0.05). The difference in recurrence-free survival rates between endoscopically mucosal and submucosal cancers was significant (P = 0.026). Conclusion: The novel endoscopic criteria appear to be accurate and useful in predicting invasion depth in SESC. Our criteria might help not only to decide the treatment strategy between surgery and endoscopic resection but also to predict the outcomes of SESC.