아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

실버타운 개발에 대한 의식분석

鄭憲永,崔容壽 釜山大學校 都市問題硏究所 1997 都市硏究報 Vol.5 No.-

In this paper, the consciousness about Silver Town was analyzed through the questionnaire survey and some considerations of the way of development in Silver Town were conducted. The conclusions in this paper are shown as follows ; (1) The respondents feel concern about their health above all in their old age and they want to live independently without their child. (2) They want to live at a small apartment complex where is located far from city about 1 hour. (3) They feel sensitively about living-in cost. (4) They think that the most important facilities at the Silver Town are hospital and health care center. (5) Since the increasing of the aged is a kind of social phenomena, the government should consider a counterplan for the aged.

分割最適電力潮流計算의 改善에 관한 硏究

李鳳容,金正勳 弘益大學校 1981 弘大論叢 Vol.13 No.-

Nonlinear optimization models for econmoic power system operations are particularly attractive, because, in these models, active as well as reactive power can be taken into consideration so that more saving in fuel cost can be expected and voltage-reactive power control can simultaneously be achieved. However, speed and reliability of convergence remain as the main obstacles to be considered in real-time power systems. To overcome the above-mentioned shortcoming, Newton-Raphson decoupled optimal load flow was extended and convergence characteristics were improved in this study. The results showed an acceptable convergence with which the real-time operation is possible. Further, it is noted that voltage-reactive power control could effectively be performed. The savings to the total system fuel cost were 0.7%, or to equivalent fuel cost for transmission loss 30%, which amounts to 6 billion [won] annually with assumed load level. 1. 序 論 2. 分割最適潮流計算 要約 3. 水火力協調系統에서의 考慮 4. 한 母線에 連結된 多數機의 境遇 5. 電壓과 變壓器의 탭 6. 潮流計算의 收????特性改善 7. 燃料費 最少化 過程의 收????特性改善 8. 實規模系統에의 適用結果 9. 結 論 Nonlinear optimization models for econmoic power system operations are particularly attractive, because, in these models, active as well as reactive power can be taken into consideration so that more saving in fuel cost can be expected and voltage-reactive power control can simultaneously be achieved. However, speed and reliability of convergence remain as the main obstacles to be considered in real-time power systems. To overcome the above-mentioned shortcoming, Newton-Raphson decoupled optimal load flow was extended and convergence characteristics were improved in this study. The results showed an acceptable convergence with which the real-time operation is possible. Further, it is noted that voltage-reactive power control could effectively be performed. The savings to the total system fuel cost were 0.7%, or to equivalent fuel cost for transmission loss 30%, which amounts to 6 billion [won] annually with assumed load level.

표고 폐골목으로 제조한 목질보드의 성질

최용순,황원중,한태형,김남훈,권진헌 江原大學校 森林科學硏究所 1998 Journal of Forest Science Vol.14 No.-

要約표고폐골목의 재활용을 목적으로 폐골목과 정상재의 칩을 일정비율로 혼합하여 얻은 목질보드의 성질을 조사, 검토하였다. 그 결과 폐골목의 목섬유는 정상재보다 다소 짧고 표 면이 거칠었으며 폐골목 변재부의 밀도는 정상재에 비해 상당히 낮았다. 파티클보드의 두께 팽윤율 및 파괴계수의 시험결과 폐골목을 25~50% 정도 혼합한 경우는 정상재와 비슷한 값 을 나타냈다.결론적으로 폐골목은 파티클보드의 재료로 사용될 수 있고 정상재와의 혼합비율은 25~50% 범위에서 조정되어야 할 것으로 생각되었다.ABSTRACTTo provide further information for reutilization of the bed-logs decayed by oak mushroomfLentinus edodes), the properties of wood-based board prepared with mixed materials of normal wood and bed-logs were examined.Wood fibers in bed-logs showed different morphology from normal wood fibers, that is, shorter length and rough surface. Thickness swelling increased with increasing mixing ratio of bed-log. On the other hand, modulus of rupture(MOR) in bending strength decreased. In products, the visual surface of board prepared from higher mixing rate of bed-log chips was smooth.Consquently, it is considered that the optimum mixing rate of bed-log to normal wood is the range of 25-50% and the bed-log can be used for raw material of board instead of normal wood.

갈치속젓의 휘발성성분에 관한 연구

김훈,장성민,윤성숙,박승영,김소정,차용준 Institute of Genetic Engineering Changwon National 1999 Gene and Protein Vol.3 No.1

Volatile components in salt-fermented hair tail viscera were anlayzed by simultaneous steam distillation-solvent extraction method and gas chromatography/mass spectrometry method. Seventy four compounds were detected and composed mainly of aldehydes(15 compounds), ketones(7), alcohols(13), nitrogen containing compounds(5), esters(6), sulfur containing compounds(4), aromatic compounds(10) and miscellaneous compounds(14). Among these, some compound groups which were known to have generally the low flavor thresholds, such as aldehydes, ketones, nitrogen containing compounds, esters having low molecular weight and sulfur containing compounds, were supposed to be having major effects on the overall flavor of salt-fermented hair tail viscera.

Anisakids larvae의 형태학적 분류 : 해산어류 및 두족류를 중심으로 On the Marine fishes and Cephalopoda

이정훈,정영모,한성용,손성원 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-

In order to study classification of the morphological features and types of anisakids larvae eight species of marine fishes and two cephalopoda purchased in the near southern sea in Korea, were investigated and classified into the morphological characteristics of each type of the larvae, and the following results were obtained on the basis of the methods of Berland(1961), Koyama et al(1969) and Chai et al(1986). 1. Anisakis(typeⅠ) larva: The length and width of nematode are 14.2∼26.4mm and 0.22∼0.51mm respectively. The anterior region has well-developed boring tooth. Tail is 0.09∼0.12mm and the tip of tail has a globular form and well-developed a mucron. 2. Terranova (type A) larva: The length is 24.5∼34.1mm and longest among anisakids larvae. Width is 0.50-0.84mm, and intestinal cecum had reached one-third of anterior larva of ventriculus, and the worm has three lips at anterior end, and had boring tooth on the lips. The tail is 0.08∼0.12mm and has well-developed a mucron. 3. Raphidascaris spp. larva: The nematode was 8.20∼8.42mm in length and 0.21∼ 0.29mm in width. The anterior region has boring tooth. Especially, the genital organ was developed. The tail is 0.11∼0.12mm and has well-developed mucron at the tip of it. 4. Contracaecum(type A) larva: The nematode was 6.8∼9.4mm in length and 0.09∼ 0.15mm in width. The lips were depressed. The Anterior region do not have boring tooth. The tail is 0.08∼0.09mm relatively short and has about 15∼30 micro-spines and mucron at its terminal portion. 5. Contracaecum (Type A') larva: The nematode was 17.5∼24.4mm in length and 0.22∼0.27mm in width. The lips were depressed and the anterior region does not have boring tooth as the type of Contracaecum A. The tail whose length was 0.20∼0.31mm was very long and had about 7∼12 minutes spines at its terminal portion. 6. Contracaecum (Type C) larva: The worm was 13.6∼35.2mm and 0.28∼0.60mm in size, and the lips were depressed and the anterior region does not have boring tooth. The tail did not have mucron, as the type of Contracaecum A, A'. 7. Contracaecum(Type C') larva: The worm was 10.2∼14.8mm and 0.15∼0.22mm in size, and had boring tooth as the type of Contracaecum A, A' and C. The tail was 0.08∼0.09mm and relatively short. In addition, it did not have mucron at its terminal portion. 8. Contracaecum (Type D) larva: The worm was 12.0∼19.8mm and 0.16∼0.25mm in size, and had boring tooth as the type of Contracaecum C'. The tail was 0.11∼0.16 and had small mucron at its terminal portion. 9. Contrecaecum (Type D') larva: The worm was 7.10∼16.5mm and 0.14∼0.25mm in size, and had boring tooth as the type of Contracaecum C' and D. The tail was 0.11∼0.16mm, and covered with sheath, as the type of Contracaecum D but did not have a mucron.

흰쥐 腦의 中心扁桃核에서의 Substance P 및 Enkephalin 함유구조의 형태학적 특징

마도훈,조희중,김은희,박매자,배용철,홍해숙,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.4

흰쥐 뇌의 중심편도핵에서의 substance P (SP) 및 Enkephalin (ENK) 함유신경세포 및 축삭종말의 분포를 관찰하기 위하여 peroxidase antiperoxidase법을 행하여 다음의 결과를 얻을 수 있었다. SP함유신경세포는 중심편도핵의 medial zone에 분포하였고 SP함유축삭종말은 lateral capsular zone에서 고밀도로 관찰되었다. SP함유신경세포는 원형 내지는 타원형이었고 2∼3개의 근위수상돌기(proximal dendrite)를 가졌다. ENK함유신경세포 및 축삭종말은 공히 central 및 lateral capsular zone에 존재하였다. ENK함유 신경세포는 직경이 약 17-24㎛ 정도였고 3∼4개의 근위수상돌기를 관찰할 수 있었다. The central amygdaloid nucleus is rich in a number of neuropoptides. The present study examines the distribution and morphological characteristics of substance P (SP) and leucine-enkephalin (ENK) containing neurons in this nucleus. The results obtained were as follows: SP immunoreactive cells were observed within the medial zone and SP immunoreactive axon terminals were heaviest within the lateral capsular zone. The immunoreactive cells were round or oval shape (diameter, 15-20㎛) and had two or three proximal dendrites. ENK immunoreactive cells and axon terminals located within central and capsular zones. The immunoreactive cells were round or oval shape (diameter, 17-24㎛) and had three or four proximal dendrites.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

탐촉자 시스템의 처짐과 응력해석

공용식,류봉조,정훈택,박홍원 한밭대학교 생산기반기술연구소 2001 생산기반기술연구소 논문집 Vol.1 No.1

This paper deals with stress analysis and deflections for probe stage systems connected to semi-conductor apparatus. Most of the real probe stage systems are composed of three mechanical parts such as slider, X-base and Y-base. In order to calculate the maximum stress and deflection for probe stage systems, three-dimensional finite element model is applied. Numerical results are obtained by changing various design parameters related to the above three parts. Through the numerical simulation, optimal design shape satisfying von Mises yield criterion is presented. The analysis was performed by using commercial COSMOS/M FEA code.

돼지고기육종의 방사선 유래 휘발성 물질 분석

차용준,박지영,김훈,김소정,정연정,소양순,유영재 창원대학교 생활과학연구소 2000 생활과학연구 Vol.4 No.-

Bacillus cereus KCTC 3674 produced at least two kinds of extracellular proteases. Two major bands of the protease activity with molecular weights of approximately 100 and 38 kDa were obtained after gelatin-SDS-PAGE. The production of extracellular proteases occurred during the logarithmic growth phase and was greatest when cultures reached the stationary growth phase. On the other hand, the growth of B. cereus KCTC 3674 and the production of its extracellular proteases were severely inhibited by the addition of protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP). Thus, it was concluded that the growth of B. cereus KCTC 3674 and the production of its extracellular pretenses were strongly affected by a H+ electrochemical potential.