http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
Serologic Monitoring of Cervical Cancers Using in vitro Translated HPV Proteins
Chee, Yong-Hun,Park, Jong-Sup,Kim, Dae-Hoon,Namkoong, Seung-Eun,Kim, Seung-Jo 가톨릭중앙의료원 가톨릭암센터 1994 암심포지움 Vol.- No.1
Antibodies to E6 and E7 proteins, the transforming proteins of oncogenic HPVs, and L1, the capsid protein of HPVs, are strongly associated with the risk of cervical cancer. In radioimmunoprecipitation assay with in vitro transcripted and translated HPV 16 E6 and E7, patients with HPV-16 associated invasive cervical cancer(group I) had a greater seroreactivity than all other groups which included patients with invasive cervical cancer patients other HPVs(group Ⅲ), HPV-16-associated cervical intraepithelial neoplasia(group Ⅳ), and unaffected controls(group Ⅴ). A larger proportion of group I sera, as compared to sera of all other groups, was reactive with at least one protein(66.7% vs 0.0-25%) and with two proteins (22.2% vs 0.0%). In contrast with the cases of E6 and E7 protein, in the assay with L1 protein, patients with HPV-associated invasive cervical cancer(group Ⅰ and Ⅱ) had a greater seroreactivity than other groups(group Ⅲ, Ⅳ and Ⅴ)(25.0% vs 0.0-10.0%). Although significant differences in reactivity to E6, E7 and L1 protein across stages of cervical cancer were limited, increasing proportions of positivity to HPV E6 and E7 with stage of disease was demonstrated. The prevalence E6 positive sera was 0.0, 0.33, 0.35, and 0.56, and E7 was 0.0, 0.06, 0.25 and 0.44, and L1 was 0.0, 0.26, 0.14 and 0.31 for stages CIN through stage Ⅱb respectively. E6 seroreactivity was lower in case with CIN than in cases with stage Ⅰ to Ⅱb and E7 seroreactivity was higher in cases with stage Ⅱa and Ⅱb than in cases with CIN and stage Ⅰ. To examine whether antibody titres change after diagnosis and treatment and correlate the progression of disease, we tested serial serum samples from 14 patients of group Ⅰ, the positive levels of E7 antibody were decreased when treatment was effective but in a patient showing reccurence, positive seroreactivity was maintained. Antibodies to HPV-16 E6, E7 and L1 proteins appear to be virus-specific and disease state-specific markers of HPV-associated cervical cancer.
Relative Bioavailability of Coenzyme Q10 in Emulsion and Liposome Formulations
( Chee Ho Choi ),( Si Hun Kim ),( Srinivasan Shanmugam ),( Rengarajan Baskaran ),( Jeong Sook Park ),( Chul Soon Yong ),( Han Gon Choi ),( Bong Kyu Yoo ),( Kun Han ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.1
A Research of Digital Interaction Mode for Element of Paper-cut
악소령(Xiaoling Yue),이동훈(Dong-Hun Lee),김치용(Chee-Yong Kim) 한국멀티미디어학회 2006 한국멀티미디어학회 학술발표논문집 Vol.2006 No.1
Our society environments have been changed in radically by the reason of appearance of digital media. With the swift renewal of digital technology at present, the preservation and inheriting of traditional culture especially Paper-cuts became more and more necessary, even stringency. Pluralistic visual conception hints that new visual communication mode will break the limitation and the mode of traditional paper cuts. The great compatibility of digital network media makes paper-cut art a medium that can fuse various disciplines and unexampled transmission platform. The technology of HCI or o ther interaction methods make it possible to develop paper-cut art content in new form or new model. Under such background, the Interactive Visual paper cuts platform adds contemporary factors into the traditional paper cuts concept and extends its domination. So, Traditional paper-cut art can be imported in cyberspace, more users can get the chance of be concerned with this events, experience more suitable and more meaningful interaction control of this valuable Art.