골반경수술 146예에 대한 임상적 고찰

나준희,김용만,남주현,김영탁,김종혁,목정은 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.2

Pelviscopic surgery has been reported to have minimal tissue damage and bleeding, and to reduce cost and recovery time for patients undergoing a variety of procedures. The field of gynecologic operations that can be performed by pelviscopic procedures has expanded rapidly. This report is a retrospective review of 146 cases of pelviscopic surgery from January, 1991 to February 1996 to evaluate the efficacy of pelviscopic surgery in gynecologic patients. The results of this review were summarized as follows; 1. The majority of patients was between 21 and 40 years of age(84.2%), mean age was 33.1 years. 2. Preoperative clinical indications were adnexal mass 77 cases(52.7%), ectopic pregnancy 48 cases(33.9%), uterine myoma 9 cases(6.2%), and etc. 3. Types of surgery were salpingectomy 43 cases(29.5%), salpingoophorectomy 41cases(28.1%), LAVH 9 cases(6.2%) and etc. 4. The previous operation history was found in 34 cases(23.3%), and the type of previous operation were Cesarean section 11 cases(32.4%), appendectomy 10 cases(29.4%), and there were 5 cases of previous history of ectopic pregnancy. 5. The mean duration of hospitalization was 5.8 days.

뇌손상 후 인지기능장애에 대한 메칠페니데이트의 효과-이중맹검 위약대조 연구-

김연희,나승용,신용일,서정환 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

고산에서 측정한 PM_(2.5) 이온 농도 특성 : 1998~2002년 측정자료 Measurement Data between 1998 and 2002

김나경,김용표,강창회,문길주 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.3

The aerosol ionic composition of PM2.5 measured at Gosan, Jeju Island, Korea, for years between March 1998 and February 2002 are presented and discussed. The annual mean concentration of non-sea-salt sulfate(nss-SO₄²^(-)) and ammonium(NH₄+) ions are high (0.094 μeq/m³ and 0.085μeq/m³, respectively). Also, nss-SO₄²^(-) and NH₄^(+) show high correlation(0.892). The concentrations of most ions are high in springtime. As the result of factor analysis, Gosan area mainly affected by sea-salt, anthropogenic species, and crustal species.

사람 Adenylate Kinase 1의 p-Loop부위에 위치한 Serine^(19) 잔기의 돌연변이에 의한 구조 활정 상관관계

문재희,이한나,류용구,김효준 한양대학교 이학기술연구소 2007 이학기술논문지 Vol.10 No.-

Adenylate kinase (AK)는 모든 세포에 존재하는 에너지대사에 관련하는 효소로서 short form과 long form의 두 종류의 isoform으로 분류된다. 포유류 세포의 세포질에 존재하는 short form은 높은 효소 활성(1,800 U/mg)을 나타내며, 전핵생물이나 미토콘드리아에 존재하는 long form은 매우 낮은 활성(200 U/mg)을 나타낸다. 한편, 박테리아인 Mycobacterium tuberculosis의 AK(AKmt)는 구조적으로는 진핵세포와 같은 short form이지만, 활성은 long form의 전형적인 낮은 활성을 갖고 있는 것으로 밝혀졌다. 본 연구에서 사람의AK1(hAK1)과 AKmt의 효소의 촉매활성에 중요한 부위인 P-loop의 아미노산 서열 중 활성이 높은 isoform과 활성이 낮은 isoform에서 serine(Ser^(19)hAK1)과 alanine(Ala^(11)AKmt)으로 각각의 보존성이 상이하여 이 부분이 효소 활성에 미치는 영향을 분석하였다. 부위지정 돌연변이법을 이용하여 hAK1의 19번째 Ser을 Ala으로 치환시킨 돌연변이체(S19AhAK1)를 작성하여 hAK1 및 AKmt간의 활성 및 기질 친화도를 반응속도론적으로 비교한 결과 S19AhAK1의 활성은 450 U/mg으로 AKmt 수준으로 낮아졌으나, 기질 친화도인 Km 값은 ATP 및 AMP에 대하여 큰 변화를 보이지 않았다. 이로서 P-loop의 serine은 side chain의 polarity를 통해 phosphoryl-transfer의 촉매능을 촉진하고 있음을 확인하였다. Adenylate kinase (AK) is a ubiquitous enzyme which related with the energy metabolism in living cells. AK has two kinds of isoforms: short form and long form. Generally the short form has high enzymatic activity (1800 U/mg) and exists in eukaryotic cytosol, while long form has low activity (200 U/mg) and exists in mitochondria and bacteria. Interestingly, AK from Mycobacterium tuberculosis (AKmt) belongs to the short form isozyme, but catalytic activity is as low as that of bacterial long forms'. To characterize this discrepancy, we shed light on the conserved residues in the p-loop of the enzyme. In the flexible P-loop of AK, serine is conserved in high-activity isozymes and alanine is conserved in low-activity isozymes, respectively. Ser^(19) of high activity hAK1 is replaced by Ala at P-loop in low activity AKmt. We substituted Ala for Ser^(19) in hAK1 by site-directed mutagenesis to get a mutant enzyme, S19AhAK1. Enzyme activity of S19AhAK1 was greatly reduced to 450 U/mg, as expected. However, minor changes in Km values for both of ATP and AMP were detected. In condusion, the serine^(19) in hAKl enhances the phosphoryl-transfer catalysis but not in substrate binding, by utilizing the polarity in p-loop environment.

클랩(Clap)과 노말(Normal) 스케이트 착용에 따른 남ㆍ여 스피드 스케이트 출발 구간의 운동학적 분석

윤희중,나윤수,최재용,김태삼 한국체육대학교 체육과학연구소 2000 韓國體育大學校附屬 體育科學硏究所論文集 Vol.19 No.1

The purpose of this study is to examine the kinematic characteristics of starting phase of players weared clap and normal skate in speed skating. The subjects of this study were current members of high ranked skaters in university. The Direct Linear Transformation(DLT) technique was employed to obtain 3-D position coordination of 22 joint points. Butter-worth low-pass filtering method was used to data smoothing at cut-off frequency of 7.4Hz. From the results of this study, the following conclusions were drawn; 1.At the of landing, male athlete showed slightly fast time in the first left-step and they also showed take-off by fast swing motion during gliding. 2.To get propel acceleration, female athlete showed large tranverse displacement and, on the other hand, male athlete showed large horizontal displacement. According to this results, COG showed steep change of motion in the high position during starting. 3.In the velocity of COG, both male an female athlete show a gradual rise-pattern of the velocity rate, In the velocity of skate front blade, they showed the swift change of the velocity during the second and third phase. 4.In the front angle of trunk, both and female athlete showed the big motion of trunk by the change of angle. In the angle of lower-segments, the better record athlete have, the faster motion of flexion and extention. Especially, female athlete showed the flexion of the angle-change and do not fast swing. In the knee, male athlete show take-off motion as increasing angle of left knee during starting, On the other hand, female athlete showed unnecessary pre-motion by decreasing knee angle and increasing it again.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

선천성 발진성 연모 낭종 1예

이나영,김지숙,최유원,황규광,함정희 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3

An eruptive vellus hair cyst is an uncommon, benign, epithelial tumor with hair differentiation. Clinically, it presents as asymptomatic, flesh-colored to yellowish, follicular papules, 1 to 4 ㎜ in diameter, most commonly on the chest. It is usually sen in children and young adults but may be congenital. Histologically, it shows a middermal cyst lined by squamous epithelium containing keratinous material and vellus hairs. It has a tendency to clear spontaneously but may be persistent. We report a case of congenital eruptive vellus hair cyst in an 11-year-old girl who presented multiple pinhead-sized brown to black papules on her anterior chest since birth. (Korean J Dermatol 2004;42(3):362~363)

위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.

HPLC를 이용한 고추의 품종별 Capsaicin 및 Dihydrocapsaicin 성분의 함량 분석

맹주양;이용구;이숙재;정진아;나성희;김창원;심혜진 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

Five kinds of Korean red pepper-pinkish, perfect, cucumber, blue, and ground cherry-were used, respectively, to analyze the contents of Capsaicin and Dihydrocapsaicin. The comparative analysis was performed separately in the seed removed red pepper and the seed included red pepper by HPLC. Among the seed removed pepper, the results for the content of Capsaicin were shown as follows: ground cherry(2204.0ppm) > pinkish(1324.9ppm) > blue(906.7ppm) > cucumber (77.2ppm) > perfect(12.9ppm), and the results for the content of Dihydrocapsaicin were shown as follows: ground cherry (1004.8ppm) > pinkish(248.3ppm) > blue(165.7ppm) > cucumber(13.9ppm) > perfect(0.0ppm). Among the seed included red pepper, the results for the content of Capsaicin were shown as follows: ground cherry(2190.lppm) > pinkish(1324.4ppm) > blue (919.9ppm) > cucumber(79.5ppm) > perfect(11.7ppm), and the results for the content of Dihydrocapsaicin were shown as follows: ground cherry(1017.4ppm) > pinkish(270.6ppm) > blue(189.0ppm) > cucumber(39.4ppm) > perfect(0.0ppm). Overall results suggest that in the contents of Capsaicin and Dihydrocapsaicin, the seed removed pepper and the seed included red pepper both were decreased in the order of ground cherry > pinkish > blue > cucumber > perfect, and this order is proportional to the strength of hot taste of red pepper.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.