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Choi, Yeong-Gon,Lim, Sabina Taylor Francis 2009 JOURNAL OF IMMUNOASSAY AND IMMUNOCHEMISTRY Vol.30 No.4
<P> N&epsis;-(carboxymethyl)lysine (CML) and N&epsis;-(carboxyethyl)lysine (CEL) termed advanced glycation end products (AGEs) are known to be produced by nonenzymatic glycation between bovine serum albumin (BSA) and D-glucose. This study is to characterize the immunoreactivity of anti-AGE antibodies including anti-CML and anti-CEL antibodies. Using AGE-modified BSA (AGE-BSA) as an immunogen, a polyclonal anti-AGE immunoglobulin G (IgG) was produced. The anti-AGE IgG could strongly detect AGEs formed on BSA, at least in part, AGEs produced on both residues Lys and Arg due to its immunoreaction with Lys-derived and Arg-derived AGEs produced by NaCNBH3, a reducing agent, in amino acid glycation analysis, but the pre-immune serum could not. As the anti-CML antibody could also strongly react with AGE-BSA, this suggests that CML is a major nonenzymatically glycated product cross-linked to BSA. Furthermore, CEL is associated with distinguishable polymerization of BSA from CML polymerization of BSA, though weaker than CML and was not produced by Lys glycation analysis. These results indicate that the anti-AGE antibody is effective for detecting both Lys-derived and Arg-derived AGEs, and CML and CEL distinctively polymerize albumin as major AGEs present on AGE-BSA.</P>
Preparation and Properties of Polypropylene/Thermoplastic Polyester Elastomer Blends
Yeong Gon Kim(김영곤),Yeongseon Kim(김영선),Jin Kyu Choi(최진규),Sung-Hyeon Baeck(백성현),Sang Eun Shim(심상은) 한국고분자학회 2017 폴리머 Vol.41 No.3
폴리프로필렌/열가소성 폴리에스터 엘라스토머(PP/TPEE) 블렌드를 제조하였다. 두 상의 상용성을 증가시키기 위하여 maleic anhydride-grafted polypropylene(MA-g-PP)를 배합 도중 첨가하였다. SEM을 통한 모폴로지 분석결과, 두 상은 상용성이 없었으며 MA-g-PP를 첨가한 결과 상용성이 발현되어 MA-g-PP가 효과적인 상용화제로 작용하였다. MA-g-PP를 첨가한 PP/TPEE 블렌드는 XRD 분석 결과 20.9° 피크의 강도가 증가하였으며 21.6° 피크는 점차적으로 감소하였다. 상용화제가 첨가된 경우의 기계적 물성 증가는 SEM 및 XRD의 분석 결과와 부합하였다. DSC 분석 결과, TPEE의 함량이 증가할수록 결정화도가 감소하였으며 MA-g-PP가 첨가된 경우 상용성으로 인하여 단일의 유리전이온도가 관찰되었으며 열적 안정성이 증가되었다. Polypropylene (PP)/thermoplastic polyester elastomer (TPEE) blends were prepared. To enhance the compatibility between the two phases, maleic anhydride-grafted polypropylene (MA-g-PP) was applied during melt-mixing. The morphology obtained from scanning electron microscopy (SEM) showed that TPEE was not miscible with PP, however, those of the PP/TPEE/MA-g-PP indicated that PP and TPEE turned to miscible because MA-g-PP served as an effective compatibilizer. The tensile tests confirmed that the tensile strength of the PP/TPEE blends decreased and the elongation increased with increasing TPEE content. The increase in tensile strength of the PP/TPEE/MA-g-PP blends was associated with the morphology shown by SEM and internal structure. X-ray diffraction (XRD) confirmed that compared to the PP/TPEE blend, the intensity of the 20.9° peak of the PP/TPEE/MA-g-PP increased and that of the 21.6° peak decreased gradually due to the MA-g-PP. In differential scanning calorimetry (DSC), the crystallinity (Xc) of the PP/TPEE blends decreased with increasing TPEE content. The PP/TPEE/MA-g-PP blends showed a single weak glass transition (Tg) peak due to the compatibility between the PP and TPEE. The thermal stability of the PP/TPEE blends with MAg-PP was also higher than that of the PP/TPEE.
실시간 산사태 모니터링 및 탐지기술에 대한 비즈니스 생태계 기반 기술사업화 전략 연구
송영화 ( Yeong Wha Sawng ),임동현 ( Dong Hyun Lim ),채병곤 ( Byung Gon Chae ),최정해 ( Junghae Choi ) 대한지질공학회 2016 지질공학 Vol.26 No.2
본 연구는 실시간 산사태 모니터링 및 탐지기술에 대한 기술사업화 전략 수립을 목적으로 수행되었다. 해당 기술의 가치를 극대화하고 성공적인 기술사업화 전략 도출을 위해 정성·정량적 방법을 활용하여 통합적인 분석을 수행하였다. 정성적 방법 으로 해당 기술의 비즈니스 생태계를 분석하였고, 정량적 방법으로는 관련 특허를 수집하여 주요 출원인과 핵심기술 간 구 를 가시화하였다. 통합적 분석으로는 정성적 및 정량적 분석 각각의 결과를 비즈니스 생태계 관점에서 통합 표시하여 실시간 사 태 모니터링 및 탐지기술의 세부 생태계 영역과 기술의 발전강도 및 현황을 분석하였다. 분석 결과, 비즈니스 생태계 내 보완 재 영역의 기술이 발전정도가 높고 관련 주체의 수가 가장 많은 것으로 분석되었으며, 이를 토대로 기술사업화 선순환 시스템 구축을 사업화 전략으로 제시하였다. 기술사업화 선순환 시스템 구축을 위한 세부 전략으로 보완자산을 활용한 기술수요자 탐 색과 탐색된 기술수요자를 중심으로 한 기술 예고제를 제시하였다. 도출한 사업화 전략을 활용하여 기술 및 시장의 불확실 이 높은 해당 기술의 사업화 성공가능성을 제고함과 동시에 기술공급자와 기술수요자 간의 연계를 강화하여, 장기적으로 지속 인 경제적 성과를 창출할 것으로 기대된다. This study establishes a commercialization strategy for technology that can monitor and detect landslides in real time. An effective commercialization strategy was sought through both qualitative and quantitative analyses. The qualitative analysis considered the business environment in detail, while the quantitative analysis examined technologically strong and weak areas by visualizing the links between IPC (International Patent Classification) code structure and patent applicants. The results from both analyses are considered together, with particular attention paid to the business environment. The resulting integrated analysis comprehensively explores the degree of technological development and the current state of real-time monitoring and detection technology for landslides. The integrated analysis identified complementary assets in the business environment, as there is strong development and many research entities in this area. This suggests positive reinforcement for commercialization with two sub strategies: (1) exploring demand with complementary assets, and (2) providing technology information for explored demand, which should facilitate successful commercialization. Exploiting this positive reinforcement for technology commercialization could reduce the high uncertainty of the technology and the market, and thus increase the probability of successful commercialization. It is also expected to contribute to long-term success by strengthening collaboration between the supply and demand sides.