노년여성의 귀환과 탈가부장제의 징후들

김경연 ( Kim Kyung-yeon ) 민족어문학회 2018 어문논집 Vol.- No.82

이 글은 청년을 인간의 표준으로 결정하고 미개인, 광인, 여성과 더불어 노인을 비인간으로 축출한 근대 휴머니즘의 폭력적 메커니즘에 주목하면서, 젠더적 관점에서 노년을 재독하고자 했다. 젠더·인종·계층/계급에 따라 노년을 살아가는 경험은 다르며, 때문에 이러한 차이를 간과한 노년 연구란 부분적이며 추상적일 수밖에 없다. 노년을 젠더의 관점에서 읽어야 하는 이유도 여기에 있다. 가부장적 자본주의 체제를 살아온/가는 노년여성들의 삶이 남성노년들과 같을 수 없으며, 중산층 여성노인과 가난한 박카스 할머니의 현실이, 혹은 칠십의 나이에 일본군 위안부였다는 사실을 증언한 김학순이나 밀양 송전탑 투쟁의 최전선에 서는 여든 일곱 김말해의 노년이 침묵하는 노년여성들의 삶과 같을 수는 없다. 이 같은 복수의 노년여성들의 실존을 상기하면서 본고는 노년의 여성들을 재현하는 여성서사에 주목했다. 남성중심적인 문학의 주변부에서 거대/주류 서사가 누락하거나 은폐한 여성/타자들의 삶을 미시적으로 천착한/하고자한 것이 여성문학이라면, 노년여성의 억압, 침묵, 분투를 가시화한 여성서사를 통해 가부장적 자본주의 체제를 이반하는 노년여성의 재현 가능성을 탐사해 보는 일은 유의미할 것이다. 이를 위해 먼저 노년여성들의 삶을 기록/재현한 서사물의 계보들, 특히 청년의 시대였던 근대의 여성문학 속에서 여성노인들이 재현되는 양상에 주목하였다 전통적인 가부장제와 대결하면서. 새로운 집의 발명을 열망했던 근대 청년여자들의 서사는 근대가 배제하거나 누락한 노년여성의 삶을 가시화하는 한편, 전근대 가부장들이 상상한 ‘헌신적인 어머니’와 근대 청년들이 매도한 ‘혐오스러운 노파’와는 변별되는 이질적인 어머니/할머니들을 조형했다. 그러나 이 차별화된 재현에도 불구하고, 문학을 통한 근대적 가치의 전파가 신여성 작가들의 욕망이자 사명인 이상 노년여성들의 삶을 부조한 경우는 드물었으며, 더구나 어머니/할머니라는 젠더 역할을 국한되지 않는 개별적 욕구를 지닌 인간으로서 노년여성의 삶을 천착한 경우는 거의 부재했다. 그렇다면 근대의 황혼이 도래하고 전지구적 노후의 시간을 살고 있는 지금 이곳의 여성작가들은 다시 노년과 젠더의 문제를 어떻게 사유하고 있을까. 이 글은 근대 청년여자의 서사에 이어 신경숙, 김숨, 권여선 등 87년 이후 집의 혁명을 추동하고 자본주의 가부장제의전복을 열망했던 이른바386세대 계보의 여성작가들의 소설 속에서 노년여성의 삶이 재현되는 양상을 살폈다. 그들이 다시 쓰는 늙은 여자들의 이야기 속에서 가부장제가 발명한 숭고한 어머니/할머니는 더 이상 매끄럽게 관철되지 않는다. 어머니/할머니가 아닌 단지 ‘이모’로 늙어가는 「이모」 (권여선)의 ‘윤경호’는 물론이고, 어머니/할머니라는 젠더호명에 복종하며 살아왔던 『엄마를 부탁해』 (신경숙)의 ‘박소녀『’나 여인들과 진화하는 적들』 (김숨)의 ‘정순자’ 역시 더 이상 “길들여진 좌절의 협조자”로 남지 않는다. 실종을 빌어 가부장의 집으로부터 탈주하고(박소녀), 자기를 멸함으로써 모성으로부터 해방되고자 하며(정순자), 가족/세상과 절연하고 고유한 ‘나’로 말년을 살아가는(윤경호) 그들은 세상과 화해하기보다 불화하며 가부장제가 가공한 사랑과 행복의 집에 은폐되었던 폭력과 슬픔을 적발하는 불길하고 불온한 모성/여성이 된다. 집/친밀성의 오랜 수호자였던 이들 늙어가는 여자들을 통해서 아이러니하게도 친밀성의 판타지는 내파되는 것이다. This paper aimed to reperuse the elderly life from gender perspective, while paying attention to the violent mechanism of modern humanism that defined youth as the human standard and inhumanely ousted the elderly in the same way as barbarians, madmen and women. The experience of the elderly life varies among different genders, ethnicities and social classes. For this reason, studies on the elderly life that overlook such differences are partial and abstract. This is the very reason why the elderly life must be interpreted from gender perspective. Lives of elderly women who lived or are living in patriarchal capitalism cannot be identical to lives of elderly men. The reality of an elderly middle class woman cannot be the same as the reality faced by a poor elderly prostitute. Recalling the existence of such diverse lives of elderly women, this paper focused on the female narratives reproducing elderly women. If women’s literature attempted to inquire microscopic lives of women or the others either omitted or concealed by the major or mainstream narratives in the peripherals of the male-centered literary world, it would be a meaningful effort to explore the reproducibility of elderly women deserting from the patriarchal capitalism through the female narratives that visualize the oppression, silence and struggle of elderly women. As a part of such effort, the author of this study examined the genealogy of narrative works that recorded or reproduced lives of elderly women, especially the ways in which elderly women were reproduced in modern women’s literature from the era of youth. Narratives of young modern women who longed for new finding of home and confronted the traditional patriarchy visualized lives of elderly women either excluded or omitted by the modern world, while on the other hand shaping new mothers and grandmothers who are differentiated from ‘devoted mothers’ imagined by the pre-modern patriarchs and ‘hateful old women’ denounced by modern youths. Despite such differentiated reproduction, it was rare to find works that depicted lives of elderly women because the desire and mission of modern female authors were to spread modern values through literature. Furthermore, there was almost complete absence of works that viewed lives of elderly women as human beings with their own needs instead of constraining them to the gender role of a mother or grandmother. As the entire world is welcoming the dusk of the modern era with global aging, how are female authors of the contemporary world dealing with the elderly and gender issues? This paper examined the ways in which lives of elderly women were reproduced in novels written by female authors of the so-called 386 generation who drove household revolution and wished for overturn of the patriarchal capitalism since 1987, such as Kyung-sook Shin, Soom Kim and Yeo-sun Kwon. In the midst of their stories about old women, the noble mothers and grandmothers invented by patriarchy are no longer found to be a matter of course. ‘Gyeong-ho Yoon’ in “Aunt” (Yeo-sun Kwon) simply grows old as an aunt instead of a mother or grandmother. ‘So-nyeo Park’ in “Please Look After Mon” (Kyung-sook Shin) yields to the gender-bound nicknames like mother and grandmother. ‘Soon-ja Jeong’ in “Women and Their Evolving Enemies” (Soom Kim) no longer remains to be a tamed helper of frustration. She runs away from patriarchal home as if she has gone missing (So-nyeo Park), she tries to be freed from maternity by destroying her existence (Soon-ja Jeong) and she lives an independent elderly life isolated from her family and the world (Gyeong-ho Yoon). These figures become unfortunate and rebellious mothers or women who confront the world instead of reconciling with it, revealing the violence and sorrow concealed underneath fake love and happiness created by patriarchy. The fantasy of intimacy is ironically imploded by these aging women, who have long been the guardians of their home and intimacy.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

중합효소연쇄반응을 통해 확진되고 Atovaquone과 Azithromycin으로 치료한 Human Babesiosis 1예

윤기태,김연아,구남수,김준형,정세진,김홍정,송경호,최유경,신소연,김영근,김명수,박윤선,최준용,송영구,김준명 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

저자들은 국내에서 처음으로 중합효소연쇄반응 검사를 통하여 B. microti에 의한 인체 바베시오시를 진단하였으며, atovaquone과 azithromycin 병합요법을 사용하여 치유한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Human babesiosis is a tick-borne infectious disease caused by Babesia species. The clinical diagnosis is difficult because of nonspecific symptoms like flu. Rapid diagnosis of human babesiosis is microscopic examination in peripheral blood smear (Giemsa-stain) which reveals characteristic forms of an intracellular quadruplet parasite. But differentiation between Babesia microti and Plasmodium species can be quite difficult because of the morphologic similarity. We experienced a case of human babesiosis. The patient was a 62-year old Korean male who had been in New Jersey, U.S.A for 2 months. We initially diagnosed as malaria infection because the peripheral blood smear revealed intracellular single ring form organism. But the patient was not improved significantly by the treatment with chloroquine regimen. Finally we confirmed human babesiosis by polymerase chain reaction for Babesia microti. We treated the patient successfully with a regimen of atovaquone and azithromycin which has fewer adverse reactions than a regimen of clindamycin and quinine.

Clostridium difficile에 의한 설사의 예후인자

김준형,김희정,구남수,김영근,최준용,신소연,박윤선,김연아,김명수,정수진,최희경,송영구,이경원,김준명 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

배경 : Clostridium difficile에 의한 설사(Clostridium difficile associated diarrhea; CDAD)는 임상 경과가 다양하다. 최근에 유럽과 북미에서 C. difficile 감염의 발생률이 증가하고 고전적 치료에 잘 반응하지 않으며 이환률이 증가하였고, 이러한 원인이 새로운 균주의 탄생에 기인한다고 보고되었다. CDAD의 예후에 영향을 미치는 세균성 요인과 숙주 요인을 확인하기 위해 본 연구를 진행하였다. 재료 및 방법 : 2002년 8월부터 2003년 12월까지 CDAD가 진단된 20세 이상인 환자들을 대상으로 후향적 Cohort 연구를 하였다. 세균성 요인을 확인하기 위해 cdt A, cdtB, tcd A, tcd A rep 그리고 tcd B 유전자(binary toxin)를 확인하였다. 설사가 치료 시작 후 11일 이상 지속되거나, 2달 이내에 재발하거나, 수술 혹은 다른 시술이 필요한 경우, 사망한 경우 예후가 좋지 않은 것으로 정의하였다. 결과 : 총 115예에서 toxin을 생성하는 C. difficile가 동정되었으며, Toxin A와 toxin B 모두 양성인 균이 91예, toxin B만 양성인 균이 24예였다. Toxin A 생성 여부가 예후에 영향을 미치지 않았지만, 제산제를 사용한 환자에서 그렇지 않은 환자에 비해 toxin B만 양성인 균이 많이 동정되었다(P<0.05). 예후가 좋지 않은 경우는 39예(33.9%)였고 76예(66.1%)에서 예후는 양호하였다. 단변량 분석에서 70세 이상의 고령, 남성, 증상 발현 후 사용한 항생제의 개수 사용, 증상 발현 후 carbapenem, aminoglycoside, glycopeptide 사용, 당뇨 및 뇌졸중 병력이 있는 경우, 그리고 높은 Charlson index가 불량한 예후 인자로 확인되었다. 그러나 독립적인 예후 인자를 조사했을 때에는70세 이상의 고령(odds ratio=3.378, P=0.009), 증상 발현후 carbapenem 사용(odds ratio 7.210, P<0.001)이 예후에 중요한 영향을 미치는 요소로 확인되었다. 결론 : 70세 이상의 고령과 증상 발현 후 carbapenem 사용이 CDAD 독립적인 불량한 예후인자이다. Background : Clostridium difficile associated diarrhea (CDAD) has a wide range of clinical manifestations. The prognostic factors of CDAD are not fully understood. Materialsand Methods : A retrospective cohort study of 115 patients with CDAD from Aug. 2002 to Dec. 2003 was conducted to evaluate prognostic factors of CDAD. Bacteriologic factors were determined by detecting the binary toxin gene, tcd A, tcd A rep and tcd B gene. Poor prognosis was defined as diarrhea more than 10 days even with classic treatment, recurrence, death, and moribund discharge. Results : Approximately 79% of isolated strains were toxin A+/B+ strains and 21% were toxin A-/B+ strains. There was no difference in prognosis between toxin A+ and toxin A- strains. 39 (33.9%) cases showed poor prognosis and 76 (66.1%) cases showed good prognosis. Univariate analyses revealed that the poor prognostic factors were old age over 70 years old, male, the number of antibiotics used after onset of symptom, the administration of carbapenems, aminoglycosides, glycopeptides after onset of symptom, history of DM and stroke, and high Charlson comorbidity index. Multiple logistic regression analysis identified old age over 70 years old (odds ratio=3.378, P=0.009) and the administration of carbapenems after onset of symptom (odds ratio 7.210, P<0.001) as the independent poor prognostic factors. Conclusion : Old age over 70 and the administration of carbapenems after onset of symptom were the poor prognostic factors for CDAD caused by none-binary toxin producing strains.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

FDTD Modeling for the Accurate Electromagnetic Wave Analysis of Graphene

Yeon‑Hwa Kim,Hongjin Choi,Jeahoon Cho,Kyung‑Young Jung 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

We develop a fnite-diference time-domain (FDTD) method suitable for the electromagnetic (EM) analysis of graphene. In this work, we employ the modifed Lorentz model for dispersion modeling, the two-dimensional (2-D) sheet model for geometrical modeling, and the complex-frequency-shifted (CFS)-perfectly matched layer (PML) for the absorbing boundary condition. In specifc, the accurate complex-conjugate pole-residue (CCPR) dispersion model is frst adapted for the electrical modeling of graphene by using the robust vector ftting. Next, the CCPR parameters are converted to the modifed Lorentz parameters and then the modifed Lorentz-based dispersive FDTD formulation is used to enhance the computational efciency. In FDTD cell modeling, the 2-D sheet cells are allocated for graphene rather than the conventional FDTD cell-based modeling. Finally, CFS-PML are employed for terminating the computational domain to avoid the late-time instability. The presented FDTD approach is validated in numerical examples for graphene-based parallel plate waveguides.

민들레 추출액 농도에 따른 민들레 코팅쌀밥의 품질에 관한 연구

유경미,이연경,김세희,황인경,이부용,김성수,홍희도,김영찬 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1

Washed rice was coated by spraying aqueous dandelion (Taraxacum officinale) extracts at 20, 30, 40 'Brix and dried at room temperature. The coating procedure was conducted 5 mL/min for 10min. Property changes in the dandelion coated rice and un-coated cooked rice were observed during 2 days of storage. Increasing the coating concentration was associated with lower color values (L, a value) and moisture contents. Sensory and texture properties generally decreased in the cooked rice coated with dandelion more than the control (non-coated rice). But, D-20(20 °Brix of the dandelion concentration) resulted in better textural properties and s ensnry scores for hardness and overall acceptability in cooked rice. Compared to the control, the washed rice roated with 20 °Brix for 0 and 2 days showed better quality in sensory activities, a lower gel consistency and better textural activities. It was concluded that the optimum coating ration of rice and added dandelion extract for cooking were 20 °Brix and 5% respectively, in proportion to the total weight of raw rice.

Medicinal Chemistry : EVALUATION OF CADMIUM-INDUCED NEPHROTOXICITY USING URINARY METABOLOMIC PROFILES IN SPRAGUE-DAWLEY MALE RATS

( Yu Kyung Lee ),( Eun Young Park ),( Shi Won Kim ),( Ji Yeon Son ),( Tae Hyung Kim ),( Won Gu Kang ),( Tae Chun Jeong ),( Kyu Bong Kim ),( Seung Jun Kwack ),( Jae Won Lee ),( Suh Mann Kim ),( Byung M 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-

The aim of this study was to investigate urinary metabolomics profiles associated with cadmium (Cd)-induced nephrotoxicity and their potential mechanisms. Metabolomic profiles were measured by high-resolution 1H-nuclear magnetic resonance (NMR) spectroscopy in the urine of rats after oral exposure to CdCl2 (1, 5, or 25 mg/kg) for 6 wk. The spectral data were further analyzed by a multivariate analysis to identify specific urinary metabolites. Urinary excretion levels of protein biomarkers were also measured and CdCl2 accumulated dose-dependently in the kidney. High-dose (25 mg/kg) CdCl2 exposure significantly increased serum blood urea nitrogen (BUN), but serum creatinine (sCr) levels were unchanged. High-dose CdCl2 (25 mg/kg) exposure also significantly elevated protein-based urinary biomarkers including osteopontin, monocyte chemoattractant protein-1 (MCP-1), kidney injury molecules-1 (Kim-1), and selenium-bingding protein 1 (SBP1) in rat urine. Under these conditions, six urinary metabolites (citarate, serine, 3-hydroxyisovalerate, 4-hydroxyphentllactate, dimethylamine, and betaine) were involved in mitochondrial energy metabolism. In addition, a few number of amino acids such as glycine, glutamate, tyrosine, proline, or phentlalanine and carbohydrate (glucose) were altered in urine afrer CdCl2 exposure. In particular, the metabolites involved in the glutathione biosynthesis pathway, including cysteine, serine, methionine, and glutamate, were markedly decreased compared to the control. Thus, these metabolites are potential biomarkers for detection of Cd-induced nephrotoxicity. Our results further indicate that redox metabolomics pathways may be associated with Cd-mediated chronic kidney injury. These findings provide a biochemical pathway for better understanding of cellulat mechanism underlying Cd-induced renal injury in hunmans.

손마사지가 허혈성 심질환 환자의 불안에 미치는 효과

현경선,이향련,공송심,윤경자,김현섭,김효남,최지원,김운정 성인간호학회 2001 성인간호학회지 Vol.13 No.2

The purpose of this study was to investigate the effect of a hand massage program on anxiety, vital sign and pain in clients with ischemic heart disease. The design utilized for this stuffy was quail-experimental with a nonequivalent control group non-synchronized design The subjects were fifty-four patients, twenty-eight for the experimental and twenty-six for the control group, who were admitted with ischemic heart diease at a cardiac intensive care unfit in K medical center of K university. This study was carried out from May, 1999 to March, 2000. The level of anxiety and pain measured by Visual Analogue Scale, systolic blood pressure, diastolic blood pressure and pulse rate were measured before and after hand massage, the state of Anxiety was measured by the Spielberger (1970) scale at admission and after hand massage for three days. The collected data were processed by using the SPSS PC program and analyzed using χ2-test and t-test. The result of this study are as follows : 1. The scores of VAS anxiety and State of anxiety of the experimental group were lower than those of the control group. 2. The degree of systolic blond pressure, diastolic blood pressure and pulse rate of the experimental group were lower than that of the control group. 3. The score of VAS pain of the experimental group was lower than that of the control group. The results suggested that hand massage can decrease VAS anxiety, State of anxiety, vital signs and VAS pain of patients who were admitted with ischemic heart disease at cardiac intensive care unit Therefore, It Is proposed that hand massage is an appropriate nursing intervention to relieve anxiety of the patients who were admitted with ischemic heart disease at a cardiac intensive care unit.