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Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide
Lee, Byung-Ryong,Lee, Yeom-Pyo,Kim, Dae-Won,Song, Ha-Yong,Yoo, Ki-Yeon,Won, Moo-Ho,Kang, Tae-Cheon,Lee, Kwang-Jae,Kim, Kyung-Hee,Joo, Jin-Ho,Ham, Hun-Ju,Hur, Jang-Hyun,Cho, Sung-Woo,Han, Kyu-Hyung,Lee Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.4
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic ${\beta}$-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic ${\beta}$-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.
Lee, Yeom Pyo,Kim, Dae Won,Kang, Hye Won,Hwang, Jae Hyeok,Jeong, Hoon Jae,Sohn, Eun Jeong,Kim, Mi Jin,Ahn, Eun Hee,Shin, Min Jea,Kim, Duk‐,Soo,Kang, Tae‐,Cheon,Kwon, Oh‐,Shin,Cho, Su Blackwell Publishing Ltd 2012 The FEBS journal Vol.279 No.11
<P>Heat shock proteins (HSPs) are a highly conserved family of proteins that are induced in response to various environmental stressors including reactive oxygen species. HSP27 is a chaperone protein with the ability to increase cell survival in response to oxidative stress. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Although the mechanism of PD remains unclear, oxidative stress is known to be important in its pathogenesis. This study investigated the protective effects of PEP‐1‐HSP27 on neuronal damage induced by 1‐methyl‐4‐phenyl pyridinium (MPP<SUP>+</SUP>) in SH‐SY5Y cells and in a 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced PD mouse model. PEP‐1‐HSP27 rapidly entered the cells and protected them against MPP<SUP>+</SUP>‐induced toxicity by inhibiting the reactive oxygen species levels and DNA fragmentation. Furthermore, transduced PEP‐1‐HSP27 prevented dopaminergic neuronal cell death in the substantia nigra of MPTP‐induced PD mouse models. These results demonstrate that PEP‐1‐HSP27 provides a potential strategy for therapeutic delivery against various diseases and is a potential tool for the treatment of PD.</P>
Erratum to: “Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide”
Lee, Byung Ryong,Lee, Yeom Pyo,Kim, Dae Won,Song, Ha Yong,Yoo, Ki-Yeon,Won, Moo Ho,Kang, Tae-Cheon,Lee, Kwang Jae,Kim, Kyung Hee,Joo, Jin Ho,Ham, Hun Ju,Hur, Jang Hyun,Cho, Sung-Woo,Han, Kyu Hyung,Lee Springer-Verlag 2013 Molecules and cells Vol.36 No.1
Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide
Byung Ryong Lee,김대원,Yeom Pyo Lee,송하용,유기연,원무호,강태천,Kwang Jae Lee,Kyung Hee Kim,주진호,Hun Ju Ham,허장현,조성우,한규형,Kil Soo Lee,박진서,음원식,최수영 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.4
The aim of this study was to investigate the preventive effect of Agrocybe chaxingu polysaccharide on streptozocin (STZ)-induced pancreatic β-cells destruction. Agrocybe chaxingu polysaccharide markedly reduced nitric oxide (NO) production and iNOS expression levels in RINm5F cells in a dose-dependent manner. In addition, Agrocybe chaxingu polysaccharide significantly inhibited iNOS expression and blood glucose levels in STZ-induced diabetic mice. Moreover, immunohistochemical analysis revealed that it enhanced pancreatic β-cells resistance to destruction by STZ. These results suggest that Agrocybe chaxingu polysaccharide may have value as a therapeutic agent against diabetes mellitus.